Pedunculated Brunner's gland hamartoma of the duodenum causing upper gastrointestinal hemorrhage.


:A case of pedunculated Brunner's gland hamartoma (BGH) of the duodenum causing upper gastrointestinal (GI) hemorrhage is reported. The patient was a 47-year-old man who visited our hospital for further evaluation of tarry stools and shortness of breath. Endoscopic examination of the upper digestive tract revealed a large peduncular polyp with bleeding, about 30 mm in diameter, arising from the wall of the second portion of the duodenum. GI bleeding occurred from the base of the stalk of the polyp. Endoscopic polypectomy was performed. Histological examination of the specimen revealed that the main body of the polyp contained several lobules of mature Brunner's gland with areas of cystic dilatation. The surface epithelium consisted of normal duodenal mucosa with areas of focal ulceration. This polyp was diagnosed as a BGH. The symptom of tarry stools resolved after endoscopic resection. Our case shows that treatment is necessary for duodenal BGH if GI bleeding occurs.


World J Gastroenterol


Hirasaki S,Kubo M,Inoue A,Miyake Y,Oshiro H




Has Abstract


2009-01-21 00:00:00












  • Successful isolation of Helicobacter pylori after prolonged incubation from a patient with failed eradication therapy.

    abstract::Helicobacter pylori (H pylori), a gastric pathogen, is a major cause of chronic gastritis and peptic ulcer disease, and is an important risk factor for the development of gastric malignancies. Culture of the bacterium from gastric biopsy is essential for the determination of drug resistance of H pylori. However, the i...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Yin Y,He LH,Zhang JZ

    更新日期:2009-03-28 00:00:00

  • Mucosa repair mechanisms of Tong-Xie-Yao-Fang mediated by CRH-R2 in murine, dextran sulfate sodium-induced colitis.

    abstract:AIM:To explore the significance of corticotropin-releasing hormone (CRH)-receptor (R)2 in mucosal healing of dextran sulfate sodium (DSS)-induced colitis and the effect of Tong-Xie-Yao-Fang (TXYF) on CRH-R2 expression and regulation. METHODS:Ulcerative colitis was induced in mice by administration of 3% (w/v) DSS for ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Gong SS,Fan YH,Wang SY,Han QQ,Lv B,Xu Y,Chen X,He YE

    更新日期:2018-04-28 00:00:00

  • Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children.

    abstract:AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated (polyethylene glycol) interferon (IFN)-alpha-2a (Reiferon Retard) plus ribavirin customized regimen in treatment-naïve and previously treated (non-responders and relapsers) Egyptian children with chronic hepatitis C infection. METHODS:Forty-si...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: El Naghi S,Abdel-Ghaffar TY,El-Karaksy H,Abdel-Aty EF,El-Raziky MS,Allam AA,Helmy H,El-Araby HA,Behairy BE,El-Guindi MA,El-Sebaie H,Abdel-Ghaffar AY,Ehsan NA,El-Hennawy AM,Sira MM

    更新日期:2014-04-28 00:00:00

  • Changes of gut flora and endotoxin in rats with D-galactosamine-induced acute liver failure.

    abstract:AIM:To investigate the changes of gut microflora and endotoxin levels in rats with acute liver failure (ALF) induced by D-galactosamine (GalN). METHODS:Flora and endotoxin levels in the jejunum, ileum and colon in normal rats (group A) and rats with GalN -induced ALF were determined at 24 h (group B) or 48 h (group C)...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Li LJ,Wu ZW,Xiao DS,Sheng JF

    更新日期:2004-07-15 00:00:00

  • No evidence demonstrating hepatotoxicity associated with hydroxycitric acid.

    abstract::Although a number of cases of hepatotoxicity are associated with the use of Hydroxycut weight management products, it has been alleged that their effects are primarily due to the presence of hydroxycitric acid (HCA, as Super CitriMax) in the formulations. However, while these products contain up to 20 different ingred...

    journal_title:World journal of gastroenterology

    pub_type: 评论,信件


    authors: Stohs SJ,Preuss HG,Ohia SE,Kaats GR,Keen CL,Williams LD,Burdock GA

    更新日期:2009-08-28 00:00:00

  • Endoscopic full-thickness resection and laparoscopic surgery for treatment of gastric stromal tumors.

    abstract:AIM:To assess the effectiveness of endoscopic full-thickness resection (EFR) and laparoscopic surgery in the treatment of gastric stromal tumors arising from the muscularis propria. METHODS:Out of 62 gastric stromal tumors arising from the muscularis propria, each > 1.5 cm in diameter, 32 were removed by EFR, and 30 w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Huang LY,Cui J,Wu CR,Zhang B,Jiang LX,Xian XS,Lin SJ,Xu N,Cao XL,Wang ZH

    更新日期:2014-07-07 00:00:00

  • Successful resection of metachronous para-aortic, Virchow lymph node and liver metastatic recurrence of rectal cancer.

    abstract::A 66-year-old female presented with the main complaint of defecation trouble and abdominal distention. With diagnosis of rectal cancer, cSS, cN0, cH0, cP0, cM0 cStage II, Hartmann's operation with D3 lymph node dissection was performed and a para-aortic lymph node and a disseminated node near the primary tumor were re...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Takeshita N,Fukunaga T,Kimura M,Sugamoto Y,Tasaki K,Hoshino I,Ota T,Maruyama T,Tamachi T,Hosokawa T,Asai Y,Matsubara H

    更新日期:2015-11-28 00:00:00

  • Two cases of neuroendocrine carcinoma of the gallbladder.

    abstract::Neuroendocrine carcinoma (NEC) of the gallbladder is a rare subtype of gallbladder tumor. Here, we report two cases of NEC in two patients initially suspected to have gallbladder carcinoma. No specific symptoms or abnormal blood test results were observed preoperatively. Abdominal computed tomography scans indicated i...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Chen H,Shen YY,Ni XZ

    更新日期:2014-09-07 00:00:00

  • A case of gas gangrene in an immunosuppressed Crohn's patient.

    abstract::Clostridium septicum (C. septicum) gas gangrene is well documented in the literature, typically in the setting of trauma or immunosuppression. In this paper, we report a unique case of spontaneous clostridial myonecrosis in a patient with Crohn's disease and sulfasalazine-induced neutropenia. The patient presented wit...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Kiel N,Ho V,Pascoe A

    更新日期:2011-09-07 00:00:00

  • Postprandial transduodenal bolus transport is regulated by complex peristaltic sequence.

    abstract:AIM:To study the relationship between the patterns of postprandial peristalsis and transduodenal bolus transport in healthy subjects. METHODS:Synchronous recording of chyme transport and peristaltic activity was performed during the fasting state and after administration of a test meal using a special catheter device ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Nguyen HN,Winograd R,Domingues GR,Lammert F

    更新日期:2006-10-07 00:00:00

  • MiR-451 inhibits proliferation of esophageal carcinoma cell line EC9706 by targeting CDKN2D and MAP3K1.

    abstract:AIM:To investigate the underlying molecular mechanisms of miR-451 to inhibit proliferation of esophageal carcinoma cell line EC9706. METHODS:Assays for cell growth, apoptosis and invasion were used to evaluate the effects of miR-451 expression on EC cells. Luciferase reporter and Western blot assays were used to test ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Zang WQ,Yang X,Wang T,Wang YY,Du YW,Chen XN,Li M,Zhao GQ

    更新日期:2015-05-21 00:00:00

  • G and D cells in rat antral mucosa: an immunoelectron microscopic study.

    abstract:AIM:To investigate the gastrin secreting cells (G cells) and the somatostatin secreting cells (D cells) of antral mucosa in rats at the ultrastructural level. METHODS:Revised immunoelectron microscopic technique was used to detect the G cells and D cells in rat antral mucosa through gastrin and somatostatin antibodies...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Sun FP,Song YG

    更新日期:2003-12-01 00:00:00

  • Molecular mechanism and functional consequences of lansoprazole-mediated heme oxygenase-1 induction.

    abstract:AIM:To investigate the molecular mechanism and functional consequences of heme oxygenase-1 (HO-1) activation by lansoprazole in endothelial cells and macrophages. METHODS:Expression of HO-1 mRNA was analyzed by Northern blotting. Western blotting was used to determine the HO-1 and ferritin protein levels. NADPH-depend...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Schulz-Geske S,Erdmann K,Wong RJ,Stevenson DK,Schröder H,Grosser N

    更新日期:2009-09-21 00:00:00

  • Natural products and food components with anti-Helicobacter pylori activities.

    abstract::The bacterial pathogen Helicobacter pylori (H. pylori) colonizes in over half of the world's population. H. pylori that establishes life-long infection in the stomach is definitely associated with gastro-duodenal diseases and a wide variety of non-gastrointestinal tract conditions such as immune thrombocytopenia. Trip...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Takeuchi H,Trang VT,Morimoto N,Nishida Y,Matsumura Y,Sugiura T

    更新日期:2014-07-21 00:00:00

  • Campylobacter concisus and inflammatory bowel disease.

    abstract::Investigation of the possible role of Campylobacter concisus (C. concisus) in inflammatory bowel disease (IBD) is an emerging research area. Despite the association found between C. concisus and IBD, it has been difficult to explain how C. concisus, a bacterium that is commonly present in the human oral cavity, may co...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Zhang L,Lee H,Grimm MC,Riordan SM,Day AS,Lemberg DA

    更新日期:2014-02-07 00:00:00

  • Relationship between autophagy and perineural invasion, clinicopathological features, and prognosis in pancreatic cancer.

    abstract:AIM:To investigate the relationship between autophagy and perineural invasion (PNI), clinical features, and prognosis in patients with pancreatic cancer. METHODS:Clinical and pathological data were retrospectively collected from 109 patients with pancreatic ductal adenocarcinoma who underwent radical resection at the ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Yang YH,Liu JB,Gui Y,Lei LL,Zhang SJ

    更新日期:2017-10-28 00:00:00

  • Emodin and baicalein inhibit sodium taurocholate-induced vacuole formation in pancreatic acinar cells.

    abstract:AIM:To investigate the effects of combined use of emodin and baicalein (CEB) at the cellular and organism levels in severe acute pancreatitis (SAP) and explore the underlying mechanism. METHODS:SAP was induced by retrograde infusion of 5% sodium taurocholate into the pancreatic duct in 48 male SD rats. Pancreatic hist...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Li J,Zhou R,Bie BB,Huang N,Guo Y,Chen HY,Shi MJ,Yang J,Zhang J,Li ZF

    更新日期:2018-01-07 00:00:00

  • Pharmacological pain management in chronic pancreatitis.

    abstract::Intense abdominal pain is a prominent feature of chronic pancreatitis and its treatment remains a major clinical challenge. Basic studies of pancreatic nerves and experimental human pain research have provided evidence that pain processing is abnormal in these patients and in many cases resembles that seen in neuropat...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Olesen SS,Juel J,Graversen C,Kolesnikov Y,Wilder-Smith OH,Drewes AM

    更新日期:2013-11-14 00:00:00

  • Effect of early preoperative 5-fluorouracil on the integrity of colonic anastomoses in rats.

    abstract:AIM:To determine the effect of chemotherapy on wound healing by giving early preoperative 5-fluorouracil (5-FU) to rats with colonic anastomoses. METHODS:Sixty Albino-Wistar male rats (median weight, 235 g) were used in this study. The rats were fed with standard laboratory food and given tap water ad libitum. The ani...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Ozel L,Ozel MS,Toros AB,Kara M,Ozkan KS,Tellioglu G,Krand O,Koyuturk M,Berber I

    更新日期:2009-09-07 00:00:00

  • Association between obesity-related adipokines and colorectal cancer: a case-control study and meta-analysis.

    abstract:AIM:To examine the association between obesity-related adipokines (adiponectin, leptin, resistin, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) and colorectal cancer (CRC) risk. METHODS:Serum levels of adipokines were measured in 100 CRC patients and age- and sex-matched controls for the data analysis. Unc...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审


    authors: Joshi RK,Kim WJ,Lee SA

    更新日期:2014-06-28 00:00:00

  • Bevacizumab in the pre-operative treatment of locally advanced rectal cancer: a systematic review.

    abstract::Despite advances in the management of patients with locally advanced, non-metastatic rectal adenocarcinoma (LARC), prognosis remains largely unsatisfactory due to a high rate of distant relapse. In fact, currently available neoadjuvant protocols, represented by fluoropyrimidine-based chemo-radiotherapy (CT-RT) or shor...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Fornaro L,Caparello C,Vivaldi C,Rotella V,Musettini G,Falcone A,Baldini E,Masi G

    更新日期:2014-05-28 00:00:00

  • Nuclear and mitochondrial DNA microsatellite instability in hepatocellular carcinoma in Chinese.

    abstract:AIM:To study the nuclear microsatellite instability (nMSI) at BAT26 and mitochondrial microsatellite instability (mtMSI) in the occurrence and development of hepatocellular carcinoma and the relationship between nMSI and mtMSI. METHODS:nMSI was observed with PCR and mtMSI with PCR-SSCP in 52 cases of hepatocellular ca...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Fang DC,Fang L,Wang RQ,Yang SM

    更新日期:2004-02-01 00:00:00

  • Hepatoma with cardiac metastasis: an advanced cancer requiring advanced treatment.

    abstract:AIM:To investigate the clinical and pathologic findings, and to discuss the pathophysiology of hepatocellular carcinoma with cardiac metastasis. METHODS:Eight hepatoma patients with cardiac metastasis, who were treated by surgical excision from 1993 to 2006, were retrospectively studied. Detailed clinical parameters w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Lin YS,Jung SM,Tsai FC,Yeh CN,Shiu TF,Wu HH,Lin PJ,Chu PH

    更新日期:2007-07-07 00:00:00

  • Laparoscopic liver resection: wedge resections to living donor hepatectomy, are we heading in the right direction?

    abstract::Despite inception over 15 years ago and over 3000 completed procedures, laparoscopic liver resection has remained mainly in the domain of selected centers and enthusiasts. Requirement of extensive open liver resection (OLR) experience, in-depth understanding of anatomy and considerable laparoscopic technical expertise...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Cherian PT,Mishra AK,Kumar P,Sachan VK,Bharathan A,Srikanth G,Senadhipan B,Rela MS

    更新日期:2014-10-07 00:00:00

  • MicroRNAs potential utility in colon cancer: Early detection, prognosis, and chemosensitivity.

    abstract::Over the past decade, research has shown that aberrant expression of microRNA (miRNA) is involved in colorectal cancer development and progression. MicroRNAs are small sequences of non-coding RNA that regulate expression of genes involved in important cellular functions, such as cell differentiation, multiplication, a...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Hollis M,Nair K,Vyas A,Chaturvedi LS,Gambhir S,Vyas D

    更新日期:2015-07-21 00:00:00

  • Long-term outcome in patients with obscure gastrointestinal bleeding after negative capsule endoscopy.

    abstract:AIM:To investigate long-term outcome in obscure gastrointestinal bleeding (OGIB) after negative capsule endoscopy (CE) and identify risk factors for rebleeding. METHODS:A total of 113 consecutive patients underwent CE for OGIB from May 2003 to June 2010 at Seoul National University Hospital. Ninety-five patients (84.1...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Koh SJ,Im JP,Kim JW,Kim BG,Lee KL,Kim SG,Kim JS,Jung HC

    更新日期:2013-03-14 00:00:00

  • Strongyloides hyper-infection causing life-threatening gastrointestinal bleeding.

    abstract::A 55-year old male patient was diagnosed with strongy-loides hyper-infection with stool analysis and intestinal biopsy shortly after his chemotherapy for myeloma. He was commenced on albendazole anthelmintic therapy. After initiation of the treatment he suffered life-threatening gastrointestinal (GI) bleeding. Repeate...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Csermely L,Jaafar H,Kristensen J,Castella A,Gorka W,Chebli AA,Trab F,Alizadeh H,Hunyady B

    更新日期:2006-10-21 00:00:00

  • Split-dose bowel preparation improves adequacy of bowel preparation and gastroenterologists' adherence to National Colorectal Cancer Screening and Surveillance Guidelines.

    abstract:AIM:To quantify the impact of split-dose regimen on endoscopists' compliance with guideline recommendations for timing of repeat colonoscopy in patients with normal colonoscopy or 1-2 small polyps (< 10 mm). METHODS:A retrospective chart review of all endoscopy reports was undertaken in average-risk individuals > 50 y...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Menees SB,Kim HM,Schoenfeld P

    更新日期:2018-02-14 00:00:00

  • Expression and immunoreactivity of an epitope of HCV in a foreign epitope presenting system.

    abstract:AIM:To construct and highly express an epitope of hepatitis C virus (HCV) in a foreign epitope presenting vector based on an insect virus, and to study the antigenicity of the epitope. METHODS:The HCV epitope sequence (amino acid residues 315 to 328: EGHRMAWDMMMNWS) of the E1 region was constructed at different positi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章


    authors: Peng M,Dai CB,Chen YD

    更新日期:2005-06-14 00:00:00

  • Research progress of vasculopathy in portal hypertension.

    abstract::Portal hypertension, one of the vascular diseases, not only has lesions in liver, but also changes in vascular structures and functions of extrahepatic portal system, systemic system and pulmonary circulation. The pathological changes of vasculopathy in portal hypertension include remodeling of arterialized visceral v...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Li T,Yang Z

    更新日期:2005-10-21 00:00:00