Abstract:
AIM:To evaluate the outcome of chronic hepatitis B (CHB) in children with or without malignancies. METHODS:Twenty four children (15 boys and 9 girls) with malignancies, followed up by the pediatric gastroenterology outpatient clinic for CHB between January 2000 and December 2013, were enrolled in the study (Group 1). Group 2 was formed with twenty five children (11 girls and 14 boys) diagnosed with CHB without malignancies. The data from the patients' records were compared between the two groups. RESULTS:Hepatitis B e antigen (HBeAg)/antiHBe seroconversion was observed in 3 patients (12.5%) in group 1 and 15 patients (60%) in group 2, with annual seroconversion rates of 1.61% and 16.6%, respectively, and the difference was significant (P<0.01). One patient (6.6%) in Group 1 and 9 patients (53%) in Group 2 showed HBeAg/antiHBe seroconversion after treatment and the difference between the two groups was significant (P<0.06) Loss of hepatitis B surface antigen was observed in one patient in each of group 1 and 2. No clinical, laboratory and imaging findings of liver disease were observed in any of the patients at the end of the study. CONCLUSION:HBeAg/antiHBe seroconversion rate was lower in patients who had recovered from cancer.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Usta M,Urgancı N,Yıldırmak ZY,Dogan Vural Sdoi
10.3748/wjg.v21.i7.2073subject
Has Abstractpub_date
2015-02-21 00:00:00pages
2073-9issue
7eissn
1007-9327issn
2219-2840journal_volume
21pub_type
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pub_type: 杂志文章,meta分析,评审
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