Synthesis of ribozyme against vascular endothelial growth factor165 and its biological activity in vitro.

abstract：AIM:To identify the differentially over-expressed genes associated with β-catenin accumulation in nuclei of hepatocellular carcinoma (HCC) cells. METHODS:Differentially expressed genes were identified in radiation-induced B6C3 F1 mouse HCC cells by mRNA differential display, Northern blot and RT-PCR, respectively. Tot...

journal_title：World journal of gastroenterology

authors： Li YS,Liu M,Nakata Y,Tang HB

更新日期：2011-04-07 00:00:00

abstract：AIM:To assess the results of endoscopic mucosal resection with a ligation device (EMR-L) combined with three dimensional endoscopic ultrasonography (3D-EUS) using an ultrasonic probe for rectal carcinoids. In addition, diagnosis of the depth and size of lesions by EUS was evaluated. METHODS:Between January 2003 and Ma...

journal_title：World journal of gastroenterology

authors： Abe T,Kakemura T,Fujinuma S,Maetani I

更新日期：2008-07-07 00:00:00

abstract：:Of the diverse biological agents used for patients with ulcerative colitis, the anti-tumor necrosis factor-α agents infliximab and adalimumab have been used in large-scale clinical trials and are currently widely used in the treatment of inflammatory bowel disease patients. Recent studies have indicated that golimumab...

journal_title：World journal of gastroenterology

authors： Seo GS,Chae SC

更新日期：2014-10-07 00:00:00

abstract：AIM:To investigate long-term outcome in obscure gastrointestinal bleeding (OGIB) after negative capsule endoscopy (CE) and identify risk factors for rebleeding. METHODS:A total of 113 consecutive patients underwent CE for OGIB from May 2003 to June 2010 at Seoul National University Hospital. Ninety-five patients (84.1...

journal_title：World journal of gastroenterology

authors： Koh SJ,Im JP,Kim JW,Kim BG,Lee KL,Kim SG,Kim JS,Jung HC

更新日期：2013-03-14 00:00:00

abstract：AIM:To evaluate the efficacy and tolerability of herbal medicines in inflammatory bowel disease (IBD) by conducting a meta-analysis. METHODS:Electronic databases were searched for studies investigating efficacy and/or tolerability of herbal medicines in the management of different types of IBD. The search terms were: ...

journal_title：World journal of gastroenterology

authors： Rahimi R,Nikfar S,Abdollahi M

更新日期：2013-09-14 00:00:00

abstract：:Single-port laparoscopic surgery (SPLS) is proposed to be a step towards minimizing the invasiveness of surgery, and has since gained popularity in several surgical sub-specialties including hepatopancreatobiliary surgery. SPLS has since been applied to cholecystectomy, liver resection as well as pancreatectomy for a ...

journal_title：World journal of gastroenterology

authors： Chang SK,Lee KY

更新日期：2014-10-21 00:00:00

abstract：AIM:To prepare the human hepatocellular carcinoma-(HCC)-targeted liposome microbubbles and to investigate their immunological properties. METHODS:Human hepatocarcinoma specific monoclonal antibody HAb18 was attached to the surface of home-made liposome microbubbles by static attraction to prepare the targeted liposome...

journal_title：World journal of gastroenterology

authors： Bian AN,Gao YH,Tan KB,Liu P,Zeng GJ,Zhang X,Liu Z

更新日期：2004-12-01 00:00:00

abstract：:A 42-year-old woman was admitted to our hospital because of multiple liver tumors detected by ultrasonography. Colonoscopy revealed submucosal tumor in the rectum, which was considered the primary lesion. Endoscopic mucosal resection followed by histopathological examination revealed that the tumor was carcinoid. The ...

journal_title：World journal of gastroenterology

authors： Nakajima Y,Takagi H,Sohara N,Sato K,Kakizaki S,Nomoto K,Suzuki H,Suehiro T,Shimura T,Asao T,Kuwano H,Mori M,Nishikura K

更新日期：2006-03-21 00:00:00

abstract：:A cerebral lipiodol embolism is an extremely rare complication of transcatheter arterial chemoembolization for hepatocellular carcinoma. We present a case of cerebral lipiodol embolism that occurred after the third arterial chemoembolization, report the clinical and radiological findings, and review the medical litera...

journal_title：World journal of gastroenterology

authors： Choi CS,Kim KH,Seo GS,Cho EY,Oh HJ,Choi SC,Kim TH,Kim HC,Roh BS

更新日期：2008-08-14 00:00:00

abstract：AIM:To investigate whether alphastatin could inhibit human gastric cancer growth and furthermore whether sphingosine kinase (SPK) activity is involved in this process. METHODS:Using migration assay, MTT assay and Matrigel assay, the effect of alphastatin on vascular endothelial cells (ECs) was evaluated in vitro. SPK ...

journal_title：World journal of gastroenterology

authors： Chen L,Li T,Li R,Wei B,Peng Z

更新日期：2006-07-14 00:00:00

abstract：AIM:To explore the relationship among interferon-gamma (IFN-gamma) activity, fibrogenesis, T cell immune responses and hepatic inflammatory activity. METHODS:Peripheral blood samples from a total of 43 hepatitis B cirrhotic patients (LC) and 19 healthy controls (NC) were collected to measure their serum levels of IFN-...

journal_title：World journal of gastroenterology

authors： Tang JT,Fang JY,Gu WQ,Li EL

更新日期：2006-05-21 00:00:00

abstract：:In order to have an adequate view of the whole small intestine during capsule endoscopy, the preparation recommended consists of a clear liquid diet and an overnight fast. However, visualization of the small bowel during video capsule endoscopy can be impaired by intestinal contents. To improve mucosal visualization, ...

journal_title：World journal of gastroenterology

authors： Pons Beltrán V,Carretero C,Gonzalez-Suárez B,Fernandez-Urien I,Muñoz-Navas M

更新日期：2008-10-07 00:00:00

abstract：:The severity of fecal incontinence widely varies and can have dramatic devastating impacts on a person's life. Fecal incontinence is common, though it is often under-reported by patients. In addition to standard treatment options, new treatments have been developed during the past decade to attempt to effectively trea...

journal_title：World journal of gastroenterology

authors： Van Koughnett JA,Wexner SD

更新日期：2013-12-28 00:00:00

abstract：:Intense abdominal pain is a prominent feature of chronic pancreatitis and its treatment remains a major clinical challenge. Basic studies of pancreatic nerves and experimental human pain research have provided evidence that pain processing is abnormal in these patients and in many cases resembles that seen in neuropat...

journal_title：World journal of gastroenterology

authors： Olesen SS,Juel J,Graversen C,Kolesnikov Y,Wilder-Smith OH,Drewes AM

更新日期：2013-11-14 00:00:00

abstract：AIM:To investigate the expression of tumor suppressor gene p27 and spindle checkpoint gene Mad2 and to demonstrate their expression difference in colorectal cancer and normal mucosa and to evaluate its clinical significance. METHODS:Immunohistochemical staining was used for detection of expression of Mad2 and p27 in c...

journal_title：World journal of gastroenterology

authors： Li GQ,Zhang HF

更新日期：2004-11-01 00:00:00

abstract：AIM:To investigate the efficacy and side effects of the combined therapy of oxaliplatin and capecitabine in patients with metastatic esophageal squamous cell cancer (ESCC) and the survival of the patients. METHODS:Sixty-four patients (median age of 63 years) with histological or cytological confirmation of ESCC receiv...

journal_title：World journal of gastroenterology

authors： Qin TJ,An GL,Zhao XH,Tian F,Li XH,Lian JW,Pan BR,Gu SZ

更新日期：2009-02-21 00:00:00

abstract：AIM:To elucidate the molecular mechanisms leading to development of functionally impaired dendritic cells (DCs) in chronic hepatitis C (CHC) patients infected with genotype 3 virus. METHODS:This prospective study was conducted on the cohorts of CHC individuals identified as responders or non-responders to antiviral th...

journal_title：World journal of gastroenterology

authors： Tomer S,Chawla YK,Duseja A,Arora SK

更新日期：2016-06-14 00:00:00

abstract：:Pancreatic cancer is one of the most aggressive and difficult cancers to treat. Despite numerous research efforts, limited success has been achieved in the therapeutic management of patients with this disease. In the current review, we focus on one component of morphogenesis signaling, Hedgehog (Hh), with the aim of d...

journal_title：World journal of gastroenterology

authors： Onishi H,Katano M

更新日期：2014-03-07 00:00:00

abstract：:The anti-tumor necrosis factor (TNF)alpha medications demonstrate efficacy in the induction of remission and its maintenance in numerous chronic inflammatory conditions. With the increasing number of patients receiving anti-TNFalpha agents, however, less common adverse reactions will occur. Cutaneous eruptions complic...

journal_title：World journal of gastroenterology

authors： Salama M,Lawrance IC

更新日期：2009-09-21 00:00:00

abstract：BACKGROUND:Increasing levels of antibiotic resistance have reduced the Helicobacter pylori (H. pylori) eradication rates afforded by the standard triple therapy. Thus, 2-wk first-line four-drug regimens must be considered. AIM:To analyze the eradication rates of modified bismuth-containing quadruple therapy (mBCQT) an...

journal_title：World journal of gastroenterology

authors： Kim SJ,Chung JW,Woo HS,Kim SY,Kim JH,Kim YJ,Kim KO,Kwon KA,Park DK

更新日期：2019-12-14 00:00:00

abstract：AIM:To evaluate the diagnostic efficiency of endoscopic ultrasound (EUS) as the main imaging modality in patients with moderate suspicion of common bile duct stones (CBDS). METHODS:55 patients with moderate clinical suspicion of CBDS were prospectively included to the study and evaluated with EUS. This study was done ...

journal_title：World journal of gastroenterology

authors： Kohut M,Nowak A,Nowakowska-Dulawa E,Marek T,Kaczor R

更新日期：2003-03-01 00:00:00

abstract：:Colorectal cancer is one of the most common causes of cancer morbidity both in men and in women. However, females over 65 years old show higher mortality and lower 5-year survival rate of colorectal cancer compared to their age-matched male counterparts. The objective of this review is to suggest gender-based innovati...

journal_title：World journal of gastroenterology

authors： Kim SE,Paik HY,Yoon H,Lee JE,Kim N,Sung MK

更新日期：2015-05-07 00:00:00

abstract：AIM:To investigate the relationship between sense of coherence, psychological distress and health related quality of life in inflammatory bowel disease (IBD). METHODS:This cross-sectional study enrolled a consecutive sample of 147 IBD (aged 45.1 ± 14.1 years; 57.1% female) patients recruited from a tertiary gastroente...

journal_title：World journal of gastroenterology

authors： Freitas TH,Andreoulakis E,Alves GS,Miranda HL,Braga LL,Hyphantis T,Carvalho AF

更新日期：2015-06-07 00:00:00

abstract：AIM:To analyze the modulation of gene expression profile associated with inhibition of liver regeneration in hepatitis B X (HBx)-expressing transgenic mice. METHODS:Microarray technology was performed on liver tissue obtained from 4 control (LacZ) and 4 transgenic mice (HBx-LacZ), 48 h after partial hepatectomy. The s...

journal_title：World journal of gastroenterology

authors： Sidorkiewicz M,Jais JP,Tralhao G,Morosan S,Giannini C,Brezillon N,Soussan P,Delpuech O,Kremsdorf D

更新日期：2008-01-28 00:00:00

abstract：AIM:To investigate the toxicity and response of intensity-modulated radiotherapy schedule intensified with a simultaneous integrated boost in anal canal cancer. METHODS:From March 2009 to March 2014, we retrospectively analyzed 41 consecutive patients treated with intensity-modulated radiotherapy (IMRT) and concurrent...

journal_title：World journal of gastroenterology

authors： Belgioia L,Vagge S,Agnese D,Garelli S,Murialdo R,Fornarini G,Chiara S,Gallo F,Bacigalupo A,Corvò R

更新日期：2015-10-07 00:00:00

abstract：:Chronic intake of alcohol undoubtedly overwhelms the structural and functional capacity of the liver by initiating complex pathological events characterized by steatosis, steatohepatitis, hepatic fibrosis and cirrhosis. Subsequently, these initial pathological events are sustained and ushered into a more complex and p...

journal_title：World journal of gastroenterology

authors： Boye A,Zou YH,Yang Y

更新日期：2016-01-07 00:00:00

abstract：AIM:To evaluate the feasibility of using multiphoton microscopy (MPM) to assess a tumor regression grading (TRG) system. METHODS:Fresh specimens from seven patients with colorectal carcinoma undergoing neoadjuvant radiochemotherapy at the Fujian Medical University Union Hospital were obtained immediately after proctec...

journal_title：World journal of gastroenterology

authors： Li LH,Chen ZF,Wang XF,Zhuo SM,Li HS,Jiang WZ,Guan GX,Chen JX

更新日期：2015-04-14 00:00:00

abstract：:Anti-tumor necrosis factor alpha (TNF-alpha) inhibitors are effective in the treatment of various inflammatory rheumatic conditions. Increased risks of serious infections are the major issues concerning the long-term safety of these agents. We present a case of a young male Behcet's patient whose disease was complicat...

journal_title：World journal of gastroenterology

authors： Sari I,Birlik M,Gonen C,Akar S,Gurel D,Onen F,Akkoc N

更新日期：2008-05-14 00:00:00

abstract：:The risk factors for hepatocellular carcinoma (HCC) development have been established, and include chronic hepatitis B and C, heavy alcohol consumption, and aflatoxins. In fact, 5%-30% of patients with HCC still lack a readily identifiable risk factor. It has been reported that the majority of ''cryptogenic'' HCC may ...

journal_title：World journal of gastroenterology

authors： Wang SN,Lee KT,Ker CG

更新日期：2010-12-14 00:00:00

abstract：:Gastrin is the main hormone responsible for the stimulation of gastric acid secretion; in addition, gastrin and its derivatives exert proliferative and antiapoptotic effects on several cell types. Gastrin synthesis and secretion are increased in certain situations, for example, when proton pump inhibitors are used. Th...

journal_title：World journal of gastroenterology

authors： Chueca E,Lanas A,Piazuelo E

更新日期：2012-12-07 00:00:00