Abstract:
AIM:To examine the possible effects of honey supplementation on hepatic damage due to obstruction of the common bile duct in an experimental rat model. METHODS:The study was performed with 30 male rats divided into three groups: a sham group, an obstructive jaundice group, and an obstructive jaundice plus honey group. At the end of the study period, the animals were sacrificed, and levels of nitric oxide (NO), and NO synthase (NOS) activities were measured in liver tissues, and levels of adenosine deaminase (ADA) and alanine transaminase (ALT) activities were measured in serum. RESULTS:Blood ALT and ADA activities were significantly elevated in the jaundice group as compared to those of the sham group. In the obstructive jaundice plus honey group, blood ALT and ADA activities were significantly decreased as compared to those of the jaundice group. In erythrocytes and liver tissues, NO levels were found to be significantly higher in the obstructive jaundice plus honey group compared to those of the sham group. Additionally, NO levels were found to be significantly higher in liver tissues from the animals in the obstructive jaundice plus honey group than those of the jaundice group. CONCLUSION:Honey was found to be beneficial in the prevention of hepatic damage due to obstruction of the common bile duct.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Erguder BI,Kilicoglu SS,Namuslu M,Kilicoglu B,Devrim E,Kismet K,Durak Idoi
10.3748/wjg.14.3729subject
Has Abstractpub_date
2008-06-21 00:00:00pages
3729-32issue
23eissn
1007-9327issn
2219-2840journal_volume
14pub_type
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