P53 immunohistochemical scoring: an independent prognostic marker for patients after hepatocellular carcinoma resection.


AIM:To confirm if p53 mutation could be a routine predictive marker for the prognosis of hepatocellular carcinoma (HCC) patients. METHODS:Two hundreds and forty-four formalin-fixed paraffin-embedded tumor samples of the patients with HCC receiving liver resection were detected for nuclear accumulation of p53. The percent of P53 immunoreactive tumor cells was scored as 0 to 3+ in P53 positive region (<10% -, 10-30% +, 31-50% ++, >50% +++). Proliferating cell nuclear antigen (PCNA) and some clinicopathological characteristics, including patients' sex, preoperative serum AFP level, tumor size, capsule, vascular invasion (both visual and microscopic), and Edmondson grade were also evaluated. RESULTS:In univariate COX harzard regression model analysis, tumor size, capsule status, vascular invasion, and p53 expression were independent factors that were closely related to the overall survival (OS) rates of HCC patients. The survival rates of patients with 3+ for P53 expression were much lower than those with 2+ or + for P53 expression. Only vascular invasion (P<0.05) and capsule (P<0.01) were closely related to the disease-free survival (DFS) of HCC patients. In multivariate analysis, p53 overexpression (RI 0.5456, P<0.01) was the most significant factor associated with the OS rates of patients after HCC resection, while tumor size (RI 0.5209, P<0.01), vascular invasion (RI 0.5271, P<0.01) and capsule (RI-0.8691, P<0.01) were also related to the OS. However, only tumor capsular status was an independent predictive factor (P<0.05) for the DFS. No significant prognostic value was found in PCNA-LI, Edmondson's grade, patients' sex and preoperative serum AFP level. CONCLUSION:Accumulation of p53 expression, as well as tumor size, capsule and vascular invasion, could be valuable markers for predicting the prognosis of HCC patients after resection. The quantitative immunohistochemical scoring for P53 nuclear accumulation might be more valuable for predicting prognosis of patients after HCC resection than the common qualitative analysis.


World J Gastroenterol


Qin LX,Tang ZY,Ma ZC,Wu ZQ,Zhou XD,Ye QH,Ji Y,Huang LW,Jia HL,Sun HC,Wang L





Has Abstract


2002-06-01 00:00:00












  • Protective effect of melatonin against liver injury in mice induced by Bacillus Calmette-Guerin plus lipopolysaccharide.

    abstract:AIM:To investigate the effects and mechanisms of melatonin on immunological liver injury in mice. METHODS:A model of liver injury was induced by tail vein injection of Bacillus Calmette Guerin (BCG) and lipopolysaccharide (LPS) in mice. Kupffer cells and hepatocytes were isolated and cultured according to a modified t...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Wang H,Wei W,Shen YX,Dong C,Zhang LL,Wang NP,Yue L,Xu SY

    更新日期:2004-09-15 00:00:00

  • Drug induced acute pancreatitis: does it exist?

    abstract::As the incidence of acute pancreatitis continues to rise, establishing the etiology in order to prevent recurrence is important. Although the etiology of acute pancreatitis is not difficult in the majority of patients, almost a quarter of patients are initially labeled as having idiopathic acute pancreatitis. When con...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Tenner S

    更新日期:2014-11-28 00:00:00

  • Oxidative stress and nitric oxide in rats with alcohol-induced acute pancreatitis.

    abstract:AIM:Oxygen free radical mediated tissue damage is well established in pathogenesis of acute pancreatitis (AP). Whether nitric oxide (NO) plays a deleterious or a protective role is unknown. In alcohol-induced AP, we studied NO, lipooxidative damage and glutathione in pancreas, lung and circulation. METHODS:AP was indu...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Andican G,Gelisgen R,Unal E,Tortum OB,Dervisoglu S,Karahasanoglu T,Burçak G

    更新日期:2005-04-21 00:00:00

  • Prolongation of liver allograft survival by dendritic cells modified with NF-kappaB decoy oligodeoxynucleotides.

    abstract:AIM:To induce the tolerance of rat liver allograft by dendritic cells (DCs) modified with NF-kappaB decoy oligodeoxynucleotides (ODNs). METHODS:Bone marrow (BM)-derived DCs from SD rats were propagated in the presence of GM-CSF or GM-CSF+IL-4 to obtain immature DCs or mature DCs. GM-CSF+IL-4-propagated DCs were treate...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Xu MQ,Suo YP,Gong JP,Zhang MM,Yan LN

    更新日期:2004-08-15 00:00:00

  • Confocal laser endomicroscopy and immunoendoscopy for real-time assessment of vascularization in gastrointestinal malignancies.

    abstract::Gastrointestinal cancers represent a major cause of morbidity and mortality, with incomplete response to chemotherapy in the advanced stages and poor prognosis. Angiogenesis plays a crucial part in tumor growth and metastasis, with most gastrointestinal cancers depending strictly on the development of a new and devote...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Gheonea DI,Cârţână T,Ciurea T,Popescu C,Bădărău A,Săftoiu A

    更新日期:2011-01-07 00:00:00

  • Retroperitoneal fibrosis associated with immunoglobulin G4-related disease.

    abstract::Retroperitoneal fibrosis is a rare disease characterized by the development of inflammation and fibrosis in the soft tissues of the retroperitoneum and other abdominal organs. Retroperitoneal fibrosis can be of 2 types: idiopathic and secondary. The recently advocated concept and diagnostic criteria of immunoglobulin ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Fujimori N,Ito T,Igarashi H,Oono T,Nakamura T,Niina Y,Hijioka M,Lee L,Uchida M,Takayanagi R

    更新日期:2013-01-07 00:00:00

  • Etiology of chronic liver diseases in the Northwest of Italy, 1998 through 2014.

    abstract:AIM:To assess the etiology of chronic liver diseases (CLD) from 1998 to 2014 at the outpatient clinic of Gastroenterology of the main hospital in Northwest of Italy among those dedicated to hepatology. METHODS:A random sample of charts of patients referred to for increased liver enzymes between January 1998 and Decemb...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Saracco GM,Evangelista A,Fagoonee S,Ciccone G,Bugianesi E,Caviglia GP,Abate ML,Rizzetto M,Pellicano R,Smedile A

    更新日期:2016-09-28 00:00:00

  • Prognostic implication of isolated tumor cells and micrometastases in regional lymph nodes of gastric cancer.

    abstract:AIM:To determine the prognostic significance of isolated tumor cells (ITCs) and lymph node micrometastases in gastric cancer. METHODS:Hematoxylin and eosin-stained slides of lymph node dissections of 632 consecutive gastric cancers were reviewed. Cytokeratin immunostaining was performed in 280 node-negative cases and ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Lee HS,Kim MA,Yang HK,Lee BL,Kim WH

    更新日期:2005-10-14 00:00:00

  • Immune response to vaccines in children with celiac disease.

    abstract::Celiac disease (CD) is an immune-mediated systemic condition evoked by ingestion of gluten and related prolamines in genetically susceptible subjects. The disease is featured by a variable combination of clinical signs, specific antibodies, HLA-DQ2 and HLA-DQ8 haplotypes, and enteropathy. Vaccination is the most poten...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审


    authors: Anania C,Olivero F,Spagnolo A,Chiesa C,Pacifico L

    更新日期:2017-05-14 00:00:00

  • Prevalence and factors associated with irritable bowel syndrome among university students in Lebanon: findings from a cross-sectional study.

    abstract:AIM:To describe the bowel habits and the prevalence of irritable bowel syndrome (IBS) and to investigate the influence of health behavior and social factors on IBS prevalence in university students. METHODS:This cross-sectional study was conducted at five major universities in Greater Beirut and its suburbs, between F...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Costanian C,Tamim H,Assaad S

    更新日期:2015-03-28 00:00:00

  • Molecular mechanism and functional consequences of lansoprazole-mediated heme oxygenase-1 induction.

    abstract:AIM:To investigate the molecular mechanism and functional consequences of heme oxygenase-1 (HO-1) activation by lansoprazole in endothelial cells and macrophages. METHODS:Expression of HO-1 mRNA was analyzed by Northern blotting. Western blotting was used to determine the HO-1 and ferritin protein levels. NADPH-depend...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Schulz-Geske S,Erdmann K,Wong RJ,Stevenson DK,Schröder H,Grosser N

    更新日期:2009-09-21 00:00:00

  • Hemorrhoidectomy - making sense of the surgical options.

    abstract::While debate continues as to which is the best surgical method for the treatment of hemorrhoids, none of the currently available surgical methods approach the ideal surgical option, which is one that is effective while being safe and painless. In reality, the less painful the procedure, the more likely it is to be ass...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Yeo D,Tan KY

    更新日期:2014-12-07 00:00:00

  • Cancer in inflammatory bowel disease.

    abstract::Patients with long-standing inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer (CRC). Many of the molecular alterations responsible for sporadic colorectal cancer, namely chromosomal instability, microsatellite instability, and hypermethylation, also play a role in colitis-associat...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Xie J,Itzkowitz SH

    更新日期:2008-01-21 00:00:00

  • Primary biliary cirrhosis: Clinical and laboratory criteria for its diagnosis.

    abstract::Primary biliary cirrhosis (PBC) is a chronic progressive cholestatic granulomatous, and destructive inflammatory lesion of small intralobular and septal bile ducts, which is likely to be caused by an autoimmune mechanism with a the presence of serum antimitochondrial antibodies and a potential tendency to progress to ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Reshetnyak VI

    更新日期:2015-07-07 00:00:00

  • Management of antiviral drug resistance in chronic hepatitis B.

    abstract::Rescue antiviral treatment for patients with resistance to preexisting nucleos(t)ide analogues remains a clinical challenge. The correct choice of a first-line treatment of high potency and with a high genetic barrier to achieve sustained long-term suppression of viral replication provides the best chance of preventin...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Bang KB,Kim HJ

    更新日期:2014-09-07 00:00:00

  • Inflammatory bowel disease: a proposal to facilitate the achievement of an unequivocal diagnosis.

    abstract::Following the international guidelines criteria an adequate "diagnostic conclusion" of inflammatory bowel disease (IBD) can be achieved only if clinical, endoscopic and laboratory findings, together with sample technical adequacy and unequivocal histomorphological signs of the disease are available. Thus, a conclusive...

    journal_title:World journal of gastroenterology

    pub_type: 信件


    authors: Canavese G,Bassotti G,Astegiano M,Castellano I,Cassoni P,Sapino A,Villanacci V

    更新日期:2013-01-21 00:00:00

  • Grasper type scissors for endoscopic submucosal dissection of gastric epithelial neoplasia.

    abstract:AIM:To evaluate the efficacy and safety of grasper type scissors (GTS) for endoscopic submucosal dissection (ESD) of gastric epithelial neoplasia. METHODS:The study was performed by 4 endoscopists in 4 institutions affiliated to The Catholic University of Korea. ESD was performed in 76 consecutive patients with gastri...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Chung WC,Kim BW,Lim CH,Kim TH,Park JM,Kim JS

    更新日期:2013-10-07 00:00:00

  • Repression of allo-cell transplant rejection through CIITA ribonuclease P+ hepatocyte.

    abstract:AIM:Allo-cell transplant rejection and autoimmune responses were associated with the presence of class II major histocompatibility complex (MHC II) molecules on cells. This paper studied the effect of Ribonuclease P (RNase P) against CIITA, which was a major regulator of MHCII molecules, on repressing the expression of...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Guo R,Zou P,Fan HH,Gao F,Shang QX,Cao YL,Lu HZ

    更新日期:2003-05-01 00:00:00

  • Dynamical changing patterns of glycogen and enzyme histochemical activities in rat liver graft undergoing warm ischemia injury.

    abstract:AIM:To investigate the changing patterns of glycogen and enzyme histochemical activities in rat liver graft under a different warm ischemia time (WIT) and to predict the tolerant time limitation of the liver graft to warm ischemia injury. METHODS:The rats were randomized into five groups, WIT was 0, 15, 30, 45, 60 min...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: He XS,Ma Y,Wu LW,Wu JL,Hu RD,Chen GH,Huang JF

    更新日期:2005-05-07 00:00:00

  • Inflammatory pathways in the early steps of colorectal cancer development.

    abstract::Colorectal cancer is a major cause of cancer-related death in many countries. Colorectal carcinogenesis is a stepwise process which, from normal mucosa leads to malignancy. Many factors have been shown to influence this process, however, at present, several points remain obscure. In recent years some hypotheses have b...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Mariani F,Sena P,Roncucci L

    更新日期:2014-08-07 00:00:00

  • Emerging use of artificial intelligence in inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD) is a complex, immune-mediated gastrointestinal disorder with ill-defined etiology, multifaceted diagnostic criteria, and unpredictable treatment response. Innovations in IBD diagnostics, including developments in genomic sequencing and molecular analytics, have generated tremendous int...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Kohli A,Holzwanger EA,Levy AN

    更新日期:2020-11-28 00:00:00

  • Helicobacter pylori and gastric mucin expression: A systematic review and meta-analysis.

    abstract:AIM:To investigate the relationship between Helicobacter pylori (H. pylori) and mucin expression in gastric mucosa. METHODS:English Medical literature searches were conducted for gastric mucin expression in H. pylori infected people vs uninfected people. Searches were performed up to December 31(th) 2014, using MEDLIN...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审


    authors: Niv Y

    更新日期:2015-08-21 00:00:00

  • Portal hypertension due to portal venous thrombosis: etiology, clinical outcomes.

    abstract::The thrombophilia in adult life has major implications in the hepatic vessels. The resulting portal vein thrombosis has various outcomes and complications. Esophageal varices, portal gastropathy, ascites, severe hypersplenism and liver failure needing liver transplantation are known well. The newly formed collateral v...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Harmanci O,Bayraktar Y

    更新日期:2007-05-14 00:00:00

  • Diagnosis and evaluation of gastric cancer by positron emission tomography.

    abstract::Gastric cancer is the second leading cause of cancer mortality worldwide. The diagnosis of gastric cancer has been significantly improved with the broad availability of gastrointestinal endoscopy. Effective technologies for accurate staging and quantitative evaluation are still in demand to merit reasonable treatment ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Wu CX,Zhu ZH

    更新日期:2014-04-28 00:00:00

  • Role of mitochondria in cell apoptosis during hepatic ischemia-reperfusion injury and protective effect of ischemic postconditioning.

    abstract:AIM:To investigate the role of mitochondria in cell apoptosis during hepatic ischemia-reperfusion injury and protective effect of ischemic postconditioning (IPC). METHODS:A rat model of acute hepatic ischemia-reperfusion was established, 24 healthy male Wistar rats were randomly divided into sham-operated group, ische...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Sun K,Liu ZS,Sun Q

    更新日期:2004-07-01 00:00:00

  • Early prediction of major depression in chronic hepatitis C patients during peg-interferon alpha-2b treatment by assessment of vegetative-depressive symptoms after four weeks.

    abstract:AIM:To study the predictive value of the vegetative-depressive symptoms of the Zung Depression Rating Scale for the occurrence of depression during treatment with peg-interferon alpha-2b of chronic hepatitis C (CHC) patients. METHODS:The predictive value of vegetative-depressive symptoms at 4 wk of treatment for the o...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Robaeys G,De Bie J,Wichers MC,Bruckers L,Nevens F,Michielsen P,Van Ranst M,Buntinx F

    更新日期:2007-11-21 00:00:00

  • Metastasis of hepatocellular carcinoma to the small bowel manifested by intussusception.

    abstract::Hepatocellular carcinoma (HCC) is a highly invasive tumor that metastasizes hematogenously and lymphogenously to distant site. Frequent sites are lung, regional lymph node, bone, and adrenal gland. But metastasis to the gastrointestinal (GI) tract is rare, and most common site is stomach. Metastasis to the small intes...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Kim HS,Shin JW,Kim GY,Kim YM,Cha HJ,Jeong YK,Jeong ID,Bang SJ,Kim DH,Park NH

    更新日期:2006-03-28 00:00:00

  • Use of pre-, pro- and synbiotics in patients with acute pancreatitis: a meta-analysis.

    abstract:AIM:To assess the clinical outcomes of pre-, pro- and synbiotics therapy in patients with acute pancreatitis. METHODS:The databases including Medline, Embase, the Cochrane Library, Web of Science and Chinese Biomedicine Database were searched for all relevant randomized controlled trials that studied the effects of pr...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析


    authors: Zhang MM,Cheng JQ,Lu YR,Yi ZH,Yang P,Wu XT

    更新日期:2010-08-21 00:00:00

  • What is a reliable CT scan for diagnosing splenosis under emergency conditions?

    abstract::Splenosis is a condition in which splenic tissue is present in a non-anatomical position. Implants of splenic tissue can mimic neoplasms and only specific examinations can confirm the correct diagnosis. Here we report a case of a 23-year-old male patient with a history of surgical splenectomy during childhood after tr...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Garaci FG,Grande M,Villa M,Mancino S,Konda D,Attinà GM,Galatà G,Simonetti G

    更新日期:2009-08-07 00:00:00

  • Over-expression of fibroblast growth factor receptor 3 in human hepatocellular carcinoma.

    abstract:AIM:To describe the significant over-expression of fibroblast growth factor receptor 3 (FGFR3), which is a signal transduction and cell proliferation related gene in hepatocellular carcinoma (HCC). METHODS:Following DNA microarray, Northern blot and quantitative real-time PCR were employed to confirm FGFR3 expression ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Qiu WH,Zhou BS,Chu PG,Chen WG,Chung C,Shih J,Hwu P,Yeh C,Lopez R,Yen Y

    更新日期:2005-09-14 00:00:00