Altered distribution of regulatory lymphocytes by oral administration of soy-extracts exerts a hepatoprotective effect alleviating immune mediated liver injury, non-alcoholic steatohepatitis and insulin resistance.

abstract：AIM:To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of non-alcoholic steatohepatitis (NASH). METHODS:Twelve patients with biopsy-proven NASH were randomized to sitagliptin (100 mg daily) (n = 6) or placebo (n = 6) for 24 wk. The primary outcome was improvement in liver fibr...

journal_title：World journal of gastroenterology

authors： Joy TR,McKenzie CA,Tirona RG,Summers K,Seney S,Chakrabarti S,Malhotra N,Beaton MD

更新日期：2017-01-07 00:00:00

abstract：AIM:To investigate possible associations of anti-nuclear envelope antibody (ANEA) with disease severity and survival in Greek primary biliary cirrhosis (PBC) patients. METHODS:Serum samples were collected at diagnosis from 147 PBC patients (85% female), who were followed-up for a median 89.5 mo (range 1-240). ANEA wer...

journal_title：World journal of gastroenterology

authors： Sfakianaki O,Koulentaki M,Tzardi M,Tsangaridou E,Theodoropoulos PA,Castanas E,Kouroumalis EA

更新日期：2010-10-21 00:00:00

abstract：AIM:To investigate the effect of APOBEC3G mediated antiviral activity against hepatitis B virus (HBV) in cell cultures and replication competent HBV vector-based mouse model. METHODS:The mammalian hepatoma cells Huh7 and HepG2 were cotransfected with various amounts of CMV-driven expression vector encoding APOBEC3G an...

journal_title：World journal of gastroenterology

authors： Lei YC,Hao YH,Zhang ZM,Tian YJ,Wang BJ,Yang Y,Zhao XP,Lu MJ,Gong FL,Yang DL

更新日期：2006-07-28 00:00:00

abstract：AIM:Quasispecies of hepatitis C virus (HCV) are the foundation for rapid sequence evolution of HCV to evade immune surveillance of hosts. The consensus sequence evolution of a segment of HCV NS3 region, which encompasses putative cytotoxic T cell epitopes, was evaluated. METHODS:Three male patients, infected with HCV ...

journal_title：World journal of gastroenterology

authors： Guo HZ,Yin Y,Wang WL,Zhang CS,Wang T,Wang Z,Zhang J,Cheng H,Wang HT

更新日期：2004-03-15 00:00:00

abstract：:P21-activated kinases (PAKs) are central players in various oncogenic signaling pathways. The six PAK family members are classified into group I (PAK1-3) and group II (PAK4-6). Focus is currently shifting from group I PAKs to group II PAKs. Group II PAKs play important roles in many fundamental cellular processes, som...

journal_title：World journal of gastroenterology

authors： Shao YG,Ning K,Li F

更新日期：2016-01-21 00:00:00

abstract：:Systemic therapy for hepatocellular carcinoma (HCC) has markedly advanced since the survival benefit of a molecular targeted agent, sorafenib, were demonstrated in the SHARP and Asia Pacific trials in 2007. Treatment options for patients with advanced HCC increased by sorafenib, and long-term survival for patients wit...

journal_title：World journal of gastroenterology

authors： Kudo M

更新日期：2019-02-21 00:00:00

abstract：AIM:To assess the use of topical negative pressure (TNP) in the management of severe peritonitis. METHODS:This is a four-year prospective analysis from January 2005 to December 2008 of 20 patients requiring TNP following laparotomy for severe peritonitis. RESULTS:There were 11 males with an average age of (59.3 +/- 3...

journal_title：World journal of gastroenterology

authors： Amin AI,Shaikh IA

更新日期：2009-07-21 00:00:00

abstract：:Laparoscopic cholecystectomy (LC) does not require advanced techniques, and its performance has therefore rapidly spread worldwide. However, the rate of biliary injuries has not decreased. The concept of the critical view of safety (CVS) was first documented two decades ago. Unexpected injuries are principally due to ...

journal_title：World journal of gastroenterology

authors： Hori T,Oike F,Furuyama H,Machimoto T,Kadokawa Y,Hata T,Kato S,Yasukawa D,Aisu Y,Sasaki M,Kimura Y,Takamatsu Y,Naito M,Nakauchi M,Tanaka T,Gunji D,Nakamura K,Sato K,Mizuno M,Iida T,Yagi S,Uemoto S,Yoshimura T

更新日期：2016-12-21 00:00:00

abstract：:It has been known that peripheral adverse event is caused by peripheral antimuscarinic action, from hyoscine butylbromide (Buscopan; Boehringer Ingelheim, Germany) used as a premedication for endoscopy. However, symptoms or signs associated with the central nervous system are rarely reported in the field of anesthesio...

journal_title：World journal of gastroenterology

authors： Lee H,Son HJ,Rhee PL,Kim JJ,Rhee JC

更新日期：2007-07-28 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a disease in which excessive fat accumulates in the liver of a patient without a history of alcohol abuse. This disease includes simple steatosis and nonalcoholic steatohepatitis (NASH). NAFLD/NASH is recognized as a hepatic manifestation of metabolic syndrome. In recent yea...

journal_title：World journal of gastroenterology

authors： Takahashi Y,Fukusato T

更新日期：2010-11-14 00:00:00

abstract：AIM:To unravel the differences between systematic inflammatory response syndrome (SIRS) of acute pancreatitis compared to the same syndrome in sepsis. METHODS:Twenty-five patients were enrolled, 12 with sepsis and 13 acute pancreatitis. After diagnosis 20 mL blood was sampled. Half were assayed for isolation of monocy...

journal_title：World journal of gastroenterology

authors： Koussoulas V,Tzivras M,Karagianni V,Spyridaki E,Plachouras D,Giamarellou H,Giamarellos-Bourboulis EJ

更新日期：2006-11-07 00:00:00

abstract：AIM:To investigate the relationship between the expression of p16 gene and the gastric carcinogenesis, depth of invasion and lymph node metastases, and to evaluate the deletion and mutation of exon 2 in p16 gene in gastric carcinoma. METHODS:The expression of p16 protein was examined by streptavidin-peroxidase conjuga...

journal_title：World journal of gastroenterology

authors： He XS,Su Q,Chen ZC,He XT,Long ZF,Ling H,Zhang LR

更新日期：2001-08-01 00:00:00

abstract：:Casais et al have reported an inverse correlation between serum phosphate and body weight after administration of sodium phosphate at a dose of 60 g. Our group has already described the relationship between body weight and hyperphosphatemia with these preparations, although our study was not quoted by Casais. We perfo...

journal_title：World journal of gastroenterology

authors： Deepak P,Ehrenpreis ED

更新日期：2011-06-07 00:00:00

abstract：:In their seminal papers Hanahan and Weinberg described oncogenic processes a normal cell undergoes to be transformed into a cancer cell. The functions of ion channels in the gastrointestinal (GI) tract influence a variety of cellular processes, many of which overlap with these hallmarks of cancer. In this review we fo...

journal_title：World journal of gastroenterology

authors： Anderson KJ,Cormier RT,Scott PM

更新日期：2019-10-14 00:00:00

abstract：AIM:To explore the correlation between expression of somatostatin (SS), gastrin (GAS) and cell apoptosis regulation gene bcl-2/bax in large intestine carcinoma. METHODS:Sixty-two large intestine cancer tissue samples were randomly and retrospectively selected from patients with large intestine carcinoma. Immunohistoch...

journal_title：World journal of gastroenterology

authors： Mao JD,Wu P,Xia XH,Hu JQ,Huang WB,Xu GQ

更新日期：2005-02-07 00:00:00

abstract：:The KRAS oncogene is mutated in approximately 35%-45% of colorectal cancers, and KRAS mutational status testing has been highlighted in recent years. The most frequent mutations in this gene, point substitutions in codons 12 and 13, were validated as negative predictors of response to anti-epidermal growth factor rece...

journal_title：World journal of gastroenterology

authors： Tan C,Du X

更新日期：2012-10-07 00:00:00

abstract：:Abnormal bone metabolism and dysfunction of the calcium-parathyroid hormone-vitamin D axis have been reported in patients with viral hepatitis. Some studies suggested a relationship between vitamin D and viral hepatitis. Genetic studies have provided an opportunity to identify the proteins that link vitamin D to the p...

journal_title：World journal of gastroenterology

authors： Lương Kv,Nguyễn LT

更新日期：2012-10-14 00:00:00

abstract：AIM:To assess the outcomes of drug therapy (DT) followed by pancreatic endotherapy for continuing painful episodes in recurrent acute pancreatitis. METHODS:DT comprised of pancreatic enzymes and anti-oxidants failing which, endotherapy (ET; pancreatic sphincterotomy and stent placement) was done. The frequency of pain...

journal_title：World journal of gastroenterology

authors： Pai CG,Kamath MG,Shetty MV,Kurien A

更新日期：2017-05-21 00:00:00

abstract：BACKGROUND:The digestive tract is the maximal immunizing tissue in the body, and mucosal integrity and functional status of the gut is very important to maintain a healthy organism. Severe infection is one of the most common causes of gastrointestinal dysfunction, and the pathogenesis is closely related to endotoxemia ...

journal_title：World journal of gastroenterology

authors： Wang W,Sun M,Zheng YL,Sun LY,Qu SQ

更新日期：2019-06-21 00:00:00

abstract：:Alcoholic fatty liver disease (AFLD), a potentially pathologic condition, can progress to steatohepatitis, fibrosis, and cirrhosis, leading to an increased probability of hepatic failure and death. Alcohol induces fatty liver by increasing the ratio of reduced form of nicotinamide adenine dinucleotide to oxidized form...

journal_title：World journal of gastroenterology

authors： Liu J

更新日期：2014-10-28 00:00:00

abstract：AIM:To assess the rate of infection, appropriateness of antimicrobial-therapy and mortality on intensive care unit (ICU). Special focus was drawn on patients with liver cirrhosis. METHODS:The study was approved by the local ethical committee. All patients admitted to the Internal Medicine-ICU between April 1, 2007 and...

journal_title：World journal of gastroenterology

authors： Friedrich-Rust M,Wanger B,Heupel F,Filmann N,Brodt R,Kempf VA,Kessel J,Wichelhaus TA,Herrmann E,Zeuzem S,Bojunga J

更新日期：2016-04-28 00:00:00

abstract：AIM:To observe the kinetics of D (-)-lactate alteration in both portal and systemic circulation systems, and its relationship with intestinal injury in rats subjected to acute intestinal ischemia-reperfusion. METHODS:Anesthetized rats underwent a 75-min superior mesenteric artery occlusion followed by a 6-h reperfusio...

journal_title：World journal of gastroenterology

authors： Yao YM,Yu Y,Wu Y,Lu LR,Sheng ZY

更新日期：1997-12-15 00:00:00

abstract：AIM:To determine the pattern and distribution of colonic diverticulosis in Thai adults. METHODS:A review of the computerized radiology database for double contrast barium enema (DCBE) in Thai adults was performed at the Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Incomplete studies and...

journal_title：World journal of gastroenterology

authors： Lohsiriwat V,Suthikeeree W

更新日期：2013-12-14 00:00:00

abstract：:AIM:To investigate the expression of somatostatin mRNA in various differentiated types of gastric carcinoma.METHODS: By using in situ hybridization and immunohistochemical techniques, the expression of somatostatin mRNA and somatostatin immunoreactivity in the normal gastric mucosa, the poorly, moderately and well-dif...

journal_title：World journal of gastroenterology

authors： Zhang QX,Dou YL,Shi XY,Ding Y

更新日期：1998-02-01 00:00:00

abstract：:A 70-year-old woman was found to have 2 cystic lesions in the head of the pancreas on abdominal ultrasonography during a routine medical examination. Endoscopic ultrasonography (EUS) and magnetic resonance cholangiopancreatography showed multilocular cysts in the head of the pancreas without dilation of the main pancr...

journal_title：World journal of gastroenterology

authors： Urata T,Naito Y,Izumi Y,Takekuma Y,Yokomizo H,Nagamine M,Fukuda S,Notohara K,Hifumi M

更新日期：2013-12-21 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta), a prototype of multifunctional cytokine, is a key regulator of extracellular matrix (ECM) assembly and remodeling. Specifically, TGF-beta isoforms have the ability to induce the expression of ECM proteins in mesenchymal cells, and to stimulate the production of protease inhi...

journal_title：World journal of gastroenterology

authors： Verrecchia F,Mauviel A

更新日期：2007-06-14 00:00:00

abstract：AIM:To study the distribution and expression of non-muscle myosin light chain kinase (nmMLCK) in rabbit livers. METHODS:Human nmMLCK N-terminal cDNA was amplified by polymerase chain reaction (PCR) and was inserted into pBKcmv to construct expression vectors. The recombinant plasmid was transformed into XL1-blue. Expr...

journal_title：World journal of gastroenterology

authors： Zhu HQ,Wang Y,Hu RL,Ren B,Zhou Q,Jiang ZK,Gui SY

更新日期：2003-12-01 00:00:00

abstract：AIM:To estimate the incidence of catheter tract implantation metastasis among patients undergoing percutaneous transhepatic biliary drainage (PTBD) for extrahepatic cholangiocarcinoma, and to provide data regarding the management of this unusual complication of PTBD by reviewing cases reported in the literature. METHO...

journal_title：World journal of gastroenterology

authors： Sakata J,Shirai Y,Wakai T,Nomura T,Sakata E,Hatakeyama K

更新日期：2005-11-28 00:00:00

abstract：AIM:To describe the clinical and epidemiologic profiles of the disease and to compare the findings with those generated from the previous hospital-based studies. METHODS:The Gharbiah cancer registry is the only population-based cancer registry in Egypt since 1998. We analyzed the data of all colorectal cancer patients...

journal_title：World journal of gastroenterology

authors： Veruttipong D,Soliman AS,Gilbert SF,Blachley TS,Hablas A,Ramadan M,Rozek LS,Seifeldin IA

更新日期：2012-08-14 00:00:00

abstract：AIM:To validate the Rockall scoring system for predicting outcomes of rebleeding, and the need for a surgical procedure and death. METHODS:We used data extracted from the Registry of Upper Gastrointestinal Bleeding and Endoscopy including information of 1869 patients with non-variceal upper gastrointestinal bleeding t...

journal_title：World journal of gastroenterology

authors： Enns RA,Gagnon YM,Barkun AN,Armstrong D,Gregor JC,Fedorak RN,RUGBE Investigators Group.

更新日期：2006-12-28 00:00:00