One case of intrahepatic cholangiocarcinoma amenable to resection after radioembolization.

Abstract:

:We report the case of a 57-year-old man who was diagnosed with a large unresectable cholangiocarcinoma associated with 2 satellite nodules and without clear margins with the right hepatic vein. Despite 4 cycles of GEMOX (stopped due to a hypertransaminasemia believed to be due to gemcitabine) and 4 cycles of FOLFIRINOX, the tumor remained stable and continued to be considered unresectable. Radioembolization (resin microspheres, SIRS-spheres) targeting the left liver (474 MBq) and segment IV (440 MBq) was performed. This injection was very well tolerated, and 4 more cycles of FOLFIRINOX were given while waiting for radioembolization efficacy. On computed tomography scan, a partial response was observed; the tumor was far less hypervascularized, and a margin was observed between the tumor and the right hepatic vein. A left hepatectomy enlarged to segment VIII was performed. On pathological exam, most of the tumor was acellular, with dense fibrosis around visible microspheres. Viable cells were observed only at a distance from beads. Radioembolization can be useful in the treatment of cholangiocarcinoma, allowing in some cases a secondary resection.

journal_name

World J Gastroenterol

authors

Servajean C,Gilabert M,Piana G,Monges G,Delpero JR,Brenot I,Raoul JL

doi

10.3748/wjg.v20.i17.5131

subject

Has Abstract

pub_date

2014-05-07 00:00:00

pages

5131-4

issue

17

eissn

1007-9327

issn

2219-2840

journal_volume

20

pub_type

杂志文章
  • Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats.

    abstract:AIM:To test the hypothesis that enhancement of the activity of heme oxygenase can interfere with processes of fibrogenesis associated with recurrent liver injury, we investigated the therapeutic potential of over-expression of heme oxygense-1 in a CCl(4)-induced micronodular cirrhosis model. METHODS:Recombinant adeno-...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i13.2016

    authors: Tsui TY,Lau CK,Ma J,Glockzin G,Obed A,Schlitt HJ,Fan ST

    更新日期:2006-04-07 00:00:00

  • Identification of a new target region on the long arm of chromosome 7 in gastric carcinoma by loss of heterozygosity.

    abstract:AIM:To define the common deleted region on the long arm of haman chromosome 7q linked to primary gastric carcinomas in Chinese by loss of heterozygosity (LOH) and its clinical significance. METHODS:Nine microsatellite markers distributed over chromosome 7q with an average marker density of 10cM were used to examine 70...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i15.2437

    authors: Weng DS,Li JT,Mai SJ,Pan ZZ,Feng BJ,Feng QS,Huang LX,Wang QJ,Li YQ,Yu XJ,Chen SP,He J,Xia JC

    更新日期:2006-04-21 00:00:00

  • Clinical and experimental study of oxaliplatin in treating human gastric carcinoma.

    abstract:AIM:To evaluate the therapeutic effectiveness of oxaliplatin on human gastric carcinoma and to explore its mechanisms. METHODS:Twenty-two cases of stage IV gastric carcinoma received 4-6 (mean 4.6) cycles of first line combined chemotherapy with oxaliplatin (oxaliplatin 85 mg/m(2), iv, gtt, 1 h, d 1; leukovorin 200 mg...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i19.2911

    authors: Lin WL,Li DG,Chen Q,Lu HM

    更新日期:2004-10-01 00:00:00

  • Culture-guided treatment approach for Helicobacter pylori infection: review of the literature.

    abstract::The progressive loss of efficacy of standard eradication therapies has made the treatment of Helicobacter pylori (H. pylori) more challenging than ever. Endoscopic-guided antibiotic susceptibility testing had previously been suggested to guide treatment after failure of second-line therapies. However, its role has exp...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i18.5205

    authors: Cammarota G,Ianiro G,Bibbò S,Di Rienzo TA,Masucci L,Sanguinetti M,Gasbarrini A

    更新日期:2014-05-14 00:00:00

  • Endoscopic submucosal dissection for early gastric cancer with undifferentiated-type histology: A meta-analysis.

    abstract:AIM:To evaluate the efficacy and safety of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) with undifferentiated-type histology. METHODS:A systematic literature review was conducted using the core databases. Complete resection, curative resection, en bloc resection, recurrence and adverse event r...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v21.i19.6032

    authors: Bang CS,Baik GH,Shin IS,Kim JB,Suk KT,Yoon JH,Kim YS,Kim DJ,Shin WG,Kim KH,Kim HY,Lim H,Kang HS,Kim JH,Kim JB,Jung SW,Kae SH,Jang HJ,Choi MH

    更新日期:2015-05-21 00:00:00

  • Oxaliplatin-induced severe anaphylactic reactions in metastatic colorectal cancer: case series analysis.

    abstract:AIM:To investigate oxaliplatin-induced severe anaphylactic reactions (SAR) in metastatic colorectal cancer in a retrospective case series analysis and to conduct a systemic literature review. METHODS:During a 6-year period from 2006 to 2011 at Kaohsiung Veterans General Hospital, a total of 412 patients exposed to oxa...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v18.i38.5427

    authors: Wang JH,King TM,Chang MC,Hsu CW

    更新日期:2012-10-14 00:00:00

  • Adult to adult living related liver transplantation: where do we currently stand?

    abstract::Adult to adult living donor liver transplantation (AALDLT) was first preformed in the United States in 1997. The procedure was rapidly integrated into clinical practice, but in 2002, possibly due to the first widely publicized donor death, the number of living liver donors plummeted. The number of donors has since rea...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v18.i46.6729

    authors: Carlisle EM,Testa G

    更新日期:2012-12-14 00:00:00

  • Chemotherapy for transarterial chemoembolization in patients with unresectable hepatocellular carcinoma.

    abstract:AIM:To compare the efficacy of different chemotherapeutic agents during conventional transarterial chemoembolization (cTACE) in the treatment of unresectable hepatocellular carcinoma (HCC). METHODS:A retrospective review was undertaken of patients with unresectable HCC undergoing cTACE from May 2003 to November 2011. ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i31.10960

    authors: Wu J,Song L,Zhao DY,Guo B,Liu J

    更新日期:2014-08-21 00:00:00

  • Effects of premedication with Pronase for endoscopic ultrasound of the stomach: A randomized controlled trial.

    abstract:AIM:To analyze the effects of premedication with Pronase for endoscopic ultrasound (EUS) examination of the stomach. METHODS:This was a prospective, randomized and controlled clinical study. All patients were randomly assigned to either the Pronase group or placebo group. The pretreatment solution was a mixed solution...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.v22.i48.10673

    authors: Wang GX,Liu X,Wang S,Ge N,Guo JT,Sun SY

    更新日期:2016-12-28 00:00:00

  • Therapeutic proteasome inhibition in experimental acute pancreatitis.

    abstract:AIM:To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis. METHODS:Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i33.4452

    authors: Letoha T,Fehér LZ,Pecze L,Somlai C,Varga I,Kaszaki J,Tóth G,Vizler C,Tiszlavicz L,Takács T

    更新日期:2007-09-07 00:00:00

  • Long-term culture-induced phenotypic difference and efficient cryopreservation of small intestinal organoids by treatment timing of Rho kinase inhibitor.

    abstract:AIM:To investigate a suitable long-term culture system and optimal cryopreservation of intestinal organoid to improve organoid-based therapy by acquiring large numbers of cells. METHODS:Crypts were isolated from jejunum of C57BL/6 mouse. Two hundred crypts were cultured in organoid medium with either epidermal growth ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i6.964

    authors: Han SH,Shim S,Kim MJ,Shin HY,Jang WS,Lee SJ,Jin YW,Lee SS,Lee SB,Park S

    更新日期:2017-02-14 00:00:00

  • New trends in colorectal surgery: single port and natural orifice techniques.

    abstract::Single-incision laparoscopic surgery (SILS) and natural orifice transluminal endoscopic surgery (NOTES) have rapidly gained pace worldwide, potentially replacing conventional laparoscopic surgery (CLS) as the preferred colorectal surgery technique. Currently available data mainly consist of retrospective series analyz...

    journal_title:World journal of gastroenterology

    pub_type: 历史文章,杂志文章,评审

    doi:10.3748/wjg.v20.i48.18104

    authors: Daher R,Chouillard E,Panis Y

    更新日期:2014-12-28 00:00:00

  • Effect of rifaximin on gut microbiota composition in advanced liver disease and its complications.

    abstract::Liver cirrhosis is a paradigm of intestinal dysbiosis. The qualitative and quantitative derangement of intestinal microbial community reported in cirrhotic patients seems to be strictly related with the impairment of liver function. A kind of gut microbial "fingerprint", characterized by the reduced ratio of "good" to...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i43.12322

    authors: Ponziani FR,Gerardi V,Pecere S,D'Aversa F,Lopetuso L,Zocco MA,Pompili M,Gasbarrini A

    更新日期:2015-11-21 00:00:00

  • Guillain-Barré syndrome following hepatitis E.

    abstract::Guillain-Barré syndrome (GBS) is often triggered by a preceding bacterial or viral infection. Occasionally, it has been observed in association with acute hepatitis A, B and C, and three cases have been previously described in India in which GBS was associated with acute hepatitis E. A molecular mimicry mechanism is s...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.1645

    authors: Loly JP,Rikir E,Seivert M,Legros E,Defrance P,Belaiche J,Moonen G,Delwaide J

    更新日期:2009-04-07 00:00:00

  • Strangulated diaphragmatic hernia presenting clinically as pericarditis.

    abstract::A case of strangulation of the transverse colon in a traumatic left diaphragmatic hernia manifesting as pericarditis is reported. This is unusual because pericardial signs in traumatic diaphragmatic hernia have been previously described in association with direct pericardial injury. This is the only such case where el...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i9.1449

    authors: Makhija R,Akoh JA

    更新日期:2007-03-07 00:00:00

  • Vascular tumors and malformations of the colon.

    abstract::The term "hemangioma" refers to the common tumor of infancy that exhibits rapid postnatal growth and slow regression during childhood. It may cause confusion with venous malformations that are often incorrectly called "cavernous hemangioma". Venous malformations comprise abnormally formed channels that are lined by qu...

    journal_title:World journal of gastroenterology

    pub_type: 评论,信件

    doi:10.3748/wjg.15.5242

    authors: Fernandez-Pineda I

    更新日期:2009-11-07 00:00:00

  • Biochemical determination of lipid content in hepatic steatosis by the Soxtec method.

    abstract:AIM:To establish a quantitative method to measure the amount of lipids. METHODS:The livers of 53 male Wistar rats (225 g) with different degrees of hepatic steatosis were studied. This model of hepatic steatosis was based on a high carbohydrate, fat-free modified diet. Biopsies were classified into four grades dependi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i12.1495

    authors: Hijona E,Hijona L,Larzabal M,Sarasqueta C,Aldazabal P,Arenas J,Bujanda L

    更新日期:2010-03-28 00:00:00

  • Prominent role of gamma-glutamyl-transpeptidase on the growth of Helicobacter pylori.

    abstract:AIM:gamma-glutamyl transpeptidase (GGT) has been reported as a virulence and colonizing factor of Helicobacter pylori (H pylori). This study examined the effect of GGT on the growth of H pylori. METHODS:Standard H pylori strain NCTC 11637 and 4 clinical isolates with different levels of GGT activity as measured by an ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i20.2994

    authors: Gong M,Ho B

    更新日期:2004-10-15 00:00:00

  • Increased risk of second malignancy in pancreatic intraductal papillary mucinous tumors: Review of the literature.

    abstract:AIM:To analyze the available evidence about the risk of extrapancreatic malignancies and pancreatic ductal adenocarcinoma associated to pancreatic intraductal papillary mucinous tumors (IPMNs). METHODS:A systematic search of literature was undertaken using MEDLINE, EMBASE, Cochrane and Web-of-Science libraries. No lim...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i23.7313

    authors: Baiocchi GL,Molfino S,Frittoli B,Pigozzi G,Gheza F,Gaverini G,Tarasconi A,Ricci C,Bertagna F,Grazioli L,Tiberio GA,Portolani N

    更新日期:2015-06-21 00:00:00

  • Liver bioengineering: current status and future perspectives.

    abstract::The present review aims to illustrate the strategies that are being implemented to regenerate or bioengineer livers for clinical purposes. There are two general pathways to liver bioengineering and regeneration. The first consists of creating a supporting scaffold, either synthetically or by decellularization of human...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v18.i47.6926

    authors: Booth C,Soker T,Baptista P,Ross CL,Soker S,Farooq U,Stratta RJ,Orlando G

    更新日期:2012-12-21 00:00:00

  • Prognostic and predictive significance of MSI in stages II/III colon cancer.

    abstract::In colon cancer, classic disease staging remains the key prognosis and treatment determinant. Although adjuvant chemotherapy has an established role in stage III colon cancer patients, in stage II it is still a subject of controversy due to its restriction to a small subgroup of patients with high-risk histopathologic...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i22.6809

    authors: Saridaki Z,Souglakos J,Georgoulias V

    更新日期:2014-06-14 00:00:00

  • Giant duodenal ulcers.

    abstract::Giant duodenal ulcers (GDUs) are a subset of duodenal ulcers that have historically resulted in greater morbidity than usual duodenal ulcers. Until recently, few cases had been successfully treated with medical therapy. However, the widespread use of endoscopy, the introduction of H-2 receptor blockers and proton pump...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.14.4995

    authors: Newton EB,Versland MR,Sepe TE

    更新日期:2008-08-28 00:00:00

  • Predictors of vitamin D deficiency in inflammatory bowel disease and health: A Mississippi perspective.

    abstract:AIM:To identify the predictors of vitamin D deficiency in patients with and without inflammatory bowel disease (IBD). METHODS:Patients with ulcerative colitis (UC) or Crohn's disease (CD) related diagnostic codes who received medical care at University of Mississippi Medical Center between July 2012 and 2015 were iden...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i4.638

    authors: Pallav K,Riche D,May WL,Sanchez P,Gupta NK

    更新日期:2017-01-28 00:00:00

  • Is endoscopic ultrasonography essential for endoscopic resection of small rectal neuroendocrine tumors?

    abstract:AIM:To evaluate the importance of endoscopic ultrasonography (EUS) for small (≤ 10 mm) rectal neuroendocrine tumor (NET) treatment. METHODS:Patients in whom rectal NETs were diagnosed by endoscopic resection (ER) at the Pusan National University Yangsan Hospital between 2008 and 2014 were included in this study. A tot...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i11.2037

    authors: Park SB,Kim DJ,Kim HW,Choi CW,Kang DH,Kim SJ,Nam HS

    更新日期:2017-03-21 00:00:00

  • Entering the duodenal diverticulum: a method for cannulation of the intradiverticular papilla.

    abstract::Successful cannulation of the common bile duct may be difficult in patients in whom the papilla is located entirely within a diverticulum. In this study, we report successful biliary cannulation in three patients following intubation of the distal tip of the duodenoscope into the duodenal diverticulum and locating the...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i48.7394

    authors: Wang BC,Shi WB,Zhang WJ,Gu J,Tao YJ,Wang YQ,Wang XF

    更新日期:2012-12-28 00:00:00

  • Altered profiles of nuclear matrix proteins during the differentiation of human gastric mucous adenocarcinoma MGc80-3 cells.

    abstract:AIM:To find and identify specific nuclear matrix proteins associated with proliferation and differentiation of carcinoma cells, which will be potential markers for cancer diagnosis and targets in cancer therapy. METHODS:Nuclear matrix proteins were selectively extracted from MGc80-3 cells treated with or without hexam...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i30.4628

    authors: Zhao CH,Li QF

    更新日期:2005-08-14 00:00:00

  • Expression of the c-erbB-2 proto-oncogene product in gastric carcinoma and precancerous lesions.

    abstract:AIM:To study the relationship between the expression of the c-erbB-2 proto-oncogene product with gastric mucosal carcinogenesis and the behavior of gastric carcinoma. METHODS:Specimens from nine normal gastric mucosa, 23 gastric mucosal dysplasia (10 slight, six moderate, seven severe), 18 early gastric carcinoma, and...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v3.i2.122

    authors: Mi JQ,Yang SQ,Shen MC

    更新日期:1997-06-15 00:00:00

  • Virulence and potential pathogenicity of coccoid Helicobacter pylori induced by antibiotics.

    abstract:AIM:To explore the virulence and the potential pathogenicity of coccoid Helicobacter pylori (H. pylori) transformed from spiral form by exposure to antibiotic. METHODS:Three strains of H. pylori, isolated from gastric biopsy specimens of confirmed peptic ulcer, were converted from spiral into coccoid from by exposure ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v7.i2.254

    authors: She FF,Su DH,Lin JY,Zhou LY

    更新日期:2001-04-01 00:00:00

  • Expression of matrix metalloproteinases and tissue inhibitor metalloproteinases increases in X-irradiated rat ileum despite the disappearance of CD8a T cells.

    abstract:AIM:To investigate their expression and activity in the rat ileum after exposure to ionizing radiation along with that of the cellular effectors and molecular mediators involved in the regulation of MMPs. METHODS:Rats were exposed to a single 10-Gy dose of X-rays delivered to the abdomen. A combination of methods, suc...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i40.6312

    authors: Strup-Perrot C,Vozenin-Brotons MC,Vandamme M,Linard C,Mathé D

    更新日期:2005-10-28 00:00:00

  • Locally advanced undifferentiated carcinoma with osteoclast-like giant cells of the pancreas.

    abstract::Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas (UCOGCP) is an unusual pancreatic neoplasm that represents < 1% of all pancreatic malignancies. Moreover, the giant cells of UCOGCP morphologically resemble the benign giant cells of bone tumors. Due to the rarity of this tumor type, the histo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i2.694

    authors: Gao HQ,Yang YM,Zhuang Y,Liu P

    更新日期:2015-01-14 00:00:00