Endoscopic submucosal dissection for early gastric cancer with undifferentiated-type histology: A meta-analysis.

Abstract:

AIM:To evaluate the efficacy and safety of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) with undifferentiated-type histology. METHODS:A systematic literature review was conducted using the core databases. Complete resection, curative resection, en bloc resection, recurrence and adverse event rate were extracted and analyzed. A random effect model was applied. The methodological quality of the enrolled studies was assessed using the Newcastle-Ottawa Scale. Publication bias was evaluated using a funnel plot, the trim and fill method, Egger's test, and a rank correlation test. RESULTS:Fourteen retrospective studies between 2009 and 2014 were identified (972 EGC lesions with undifferentiated-type histology). The total en bloc and complete resection rates were estimated as 92.1% (95%CI: 87.4%-95.2%) and 77.5% (95%CI: 69.3%-84%), respectively. The total curative resection rate was 61.4% (95%CI: 44.5%-75.9%). The overall recurrence rate was 7.6% (95%CI: 3.4%-16%). Limited to histologically diagnosed expanded-criteria lesions, the en bloc and complete resection rates were 91.2% and 85.6%, respectively. The curative resection rate was 79.8%. CONCLUSION:In this analysis, ESD is a technically feasible treatment modality for EGC with undifferentiated-type histology. Long-term studies are needed to confirm these therapeutic outcomes.

journal_name

World J Gastroenterol

authors

Bang CS,Baik GH,Shin IS,Kim JB,Suk KT,Yoon JH,Kim YS,Kim DJ,Shin WG,Kim KH,Kim HY,Lim H,Kang HS,Kim JH,Kim JB,Jung SW,Kae SH,Jang HJ,Choi MH

doi

10.3748/wjg.v21.i19.6032

subject

Has Abstract

pub_date

2015-05-21 00:00:00

pages

6032-43

issue

19

eissn

1007-9327

issn

2219-2840

journal_volume

21

pub_type

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