Penicillium marneffei chylous ascites in acquired immune deficiency syndrome: a case report.

Abstract:

:Penicillium marneffei (P. marneffei) infection usually occurs with skin, bone marrow, lung or hepatic involvement. However, no cases of P. marneffei infection with chylous ascites have been reported thus far. In this report, we describe the first case of acquired immune deficiency syndrome (AIDS) which has been complicated by a P. marneffei infection causing chylous ascites. We describe the details of the case, with an emphasis on treatment regimen. This patient was treated with amphotericin B for 3 mo, while receiving concomitant therapy with an efavirenz-containing antiretroviral regimen, but cultures in ascitic fluid were persistently positive for P. marneffei. The infection resolved after treatment with high-dose voriconazole (400 mg every 12 h) for 3 mo. P. marneffei should be considered in the differential diagnosis of chylous ascites in human immunodeficiency virus patients. High-dose voriconazole is an effective, well-tolerated and convenient option for the treatment of systemic infections with P. marneffei in AIDS patients on an efavirenz-containing antiretroviral regimen.

journal_name

World J Gastroenterol

authors

Shen YZ,Wang ZY,Lu HZ

doi

10.3748/wjg.v18.i37.5312

subject

Has Abstract

pub_date

2012-10-07 00:00:00

pages

5312-4

issue

37

eissn

1007-9327

issn

2219-2840

journal_volume

18

pub_type

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