Role of cenicriviroc in the management of nonalcoholic fatty liver disease.

Abstract:

:Nonalcoholic fatty liver disease (NAFLD) is the commonest chronic liver disease in high-income countries and is associated with increased morbidity and mortality. Macrophages appear to play an important role in the development and progression of hepatic fibrosis in patients with NAFLD. Accordingly, modulation of macrophage trafficking might represent an attractive therapeutic strategy in this population. Cenicriviroc is an oral inhibitor of the chemokine ligand 2/C-C chemokine receptor 2 pathway, which plays an important role in the hepatic recruitment of the macrophages. Preclinical studies and a phase 2b study in humans suggest that this agent might hold promise in the management of NAFLD.

journal_name

World J Gastroenterol

authors

Neokosmidis G,Tziomalos K

doi

10.3748/wjg.v24.i48.5415

subject

Has Abstract

pub_date

2018-12-28 00:00:00

pages

5415-5417

issue

48

eissn

1007-9327

issn

2219-2840

journal_volume

24

pub_type

社论
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