Abstract:
:We report the case of a 57-year-old man who was diagnosed with a large unresectable cholangiocarcinoma associated with 2 satellite nodules and without clear margins with the right hepatic vein. Despite 4 cycles of GEMOX (stopped due to a hypertransaminasemia believed to be due to gemcitabine) and 4 cycles of FOLFIRINOX, the tumor remained stable and continued to be considered unresectable. Radioembolization (resin microspheres, SIRS-spheres) targeting the left liver (474 MBq) and segment IV (440 MBq) was performed. This injection was very well tolerated, and 4 more cycles of FOLFIRINOX were given while waiting for radioembolization efficacy. On computed tomography scan, a partial response was observed; the tumor was far less hypervascularized, and a margin was observed between the tumor and the right hepatic vein. A left hepatectomy enlarged to segment VIII was performed. On pathological exam, most of the tumor was acellular, with dense fibrosis around visible microspheres. Viable cells were observed only at a distance from beads. Radioembolization can be useful in the treatment of cholangiocarcinoma, allowing in some cases a secondary resection.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Servajean C,Gilabert M,Piana G,Monges G,Delpero JR,Brenot I,Raoul JLdoi
10.3748/wjg.v20.i17.5131subject
Has Abstractpub_date
2014-05-07 00:00:00pages
5131-4issue
17eissn
1007-9327issn
2219-2840journal_volume
20pub_type
杂志文章abstract:AIM:To test the hypothesis that enhancement of the activity of heme oxygenase can interfere with processes of fibrogenesis associated with recurrent liver injury, we investigated the therapeutic potential of over-expression of heme oxygense-1 in a CCl(4)-induced micronodular cirrhosis model. METHODS:Recombinant adeno-...
journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v12.i13.2016
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journal_title:World journal of gastroenterology
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doi:10.3748/wjg.v12.i15.2437
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doi:10.3748/wjg.v10.i19.2911
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journal_title:World journal of gastroenterology
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更新日期:2015-05-21 00:00:00
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journal_title:World journal of gastroenterology
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pub_type: 杂志文章
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更新日期:2007-09-07 00:00:00
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pub_type: 杂志文章
doi:10.3748/wjg.v23.i6.964
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pub_type: 历史文章,杂志文章,评审
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更新日期:2014-12-28 00:00:00
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pub_type: 杂志文章
doi:10.3748/wjg.15.1645
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v13.i9.1449
更新日期:2007-03-07 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 评论,信件
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更新日期:2009-11-07 00:00:00
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pub_type: 杂志文章
doi:10.3748/wjg.v16.i12.1495
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pub_type: 杂志文章,评审
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更新日期:2014-06-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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更新日期:2017-03-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2015-01-14 00:00:00