Involvement of heat shock proteins in gluten-sensitive enteropathy.

Abstract:

:Gluten-sensitive enteropathy, also known as coeliac disease (CD), is an autoimmune disorder occurring in genetically susceptible individuals that damages the small intestine and interferes with the absorption of other nutrients. As it is triggered by dietary gluten and related prolamins present in wheat, rye and barley, the accepted treatment for CD is a strict gluten-free diet. However, a complete exclusion of gluten-containing cereals from the diet is often difficult, and new therapeutic strategies are urgently needed. A class of proteins that have already emerged as drug targets for other autoimmune diseases are the heat shock proteins (HSPs), which are highly conserved stress-induced chaperones that protect cells against harmful extracellular factors. HSPs are expressed in several tissues, including the gastrointestinal tract, and their levels are significantly increased under stress circumstances. HSPs exert immunomodulatory effects, and also play a crucial role in the maintenance of epithelial cell structure and function, as they are responsible for adequate protein folding, influence the degradation of proteins and cell repair processes after damage, and modulate cell signalling, cell proliferation and apoptosis. The present review discusses the involvement of HSPs in the pathophysiology of CD. Furthermore, HSPs may represent a useful therapeutic target for the treatment of CD due to the cytoprotective, immunomodulatory, and anti-apoptotic effects in the intestinal mucosal barrier.

journal_name

World J Gastroenterol

authors

Sziksz E,Pap D,Veres G,Fekete A,Tulassay T,Vannay Á

doi

10.3748/wjg.v20.i21.6495

subject

Has Abstract

pub_date

2014-06-07 00:00:00

pages

6495-503

issue

21

eissn

1007-9327

issn

2219-2840

journal_volume

20

pub_type

杂志文章,评审
  • CMA down-regulates p53 expression through degradation of HMGB1 protein to inhibit irradiation-triggered apoptosis in hepatocellular carcinoma.

    abstract:AIM:To investigate the mechanism of chaperone-mediated autophagy (CMA)-induced resistance to irradiation-triggered apoptosis through regulation of the p53 protein in hepatocellular carcinoma (HCC). METHODS:Firstly, we detected expression of lysosome-associated membrane protein 2a (Lamp-2a), which is the key protein of...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i13.2308

    authors: Wu JH,Guo JP,Shi J,Wang H,Li LL,Guo B,Liu DX,Cao Q,Yuan ZY

    更新日期:2017-04-07 00:00:00

  • Incidence of hepatocellular carcinoma in outpatients with cirrhosis in Brazil: A 10-year retrospective cohort study.

    abstract:AIM:To determine the incidence of hepatocellular carcinoma (HCC) and the impact of HCC surveillance on early diagnosis and survival of cirrhotic outpatients. METHODS:In this retrospective cohort study, cirrhotic outpatients undergoing HCC surveillance between March 2005 and March 2014 were analyzed. Exclusion criteria...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i46.10219

    authors: Appel-da-Silva MC,Miozzo SA,Dossin IA,Tovo CV,Branco F,de Mattos AA

    更新日期:2016-12-14 00:00:00

  • Efficacy of noninvasive evaluations in monitoring inflammatory bowel disease activity: A prospective study in China.

    abstract:AIM:To optimize the efficacy of noninvasive evaluations in monitoring the endoscopic activity of inflammatory bowel disease (IBD). METHODS:Fecal calprotectin (FC), clinical activity index (CDAI or CAI), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and procalcitonin (PCT) were measured for 136 IBD pa...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i46.8235

    authors: Chen JM,Liu T,Gao S,Tong XD,Deng FH,Nie B

    更新日期:2017-12-14 00:00:00

  • Effectiveness and safety of herbal medicines in the treatment of irritable bowel syndrome: a systematic review.

    abstract:AIM:To explore the efficacy and safety of herbal medicines (HM) in the treatment of irritable bowel syndrome (IBS). METHODS:A computer-based as well as manual literature search was performed. We reviewed randomized controlled trials on the treatment of IBS with and without HM. RESULTS:A total of 22 studies with 25 HM...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.14.454

    authors: Shi J,Tong Y,Shen JG,Li HX

    更新日期:2008-01-21 00:00:00

  • Liver-directed therapies for liver metastases from neuroendocrine neoplasms: Can laser ablation play any role?

    abstract::Aggressive cytoreduction can prolong survival in patients with unresectable liver metastases (LM) from neuroendocrine neoplasms (NEN), and minimally invasive, liver-directed therapies are gaining increasing interest. Catheter-based treatments are used in disseminated disease, whereas ablation techniques are usually in...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v26.i23.3118

    authors: Sartori S,Bianchi L,Di Vece F,Tombesi P

    更新日期:2020-06-21 00:00:00

  • Hepatoid adenocarcinoma of the stomach: a report of three cases.

    abstract::Hepatoid adenocarcinoma of the stomach (HAS) is a rare form of gastric cancer that has unique clinicopathological features and an extremely poor prognosis. Here, we report on three patients with suspected gastric cancer who were referred to our hospital. Gastrointestinal fiberscopy on the three patients revealed two l...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i27.4437

    authors: Ye MF,Tao F,Liu F,Sun AJ

    更新日期:2013-07-21 00:00:00

  • Enhanced expression of epidermal growth factor receptor gene in gastric mucosal cells by the serum derived from rats treated with electroacupuncture at stomach meridian acupoints.

    abstract:AIM:To investigate the effect of serum derived from rats treated with electroacupuncture at stomach meridian acupoints on the expression of epidermal growth factor receptor (EGFR) gene in gastric mucosal cells. METHODS:The stress-induced gastric mucosal injury in rat model was established by water-immersion and restra...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i34.5557

    authors: Yang ZB,Yan J,Zou XP,Yi SX,Chang XR,Lin YP,Li XP

    更新日期:2006-09-14 00:00:00

  • Endoscopic trans-esophageal submucosal tunneling surgery: A new therapeutic approach for diseases located around the aorta ventralis.

    abstract:AIM:To assess the efficiency of endoscopic trans-esophageal submucosal tunneling surgery (EESTS) technique for diseases located around the aorta ventralis. METHODS:Nine pigs were assigned to EESTs. The procedures were as follows: First, a long esophageal submucosal tunnel was established. Second, full-thickness myotom...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v25.i1.85

    authors: Xiong Y,Chen QQ,Chai NL,Jiao SC,Ling Hu EQ

    更新日期:2019-01-07 00:00:00

  • Reprogramming of glucose metabolism in hepatocellular carcinoma: Progress and prospects.

    abstract::Hepatocellular carcinoma (HCC) is one of the most lethal cancers, and its rate of incidence is rising annually. Despite the progress in diagnosis and treatment, the overall prognoses of HCC patients remain dismal due to the difficulties in early diagnosis and the high level of tumor invasion, metastasis and recurrence...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i45.9933

    authors: Shang RZ,Qu SB,Wang DS

    更新日期:2016-12-07 00:00:00

  • New trends in colorectal surgery: single port and natural orifice techniques.

    abstract::Single-incision laparoscopic surgery (SILS) and natural orifice transluminal endoscopic surgery (NOTES) have rapidly gained pace worldwide, potentially replacing conventional laparoscopic surgery (CLS) as the preferred colorectal surgery technique. Currently available data mainly consist of retrospective series analyz...

    journal_title:World journal of gastroenterology

    pub_type: 历史文章,杂志文章,评审

    doi:10.3748/wjg.v20.i48.18104

    authors: Daher R,Chouillard E,Panis Y

    更新日期:2014-12-28 00:00:00

  • Current treatment for colorectal liver metastases.

    abstract::Surgical resection offers the best opportunity for survival in patients with colorectal cancer metastatic to the liver, with five-year survival rates up to 58% in selected cases. However, only a minority are resectable at the time of diagnosis. Continuous research in this field aims at increasing the percentage of pat...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v17.i36.4067

    authors: Misiakos EP,Karidis NP,Kouraklis G

    更新日期:2011-09-28 00:00:00

  • Non-invasive prediction of oesophageal varices in cirrhosis.

    abstract::Non-invasive predictors of varices in cirrhosis would reduce the need for screening endoscopies. Platelet count and spleen size have been shown to be useful parameters, in mixed groups of cirrhotics with different aetiologies. We evaluated this in two homogeneous groups with cirrhosis due to hepatitis C and alcohol. N...

    journal_title:World journal of gastroenterology

    pub_type: 评论,信件

    doi:10.3748/wjg.14.2454

    authors: Sen S,Griffiths WJ

    更新日期:2008-04-21 00:00:00

  • Predictors of colorectal cancer testing using the California Health Inventory Survey.

    abstract:AIM:To identify key variables associated with colon cancer testing using the 2009 California Health Inventory Survey (CHIS). METHODS:The CHIS has been conducted biennially since 2001 using a two-stage, geographically stratified random-digit-dial sample design to produce a representative sample of the entire State. For...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i8.1247

    authors: Modiri A,Makipour K,Gomez J,Friedenberg F

    更新日期:2013-02-28 00:00:00

  • Advanced imaging techniques in the therapeutic response of transarterial chemoembolization for hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is one of the major causes of morbidity and mortality in patients with chronic liver disease. Transarterial chemoembolization (TACE) can significantly improve the survival rate of patients with HCC and is the first treatment choice for patients who are not suitable for surgical resection...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i20.4835

    authors: Yang K,Zhang XM,Yang L,Xu H,Peng J

    更新日期:2016-05-28 00:00:00

  • Expression of alpha smooth muscle actin in living donor liver transplant recipients.

    abstract::Recently, there have been reports from liver biopsies that showed the progression of liver fibrosis in liver transplant patients after the cessation of immunosuppression. Herein, we focused on activated hepatic stellate cells expressing alpha smooth muscle actin (α-SMA) to understand the correlation between immunosupp...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i22.7067

    authors: Hirabaru M,Mochizuki K,Takatsuki M,Soyama A,Kosaka T,Kuroki T,Shimokawa I,Eguchi S

    更新日期:2014-06-14 00:00:00

  • Mycobacterium avium subspecies paratuberculosis in the etiology of Crohn's disease, cause or epiphenomenon?

    abstract::The origin of inflammatory bowel disease is unknown. Attempts have been made to isolate a microorganism that could explain the onset of inflammation, but no pathological agent has ever been identified. Johne's disease is a granulomatous chronic enteritis of cattle and sheep caused by Mycobacterium avium subspecies par...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i36.13060

    authors: Liverani E,Scaioli E,Cardamone C,Dal Monte P,Belluzzi A

    更新日期:2014-09-28 00:00:00

  • Strongyloides hyper-infection causing life-threatening gastrointestinal bleeding.

    abstract::A 55-year old male patient was diagnosed with strongy-loides hyper-infection with stool analysis and intestinal biopsy shortly after his chemotherapy for myeloma. He was commenced on albendazole anthelmintic therapy. After initiation of the treatment he suffered life-threatening gastrointestinal (GI) bleeding. Repeate...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i39.6401

    authors: Csermely L,Jaafar H,Kristensen J,Castella A,Gorka W,Chebli AA,Trab F,Alizadeh H,Hunyady B

    更新日期:2006-10-21 00:00:00

  • Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma.

    abstract::High-throughput short-read sequencing of exomes and whole cancer genomes in multiple human hepatocellular carcinoma (HCC) cohorts confirmed previously identified frequently mutated somatic genes, such as TP53, CTNNB1 and AXIN1, and identified several novel genes with moderate mutation frequencies, including ARID1A, AR...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v19.i47.8873

    authors: Gu DL,Chen YH,Shih JH,Lin CH,Jou YS,Chen CF

    更新日期:2013-12-21 00:00:00

  • Is concomitant radiotherapy necessary with gemcitabine-based chemotherapy in pancreatic cancer?

    abstract:AIM:To evaluate the efficacy and safety of gemcitabine (GEM) plus radiotherapy compared with GEM alone for pancreatic cancer (PC). METHODS:A systematic search for eligible studies comparing gemcitabine plus radiotherapy with gemcitabine alone for PC was performed using MEDLINE, EMBASE, and the Cochrane Library. A qual...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v20.i46.17648

    authors: Zhang X,Huang HJ,Feng D,Yang DJ,Wang CM,Cai QP

    更新日期:2014-12-14 00:00:00

  • Predictive biomarkers of sorafenib efficacy in advanced hepatocellular carcinoma: Are we getting there?

    abstract::Sorafenib is the current standard treatment for advanced hepatocellular carcinoma (HCC), but its efficacy is modest with low response rates and short response duration. Predictive biomarkers for sorafenib efficacy are necessary. However, efforts to determine biomarkers for sorafenib have led only to potential candidat...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i36.10336

    authors: Shao YY,Hsu CH,Cheng AL

    更新日期:2015-09-28 00:00:00

  • Laparoscopic liver resection: wedge resections to living donor hepatectomy, are we heading in the right direction?

    abstract::Despite inception over 15 years ago and over 3000 completed procedures, laparoscopic liver resection has remained mainly in the domain of selected centers and enthusiasts. Requirement of extensive open liver resection (OLR) experience, in-depth understanding of anatomy and considerable laparoscopic technical expertise...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i37.13369

    authors: Cherian PT,Mishra AK,Kumar P,Sachan VK,Bharathan A,Srikanth G,Senadhipan B,Rela MS

    更新日期:2014-10-07 00:00:00

  • Safety of Curcuma aromatica oil gelatin microspheres administered via hepatic artery.

    abstract:AIM:To evaluate the safety of Curcuma aromatica oil gelatin microspheres (CAO-GMS) infused via hepatic artery against primary liver cancer. METHODS:The safety of CAO-GMS was evaluated in view of its acute toxicity in rats, long-term toxicity in Beagle dogs and general pharmacology in rats and mongrel dogs. RESULTS:Th...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i18.2637

    authors: Deng SG,Wu ZF,Li WY,Yang ZG,Chang G,Meng FZ,Mo LL

    更新日期:2004-09-15 00:00:00

  • Antitumor mechanism of antisense cantide targeting human telomerase reverse transcriptase.

    abstract:AIM:To investigate the anti-tumor mechanism of antisense oligodeoxynucleotide cantide against hTERT. METHODS:Tumor cells were cultured overnight and grown to 50-60 % confluence. HepG2 and SMMC-7721 were treated with cantide mixed with lipofectin, or lipofectin alone. After inducted for 6 h at 37 degrees, 10 % FCS in D...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i9.2030

    authors: Du QY,Wang XB,Chen XJ,Zheng W,Wang SQ

    更新日期:2003-09-01 00:00:00

  • Pernicious anemia: new insights from a gastroenterological point of view.

    abstract::Pernicious anemia (PA) is a macrocytic anemia that is caused by vitamin B(12) deficiency, as a result of intrinsic factor deficiency. PA is associated with atrophic body gastritis (ABG), whose diagnosis is based on histological confirmation of gastric body atrophy. Serological markers that suggest oxyntic mucosa damag...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审

    doi:10.3748/wjg.15.5121

    authors: Lahner E,Annibale B

    更新日期:2009-11-07 00:00:00

  • Endoscopic response to tumor necrosis factor inhibitors predicts long term benefits in Crohn's disease.

    abstract:BACKGROUND:Identifying predictors of therapeutic response is the cornerstone of personalized medicine. AIM:To identify predictors of long-term mucosal healing (MH) in patients with Crohn's disease (CD) treated with tumor necrosis factor α (TNF-α) inhibitors. METHODS:Prospective single center study. Consecutive patien...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v25.i14.1764

    authors: Alfaro I,Masamunt MC,Planell N,López-García A,Castro J,Gallego M,Barastegui R,Giner A,Vara A,Salas A,Ricart E,Panés J,Ordás I

    更新日期:2019-04-14 00:00:00

  • Incidence and clinical features of endoscopic ulcers developing after gastrectomy.

    abstract:AIM:To determine the precise incidence and clinical features of endoscopic ulcers following gastrectomy. METHODS:A consecutive series of patients who underwent endoscopic examination following gastrectomy between 2005 and 2010 was retrospectively analyzed. A total of 78 patients with endoscopic ulcers and 759 without ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i25.3260

    authors: Chung WC,Jeon EJ,Lee KM,Paik CN,Jung SH,Oh JH,Kim JH,Jun KH,Chin HM

    更新日期:2012-07-07 00:00:00

  • Inflammatory bowel disease: a proposal to facilitate the achievement of an unequivocal diagnosis.

    abstract::Following the international guidelines criteria an adequate "diagnostic conclusion" of inflammatory bowel disease (IBD) can be achieved only if clinical, endoscopic and laboratory findings, together with sample technical adequacy and unequivocal histomorphological signs of the disease are available. Thus, a conclusive...

    journal_title:World journal of gastroenterology

    pub_type: 信件

    doi:10.3748/wjg.v19.i3.426

    authors: Canavese G,Bassotti G,Astegiano M,Castellano I,Cassoni P,Sapino A,Villanacci V

    更新日期:2013-01-21 00:00:00

  • Treatment of metastatic colorectal carcinomas by systemic inhibition of vascular endothelial growth factor signaling in mice.

    abstract:AIM:Tumor angiogenesis has been shown to be promoted by vascular endothelial growth factor (VEGF) via stimulating endothelial cell proliferation, migration, and survival. Blockade of VEGF signaling by different means has been demonstrated to result in reduced tumor growth and suppression of tumor angiogenesis in distin...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i28.4332

    authors: Schmitz V,Kornek M,Hilbert T,Dzienisowicz C,Raskopf E,Rabe C,Sauerbruch T,Qian C,Caselmann WH

    更新日期:2005-07-28 00:00:00

  • Comparison of two types of colectomy in treating slow transit constipation with or without melanosis coli.

    abstract:AIM:To compare the follow-up outcomes of ileosigmoidal anastomosis (ISA) and caecorectal anastomosis (CRA) in patients with slow transit constipation (STC) with or without melanosis coli (MC). METHODS:We collected the clinical data of 48 STC patients with or without MC from May 2002 to May 2007. Twenty-six patients un...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i33.9736

    authors: Sun JW,Gu JN,Du P,Chen W

    更新日期:2015-09-07 00:00:00

  • Interleukin-28 and hepatitis C virus genotype-4: treatment-induced clearance and liver fibrosis.

    abstract:AIM:To investigate the association between interleukin-28B (IL28B) genotype and response to treatment and hepatic fibrosis in patients with hepatitis C virus (HCV) genotype 4. METHODS:Two hundred and one HCV-genotype 4 patients were included. All patients were treated with Peginterferon alph2a/Ribavirin for 48 wk. End...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i47.7003

    authors: Derbala M,Rizk N,Shebl F,Alkaabi S,Eldweik N,John A,Sharma M,Yaqoob R,Almohanadi M,Butt M,Alejji K

    更新日期:2012-12-21 00:00:00