Efficacy of mycofenolate mofetil for steroid-resistant acute rejection after living donor liver transplantation.

Abstract:

AIM:To discuss the use of mycophenolate mofetil (MMF) as an immunosuppressant in steroid resistant rejection after liver transplantation. METHODS:The clinical records of 260 adult patients who underwent living donor liver transplantation (LDLT) were reviewed. Tacrolimus and methylprednisolone were used for primary immunosuppression. Acute rejection was first treated with steroids. When steroid resistance occurred, the patient was treated with a combination of steroids and MMF. Anti-T-cell monoclonal antibody was administered to patients who were not responsive to steroids in combination with MMF. RESULTS:A total of 90 (35%) patients developed acute rejection. The median interval time from transplantation to the first episode was 15 d. Fifty-four patients were steroid resistant. Forty-four patients were treated with MMF and the remaining 10 required anti-T-cell monoclonal antibody treatment. Progression to chronic rejection was observed in one patient. Bone marrow suppression and gastrointestinal symptoms were the most common side effects associated with MMF use. There was no significant increase in opportunistic infections. CONCLUSION:Our results demonstrate that MMF is a potent and safe immunosuppressive agent for rescue therapy in patients with acute rejection after LDLT.

journal_name

World J Gastroenterol

authors

Akamatsu N,Sugawara Y,Tamura S,Matsui Y,Kaneko J,Makuuchi M

doi

10.3748/wjg.v12.i30.4870

subject

Has Abstract

pub_date

2006-08-14 00:00:00

pages

4870-2

issue

30

eissn

1007-9327

issn

2219-2840

journal_volume

12

pub_type

杂志文章
  • Alcohol-induced steatosis in liver cells.

    abstract::Alcohol-induced fatty liver (steatosis) was believed to result from excessive generation of reducing equivalents from ethanol metabolism, thereby enhancing fat accumulation. Recent findings have revealed a more complex picture in which ethanol oxidation is still required, but specific transcription as well as humoral ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v13.i37.4974

    authors: Donohue TM Jr

    更新日期:2007-10-07 00:00:00

  • Biliary carcinoembryonic antigen levels in diagnosis of occult hepatic metastases from colorectal carcinoma.

    abstract:AIM:To prospectively explore the role of carcinoembryonic antigen (CEA) in gallbladder bile in patients with colorectal carcinoma and the morphological and clinical features of neoplasia and the occurrence of hepatic metastases. METHODS:CEA levels in the gallbladder and peripheral blood were studied in 44 patients wit...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i7.1589

    authors: Waisberg J,Palma RT,Neto LC,Martins LC,Oliveira MS,Nagashima CA,Godoy AC,Goffi FS

    更新日期:2003-07-01 00:00:00

  • Addition of prokinetics to PPI therapy in gastroesophageal reflux disease: a meta-analysis.

    abstract:AIM:To investigate the efficacy of adding prokinetics to proton pump inhibitors (PPIs) for the treatment of gastroesophageal reflux disease (GERD). METHODS:PubMed, Cochrane Library, and Web of Knowledge databases (prior to October 2013) were systematically searched for randomized controlled trials (RCTs) that compared...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v20.i9.2412

    authors: Ren LH,Chen WX,Qian LJ,Li S,Gu M,Shi RH

    更新日期:2014-03-07 00:00:00

  • Epigenetic regulation of DNA repair machinery in Helicobacter pylori-induced gastric carcinogenesis.

    abstract::Although thousands of DNA damaging events occur in each cell every day, efficient DNA repair pathways have evolved to counteract them. The DNA repair machinery plays a key role in maintaining genomic stability by avoiding the maintenance of mutations. The DNA repair enzymes continuously monitor the chromosomes to corr...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i30.9021

    authors: Santos JC,Ribeiro ML

    更新日期:2015-08-14 00:00:00

  • Novel approaches towards conquering hepatitis B virus infection.

    abstract::Currently approved treatments for hepatitis B virus (HBV) infection include the immunomodulatory agent, IFN-alpha, and nucleos(t)ide analogues. Their efficacy is limited by their side effects, as well as the induction of viral mutations that render them less potent. It is thus necessary to develop drugs that target ad...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v13.i6.830

    authors: Wu GY,Chen HS

    更新日期:2007-02-14 00:00:00

  • Castleman's disease of the spleen.

    abstract::Castleman's disease (CD) is a rare lymphoproliferative disorder of unknown etiology. Clinically, it occurs as a localized (unicentric) disease or as a systemic (multicentric) disease. Unicentric Castleman's disease (UCD) presents as a solitary mass and primarily affects the mediastinal, retroperitoneal, and cervical l...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i5.1675

    authors: Lee HJ,Jeon HJ,Park SG,Park CY

    更新日期:2015-02-07 00:00:00

  • Three-dimensional morphometric analysis for hepatectomy of centrally located hepatocellular carcinoma: a pilot study.

    abstract:AIM:To describe a three-dimensional model (3DM) to accurately reconstruct anatomic relationships of centrally located hepatocellular carcinomas (HCCs). METHODS:From March 2013 to July 2014, reconstructions and visual simulations of centrally located HCCs were performed in 39 patients using a 3D subject-based computed ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i15.4607

    authors: Tian F,Wu JX,Rong WQ,Wang LM,Wu F,Yu WB,An SL,Liu FQ,Feng L,Bi C,Liu YH

    更新日期:2015-04-21 00:00:00

  • Analysis of infections in the first 3-month after living donor liver transplantation.

    abstract:AIM:To identify factors related to serious postoperative bacterial and fungal infections in the first 3 mo after living donor liver transplantation (LDLT). METHODS:In the present study, the data of 207 patients from 2004 to 2011 were reviewed. The pre-, intra- and post-operative factors were statistically analyzed. Al...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i16.1975

    authors: Li C,Wen TF,Mi K,Wang C,Yan LN,Li B

    更新日期:2012-04-28 00:00:00

  • Hypoxia inducible factor-1alpha mediates protective effects of ischemic preconditioning on ECV-304 endothelial cells.

    abstract:AIM:To investigate whether hypoxia inducible factor-1alpha (HIF-1alpha) is linked to the protective effects of ischemic preconditioning (IP) on sinusoidal endothelial cells against ischemia/reperfusion injury. METHODS:Sinusoidal endothelial cell lines ECV-304 were cultured and divided into four groups: control group, ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i16.2369

    authors: Shi LB,Huang JH,Han BS

    更新日期:2007-04-28 00:00:00

  • Case of familial hyperlipoproteinemia type III hypertriglyceridemia induced acute pancreatitis: Role for outpatient apheresis maintenance therapy.

    abstract::Hypertriglyceridemic pancreatitis (HTGP) accounts for up to 10% of acute pancreatitis presentations in non-pregnant individuals and is the third most common cause of acute pancreatitis after alcohol and gallstones. There are a number of retrospective studies and case reports that have suggested a role for apheresis an...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v23.i40.7332

    authors: Saleh MA,Mansoor E,Cooper GS

    更新日期:2017-10-28 00:00:00

  • Association of Fusobacterium nucleatum infection with colorectal cancer in Chinese patients.

    abstract:AIM:To investigate Fusobacterium nucleatum (F. nucleatum) abundance in colorectal cancer (CRC) tissues and its association with CRC invasiveness in Chinese patients. METHODS:The resected cancer and adjacent normal tissues (10 cm beyond cancer margins) from 101 consecutive patients with CRC were collected. Fluorescent ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i11.3227

    authors: Li YY,Ge QX,Cao J,Zhou YJ,Du YL,Shen B,Wan YJ,Nie YQ

    更新日期:2016-03-21 00:00:00

  • Influence of continuous veno-venous hemofiltration on the course of acute pancreatitis.

    abstract:AIM:To investigate whether continuous veno-venous hemofiltration (CVVH) in different filtration rate to eliminate cytokines would result in different efficiency in acute pancreatitis, whether the saturation time of filter membrane was related to different filtration rate, and whether the onset time of CVVH could influe...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3748/wjg.v11.i31.4815

    authors: Jiang HL,Xue WJ,Li DQ,Yin AP,Xin X,Li CM,Gao JL

    更新日期:2005-08-21 00:00:00

  • Overexpression of c-fos in Helicobacter pylori-induced gastric precancerosis of Mongolian gerbil.

    abstract:AIM:To explore dysregulation of c-fos in several human malignancies, and to further investigate the role of c-fos in Helicobacter pylori (H. pylori)-induced gastric precancerosis. METHODS:Four-week-old male Mongolian gerbils were employed in the study. 0.5 mL 1X10(8) cfu/L suspension of H. pylori NCTC 11 637 in Brucel...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i3.521

    authors: Yang YL,Xu B,Song YG,Zhang WD

    更新日期:2003-03-01 00:00:00

  • Performance of tacrolimus in hospitalized patients with steroid-refractory acute severe ulcerative colitis.

    abstract:BACKGROUND:Acute severe ulcerative colitis unresponsive to systemic steroid treatment is a life-threatening medical condition requiring hospitalization and often colectomy. Despite the increasing choice of medical therapy options for ulcerative colitis, the condition remains a great challenge in the field of inflammato...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v25.i13.1603

    authors: Hoffmann P,Wehling C,Krisam J,Pfeiffenberger J,Belling N,Gauss A

    更新日期:2019-04-07 00:00:00

  • Pathological mechanisms of alcohol-induced hepatic portal hypertension in early stage fibrosis rat model.

    abstract:AIM:To study the role of hepatic sinusoidal capillarization and perisinusoidal fibrosis in rats with alcohol-induced portal hypertension and to discuss the pathological mechanisms of alcohol-induced hepatic portal hypertension. METHODS:Fifty SD rats were divided into control group (n=20) and model group (n=30). Alcoho...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i41.6483

    authors: Li J,Niu JZ,Wang JF,Li Y,Tao XH

    更新日期:2005-11-07 00:00:00

  • Colonic lesion characterization in inflammatory bowel disease: A systematic review and meta-analysis.

    abstract:AIM:To perform a systematic review and meta-analysis for the diagnostic accuracy of in vivo lesion characterization in colonic inflammatory bowel disease (IBD), using optical imaging techniques, including virtual chromoendoscopy (VCE), dye-based chromoendoscopy (DBC), magnification endoscopy and confocal laser endomicr...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v24.i10.1167

    authors: Lord R,Burr NE,Mohammed N,Subramanian V

    更新日期:2018-03-14 00:00:00

  • Sealing of the hepatic resection area using fibrin glue reduces significant amount of postoperative drain fluid.

    abstract:AIM:To investigate whether the routine use of fibrin glue applied onto the hepatic resection area can diminish postoperative volume of bloody or biliary fluids drained via intraoperatively placed perihepatic tubes and can thus lower the complication rate. METHODS:Two groups of consecutive patients with a comparable sp...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v11.i38.5984

    authors: Eder F,Meyer F,Nestler G,Halloul Z,Lippert H

    更新日期:2005-10-14 00:00:00

  • Structural shift of gut microbiota during chemo-preventive effects of epigallocatechin gallate on colorectal carcinogenesis in mice.

    abstract:AIM:To investigate the effect of epigallocatechin gallate (EGCG) on structural changes of gut microbiota in colorectal carcinogenesis. METHODS:An azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colitis mouse model was established. Forty-two female FVB/N mice were randomly divided into the following three group...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i46.8128

    authors: Wang X,Ye T,Chen WJ,Lv Y,Hao Z,Chen J,Zhao JY,Wang HP,Cai YK

    更新日期:2017-12-14 00:00:00

  • EUS mini probes in diagnosis of cystic dystrophy of duodenal wall in heterotopic pancreas: a case report.

    abstract::Cystic dystrophy of the duodenal wall is a rare condition characterized by the development of cysts in heterotopic pancreatic tissue localized in the duodenal wall. A 38-year-old man was admitted to the hospital for abdominal pain and vomiting after food intake. The diagnosis of acute pancreatitis was initially suspec...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v10.i17.2609

    authors: Jovanovic I,Knezevic S,Micev M,Krstic M

    更新日期:2004-09-01 00:00:00

  • Evaluation of contrast-enhanced computed tomographic colonography in detection of local recurrent colorectal cancer.

    abstract:AIM:To evaluate the diagnostic accuracy, sensitivity, specificity of contrast-enhanced computed tomographic colonography in detecting local recurrence of colorectal cancer. METHODS:From January 2000 to December 2004, 434 patients after potentially curative resection for invasive colorectal cancer were followed up for ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i1.123

    authors: You YT,Chang Chien CR,Wang JY,Ng KK,Chen JS,Tang R,Chiang JM,Yeh CY,Hsieh PS

    更新日期:2006-01-07 00:00:00

  • Gene modulation associated with inhibition of liver regeneration in hepatitis B virus X transgenic mice.

    abstract:AIM:To analyze the modulation of gene expression profile associated with inhibition of liver regeneration in hepatitis B X (HBx)-expressing transgenic mice. METHODS:Microarray technology was performed on liver tissue obtained from 4 control (LacZ) and 4 transgenic mice (HBx-LacZ), 48 h after partial hepatectomy. The s...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.574

    authors: Sidorkiewicz M,Jais JP,Tralhao G,Morosan S,Giannini C,Brezillon N,Soussan P,Delpuech O,Kremsdorf D

    更新日期:2008-01-28 00:00:00

  • Diarrhea after bariatric procedures: Diagnosis and therapy.

    abstract::Diarrhea after bariatric procedures, mainly those with malabsorptive elements including Roux-Y Gastric Bypass and Biliopancreatic Diversion, is common and an essential determinant of quality of life and micro- and macronutrient deficiencies. Bariatric surgery is the only sustainably successful method to address morbid...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v23.i26.4689

    authors: Borbély YM,Osterwalder A,Kröll D,Nett PC,Inglin RA

    更新日期:2017-07-14 00:00:00

  • Impact of small-for-size liver grafts on medium-term and long-term graft survival in living donor liver transplantation: A meta-analysis.

    abstract:BACKGROUND:Small-for-size grafts (SFSGs) in living donor liver transplantation (LDLT) could optimize donor postoperative outcomes and also expand the potential donor pool. Evidence on whether SFSGs would affect medium-term and long-term recipient graft survival is lacking. AIM:To evaluate the impact of small-for-size ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.3748/wjg.v25.i36.5559

    authors: Ma KW,Wong KHC,Chan ACY,Cheung TT,Dai WC,Fung JYY,She WH,Lo CM,Chok KSH

    更新日期:2019-09-28 00:00:00

  • Expression of protein S100A4 is a predictor of recurrence in colorectal cancer.

    abstract:AIM:To investigate the prognostic significance of S100A4 expression in colorectal cancer and its correlation with expression of E-cadherin and p53. METHODS:A cohort of archival formalin-fixed paraffin-embedded specimens was selected from 127 patients with colorectal cancer who underwent surgical resection between Apri...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i31.3897

    authors: Kwak JM,Lee HJ,Kim SH,Kim HK,Mok YJ,Park YT,Choi JS,Moon HY

    更新日期:2010-08-21 00:00:00

  • Outcome of endotherapy for pancreas divisum in patients with acute recurrent pancreatitis.

    abstract:AIM:To assess the rate of relapses of acute pancreatitis (AP), recurrent AP (RAP) and the evolution of endosonographic signs of chronic pancreatitis (CP) in patients with pancreas divisum (PDiv) and RAP. METHODS:Over a five-year period, patients with PDiv and RAP prospectively enrolled were divided into two groups: (1...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i46.17468

    authors: Mariani A,Di Leo M,Petrone MC,Arcidiacono PG,Giussani A,Zuppardo RA,Cavestro GM,Testoni PA

    更新日期:2014-12-14 00:00:00

  • Molecular mechanism and functional consequences of lansoprazole-mediated heme oxygenase-1 induction.

    abstract:AIM:To investigate the molecular mechanism and functional consequences of heme oxygenase-1 (HO-1) activation by lansoprazole in endothelial cells and macrophages. METHODS:Expression of HO-1 mRNA was analyzed by Northern blotting. Western blotting was used to determine the HO-1 and ferritin protein levels. NADPH-depend...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.4392

    authors: Schulz-Geske S,Erdmann K,Wong RJ,Stevenson DK,Schröder H,Grosser N

    更新日期:2009-09-21 00:00:00

  • Tolerance in liver transplantation: Biomarkers and clinical relevance.

    abstract::Transplantation is the optimal treatment for end-stage organ failure, and modern immunosuppression has allowed important progress in short-term outcomes. However, immunosuppression poorly influences chronic rejection and elicits chronic toxicity in current clinical practice. Thus, a major goal in transplantation is to...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i34.7676

    authors: Baroja-Mazo A,Revilla-Nuin B,Parrilla P,Martínez-Alarcón L,Ramírez P,Pons JA

    更新日期:2016-09-14 00:00:00

  • Protective effect of taurine on hypochlorous acid toxicity to nuclear nucleoside triphosphatase in isolated nuclei from rat liver.

    abstract:AIM:Taurine has been shown to be an effective scavenger of hypochlorous acid (HOCl). The role of HOCl is well established in tissue damage associated with inflammation and injury. In the present study, the effect of HOCl on nuclear nucleoside triphosphatase of hepatocytes and the ability of taurine to prevent this effe...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i5.694

    authors: Li JX,Pang YZ,Tang CS,Li ZQ

    更新日期:2004-03-01 00:00:00

  • Cutaneous manifestations in celiac disease.

    abstract::Celiac disease (CD) is an autoimmune gluten-dependent enteropathy characterized by atrophy of intestinal villi that improves after gluten-free diet (GFD). CD is often associated with extra-intestinal manifestations; among them, several skin diseases are described in CD patients. The present review reports all CD-assoc...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v12.i6.843

    authors: Abenavoli L,Proietti I,Leggio L,Ferrulli A,Vonghia L,Capizzi R,Rotoli M,Amerio PL,Gasbarrini G,Addolorato G

    更新日期:2006-02-14 00:00:00

  • Single endoscopist-performed percutaneous endoscopic gastrostomy tube placement.

    abstract:AIM:To investigate whether single endoscopist-performed percutaneous endoscopic gastrostomy (PEG) is safe and to compare the complications of PEG with those reported in the literature. METHODS:Patients who underwent PEG placement between June 2001 and August 2011 at the Baskent University Alanya Teaching and Research ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i26.4172

    authors: Erdogan A

    更新日期:2013-07-14 00:00:00