Synthesis of ribozyme against vascular endothelial growth factor165 and its biological activity in vitro.

abstract：AIM:To study the effects of cortactin on the tumor biology of SGC-7901 cells and identify the mechanism involved in the process. METHODS:Cell lines in which cortactin was stably overexpressed or knocked down as well as the respective control cell lines were established by standard molecular methods. The effects of cor...

journal_title：World journal of gastroenterology

authors： Wei J,Zhao ZX,Li Y,Zhou ZQ,You TG

更新日期：2014-03-28 00:00:00

abstract：:Peritoneal carcinomatosis appears to be the most common pattern of metastasis or recurrence and is associated with poor prognosis in gastric cancer patients. Many efforts have been made to improve the survival in patients with peritoneal metastasis. Hyperthermic intraperitoneal chemotherapy remains a widely accepted s...

journal_title：World journal of gastroenterology

authors： Wei J,Wu ND,Liu BR

更新日期：2016-09-07 00:00:00

abstract：AIM:To determine the association of human antigen R (HuR) and inhibitors of apoptosis proteins (IAP1, IAP2) and prognosis in pancreatic cancer. METHODS:Protein and mRNA expression levels of IAP1, IAP2 and HuR in pancreatic ductal adenocarcinoma (PDAC) were compared with normal pancreatic tissue. The correlations among...

journal_title：World journal of gastroenterology

authors： Lukosiute-Urboniene A,Jasukaitiene A,Silkuniene G,Barauskas V,Gulbinas A,Dambrauskas Z

更新日期：2019-01-14 00:00:00

abstract：AIM:To investigate the implication of the hypoxia inducible factor HIF-1alpha mRNA in gastric carcinoma and its relation to the expression of vascular endothelial growth factor (VEGF) protein, tumor angiogenesis invasion/metastasis and the patient's survival. METHODS:In situ hybridization was used to examine expressio...

journal_title：World journal of gastroenterology

authors： Ma J,Zhang L,Ru GQ,Zhao ZS,Xu WJ

更新日期：2007-03-21 00:00:00

abstract：AIM:To investigate the location alteration of Smad2 and Smad4 mRNAs in the liver during and after fibrogenesis in rats. METHODS:Eighty male Wistar rats weighing approximately 200 g each were used. The rat models of experimental hepatic fibrosis were established by injection with carbon tetrachloride (CCl4), normal rat...

journal_title：World journal of gastroenterology

authors： Liu Y,Wang LF,Zou HF,Song XY,Xu HF,Lin P,Zheng HH,Yu XG

更新日期：2006-03-14 00:00:00

abstract：AIM:To investigate the role of peritoneal macrophage (PM) polarization in the therapeutic effect of abdominal paracentesis drainage (APD) on severe acute pancreatitis (SAP). METHODS:SAP was induced by 5% Na-taurocholate retrograde injection in Sprague-Dawley rats. APD was performed by inserting a drainage tube with a ...

journal_title：World journal of gastroenterology

authors： Liu RH,Wen Y,Sun HY,Liu CY,Zhang YF,Yang Y,Huang QL,Tang JJ,Huang CC,Tang LJ

更新日期：2018-12-07 00:00:00

abstract：AIM:To investigate the post-colonoscopy colorectal cancer (PCCRC) rate for high-definition (HD) colonoscopy compared with that for standard-definition colonoscopy reported previously. METHODS:Using medical records at Sano Hospital (SH) and Dokkyo Medical University Koshigaya Hospital (DMUKH), we retrospectively obtain...

journal_title：World journal of gastroenterology

authors： Iwatate M,Kitagawa T,Katayama Y,Tokutomi N,Ban S,Hattori S,Hasuike N,Sano W,Sano Y,Tamano M

更新日期：2017-11-14 00:00:00

abstract：AIM:To investigate the effects of exogenously mutated p27(kipl) (p27) on proliferation and apoptosis of human cholangiocarcinoma cell line, QBC(939)in vivo. METHODS:Adenviral vectors were used to transfect mutated p27 cDNA into human QBC(939)cell line. Expression of p27 was detected by RT-PCR. Western blot. Cell growt...

journal_title：World journal of gastroenterology

authors： Luo J,Chen YJ,Wang WY,Zou SQ

更新日期：2008-09-14 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a dismal prognosis, especially when diagnosed at advanced stages. Annexin A2 (ANXA2), is found to promote cancer progression and therapeutic resistance. However, the underlining mechanisms of ANXA2 in immune escape of HCC remain poorly underst...

journal_title：World journal of gastroenterology

authors： Qiu LW,Liu YF,Cao XQ,Wang Y,Cui XH,Ye X,Huang SW,Xie HJ,Zhang HJ

更新日期：2020-05-14 00:00:00

abstract：:Gallstone ileus is a rare disease and accounts for 1%-4% of all cases of mechanical intestinal obstruction. It usually occurs in the elderly with a female predominance and may result in a high mortality rate. Its diagnosis is difficult and early diagnosis could reduce the mortality. Surgery remains the mainstay of tre...

journal_title：World journal of gastroenterology

authors： Chou JW,Hsu CH,Liao KF,Lai HC,Cheng KS,Peng CY,Yang MD,Chen YF

更新日期：2007-02-28 00:00:00

abstract：AIM:To evaluate safety and effect on hepatitis B virus (HBV) suppression of a long-term treatment with lamivudine (LAM) at standard (100 mg/d) or double (200 mg/d) dose in chronic hepatitis B. METHODS:This was a case study with matched controls (1:3) in patients with chronic hepatitis B with anti-HBe antibodies. RESU...

journal_title：World journal of gastroenterology

authors： Stornaiuolo G,Stanzione M,Brancaccio G,Cuomo G,Precone V,Di Biase S,Felaco FM,Piccinino F,Gaeta GB

更新日期：2007-11-14 00:00:00

abstract：:We report the case of a 57-year-old man who was diagnosed with a large unresectable cholangiocarcinoma associated with 2 satellite nodules and without clear margins with the right hepatic vein. Despite 4 cycles of GEMOX (stopped due to a hypertransaminasemia believed to be due to gemcitabine) and 4 cycles of FOLFIRINO...

journal_title：World journal of gastroenterology

authors： Servajean C,Gilabert M,Piana G,Monges G,Delpero JR,Brenot I,Raoul JL

更新日期：2014-05-07 00:00:00

abstract：AIM:To assess the efficacy and safety of TECA type hybrid artificial liver support system (TECA-HALSS) in providing liver function of detoxification, metabolism and physiology by treating the patients with acute liver failure (ALF). METHODS:The porcine liver cells (1-2) x 10(10) were separated from the Chinese small s...

journal_title：World journal of gastroenterology

authors： Xue YL,Zhao SF,Luo Y,Li XJ,Duan ZP,Chen XP,Li WG,Huang XQ,Li YL,Cui X,Zhong DG,Zhang ZY,Huang ZQ

更新日期：2001-12-01 00:00:00

abstract：AIM:To establish a quantitative method to measure the amount of lipids. METHODS:The livers of 53 male Wistar rats (225 g) with different degrees of hepatic steatosis were studied. This model of hepatic steatosis was based on a high carbohydrate, fat-free modified diet. Biopsies were classified into four grades dependi...

journal_title：World journal of gastroenterology

authors： Hijona E,Hijona L,Larzabal M,Sarasqueta C,Aldazabal P,Arenas J,Bujanda L

更新日期：2010-03-28 00:00:00

abstract：AIM:To study the clinical outcome of antiviral therapy in hepatitis B-related decompensated cirrhotic patients. METHODS:Three hundred and twelve patients with decompensated hepatitis B cirrhosis were evaluated in a prospective cohort. With two years of follow-up, 198 patients in the group receiving antiviral therapy w...

journal_title：World journal of gastroenterology

authors： Li L,Liu W,Chen YH,Fan CL,Dong PL,Wei FL,Li B,Chen DX,Ding HG

更新日期：2013-12-07 00:00:00

abstract：:Cholelithiasis occurs infrequently in the paediatric age group. Hereditary spherocytosis, sickle cell anaemia and thalassemia are the haemolytic disorders most commonly associated with development of gall stones in paediatric age group. The question is whether an isolated episode of haemolysis can cause gallstones. ...

journal_title：World journal of gastroenterology

authors： Kejariwal D

更新日期：2006-04-14 00:00:00

abstract：AIM:To investigate the outcome of repeating endoscopic retrograde cholangiopancreaticography (ERCP) after initially failed precut sphincterotomy to achieve biliary cannulation. METHODS:In this retrospective study, consecutive ERCPs performed between January 2009 and September 2012 were included. Data from our endoscop...

journal_title：World journal of gastroenterology

authors： Pavlides M,Barnabas A,Fernandopulle N,Bailey AA,Collier J,Phillips-Hughes J,Ellis A,Chapman R,Braden B

更新日期：2014-09-28 00:00:00

abstract：AIM:To evaluate the influence of avidin chase on the side effects of radioimmunotherapy (RIT) in nude mice bearing human colon carcinoma and therapeutic outcome. METHODS:Purified anti-CEA monoclonal antibody (McAb) was biotinylated with NHS-biotin, and then radiolabeled with 188Re by the direct method. 188Re-labeled b...

journal_title：World journal of gastroenterology

authors： Li GP,Wang YX,Huang K,Zhang H,Zhang CF

更新日期：2005-04-07 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the major causes of morbidity and mortality in patients with chronic liver disease. Transarterial chemoembolization (TACE) can significantly improve the survival rate of patients with HCC and is the first treatment choice for patients who are not suitable for surgical resection...

journal_title：World journal of gastroenterology

authors： Yang K,Zhang XM,Yang L,Xu H,Peng J

更新日期：2016-05-28 00:00:00

abstract：AIM:To investigate serum insulin-like growth factor-binding protein 5 (IGFBP-5) levels and intestinal IGFBP-5 expression in patients with Crohn's disease (CD). METHODS:We analyzed the serum concentrations and intestinal expression of IGFBP-5 in 42 patients with CD, of whom 26 had endoscopically or radiologically prove...

journal_title：World journal of gastroenterology

authors： Adali G,Yorulmaz E,Ozkanli S,Ulasoglu C,Bayraktar B,Orhun A,Colak Y,Tuncer I

更新日期：2013-12-21 00:00:00

abstract：AIM:To compare therapeutic outcomes and adverse events in initial solitary hepatocellular carcinoma (HCC) treated with radiofrequency ablation (RFA) and CyberKnife(®). METHODS:Seventy three consecutive patients with initial solitary HCC treated with RFA (38 patients; RFA group) and CyberKnife(®) (35 patients; CK group...

journal_title：World journal of gastroenterology

authors： Shiozawa K,Watanabe M,Ikehara T,Matsukiyo Y,Kogame M,Kishimoto Y,Okubo Y,Makino H,Tsukamoto N,Igarashi Y,Sumino Y

更新日期：2015-12-28 00:00:00

abstract：BACKGROUND:Acute severe ulcerative colitis unresponsive to systemic steroid treatment is a life-threatening medical condition requiring hospitalization and often colectomy. Despite the increasing choice of medical therapy options for ulcerative colitis, the condition remains a great challenge in the field of inflammato...

journal_title：World journal of gastroenterology

authors： Hoffmann P,Wehling C,Krisam J,Pfeiffenberger J,Belling N,Gauss A

更新日期：2019-04-07 00:00:00

abstract：AIM:To study the expression and serum level of HBxAg, Fas and FasL in tissues of HCC patients, and to assess the relationship between HBxAg and Fas/FasL system. METHODS:Tissues from 50 patients with HCC were tested for the expression of HBxAg, Fas and FasL by S-P immunohistochemistry. Serum levels of sFas/sFasL and HB...

journal_title：World journal of gastroenterology

authors： Wang XZ,Chen XC,Chen YX,Zhang LJ,Li D,Chen FL,Chen ZX,Chen HY,Tao QM

更新日期：2003-12-01 00:00:00

abstract：AIM:To evaluate the inhibition effect of HCV NS5A on p53 transactivation on p21 promoter and explore its possible mechanism for influencing p53 function. METHODS:p53 function of transactivation on p21 promoter was studied with a luciferase reporter system in which the luciferase gene is driven by p21 promoter, and the...

journal_title：World journal of gastroenterology

authors： Gong GZ,Jiang YF,He Y,Lai LY,Zhu YH,Su XS

更新日期：2004-08-01 00:00:00

abstract：AIM:To investigate the changes that occur in E-cadherin expression during the process of metastasis in colorectal cancer. METHODS:E-cadherin expression was detected by immunohistochemistry and two indices of expression were calculated which reflected the level of expression and the locations (membrane and cytoplasm). ...

journal_title：World journal of gastroenterology

authors： Elzagheid A,Algars A,Bendardaf R,Lamlum H,Ristamaki R,Collan Y,Syrjanen K,Pyrhonen S

更新日期：2006-07-21 00:00:00

abstract：:The incidence of colonic diverticulosis with or without diverticulitis has increased in the Japanese population due to the modernization of food and aging. The rate of diverticulitis in colon diverticulosis ranges from 8.1% to 9.6%. However, few cases of stenosis due to diverticulitis have been reported. These reports...

journal_title：World journal of gastroenterology

authors： Nishiyama N,Mori H,Kobara H,Rafiq K,Fujihara S,Kobayashi M,Masaki T

更新日期：2012-07-21 00:00:00

abstract：AIM:To describe the bowel habits and the prevalence of irritable bowel syndrome (IBS) and to investigate the influence of health behavior and social factors on IBS prevalence in university students. METHODS:This cross-sectional study was conducted at five major universities in Greater Beirut and its suburbs, between F...

journal_title：World journal of gastroenterology

authors： Costanian C,Tamim H,Assaad S

更新日期：2015-03-28 00:00:00

abstract：AIM:To investigate H(+), K(+)-ATPase inhibition, anti-H pylori, antioxidant, and the in vivo antiulcer potential of a pectic polysaccharide from Swallow root (Decalepis hamiltonii; SRPP). METHODS:SRPP, with known sugar composition [rhamnose: arabinose: xylose: galactose in the ratio of 16:50:2:32 (w/w), with 141 mg/g ...

journal_title：World journal of gastroenterology

authors： Srikanta B,Siddaraju M,Dharmesh S

更新日期：2007-10-21 00:00:00

abstract：AIM:To investigate anti-apoptotic effects of glycyrrhizic acid (GA) against fibrosis in carbon tetrachloride (CCl4)-induced liver injury and its contributing factors. METHODS:Liver fibrosis was induced by administration of CCl4 for 8 wk. Pathological changes in the liver of rats were examined by hematoxylin-eosin stai...

journal_title：World journal of gastroenterology

authors： Liang B,Guo XL,Jin J,Ma YC,Feng ZQ

更新日期：2015-05-07 00:00:00

abstract：BACKGROUND:To date, the histopathological parameters predicting the risk of lymph node (LN) metastases and local recurrence, associated mortality and appropriateness of endoscopic or surgical resection in patients with gastric neuroendocrine neoplasms type 1 (GNENs1) have not been fully elucidated. AIM:To determine th...

journal_title：World journal of gastroenterology

authors： Tsolakis AV,Ragkousi A,Vujasinovic M,Kaltsas G,Daskalakis K

更新日期：2019-09-21 00:00:00