Abstract:
:Nonalcoholic fatty liver disease (NAFLD) is the commonest chronic liver disease in high-income countries and is associated with increased morbidity and mortality. Macrophages appear to play an important role in the development and progression of hepatic fibrosis in patients with NAFLD. Accordingly, modulation of macrophage trafficking might represent an attractive therapeutic strategy in this population. Cenicriviroc is an oral inhibitor of the chemokine ligand 2/C-C chemokine receptor 2 pathway, which plays an important role in the hepatic recruitment of the macrophages. Preclinical studies and a phase 2b study in humans suggest that this agent might hold promise in the management of NAFLD.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Neokosmidis G,Tziomalos Kdoi
10.3748/wjg.v24.i48.5415subject
Has Abstractpub_date
2018-12-28 00:00:00pages
5415-5417issue
48eissn
1007-9327issn
2219-2840journal_volume
24pub_type
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journal_title:World journal of gastroenterology
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journal_title:World journal of gastroenterology
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