Continuing episodes of pain in recurrent acute pancreatitis: Prospective follow up on a standardised protocol with drugs and pancreatic endotherapy.

Abstract:

AIM:To assess the outcomes of drug therapy (DT) followed by pancreatic endotherapy for continuing painful episodes in recurrent acute pancreatitis. METHODS:DT comprised of pancreatic enzymes and anti-oxidants failing which, endotherapy (ET; pancreatic sphincterotomy and stent placement) was done. The frequency of pain, its visual analogue score (VAS), quality of life (QoL), serum C peptide and faecal elastase were compared between baseline and after 1 year of follow up in all patients and in the two subgroups on DT and ET. Response was defined as at least 50% reduction in the severity of pain to below a score of 5. RESULTS:Of the thirty nine patients analysed, 21 (53.9%) responded to DT and 18 (46.1%) underwent ET. The VAS for pain (7.0 ± 2.0 vs 1.3 ± 2.5, P < 0.001) and the number of days with pain per month decreased [1.0 (1.0, 2.0) vs 1.0 (0.0, 1.0), P < 0.001], and the QoL scores [55.0 (44.0, 66.0) vs 38.0 (32.00, 51.00), P < 0.01] improved significantly during follow up. Similar significant improvements were seen in patients in the subgroups of DT and ET except for QoL in ET. The serum C-peptide (P = 0.001) and FE (P < 0.001) levels improved significantly in the entire group and in the two subgroups of patients except for the C peptide levels in patients on DT. CONCLUSION:A standardised protocol of DT, followed by ET decreased the intensity and frequency of pain in recurrent acute pancreatitis, enhanced QoL and improved pancreatic function.

journal_name

World J Gastroenterol

authors

Pai CG,Kamath MG,Shetty MV,Kurien A

doi

10.3748/wjg.v23.i19.3538

subject

Has Abstract

pub_date

2017-05-21 00:00:00

pages

3538-3545

issue

19

eissn

1007-9327

issn

2219-2840

journal_volume

23

pub_type

杂志文章
  • Rare long-term survivors of pancreatic adenocarcinoma without curative resection.

    abstract::Long-term outcome data in pancreatic adenocarcinoma are predominantly based on surgical series, as resection is currently considered essential for long-term survival. In contrast, five-year survival in non-resected patients has rarely been reported. In this report, we examined the incidence and natural history of ≥ 5-...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i48.13574

    authors: Oh SY,Edwards A,Mandelson MT,Lin B,Dorer R,Helton WS,Kozarek RA,Picozzi VJ

    更新日期:2015-12-28 00:00:00

  • Have patients with esophagitis got an increased risk of adenocarcinoma? Results from a population-based study.

    abstract:AIM:To examine an increased risk of esophageal adenocarcinoma is restricted to patients who develop Barrett's esophagus or whether esophagitis per se is a risk factor for adenocarcinoma. METHODS:A population-based cohort of patients with histological evidence of esophagitis without Barrett's esophagus was constructed ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i46.7290

    authors: Murphy SJ,Anderson LA,Johnston BT,Fitzpatrick DA,Watson PR,Monaghan P,Murray LJ

    更新日期:2005-12-14 00:00:00

  • E-cadherin expression pattern in primary colorectal carcinomas and their metastases reflects disease outcome.

    abstract:AIM:To investigate the changes that occur in E-cadherin expression during the process of metastasis in colorectal cancer. METHODS:E-cadherin expression was detected by immunohistochemistry and two indices of expression were calculated which reflected the level of expression and the locations (membrane and cytoplasm). ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i27.4304

    authors: Elzagheid A,Algars A,Bendardaf R,Lamlum H,Ristamaki R,Collan Y,Syrjanen K,Pyrhonen S

    更新日期:2006-07-21 00:00:00

  • Posttransplant lymphoproliferative disorders following liver transplantation: Where are we now?

    abstract::Liver transplantation has emerged as a life-saving treatment for several patients with acute liver failure, end stage liver disease and primary hepatic malignancies. However, long term immunosuppressive therapy aiming to reduce the risk of transplant rejection increases the incidence of several complications including...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i39.11034

    authors: Dierickx D,Cardinaels N

    更新日期:2015-10-21 00:00:00

  • TECA hybrid artificial liver support system in treatment of acute liver failure.

    abstract:AIM:To assess the efficacy and safety of TECA type hybrid artificial liver support system (TECA-HALSS) in providing liver function of detoxification, metabolism and physiology by treating the patients with acute liver failure (ALF). METHODS:The porcine liver cells (1-2) x 10(10) were separated from the Chinese small s...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v7.i6.826

    authors: Xue YL,Zhao SF,Luo Y,Li XJ,Duan ZP,Chen XP,Li WG,Huang XQ,Li YL,Cui X,Zhong DG,Zhang ZY,Huang ZQ

    更新日期:2001-12-01 00:00:00

  • Glutathione-S-transferase (GSTM1, GSTT1) and the risk of gastrointestinal cancer in a Korean population.

    abstract:AIM:To evaluate the association of glutathione S-transferase mu (GSTM1) and glutathione S-transferase theta (GSTT1) null genotypes with the risk of gastric cancer (GC) and colorectal cancer (CRC) in a South Korean population. METHODS:We conducted a population-based, large-scale case-control study including 2213 GCs, 1...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.5716

    authors: Piao JM,Shin MH,Kweon SS,Kim HN,Choi JS,Bae WK,Shim HJ,Kim HR,Park YK,Choi YD,Kim SH

    更新日期:2009-12-07 00:00:00

  • Overexpression of c-fos in Helicobacter pylori-induced gastric precancerosis of Mongolian gerbil.

    abstract:AIM:To explore dysregulation of c-fos in several human malignancies, and to further investigate the role of c-fos in Helicobacter pylori (H. pylori)-induced gastric precancerosis. METHODS:Four-week-old male Mongolian gerbils were employed in the study. 0.5 mL 1X10(8) cfu/L suspension of H. pylori NCTC 11 637 in Brucel...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i3.521

    authors: Yang YL,Xu B,Song YG,Zhang WD

    更新日期:2003-03-01 00:00:00

  • Gastroesophageal reflux disease management according to contemporary international guidelines: a translational study.

    abstract:AIM:To test the Genval recommendations and the usefulness of a short trial of proton pump inhibitor (PPI) in the initial management and maintenance treatment of gastroesophageal reflux disease (GERD) patients. METHODS:Five hundred and seventy seven patients with heartburn were recruited. After completing a psychometri...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.3748/wjg.v17.i9.1160

    authors: Pace F,Riegler G,de Leone A,Dominici P,Grossi E,EMERGE Study Group.

    更新日期:2011-03-07 00:00:00

  • Multiphoton microscopy for tumor regression grading after neoadjuvant treatment for colorectal carcinoma.

    abstract:AIM:To evaluate the feasibility of using multiphoton microscopy (MPM) to assess a tumor regression grading (TRG) system. METHODS:Fresh specimens from seven patients with colorectal carcinoma undergoing neoadjuvant radiochemotherapy at the Fujian Medical University Union Hospital were obtained immediately after proctec...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i14.4210

    authors: Li LH,Chen ZF,Wang XF,Zhuo SM,Li HS,Jiang WZ,Guan GX,Chen JX

    更新日期:2015-04-14 00:00:00

  • Cell proliferation of esophageal squamous epithelium in erosive and non-erosive reflux disease.

    abstract:AIM:To elucidate cell proliferation in erosive reflux disease (ERD) and non-erosive reflux disease (NERD), we evaluated markers in squamous epithelial cells. METHODS:Thirty-four consecutive patients with gastroesophageal-reflux-disease-related symptoms (21 NERD and 13 ERD) were evaluated for the enrolment into the stu...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i40.4496

    authors: Calabrese C,Montanaro L,Liguori G,Brighenti E,Vici M,Gionchetti P,Rizzello F,Campieri M,Derenzini M,Trerè D

    更新日期:2011-10-28 00:00:00

  • Serum anti-Helicobacter pylori antibody titer and its association with gastric nodularity, atrophy, and age: A cross-sectional study.

    abstract:AIM:To clarify the role of serum anti-Helicobacter pylori (H. pylori) antibody titers in gastric cancer. METHODS:In this cross-sectional study, the effect of patients' baseline characteristics and endoscopic findings on their serum antibody titers were assessed. We evaluated consecutive patients who underwent esophago...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v24.i35.4061

    authors: Toyoshima O,Nishizawa T,Sakitani K,Yamakawa T,Takahashi Y,Yamamichi N,Hata K,Seto Y,Koike K,Watanabe H,Suzuki H

    更新日期:2018-09-21 00:00:00

  • Reduced microRNA 375 in colorectal cancer upregulates metadherin-mediated signaling.

    abstract:BACKGROUND:The human microRNA 375 (MIR375) is significantly downregulated in human colorectal cancer (CRC) and we have previously shown that MIR375 is a CRC-associated miRNA. The metadherin (MTDH) is a candidate target gene of MIR375. AIM:To investigate the interaction and function between MIR375 and MTDH in human CRC...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v25.i44.6495

    authors: Han SH,Mo JS,Park WC,Chae SC

    更新日期:2019-11-28 00:00:00

  • Expression of CD14 protein and its gene in liver sinusoidal endothelial cells during endotoxemia.

    abstract:AIM:To observe expression of CD14 protein and CD14 gene in rat liver sinusoidal endothelial cells (LSECs) during endotoxemia, and the role of CD14 protein in the activation of lipopolysaccharide (LPS)-induced LSECs. METHODS:Wistar rat endotoxemia model was established first by injection of a dose of LPS (5mg/kg, Esche...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v8.i3.551

    authors: Gong JP,Dai LL,Liu CA,Wu CX,Shi YJ,Li SW,Li XH

    更新日期:2002-06-01 00:00:00

  • Surveillance of colonic polyps: Are we getting it right?

    abstract::Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. The identification of colonic polyps can reduce CRC mortality through earlier diagnosis of cancers and the removal of polyps: the precursor lesion of CRC. Following the finding and removal of colonic polyps at an initial colonoscopy, some p...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审

    doi:10.3748/wjg.v22.i6.1925

    authors: Bonnington SN,Rutter MD

    更新日期:2016-02-14 00:00:00

  • Inhibitor of differentiation proteins do not influence prognosis of biliary tract cancer.

    abstract:AIM:To investigate the expression and clinical relevance of inhibitor of differentiation (ID) proteins in biliary tract cancer. METHODS:ID protein expression was analyzed in 129 samples from patients with advanced biliary tract cancer (BTC) (45 extrahepatic, 50 intrahepatic, and 34 gallbladder cancers), compared to no...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i48.9334

    authors: Harder J,Müller MJ,Fuchs M,Gumpp V,Schmitt-Graeff A,Fischer R,Frank M,Opitz O,Hasskarl J

    更新日期:2013-12-28 00:00:00

  • Update on quinolone-containing rescue therapies for Helicobacter pylori infection.

    abstract::Third generation of quinolones, such as levofloxacin and moxifloxacin, -containing regimens are often used in second-line or rescue treatment of Helicobacter pylori infection. However, the increasing antibiotic resistance to quinolones affects the efficacies of quinolones-containing therapies in recent years. Therefor...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v26.i15.1733

    authors: Mori H,Suzuki H

    更新日期:2020-04-21 00:00:00

  • Screening compounds against HCV based on MAVS/IFN-β pathway in a replicon model.

    abstract:AIM:To develop a sensitive assay for screening compounds against hepatitis C virus (HCV). METHODS:The proteolytic cleavage of NS3/4A on enhanced yellow fluorescent protein (eYFP)-mitochondrial antiviral signaling protein (MAVS) was examined by reporter enzyme secreted placental alkaline phosphatase (SEAP), which enabl...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i44.5582

    authors: Fu QX,Wang LC,Jia SZ,Gao B,Zhou Y,Du J,Wang YL,Wang XH,Peng JC,Zhan LS

    更新日期:2010-11-28 00:00:00

  • Impact of remote ischemic preconditioning on wound healing in small bowel anastomoses.

    abstract:AIM:To investigate the influence of remote ischemic preconditioning (RIPC) on anastomotic integrity. METHODS:Sixty male Wistar rats were randomized to six groups. The control group (n = 10) had an end-to-end ileal anastomosis without RIPC. The preconditioned groups (n = 34) varied in time of ischemia and time of reper...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i10.1308

    authors: Holzner PA,Kulemann B,Kuesters S,Timme S,Hoeppner J,Hopt UT,Marjanovic G

    更新日期:2011-03-14 00:00:00

  • Parameters of a severe disease course in ulcerative colitis.

    abstract:AIM:To detect high risk patients with a progressive disease course of ulcerative colitis (UC) requiring immunosuppressive therapy (IT). METHODS:A retrospective, multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed. Patients were divided into two groups dep...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3748/wjg.v20.i35.12574

    authors: Stallmach A,Nickel L,Lehmann T,Bokemeyer B,Bürger M,Hüppe D,Kruis W,Nikolaus S,Preiss JC,Sturm A,Teich N,Schmidt C

    更新日期:2014-09-21 00:00:00

  • Hepatoprotective effect of manual acupuncture at acupoint GB34 against CCl4-induced chronic liver damage in rats.

    abstract:AIM:To investigate the hepatoprotective effect of manual acupuncture at Yanglingquan (GB34) on CCl4-induced chronic liver damage in rats. METHODS:Rats were injected intraperitoneally with CCl4 (1 mL/kg) and treated with manual acupuncture using reinforcing manipulation techniques at left GB34 (Yanglingquan) 3 times a ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i14.2245

    authors: Yim YK,Lee H,Hong KE,Kim YI,Lee BR,Kim TH,Yi JY

    更新日期:2006-04-14 00:00:00

  • Portal vein embolization induces compensatory hypertrophy of remnant liver.

    abstract:AIM:To evaluate the effectiveness and safety of different portal vein branch embolization agents in inducing compensatory hypertrophy of the remnant liver and to offer a theoretic basis for clinical portal vein branch embolization. METHODS:Forty-one adult dogs were included in the experiment and divided into four grou...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i3.408

    authors: Huang JY,Yang WZ,Li JJ,Jiang N,Zheng QB

    更新日期:2006-01-21 00:00:00

  • Enigmatic origin of hepatitis B virus: an ancient travelling companion or a recent encounter?

    abstract::Hepatitis B virus (HBV) is the leading cause of liver disease and infects an estimated 240 million people worldwide. It is characterised by a high degree of genetic heterogeneity because of the use of a reverse transcriptase during viral replication. The ten genotypes (A-J) that have been described so far further segr...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i24.7622

    authors: Zehender G,Ebranati E,Gabanelli E,Sorrentino C,Lo Presti A,Tanzi E,Ciccozzi M,Galli M

    更新日期:2014-06-28 00:00:00

  • Metastases of esophageal carcinoma to skeletal muscle: single center experience.

    abstract::Metastases of esophageal carcinoma to the skeletal muscle are rare, but the incidence may be increasing because of better diagnosis resulting from widespread use of positron emission tomography/computed tomography (PET/CT). A cohort of 205 patients with esophageal carcinoma treated at our center who had PET/CT between...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i35.4962

    authors: Cincibuch J,Mysliveček M,Melichar B,Neoral C,Metelková I,Zezulová M,Procházková-Študentová H,Flodr P,Zlevorová M,Aujeský R,Cwiertka K

    更新日期:2012-09-21 00:00:00

  • Natural history of hepatic metastases from colorectal cancer--pathobiological pathways with clinical significance.

    abstract::Colorectal cancer hepatic metastases represent the final stage of a multi-step biological process. This process starts with a series of mutations in colonic epithelial cells, continues with their detachment from the large intestine, dissemination through the blood and/or lymphatic circulation, attachment to the hepati...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i14.3719

    authors: Paschos KA,Majeed AW,Bird NC

    更新日期:2014-04-14 00:00:00

  • Effect of ligand of peroxisome proliferator-activated receptor gamma on the biological characters of hepatic stellate cells.

    abstract:AIM:To study the effect of rosiglitazone, which is a ligand of peroxisome proliferator-activated receptor gamma (PPARgamma), on the expression of PPARgamma in hepatic stellate cells (HSCs) and on the biological characteristics of HSCs. METHODS:The activated HSCs were divided into three groups: control group, 3 micromo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i30.4735

    authors: Guo YT,Leng XS,Li T,Peng JR,Song SH,Xiong LF,Qin ZZ

    更新日期:2005-08-14 00:00:00

  • Induction of CD69 expression by cagPAI-positive Helicobacter pylori infection.

    abstract:AIM:To investigate and elucidate the molecular mechanism that regulates inducible expression of CD69 by Helicobacter pylori (H. pylori) infection. METHODS:The expression levels of CD69 in a T-cell line, Jurkat, primary human peripheral blood mononuclear cells (PBMCs), and CD4+ T cells, were assessed by immunohistochem...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i32.3691

    authors: Mori N,Ishikawa C,Senba M

    更新日期:2011-08-28 00:00:00

  • Post-partum reactivation of chronic hepatitis B virus infection among hepatitis B e-antigen-negative women.

    abstract:AIM:To investigate the frequency and timing of post-partum chronic hepatitis B virus (HBV) reactivation and identify its pre-partum predictors. METHODS:Forty-one hepatitis B e antigen (HBeAg)-negative chronic HBV infected pregnant women were prospectively evaluated between the 28th and the 32nd week of gestation. Subj...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i4.1261

    authors: Elefsiniotis I,Vezali E,Vrachatis D,Hatzianastasiou S,Pappas S,Farmakidis G,Vrioni G,Tsakris A

    更新日期:2015-01-28 00:00:00

  • A head to head comparison of oral vs intravenous omeprazole for patients with bleeding peptic ulcers with a clean base, flat spots and adherent clots.

    abstract:AIM:To compare the effect of intravenous and oral omeprazole in patients with bleeding peptic ulcers without high-risk stigmata. METHODS:This randomized study included 211 patients [112 receiving iv omeprazole protocol (Group 1), 99 receiving po omeprazole 40 mg every 12 h (Group 2)] with a mean age of 52.7. In 144 pa...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.v12.i48.7837

    authors: Yilmaz S,Bayan K,Tüzün Y,Dursun M,Canoruç F

    更新日期:2006-12-28 00:00:00

  • Synergistic effects of interferon-alpha in combination with chemoradiation on human pancreatic adenocarcinoma.

    abstract:AIM:To determine whether IFN-alpha is the agent that turns a slightly effective treatment (radiochemotherapy) into a potent therapy, we tested IFN-alpha for its synergistic properties. METHODS:Eight pancreatic carcinoma cell lines were treated with the single agents and combinations of these. The role of IFN-alpha reg...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i10.1521

    authors: Ma JH,Patrut E,Schmidt J,Knaebel HP,Büchler MW,Märten A

    更新日期:2005-03-14 00:00:00

  • International guidelines for the management of pancreatic intraductal papillary mucinous neoplasms.

    abstract::The management of intraductal papillary mucinous neoplasms (IPMN) is presently evolving as a result of the improved understanding of the natural history and biological behavior of the different pancreatic cystic neoplasms; and better preoperative diagnosis of these neoplasms due to advancement in preoperative diagnost...

    journal_title:World journal of gastroenterology

    pub_type: 社论

    doi:10.3748/wjg.v21.i34.9833

    authors: Goh BK

    更新日期:2015-09-14 00:00:00