Confocal laser endomicroscopy and immunoendoscopy for real-time assessment of vascularization in gastrointestinal malignancies.

Abstract:

:Gastrointestinal cancers represent a major cause of morbidity and mortality, with incomplete response to chemotherapy in the advanced stages and poor prognosis. Angiogenesis plays a crucial part in tumor growth and metastasis, with most gastrointestinal cancers depending strictly on the development of a new and devoted capillary network. Confocal laser endomicroscopy is a new technology which allows in vivo microscopic analysis of the gastrointestinal mucosa and its microvascularization during ongoing endoscopy by using topically or systemically administered contrast agents. Targeting markers of angiogenesis in association with confocal laser endomicroscopic examination (immunoendoscopy), as a future challenge, will add functional analysis to the morphological aspect of the neoplastic process. This review describes previous experience in endomicroscopic examination of the upper and lower digestive tract with emphasis on vascularization, resulting in a broad spectrum of potential clinical applications, and also preclinical research that could be translated to human studies.

journal_name

World J Gastroenterol

authors

Gheonea DI,Cârţână T,Ciurea T,Popescu C,Bădărău A,Săftoiu A

doi

10.3748/wjg.v17.i1.21

subject

Has Abstract

pub_date

2011-01-07 00:00:00

pages

21-7

issue

1

eissn

1007-9327

issn

2219-2840

journal_volume

17

pub_type

杂志文章,评审
  • Comparison of percutaneous radiofrequency ablation and CyberKnife(®) for initial solitary hepatocellular carcinoma: A pilot study.

    abstract:AIM:To compare therapeutic outcomes and adverse events in initial solitary hepatocellular carcinoma (HCC) treated with radiofrequency ablation (RFA) and CyberKnife(®). METHODS:Seventy three consecutive patients with initial solitary HCC treated with RFA (38 patients; RFA group) and CyberKnife(®) (35 patients; CK group...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i48.13490

    authors: Shiozawa K,Watanabe M,Ikehara T,Matsukiyo Y,Kogame M,Kishimoto Y,Okubo Y,Makino H,Tsukamoto N,Igarashi Y,Sumino Y

    更新日期:2015-12-28 00:00:00

  • Restraint stress induces and exacerbates intestinal inflammation in interleukin-10 deficient mice.

    abstract:AIM:To investigate the effects of restraint stress on chronic colitis in interleukin (IL)-10 deficient (IL-10(-/-)) mice. METHODS:The first experiment compared the effect of restraint stress on the development of intestinal inflammation in wild-type and IL-10(-/-) mice. Both wild-type and IL-10(-/-) mice were physical...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i28.8580

    authors: Koh SJ,Kim JW,Kim BG,Lee KL,Kim JS

    更新日期:2015-07-28 00:00:00

  • Unexpected anterograde amnesia associated with Buscopan used as a predmedication for endocscopy.

    abstract::It has been known that peripheral adverse event is caused by peripheral antimuscarinic action, from hyoscine butylbromide (Buscopan; Boehringer Ingelheim, Germany) used as a premedication for endoscopy. However, symptoms or signs associated with the central nervous system are rarely reported in the field of anesthesio...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i28.3895

    authors: Lee H,Son HJ,Rhee PL,Kim JJ,Rhee JC

    更新日期:2007-07-28 00:00:00

  • Human papillomavirus does not have a causal role in colorectal carcinogenesis.

    abstract:AIM:To investigate the presence of human papillomavirus (HPV) DNA along with the integration, the quantification and the expression of the HPV16 in colorectal cancers. METHODS:A prospective series of colorectal tumors were genotyped for HPV DNA. The clinical and pathological variables of the HPV-positive tumors were c...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i1.342

    authors: Lorenzon L,Mazzetta F,Pilozzi E,Uggeri G,Torrisi MR,Ferri M,Ziparo V,French D

    更新日期:2015-01-07 00:00:00

  • Alverine citrate induced acute hepatitis.

    abstract::Alverine citrate is a commonly used smooth muscle relaxant agent. A MEDLINE search on January 2004 revealed only 1 report implicating the hepatotoxicity of this agent. A 34-year-old woman was investigated because of the finding of elevated liver function tests on biochemical screening. Other etiologies of hepatitis we...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i15.2303

    authors: Arhan M,Koklu S,Koksal AS,Yolcu OF,Koruk S,Koruk I,Kayacetin E

    更新日期:2004-08-01 00:00:00

  • Bile acid increases expression of the histamine-producing enzyme, histidine decarboxylase, in gastric cells.

    abstract:AIM:To investigate the effect of bile acid on the expression of histidine decarboxylase (HDC), which is a major enzyme involved in histamine production, and gene expression of gastric transcription factors upon cooperative activation. METHODS:HDC expression was examined by immunohistochemistry, reverse transcriptase p...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i1.175

    authors: Ku HJ,Kim HY,Kim HH,Park HJ,Cheong JH

    更新日期:2014-01-07 00:00:00

  • Mechanisms of resistance to anti-EGFR monoclonal antibody treatment in metastatic colorectal cancer.

    abstract::Metastatic colorectal cancer (mCRC) continues to be counted as a major health problem. The introduction of newer cytotoxics, irinotecan and oxaliplatin, has achieved a significant improvement in survival rates. Novel targeted therapies (bevacizumab, and cetuximab) in combination with most efficient chemotherapy regime...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v16.i10.1177

    authors: Saridaki Z,Georgoulias V,Souglakos J

    更新日期:2010-03-14 00:00:00

  • Attenuation of gastric mucosal inflammation induced by aspirin through activation of A2A adenosine receptor in rats.

    abstract:AIM:To determine whether a specific adenosine A(2A) receptor agonist (ATL-146e) can ameliorate aspirin-induced gastric mucosal lesions in rats, and reduce neutrophil accumulation and production of pro-inflammatory cytokines. METHODS:Gastric lesions were produced by oral gavage of aspirin (200 mg/kg) and HCl (0.15 mol/...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i4.568

    authors: Odashima M,Otaka M,Jin M,Komatsu K,Wada I,Horikawa Y,Matsuhashi T,Hatakeyama N,Oyake J,Ohba R,Watanabe S,Linden J

    更新日期:2006-01-28 00:00:00

  • Changing patterns of colorectal cancer in China over a period of 20 years.

    abstract:AIM:To determine whether any changes have occurred on the patterns of colorectal cancer in China. METHODS:Data from 21 Chinese articles published from 1980 to 1999, were used to analyze the time trend of colorectal cancer according to the patients' age at diagnosis, sex, the site of the tumor, stage, and the pathology...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i30.4685

    authors: Li M,Gu J

    更新日期:2005-08-14 00:00:00

  • Diagnosis and treatment of benign multicystic peritoneal mesothelioma.

    abstract::Benign multicystic peritoneal mesothelioma (BMPM) is a rare cystic mesothelial lesion that occurs predominantly in reproductive aged women. A 56-year-old Caucasian male was admitted to our surgical department with a chief complaint of a painful mass in his right lower abdomen for almost 2 years. The physical examinati...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i39.6689

    authors: Wang TB,Dai WG,Liu DW,Shi HP,Dong WG

    更新日期:2013-10-21 00:00:00

  • Sixty-four-slice computed tomography in surgical strategy of portal vein cavernous transformation.

    abstract:AIM:To investigate the role of 64-slice computed tomography (CT) in portal vein cavernous transformation to determine surgical strategy. METHODS:The site of lesions and extent of collateral circulation in 12 pediatric cases of cavernous transformation of the portal vein with surgical treatment were analyzed. RESULTS:...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i38.4334

    authors: Zhang MM,Pu CL,Li YC,Guo CB

    更新日期:2011-10-14 00:00:00

  • Successful endoscopic treatment of biliary stricture following mesenteric tear caused by blunt abdominal trauma.

    abstract::Biliary duct injuries are frequently iatrogenic, being associated with surgery for gallbladder stones. However, blunt abdominal trauma such as a motor vehicle crash is a rare cause of extrahepatic biliary stricture. A few reports have been published on biliary strictures treated with endoscopic therapy. In the present...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.2277

    authors: Kang DO,Kim TH,You SS,Min HJ,Kim HJ,Jung WT,Lee OJ

    更新日期:2008-04-14 00:00:00

  • Hypoestoxide inhibits tumor growth in the mouse CT26 colon tumor model.

    abstract:AIM:To evaluate the effect of the natural diterpenoid, hypoestoxide (HE) on the growth of established colon cancer in mice. METHODS:The CT26.WT mouse colon carcinoma cell line was grown and expanded in vitro. Following the expansion, BALB/c mice were inoculated s.c. with viable tumor cells. After the tumors had establ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i34.4586

    authors: Ojo-Amaize EA,Cottam HB,Oyemade OA,Okogun JI,Nchekwube EJ

    更新日期:2007-09-14 00:00:00

  • Pain in chronic pancreatitis: managing beyond the pancreatic duct.

    abstract::Chronic pancreatitis (CP) continues to be a clinical challenge. Persistent or recurrent abdominal pain is the most compelling symptom that drives patients to seek medical care. Unfortunately, in spite of using several treatment approaches in the clinical setting, there is no single specific treatment modality that can...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审

    doi:10.3748/wjg.v19.i38.6319

    authors: Talukdar R,Reddy DN

    更新日期:2013-10-14 00:00:00

  • Combined small bowel and reduced auxiliary liver transplantation: case report.

    abstract:AIM:To present a case of combined small bowel and reduced auxiliary liver transplantation. METHODS:A 55-year-old patient with short bowel syndrome and TPN-related liver dysfunction received small bowel transplantation combined with a reduced auxiliary liver graft. A liver was added to restore the patient's liver funct...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v8.i5.956

    authors: Zhang WJ,Liu DG,Ye QF,Sha B,Zhen FJ,Guo H,Xia SS

    更新日期:2002-10-01 00:00:00

  • Effects of CPG ODN on biological behavior of PANC-1 and expression of TLR9 in pancreatic cancer.

    abstract:AIM:To determine the expression of toll-like receptor 9 (TLR9) in pancreatic tumor and the effects of cytosine phosphate-guanosine oligodeoxynucleotides 2216 (CPG ODN2216) on biological behavior of pancreatic carcinoma cell line PANC-1 and explore their clinical significance. METHODS:The immunohistochemistry and Weste...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i8.996

    authors: Wu HQ,Wang B,Zhu SK,Tian Y,Zhang JH,Wu HS

    更新日期:2011-02-28 00:00:00

  • Characteristics of non-erosive gastroesophageal reflux disease refractory to proton pump inhibitor therapy.

    abstract:AIM:To investigate whether potent acid inhibition is effective in non-erosive reflux disease (NERD) refractory to standard rabeprazole (RPZ) treatment. METHODS:We treated 10 Japanese patients with NERD resistant to standard dosages of RPZ: 10 mg or 20 mg od, 20 mg bid, or 10 mg qid for 14 d. All patients completed a f...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i14.1858

    authors: Sugimoto M,Nishino M,Kodaira C,Yamade M,Uotani T,Ikuma M,Umemura K,Furuta T

    更新日期:2011-04-14 00:00:00

  • siRNA targeting of Cdx2 inhibits growth of human gastric cancer MGC-803 cells.

    abstract:AIM:To investigate the effects of small interference RNA (siRNA) targeting of Cdx2 on human gastric cancer MGC-803 cells in vitro and in vivo. METHODS:The recombinant pSilencer 4.1-Cdx2 siRNA plasmids were constructed and transfected into gastric cancer MGC-803 cells in vitro. The stable transfectants were selected. T...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i16.1903

    authors: Wang XT,Xie YB,Xiao Q

    更新日期:2012-04-28 00:00:00

  • Usefulness of fecal lactoferrin and hemoglobin in diagnosis of colorectal diseases.

    abstract:AIM:To evaluate prospectively usefulness of fecal lactoferrin (Lf) and fecal hemoglobin (Hb) in the diagnosis of colorectal diseases. METHODS:Fecal Lf and Hb were measured using ELISA in 872 patients before they underwent colorectal endoscopy. RESULTS:Lf was positive in 18 (50%) of 36 patients with colorectal cancer,...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v13.i10.1569

    authors: Hirata I,Hoshimoto M,Saito O,Kayazawa M,Nishikawa T,Murano M,Toshina K,Wang FY,Matsuse R

    更新日期:2007-03-14 00:00:00

  • Endoscopic stenting for recurrence-related colorectal anastomotic site obstruction: preliminary experience.

    abstract:AIM:To evaluate the efficacy of stents in treating patients with anastomotic site obstructions due to cancer recurrence following colorectal surgery. METHODS:The medical records of patients who underwent endoscopic self-expanding metal stents (SEMS) insertion for colorectal obstructions between February 2004 and Janua...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i38.13936

    authors: Kim JH,Lee JJ,Cho JH,Kim KO,Chung JW,Kim YJ,Kwon KA,Park DK,Kim JH

    更新日期:2014-10-14 00:00:00

  • Prognostic and predictive significance of MSI in stages II/III colon cancer.

    abstract::In colon cancer, classic disease staging remains the key prognosis and treatment determinant. Although adjuvant chemotherapy has an established role in stage III colon cancer patients, in stage II it is still a subject of controversy due to its restriction to a small subgroup of patients with high-risk histopathologic...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i22.6809

    authors: Saridaki Z,Souglakos J,Georgoulias V

    更新日期:2014-06-14 00:00:00

  • Factors associated with early virological response to peginterferon-α-2a/ribavirin in chronic hepatitis C.

    abstract:AIM:To evaluate the impact of sociodemographic/clinical factors on early virological response (EVR) to peginterferon/ribavirin for chronic hepatitis C (CHC) in clinical practice. METHODS:We conducted a multicenter, cross-sectional, observational study in Hepatology Units of 91 Spanish hospitals. CHC patients treated w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3748/wjg.v19.i12.1943

    authors: García-Samaniego J,Romero M,Granados R,Alemán R,Jorge Juan M,Suárez D,Pérez R,Castellano G,González-Portela C

    更新日期:2013-03-28 00:00:00

  • Epidemiology of upper gastrointestinal symptoms in Brazil (EpiGastro): a population-based study according to sex and age group.

    abstract:AIM:To determine the prevalences of symptoms consistent with gastroesophageal reflux disease (GERD) and dyspepsia in South America. METHODS:A telephone survey was conducted among adult owners of land-based telephones in São Paulo, Brazil, using previously validated computer-assisted sampling and survey protocols. The ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i46.17388

    authors: do Rosário Dias de Oliveira Latorre M,Medeiros da Silva A,Chinzon D,Eisig JN,Dias-Bastos TR

    更新日期:2014-12-14 00:00:00

  • Role of discs large homolog 5.

    abstract::In 2004, an association of genetic variation in the discs large homolog 5 (DLG5) gene with inflammatory bowel disease (IBD) was described in two large European study samples. The initial report of DLG5 as a novel IBD susceptibility gene sparked a multitude of studies investigating its effect on CD and IBD, respectivel...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v12.i23.3651

    authors: Friedrichs F,Stoll M

    更新日期:2006-06-21 00:00:00

  • Interstitial cells of Cajal in the gut--a gastroenterologist's point of view.

    abstract::Alterations of normal function of interstitial cells of Cajal (ICC) are reported in many intestinal disorders. Diagnosis of their involvement is rare (infrequent), but necessary to propose a specific treatment. This article reviews the place of ICC in the pathogenesis of achalasia, gastroesophageal reflux disease, inf...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.14.6285

    authors: Negreanu LM,Assor P,Mateescu B,Cirstoiu C

    更新日期:2008-11-07 00:00:00

  • Hemodynamics and vasoactive substance levels during renal congestion that occurs in the anhepatic phase of liver transplantation.

    abstract:AIM:To explore hemodynamics and vasoactive substance levels during renal vein congestion that occurs in the anhepatic phase of liver transplantation. METHODS:New Zealand rabbits received ligation of the hepatic pedicle, supra-hepatic vena cava and infra-hepatic vena cava [anhepatic phase group (APH); n = 8], the renal...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i18.5482

    authors: Li ZX,Wang MC,Zhang YC,Mao J,Chen M,Ni R,Wei FX,Wang GN,Zhang LY

    更新日期:2015-05-14 00:00:00

  • Structural shift of gut microbiota during chemo-preventive effects of epigallocatechin gallate on colorectal carcinogenesis in mice.

    abstract:AIM:To investigate the effect of epigallocatechin gallate (EGCG) on structural changes of gut microbiota in colorectal carcinogenesis. METHODS:An azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colitis mouse model was established. Forty-two female FVB/N mice were randomly divided into the following three group...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i46.8128

    authors: Wang X,Ye T,Chen WJ,Lv Y,Hao Z,Chen J,Zhao JY,Wang HP,Cai YK

    更新日期:2017-12-14 00:00:00

  • Serum manganese superoxide dismutase and thioredoxin are potential prognostic markers for hepatitis C virus-related hepatocellular carcinoma.

    abstract:AIM:To evaluate the clinical significance of oxidative stress markers in patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). METHODS:Sixty-four consecutive patients who were admitted to Kagoshima University Medical and Dental Hospital were enrolled in this retrospective study. All patients ha...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i44.4890

    authors: Tamai T,Uto H,Takami Y,Oda K,Saishoji A,Hashiguchi M,Kumagai K,Kure T,Mawatari S,Moriuchi A,Oketani M,Ido A,Tsubouchi H

    更新日期:2011-11-28 00:00:00

  • Biliary carcinoembryonic antigen levels in diagnosis of occult hepatic metastases from colorectal carcinoma.

    abstract:AIM:To prospectively explore the role of carcinoembryonic antigen (CEA) in gallbladder bile in patients with colorectal carcinoma and the morphological and clinical features of neoplasia and the occurrence of hepatic metastases. METHODS:CEA levels in the gallbladder and peripheral blood were studied in 44 patients wit...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i7.1589

    authors: Waisberg J,Palma RT,Neto LC,Martins LC,Oliveira MS,Nagashima CA,Godoy AC,Goffi FS

    更新日期:2003-07-01 00:00:00

  • Gastric ulcer penetrating to liver diagnosed by endoscopic biopsy.

    abstract::Liver penetration is a rare but serious complication of peptic ulcer disease. Usually the diagnosis is made by operation or autopsy. Clinical and laboratory data were no specific. A 64-year-old man was admitted with upper gastrointestinal bleeding. Hepatic penetration was diagnosed as the cause of bleeding. Endoscopy ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i12.1838

    authors: Kayacetin E,Kayacetin S

    更新日期:2004-06-15 00:00:00