Polymorphism of glutathione S-transferase mu 1 and theta 1 genes and hepatocellular carcinoma in southern Guangxi, China.

abstract：:Transforming growth factor-beta (TGF-beta), a prototype of multifunctional cytokine, is a key regulator of extracellular matrix (ECM) assembly and remodeling. Specifically, TGF-beta isoforms have the ability to induce the expression of ECM proteins in mesenchymal cells, and to stimulate the production of protease inhi...

journal_title：World journal of gastroenterology

authors： Verrecchia F,Mauviel A

更新日期：2007-06-14 00:00:00

abstract：AIM:Overexpression of tumor protein p53-induced nuclear protein 1 (TP53INP1) induces G1 cell cycle arrest and increases p53-mediated apoptosis. To clarify the clinical importance of TP53INP1, we analyzed TP53INP1 and p53 expression in gastric cancer. METHODS:TP53INP1 and p53 expression were examined using immunohistoc...

journal_title：World journal of gastroenterology

authors： Jiang PH,Motoo Y,Garcia S,Iovanna JL,Pébusque MJ,Sawabu N

更新日期：2006-02-07 00:00:00

abstract：AIM:To evaluate the protective effect and mechanism of glutamine on the intestinal barrier function in total parenteral nutrition (TPN) rats with trauma or endotoxemia. METHODS:To perform prospective, randomized and controlled animal experimentation of rats with surgical trauma, TPN and endotoxemia, thirty-four male, ...

journal_title：World journal of gastroenterology

authors： Ding LA,Li JS

更新日期：2003-06-01 00:00:00

abstract：AIM:To induce the tolerance of rat liver allograft by dendritic cells (DCs) modified with NF-kappaB decoy oligodeoxynucleotides (ODNs). METHODS:Bone marrow (BM)-derived DCs from SD rats were propagated in the presence of GM-CSF or GM-CSF+IL-4 to obtain immature DCs or mature DCs. GM-CSF+IL-4-propagated DCs were treate...

journal_title：World journal of gastroenterology

authors： Xu MQ,Suo YP,Gong JP,Zhang MM,Yan LN

更新日期：2004-08-15 00:00:00

abstract：BACKGROUND:The role of the Notch pathway in carcinogenesis and tumor progression has been demonstrated in many organs, including the colon. Accordingly, studies aimed at developing therapies targeting this pathway in various cancers require the identification of several factors that may play a role in regulating Notch-...

journal_title：World journal of gastroenterology

authors： Gonulcu SC,Unal B,Bassorgun IC,Ozcan M,Coskun HS,Elpek GO

更新日期：2020-07-14 00:00:00

abstract：:Gastrointestinal cancers represent a major cause of morbidity and mortality, with incomplete response to chemotherapy in the advanced stages and poor prognosis. Angiogenesis plays a crucial part in tumor growth and metastasis, with most gastrointestinal cancers depending strictly on the development of a new and devote...

journal_title：World journal of gastroenterology

authors： Gheonea DI,Cârţână T,Ciurea T,Popescu C,Bădărău A,Săftoiu A

更新日期：2011-01-07 00:00:00

abstract：AIM:To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer cells. METHODS:The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosis-inducing effect of linalool was measured using...

journal_title：World journal of gastroenterology

authors： Iwasaki K,Zheng YW,Murata S,Ito H,Nakayama K,Kurokawa T,Sano N,Nowatari T,Villareal MO,Nagano YN,Isoda H,Matsui H,Ohkohchi N

更新日期：2016-11-28 00:00:00

abstract：AIM:To investigate the allelic and haplotypic association of reg1alpha gene with tropical calcific pancreatitis (TCP). Since TCP is known to have a variable genetic basis, we investigated the interaction between mutations in the susceptibility genes, SPINK1 and CTSB with reg1alpha polymorphisms. METHODS:We analyzed th...

journal_title：World journal of gastroenterology

authors： Mahurkar S,Bhaskar S,Reddy DN,Rao GV,Chandak GR

更新日期：2007-11-28 00:00:00

abstract：AIM:To investigate whether enteroviral infection might trigger acute pancreatitis in patients made susceptible due to high alcohol consumption. METHODS:Patients with alcohol-induced acute pancreatitis were analyzed for signs of simultaneous or preceding enteroviral infection. We studied the serum samples of 40 patient...

journal_title：World journal of gastroenterology

authors： Khan J,Nordback I,Seppänen H,Lappalainen-Lehto R,Järvinen S,Oikarinen S,Tauriainen S,Räty S,Hyöty H,Sand J

更新日期：2013-06-28 00:00:00

abstract：AIM:To investigate GATA5, SFRP2, and ITGA4 methylation in plasma DNA as noninvasive biomarkers for colorectal cancer (CRC) or adenomas. METHODS:There were 57 CRC patients, 30 adenomas patients, and 47 control patients enrolled in this study. Methylation-specific polymerase chain reaction was used to determine the prom...

journal_title：World journal of gastroenterology

authors： Zhang X,Song YF,Lu HN,Wang DP,Zhang XS,Huang SL,Sun BL,Huang ZG

更新日期：2015-03-07 00:00:00

abstract：AIM:To elucidate the molecular mechanisms leading to development of functionally impaired dendritic cells (DCs) in chronic hepatitis C (CHC) patients infected with genotype 3 virus. METHODS:This prospective study was conducted on the cohorts of CHC individuals identified as responders or non-responders to antiviral th...

journal_title：World journal of gastroenterology

authors： Tomer S,Chawla YK,Duseja A,Arora SK

更新日期：2016-06-14 00:00:00

abstract：BACKGROUND:Serum amyloid A (SAA) is an acute phase protein mainly synthesized by the liver. SAA induces inflammatory phenotype and promotes cell proliferation in activated hepatic stellate cells, the major scar forming cells in the liver. However, few studies have reported on the serum levels of SAA in human liver dise...

journal_title：World journal of gastroenterology

authors： Yuan ZY,Zhang XX,Wu YJ,Zeng ZP,She WM,Chen SY,Zhang YQ,Guo JS

更新日期：2019-11-21 00:00:00

abstract：:The number of hepatitis C virus (HCV) infection cases is relatively low in children. This low number may be connected with the lack of screening tests and the asymptomatic course of infection. Currently, mother-to-infant transmission is the most common cause of HCV infection amongst children in developed countries. It...

journal_title：World journal of gastroenterology

authors： Pawlowska M,Domagalski K,Pniewska A,Smok B,Halota W,Tretyn A

更新日期：2015-10-14 00:00:00

abstract：:Neurofibromas of the large bowel are very rare and usually are part of the colonic involvement in neurofibromatosis type 1 (Nf1, von Recklinghausen's disease). Solitary neurofibromas of the colon are extremely rare. We describe a case of an isolated neurofibroma that was found in the large bowel of a patient who suffe...

journal_title：World journal of gastroenterology

authors： Panteris V,Vassilakaki T,Vaitsis N,Elemenoglou I,Mylonakou I,Karamanolis DG

更新日期：2005-09-21 00:00:00

abstract：:In this article, we have reviewed the hepatic perfusion disorder (HPD), etiopathogenesis of HPD and corresponding diseases. Review of the literature was based on computer searches (PubMed, Index Medicus) and personal experiences. We considered HPD reflects perfusion differences due to redistribution of arterial blood ...

journal_title：World journal of gastroenterology

authors： Tian JL,Zhang JS

更新日期：2006-05-28 00:00:00

abstract：:Following the international guidelines criteria an adequate "diagnostic conclusion" of inflammatory bowel disease (IBD) can be achieved only if clinical, endoscopic and laboratory findings, together with sample technical adequacy and unequivocal histomorphological signs of the disease are available. Thus, a conclusive...

journal_title：World journal of gastroenterology

authors： Canavese G,Bassotti G,Astegiano M,Castellano I,Cassoni P,Sapino A,Villanacci V

更新日期：2013-01-21 00:00:00

abstract：AIM:To clarify the biological feature contributing to gastric cancer with diffuse bone metastases at diagnosis. METHODS:The participants visited the Department of Clinical Oncology, Akita University Hospital, from January 2014 to August 2015. The selection criterion for gastric cancer with diffuse bone metastases at d...

journal_title：World journal of gastroenterology

authors： Shimazu K,Fukuda K,Yoshida T,Inoue M,Shibata H

更新日期：2016-07-14 00:00:00

abstract：AIM:To evaluate the diagnostic value of gadobenate dimeglumine (Gd-BOPTA)-enhanced hepatocyte-phase magnetic resonance imaging (MRI) in evaluating hepatic fibrosis and hepatitis. METHODS:Hepatocyte-phase images of Gd-BOPTA-enhanced MRI were retrospectively evaluated in 76 patients with chronic liver disease. These pat...

journal_title：World journal of gastroenterology

authors： Li XM,Chen Z,Xiao EH,Shang QL,Ma C

更新日期：2017-05-07 00:00:00

abstract：:Enterolithiasis or formation of gastrointestinal concretions is an uncommon medical condition that develops in the setting of intestinal stasis in the presence of the intestinal diverticula, surgical enteroanastomoses, blind pouches, afferent loops, incarcerated hernias, small intestinal tumors, intestinal kinking fro...

journal_title：World journal of gastroenterology

authors： Gurvits GE,Lan G

更新日期：2014-12-21 00:00:00

abstract：:Autoimmune hepatitis (AIH) is a rare chronic inflammatory disease of the liver, which affects a group of patients who lost their immunological tolerance to antigens of the liver. It is clinically characterized by hypergammaglobulinemia, elevated liver enzymes, presence of autoantibodies and histological changes. Altho...

journal_title：World journal of gastroenterology

authors： Ferri Liu PM,de Miranda DM,Fagundes ED,Ferreira AR,Simões e Silva AC

更新日期：2013-07-28 00:00:00

abstract：:Solitary fibrous tumors are predominantly benign and are most commonly found in the thoracic cavity and pleura; while reports exist in the literature of malignant solitary fibrous tumors and those located in extrathoracic organs, these cases are considered extremely rare. Herein, a case is reported of a malignant soli...

journal_title：World journal of gastroenterology

authors： Jakob M,Schneider M,Hoeller I,Laffer U,Kaderli R

更新日期：2013-06-07 00:00:00

abstract：:Alcoholic liver disease (ALD) is characterized by steatosis or fat deposition in the liver and inflammation, which leads to cirrhosis and hepatocellular carcinoma. Induction of target genes without involving changes in DNA sequence seems to contribute greatly to liver injury. Chromatin modifications including alterati...

journal_title：World journal of gastroenterology

authors： Mandrekar P

更新日期：2011-05-28 00:00:00

abstract：AIM:To evaluate whether alcohol dehydrogenase-1B (ADH1B) His47Arg and aldehyde dehydrogenase-2 (ALDH2) Glu487Lys polymorphism is involved in the esophageal squamous cell carcinoma (ESCC) risk in Chinese Han population. METHODS:Seven studies of ADH1B and ALDH2 genotypes in Chinese Han population in 1450 cases and 2459 ...

journal_title：World journal of gastroenterology

authors： Zhang GH,Mai RQ,Huang B

更新日期：2010-12-21 00:00:00

abstract：AIM:Inducible nitric oxide synthase (iNOS) plays a central role in the pathway of reactive oxygen and nitrogen species metabolism when Helicobacter pylori (H pylori) infection occurs in humans. iNOS Ser(608)Leu allele, a novel genetic polymorphism (C/T) occurring within exon 16 of the iNOS reductase domain, may have a ...

journal_title：World journal of gastroenterology

authors： Shen J,Wang RT,Wang LW,Xu YC,Wang XR

更新日期：2004-11-15 00:00:00

abstract：AIM:To establish a more sensitive method for detection of free cancer cells in peritoneal washes from gastric cancer patients during surgery and to evaluate its clinical significance. METHODS:The carcinoembryonic antigen (CEA) mRNA levels in peritoneal washes from 65 cases of gastric cancer were detected by real-time ...

journal_title：World journal of gastroenterology

authors： Zhang YS,Xu J,Luo GH,Wang RC,Zhu J,Zhang XY,Nilsson-Ehle P,Xu N

更新日期：2006-03-07 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is one of the most common comorbidities associated with overweight and metabolic syndrome (MetS). Importantly, NAFLD is one of its most dangerous complications because it can lead to severe liver pathologies, including fibrosis, cirrhosis and hepatic cellular carcinoma. Given ...

journal_title：World journal of gastroenterology

authors： Mikolasevic I,Milic S,Turk Wensveen T,Grgic I,Jakopcic I,Stimac D,Wensveen F,Orlic L

更新日期：2016-11-21 00:00:00

abstract：:Iatrogenic bile duct injuries (IBDI) remain an important problem in gastrointestinal surgery. They are most frequently caused by laparoscopic cholecystectomy which is one of the commonest surgical procedures in the world. The early and proper diagnosis of IBDI is very important for surgeons and gastroenterologists, be...

journal_title：World journal of gastroenterology

authors： Jabłońska B,Lampe P

更新日期：2009-09-07 00:00:00

abstract：AIM:To establish novel intestinal myofibroblast (IMF) cell lines from mouse colonic mucosa and investigate their biological characters. METHODS:Primary IMFs were isolated from mucosal tissues of mouse colon that was denuded of epithelial cells and smooth muscle layer. For immortalization, primary IMFs were transfected...

journal_title：World journal of gastroenterology

authors： Kawasaki H,Ohama T,Hori M,Sato K

更新日期：2013-05-07 00:00:00

abstract：AIM:To investigate the expression of human telomerase reverse transcriptase gene (hTRT) in gastric cancer (GC) and its relevance with cell cycle regulators including P16INK4, cyclin and P53. METHODS:In situ hybridization (ISH) for hTRT mRNA was performed in 53 cases of gastric cancer and adjacent cancerous tissues. Im...

journal_title：World journal of gastroenterology

authors： Shao JC,Wu JF,Wang DB,Qin R,Zhang H

更新日期：2003-03-01 00:00:00

abstract：AIM:To investigate the effect of Danzhijiangtang capsule (DJC) on monocyte chemoattractant protein-1 (MCP-1) mRNA expression in newly diagnosed type 2 diabetes mellitus (T2DM) subclinical vascular lesions. METHODS:Sixty-two patients with newly diagnosed T2DM subclinical vascular lesions were randomly divided into a co...

journal_title：World journal of gastroenterology

authors： Fang ZH,Liu Y,Bao TT,Ni YQ,Liu J,Shi GB,Wu JP,Yang JP,Zhang H

更新日期：2013-05-21 00:00:00