Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor.


AIM:To assess the rate of infection, appropriateness of antimicrobial-therapy and mortality on intensive care unit (ICU). Special focus was drawn on patients with liver cirrhosis. METHODS:The study was approved by the local ethical committee. All patients admitted to the Internal Medicine-ICU between April 1, 2007 and December 31, 2009 were included. Data were extracted retrospectively from all patients using patient charts and electronic documentations on infection, microbiological laboratory reports, diagnosis and therapy. Due to the large hepatology department and liver transplantation center, special interest was on the subgroup of patients with liver cirrhosis. The primary statistical-endpoint was the evaluation of the influence of appropriate versus inappropriate antimicrobial-therapy on in-hospital-mortality. RESULTS:Charts of 1979 patients were available. The overall infection-rate was 53%. Multiresistant-bacteria were present in 23% of patients with infection and were associated with increased mortality (P < 0.000001). Patients with infection had significantly increased in-hospital-mortality (34% vs 17%, P < 0.000001). Only 9% of patients with infection received inappropriate initial antimicrobial-therapy, no influence on mortality was observed. Independent risk-factors for in-hospital-mortality were the presence of septic-shock, prior chemotherapy for malignoma and infection with Pseudomonas spp. Infection and mortality-rate among 175 patients with liver-cirrhosis was significantly higher than in patients without liver-cirrhosis. Infection increased mortality 2.24-fold in patients with cirrhosis. Patients with liver cirrhosis were at an increased risk to receive inappropriate initial antimicrobial therapy. CONCLUSION:The results of the present study report the successful implementation of early-goal-directed therapy. Liver cirrhosis patients are at increased risk of infection, mortality and to receive inappropriate therapy. Increasing burden are multiresistant-bacteria.


World J Gastroenterol


Friedrich-Rust M,Wanger B,Heupel F,Filmann N,Brodt R,Kempf VA,Kessel J,Wichelhaus TA,Herrmann E,Zeuzem S,Bojunga J




Has Abstract


2016-04-28 00:00:00












  • NAT2 6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis.

    abstract:AIM:To investigate an association between N-acetyltransferase 2 (NAT2)-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients. METHODS:We studied 100 patients with pulmonary TB treated with anti-TB drugs including INH. The frequencies and distributions of single nucleotide polymorphisms,...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Higuchi N,Tahara N,Yanagihara K,Fukushima K,Suyama N,Inoue Y,Miyazaki Y,Kobayashi T,Yoshiura K,Niikawa N,Wen CY,Isomoto H,Shikuwa S,Omagari K,Mizuta Y,Kohno S,Tsukamoto K

    更新日期:2007-12-07 00:00:00

  • Fibroblast growth factor receptor signaling as therapeutic targets in gastric cancer.

    abstract::Fibroblast growth factor receptors (FGFRs) regulate a variety of cellular functions, from embryogenesis to adult tissue homeostasis. FGFR signaling also plays significant roles in the proliferation, invasion, and survival of several types of tumor cells. FGFR-induced alterations, including gene amplification, chromoso...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Yashiro M,Matsuoka T

    更新日期:2016-02-28 00:00:00

  • Response evaluation of chemotherapy in metastatic colorectal cancer by contrast enhanced ultrasound.

    abstract:AIM:To evaluate whether contrast enhanced ultrasound (CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer. METHODS:Thirty consecutive patients with non primary resectable liver metastases from colorectal ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Schirin-Sokhan R,Winograd R,Roderburg C,Bubenzer J,do Ó NC,Guggenberger D,Hecker H,Trautwein C,Tischendorf JJ

    更新日期:2012-02-14 00:00:00

  • Sensitivity of the suspected blood indicator: an experimental study.

    abstract:AIM:To investigate whether suspected blood indicator (SBI) in capsule endoscopy (CE) is affected by background color and capsule passage velocity. METHODS:Experimental models of the small intestine constructed from paper in a variety of colors were used to simulate the background colors observed in CE images. The back...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Park SC,Chun HJ,Kim ES,Keum B,Seo YS,Kim YS,Jeen YT,Lee HS,Um SH,Kim CD,Ryu HS

    更新日期:2012-08-21 00:00:00

  • Immunotherapy for colorectal cancer.

    abstract::The incidence of colorectal cancer (CRC) is on the rise, and the prognosis for patients with recurrent or metastatic disease is extremely poor. Although chemotherapy and radiation therapy can improve survival rates, it is imperative to integrate alternative strategies such as immunotherapy to improve outcomes for pati...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Koido S,Ohkusa T,Homma S,Namiki Y,Takakura K,Saito K,Ito Z,Kobayashi H,Kajihara M,Uchiyama K,Arihiro S,Arakawa H,Okamoto M,Gong J,Tajiri H

    更新日期:2013-12-14 00:00:00

  • Impairment of innate immune responses in cirrhotic patients and treatment by branched-chain amino acids.

    abstract::It has been reported that host defense responses, such as phagocytic function of neutrophils and natural killer (NK) cell activity of lymphocytes, are impaired in cirrhotic patients. This review will concentrate on the impairment of innate immune responses in decompensated cirrhotic patients and the effect of the trea...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Nakamura I

    更新日期:2014-06-21 00:00:00

  • Role of AXL in invasion and drug resistance of colon and breast cancer cells and its association with p53 alterations.

    abstract:AIM:To characterize AXL receptor tyrosine kinase (AXL) expression in relationship to tumor protein P53 (TP53 gene, p53 protein) and its role in tumor invasion and response to therapy. METHODS:We used 14 cell lines, including 3 isogenic pairs carrying mutant/knockout p53, to gain insight into the relationship between A...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Abdel-Rahman WM,Al-Khayyal NA,Nair VA,Aravind SR,Saber-Ayad M

    更新日期:2017-05-21 00:00:00

  • Entry of hepatitis C virus into the cell: a therapeutic target.

    abstract::Several receptors have been identified as implicated on viral entry into the hepatocyte; and, this interaction between the virus and potential receptors could modulate infection, spontaneous viral clearance, persistence of the infection and the widespread of the virus as outbreak. Nevertheless, the playing role of eac...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Del Campo JA,Rojas Á,Romero-Gómez M

    更新日期:2012-09-07 00:00:00

  • Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids.

    abstract:AIM:To evaluate the utility of measuring epigenetic alterations in pancreatic and biliary fluids in determining molecular markers for pancreatobiliary cancers. METHODS:DNA was extracted from undiluted pancreatic and biliary fluids. As a surrogate for a genome-wide hypomethylation assay, levels of long interspersed nuc...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Kato N,Yamamoto H,Adachi Y,Ohashi H,Taniguchi H,Suzuki H,Nakazawa M,Kaneto H,Sasaki S,Imai K,Shinomura Y

    更新日期:2013-03-21 00:00:00

  • Different patterns of intestinal response to injury after arterial, venous or arteriovenous occlusion in rats.

    abstract:AIM:To investigate the differences in injury patterns caused by arterial, venous or arteriovenous mesenteric occlusion. METHODS:Male Wistar rats were separated equally into four groups. Occlusion was performed by clamping the superior mesenteric artery (A), the mesenteric vein (V) or both (AV) for 30 min, followed by ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Guzmán-de la Garza FJ,Cámara-Lemarroy CR,Alarcón-Galván G,Cordero-Pérez P,Muñoz-Espinosa LE,Fernández-Garza NE

    更新日期:2009-08-21 00:00:00

  • Unusual gastric and pancreatic metastatic renal cell carcinoma presentation 10 years after surgery and immunotherapy: A case report and a review of literature.

    abstract::Renal cell carcinoma (RCC) is the most common renal tumor, accounting for 2%-3% of all malignancies. Though RCC is known to spread hematogenously, isolated RCC metastasis to the stomach is a rare event. In this article, we describe the clinical course of a patient who developed a pancreatic recurrence of RCC and 1 yea...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Riviello C,Tanini I,Cipriani G,Pantaleo P,Nozzoli C,Poma A,Riccardo V,Valeri A

    更新日期:2006-08-28 00:00:00

  • Rare cystic liver lesions: a diagnostic and managing challenge.

    abstract::Cystic formations within the liver are a frequent finding among populations. Besides the common cystic lesions, like simple liver cysts, rare cystic liver lesions like cystadenocarcinoma should also be considered in the differential diagnosis. Thorough knowledge of each entity's nature and course are key elements to s...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Bakoyiannis A,Delis S,Triantopoulou C,Dervenis C

    更新日期:2013-11-21 00:00:00

  • Effect of a nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester on invasion of human colorectal cancer cell line SL-174T.

    abstract:AIM:To investigate the effect and mechanism of action of the nitric oxide synthase (NOS) inhibitor NG-nitro-L-arginine methyl ester (L-NAME) on invasion and metastasis of human colorectal cancer cell line SL-174T. METHODS:Human colorectal cancer cell line SL-174T was cultured and treated separately with four different...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Yu LB,Dong XS,Sun WZ,Zhao DL,Yang Y

    更新日期:2005-10-28 00:00:00

  • Sickle cell cholangiopathy: an endoscopic retrograde cholangiopancreatography evaluation.

    abstract:AIM:To evaluate the role of endoscopic retrograde cholangiopancreatography (ERCP) in patients with sickle cell disease (SCD). METHODS:Two hundred and twenty four SCD patients with cholestatic jaundice (CJ) had ERCP. The indications for ERCP were based on clinical and biochemical evidence of CJ and ultrasound findings....

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Issa H,Al-Haddad A,Al-Salem A

    更新日期:2009-11-14 00:00:00

  • Pancreatic cancer: advances in treatment.

    abstract::Pancreatic cancer is a leading cause of cancer mortality and the incidence of this disease is expected to continue increasing. While patients with pancreatic cancer have traditionally faced a dismal prognosis, over the past several years various advances in diagnosis and treatment have begun to positively impact this ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Mohammed S,Van Buren G 2nd,Fisher WE

    更新日期:2014-07-28 00:00:00

  • A case of asymptomatic intraductal papillary neoplasm of the bile duct without hepatolithiasis.

    abstract::A 65-year-old woman was found to have dilatation of the intrahepatic bile duct in the right anterior segment during a general health. Laboratory data were within normal ranges and no solid mass was detected in her abdominal computer tomography (CT) or nuclear magnetic resonance imaging (MRI). However, endoscopic retro...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Hayashi J,Matsuoka S,Inami M,Ohshiro S,Ishigami A,Fujikawa H,Miyagawa M,Mimatsu K,Kuboi Y,Kanou H,Oida T,Moriyama M

    更新日期:2008-03-14 00:00:00

  • Expression of vascular endothelial growth factors A and C in human pancreatic cancer.

    abstract:AIM:To study the expression of vascular endothelial growth factor A (VEGF-A) and VEGF-C and to determine whether the presence of VEGF-A and VEGF-C was associated with the clinicopathologic characteristics of pancreatic cancer. METHODS:VEGF-A and VEGF-C mRNA transcripts were examined by Northern blot in 6 human pancrea...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Tang RF,Wang SX,Peng L,Wang SX,Zhang M,Li ZF,Zhang ZM,Xiao Y,Zhang FR

    更新日期:2006-01-14 00:00:00

  • Prevalence and factors associated with irritable bowel syndrome among university students in Lebanon: findings from a cross-sectional study.

    abstract:AIM:To describe the bowel habits and the prevalence of irritable bowel syndrome (IBS) and to investigate the influence of health behavior and social factors on IBS prevalence in university students. METHODS:This cross-sectional study was conducted at five major universities in Greater Beirut and its suburbs, between F...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Costanian C,Tamim H,Assaad S

    更新日期:2015-03-28 00:00:00

  • The genetics of nicotine dependence: relationship to pancreatic cancer.

    abstract::Smoking of tobacco products continues to be a major cause of worldwide health problems. Epidemiological studies have shown that tobacco smoking is the greatest risk factor for the development of pancreatic cancer. Smokers who are able to quit smoking can reduce their risk of pancreatic cancer by nearly 50% within two ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: MacLeod SL,Chowdhury P

    更新日期:2006-12-14 00:00:00

  • Vitamin D improves viral response in hepatitis C genotype 2-3 naïve patients.

    abstract:AIM:To examine whether vitamin D improved viral response and predicted treatment outcome in patients with hepatitis C virus (HCV) genotype 2-3. METHODS:Fifty patients with chronic HCV genotype 2-3 were randomized consecutively into two groups: Treatment group [20 subjects, age 48 ± 14 years, body mass index (BMI) 30 ±...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验


    authors: Nimer A,Mouch A

    更新日期:2012-02-28 00:00:00

  • Placement of prophylactic pancreatic stents to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis in high-risk patients: a meta-analysis.

    abstract:AIM:To assess the effectiveness of pancreatic stents for preventing pancreatitis in high-risk patients after endoscopic retrograde cholangiopancreatography (ERCP). METHODS:PubMed, Embase, Science Citation Index, and Cochrane Controlled Trials Register were searched to identify relevant trials published in English. Inc...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审


    authors: Shi QQ,Ning XY,Zhan LL,Tang GD,Lv XP

    更新日期:2014-06-14 00:00:00

  • Cavernous hemangioma arising from the gastro-splenic ligament: a case report.

    abstract::We present a rare case of a 45-year-old woman who presented with epigastric pain associated with early satiety and weight loss. Imaging revealed a large intra-abdominal mass in the epigastrium. Despite intensive investigations, including ultrasound scanning, computed tomography, upper gastrointestinal endoscopy, and p...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Chin KF,Khair G,Babu PS,Morgan DR

    更新日期:2009-08-14 00:00:00

  • Laparoscopic cholecystectomy in situs inversus totalis with "inferior" cystic artery: a case report.

    abstract::A 76-year-old man with known situs inversus totalis presented with left-sided discomfort. Abdominal ultrasonography and CT scan confirmed the diagnosis of a gallstone, as well as, situs inversus; the liver and gallbladder on the left side and the spleen on the right. The biliary system was thought to be left-right rev...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Kamitani S,Tsutamoto Y,Hanasawa K,Tani T

    更新日期:2005-09-07 00:00:00

  • A patient with spinal metastasis from hepatocellular carcinoma discovered from neurological findings.

    abstract::Although spinal tumors are uncommon, they may reduce survival or cause serious functional disorders in the extremities. Metastatic spinal tumors from malignant tumors can induce symptoms of spinal cord compression, such as paraplegia, quadriplegia, and vesicorectal disturbance, which are aggravated with progression of...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Tamaki K,Shimizu I,Urata M,Kohno N,Fukuno H,Ito S,Sano N

    更新日期:2007-05-21 00:00:00

  • Treatment of gastric outlet and duodenal obstructions with uncovered expandable metal stents.

    abstract:AIM:To investigate and evaluate the technical feasibility and clinical effectiveness of fluoroscopically guided peroral uncovered expandable metal stent placement to treat gastric outlet and duodenal obstructions. METHODS:Fifteen consecutive patients underwent peroral placement of Wallstent(TM) Enteral Endoprosthesis ...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章


    authors: Huang Q,Dai DK,Qian XJ,Zhai RY

    更新日期:2007-10-28 00:00:00

  • "Rescue" regimens after Helicobacter pylori treatment failure.

    abstract::Helicobacter pylori (H pylori) infection is the main cause of gastritis, gastroduodenal ulcer disease, and gastric cancer. After more than 20 years of experience in H pylori treatment, in my opinion, the ideal regimen to treat this infection is still to be found. Currently, apart from having to know first-line eradica...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Gisbert JP

    更新日期:2008-09-21 00:00:00

  • Coexistence of Helicobacter pylori spiral and coccoid forms in experimental mice.

    abstract::AIM:To infect mice with Helicobacter pylori and detect immune response against two form of H. pylori.METHODS:An isolate of H. pylori obtained from a patient with gastric cancer was used to infect mice. Fifty mice were divided into eight groups. Two groups served as negative control without any inoculation and internal...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Hua JS,Bow H,Zheng PY,Yeoh GK,Ng CH,Lim GS

    更新日期:1998-12-01 00:00:00

  • A unique case of collagenous colitis presenting as protein-losing enteropathy successfully treated with prednisolone.

    abstract::A 76-year-old woman with a 5-mo history of recurrent diarrhea and generalized edema was admitted to our hospital. Colonoscopy revealed edematous mucosa, and histopathological examination was compatible with collagenous colitis. Protein leakage from the colon, particularly in the ascending portion, was identified on 99...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Sano S,Yamagami K,Tanaka A,Nishio M,Nakamura T,Kubo Y,Inoue T,Ueda W,Okawa K,Yoshioka K

    更新日期:2008-10-21 00:00:00

  • Bronchial bleeding caused by recurrent pneumonia after radical esophagectomy for esophageal cancer.

    abstract::We herein report a case of bronchial bleeding after radical esophagectomy that was treated with lobectomy. A 65-year-old male who underwent subtotal esophagectomy with three-field lymph node dissection for esophageal carcinoma was referred to our hospital because of sudden hemoptysis. After the esophagectomy, bilatera...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Kitajima T,Momose K,Lee S,Haruta S,Ueno M,Shinohara H,Fujimori S,Fujii T,Takei R,Kohno T,Udagawa H

    更新日期:2015-03-21 00:00:00

  • Protective effects of panax notoginseng saponin on dextran sulfate sodium-induced colitis in rats through phosphoinositide-3-kinase protein kinase B signaling pathway inhibition.

    abstract:BACKGROUND:Intestinal inflammation is a common digestive tract disease, which is usually treated with hormone medicines. Hormone medicines are effective to some extent, but long-term use of them may bring about many complications. AIM:To explore the protective effects of panax notoginseng saponin (PNS) against dextran...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Lu QG,Zeng L,Li XH,Liu Y,Du XF,Bai GM,Yan X

    更新日期:2020-03-21 00:00:00