Effect of mutant p27(kipl) gene on human cholangiocarcinoma cell line, QBC(939).

abstract：AIM:To better understand the clinical significance of hepatitis B serologic markers in babies born to hepatitis B surface antigen (HBsAg) positive mothers, the incidence of maternal serologic markers of hepatitis B via placenta and its transformation in these babies were investigated. METHODS:Mothers with positive HBs...

journal_title：World journal of gastroenterology

authors： Wang JS,Chen H,Zhu QR

更新日期：2005-06-21 00:00:00

abstract：AIM:To examine the effect of Fusobacterium nucleatum (F. nucleatum) on the microenvironment of colonic neoplasms and the expression of inflammatory mediators and microRNAs (miRNAs). METHODS:Levels of F. nucleatum DNA, cytokine gene mRNA (TLR2, TLR4, NFKB1, TNF, IL1B, IL6 and IL8), and potentially interacting miRNAs (m...

journal_title：World journal of gastroenterology

authors： Proença MA,Biselli JM,Succi M,Severino FE,Berardinelli GN,Caetano A,Reis RM,Hughes DJ,Silva AE

更新日期：2018-12-21 00:00:00

abstract：AIM:To prospectively explore the role of carcinoembryonic antigen (CEA) in gallbladder bile in patients with colorectal carcinoma and the morphological and clinical features of neoplasia and the occurrence of hepatic metastases. METHODS:CEA levels in the gallbladder and peripheral blood were studied in 44 patients wit...

journal_title：World journal of gastroenterology

authors： Waisberg J,Palma RT,Neto LC,Martins LC,Oliveira MS,Nagashima CA,Godoy AC,Goffi FS

更新日期：2003-07-01 00:00:00

abstract：:Ghrelin, as a kind of multifunctional protein polypeptide, is mainly produced in the fundus of the stomach and can promote occurrence and development of many tumors, including gastrointestinal tumors, which has been proved by the relevant researches. Most gastrointestinal stromal tumors (GISTs, about 80%), as the most...

journal_title：World journal of gastroenterology

authors： Zhu CZ,Liu D,Kang WM,Yu JC,Ma ZQ,Ye X,Li K

更新日期：2017-03-14 00:00:00

abstract：AIM:To enhance the clinical utility of electrogastrography (EGG), which has been recorded since 1922, but is clinically unutilized. METHODS:An innovative method to salvage the promise of EGG is proposed by introducing a preliminary procedure, while maintaining the electrodes, standardized equipment, and signal process...

journal_title：World journal of gastroenterology

authors： Poscente MD,Mintchev MP

更新日期：2017-07-07 00:00:00

abstract：AIM:To highlight magnetic resonance enterography (MRE) for diagnosis of patients with refractory iron deficiency anemia and normal endoscopy results. METHODS:Fifty-three patients diagnosed with iron deficiency anemia refractory to treatment and normal gastroscopy and colonoscopy results were admitted to this prospecti...

journal_title：World journal of gastroenterology

authors： Cengic I,Tureli D,Aydin H,Bugdayci O,Imeryuz N,Tuney D

更新日期：2014-10-14 00:00:00

abstract：AIM:To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer cells. METHODS:The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosis-inducing effect of linalool was measured using...

journal_title：World journal of gastroenterology

authors： Iwasaki K,Zheng YW,Murata S,Ito H,Nakayama K,Kurokawa T,Sano N,Nowatari T,Villareal MO,Nagano YN,Isoda H,Matsui H,Ohkohchi N

更新日期：2016-11-28 00:00:00

abstract：AIM:To investigate the inhibitory effects of sinomenine (SIN) combined with 5-fluorouracil (5-FU) on esophageal carcinoma in vitro and in vivo. METHODS:Esophageal carcinoma (Eca-109) cells were cultured in DMEM. The single or combined growth inhibition effects of SIN and 5-FU on the Eca-109 cells were examined by meas...

journal_title：World journal of gastroenterology

authors： Wang J,Yang ZR,Dong WG,Zhang JX,Guo XF,Song J,Qiu S

更新日期：2013-12-07 00:00:00

abstract：AIM:To study the effect of selenium on peripheral blood mononuclear cell (PBMC) membrane fluidity and immune function in patients with chronic hepatitis. METHODS:PBMCs were pretreated with selenium (1.156x10(-7) mol/L) for 6 h in vitro or extracted directly from patients after administration of selenium-yeast continuo...

journal_title：World journal of gastroenterology

authors： He SX,Wu B,Chang XM,Li HX,Qiao W

更新日期：2004-12-01 00:00:00

abstract：AIM:To investigate the gastrin secreting cells (G cells) and the somatostatin secreting cells (D cells) of antral mucosa in rats at the ultrastructural level. METHODS:Revised immunoelectron microscopic technique was used to detect the G cells and D cells in rat antral mucosa through gastrin and somatostatin antibodies...

journal_title：World journal of gastroenterology

authors： Sun FP,Song YG

更新日期：2003-12-01 00:00:00

abstract：:Interferon (IFN) therapy is the only treatment strategy for hepatitis C virus (HCV) infection after liver transplantation (LT), but prophylactic and treatable IFN therapy after LT has been shown to be insufficient due to the adverse effects of IFN and rivabirin. In this paper, we describe the disappearance of HCV afte...

journal_title：World journal of gastroenterology

authors： Ichikawa T,Nakao K,Hamasaki K,Honda T,Shibata H,Akahoshi M,Eguchi S,Takatsuki M,Kanematsu T,Eguchi K

更新日期：2007-08-14 00:00:00

abstract：AIM:To investigate the optimum period of treatment for post endoscopic submucosal dissection (ESD) ulcers. METHODS:Patients who underwent ESD for gastric cancer were randomized to two groups and treated with esomeprazole 20 mg per day for 4 wk (4W group) or 2 wk (2W group). At 4 wk after ESD, we measured the size of t...

journal_title：World journal of gastroenterology

authors： Arai M,Matsumura T,Okimoto K,Oyamada A,Saito K,Minemura S,Maruoka D,Tanaka T,Nakagawa T,Katsuno T,Yokosuka O

更新日期：2014-11-21 00:00:00

abstract：:Ulcerative colitis (UC) is an inflammatory destructive disease of the large intestine occurred usually in the rectum and lower part of the colon as well as the entire colon. Drug therapy is not the only choice for UC treatment and medical management should be as a comprehensive whole. Azulfidine, Asacol, Pentasa, Dipe...

journal_title：World journal of gastroenterology

authors： Xu CT,Meng SY,Pan BR

更新日期：2004-08-15 00:00:00

abstract：:For an electron microscopic study of the liver, expertise and complicated, time-consuming processing of hepatic tissues and cells is needed. The interpretation of electron microscopy (EM) images requires knowledge of the liver fine structure and experience with the numerous artifacts in fixation, embedding, sectioning...

journal_title：World journal of gastroenterology

authors： Wisse E,Braet F,Duimel H,Vreuls C,Koek G,Olde Damink SW,van den Broek MA,De Geest B,Dejong CH,Tateno C,Frederik P

更新日期：2010-06-21 00:00:00

abstract：AIM:To determine if liver stiffness (LS) measurements by means of transient elastography (TE) correlate with the presence of significant esophageal varices (EV) and if they can predict the occurrence of variceal bleeding. METHODS:We studied 1000 cases of liver cirrhosis divided into 2 groups: patients without EV or wi...

journal_title：World journal of gastroenterology

authors： Sporea I,Raţiu I,Sirli R,Popescu A,Bota S

更新日期：2011-05-07 00:00:00

abstract：AIM:To investigate the dynamic features of insulin-like growth factor-I receptor (IGF-IR) expression in rat hepatocarcinogenesis, and the relationship between IGF-IR and hepatocytes malignant transformation at mRNA or protein level. METHODS:Hepatoma models were made by inducing with 2-fluorenylacetamide (2-FAA) on mal...

journal_title：World journal of gastroenterology

authors： Yan XD,Yao M,Wang L,Zhang HJ,Yan MJ,Gu X,Shi Y,Chen J,Dong ZZ,Yao DF

更新日期：2013-09-28 00:00:00

abstract：AIM:To study the protein C activation system in human liver myofibroblasts, and the effects of activated protein C (APC) on these cells. METHODS:Human liver myofibroblasts were obtained by outgrowth. Expression of protease activated receptor 1 (PAR-1), endothelial protein C receptor (EPCR) and thrombomodulin (TM) was ...

journal_title：World journal of gastroenterology

authors： Gillibert-Duplantier J,Rullier A,Neaud V,Kisiel W,Rosenbaum J

更新日期：2010-01-14 00:00:00

abstract：AIM:To evaluate the association of pre-treatment (13)C-urea breath test (UBT) results with H pylori density and efficacy of eradication therapy in patients with active duodenal ulcers. METHODS:One hundred and seventeen consecutive outpatients with active duodenal ulcer and H pylori infection were recruited. H pylori d...

journal_title：World journal of gastroenterology

authors： Lai YC,Yang JC,Huang SH

更新日期：2004-04-01 00:00:00

abstract：AIM:To explore whether HDV ribozymes have the ability to trans-cleave HCV RNA. METHODS:Three HDV genomic ribozymes were designed and named RzC1, RzC2 and RzC3. The substrate RNA contained HCV RNA 5'-noncoding region and 5'-fragment of C region (5'-NCR-C). All the ribozymes and HCV RNA 5'-NCR-C were obtained by transcr...

journal_title：World journal of gastroenterology

authors： Yu YC,Mao Q,Gu CH,Li QF,Wang YM

更新日期：2002-08-01 00:00:00

abstract：:High-throughput short-read sequencing of exomes and whole cancer genomes in multiple human hepatocellular carcinoma (HCC) cohorts confirmed previously identified frequently mutated somatic genes, such as TP53, CTNNB1 and AXIN1, and identified several novel genes with moderate mutation frequencies, including ARID1A, AR...

journal_title：World journal of gastroenterology

authors： Gu DL,Chen YH,Shih JH,Lin CH,Jou YS,Chen CF

更新日期：2013-12-21 00:00:00

abstract：AIM:To investigate the existence and clinical significance of hepatitis C virus (HCV) RNA in the serum and peripheral blood mononuclear cells (PBMC) of patients with hepatitis C. METHODS:HCV RNA was detected by nested polymerase chain reaction (Nested PCR) in serum and in PBMC of 46 patients with acute hepatitis C (AH...

journal_title：World journal of gastroenterology

authors： Zhou P,Cai Q,Chen YC,Zhang MS,Guan J,Li XJ

更新日期：1997-06-15 00:00:00

abstract：:AIM:To compare KAI1 in cancer of papilla of Vater and pancreas to evaluate whether there are differences in biologic behavior which might account for prognosis.METHODS:We compared the expression in 24 papillay and 29 pancreatic cancers using Northern blot analysis, immunochemical assay and in situ hybridization, and i...

journal_title：World journal of gastroenterology

authors： Guo XZ,Friess H,Shao XD,Liu MP,Xia YT,Xu JH,Buchler MW

更新日期：2000-12-01 00:00:00

abstract：AIM:To explore the role and potential mechanism of miR-30b regulation of autophagy in hepatic ischemia-reperfusion injury (IRI). METHODS:An animal model of hepatic IRI was generated in C57BL/6 mice. For in vitro studies, AML12 cells were immersed in mineral oil for 1 h and then cultured in complete Dulbecco's Modified...

journal_title：World journal of gastroenterology

authors： Li SP,He JD,Wang Z,Yu Y,Fu SY,Zhang HM,Zhang JJ,Shen ZY

更新日期：2016-05-14 00:00:00

abstract：AIM:To evaluate the possible influences of HCV infection and relative antiviral treatment on seminal parameters and reproductive hormonal serum levels. METHODS:Ten male patients with HCV-related chronic hepatitis and 16 healthy male volunteers were studied. In all subjects seminal parameters (nemaspermic concentration...

journal_title：World journal of gastroenterology

authors： Durazzo M,Premoli A,Di Bisceglie C,Bertagna A,Faga E,Biroli G,Manieri C,Bo S,Pagano G

更新日期：2006-05-21 00:00:00

abstract：AIM:To introduce the combination method of radiochemoembolization for the treatment of selected hepatic metastases. METHODS:Twenty patients with biopsy proven hepatic metastases were selected from those who underwent transarterial radiochemoembolization, a novel combination protocol, between January 2009 and July 2010...

journal_title：World journal of gastroenterology

authors： Akhlaghpoor S,Aziz-Ahari A,Amoui M,Tolooee S,Poorbeigi H,Sheybani S

更新日期：2012-10-07 00:00:00

abstract：:AIM:To compare the features of gastroesophageal reflux disease between elderly and younger patients.METHODS:Twenty-four hour pH-monitoring and endoscopy were performed for the 66 elderly patients with typical gastroesophageal reflux symptoms, and the results were compared with 112 symptomatic younger patients.RESULTS:...

journal_title：World journal of gastroenterology

authors： Huang X,Zhu HM,Deng CZ,Porro GB,Sangaletti O,Pace F

更新日期：1999-10-01 00:00:00

abstract：:Constitutive activation of the insulin-like growth factor (IGF)-signaling axis is frequently observed in human hepatocellular carcinoma (HCC). Especially the overexpression of the fetal growth factor IGF-II, IGF-I receptor (IGF-IR), and cytoplasmic downstream effectors such as insulin-receptor substrates (IRS) contrib...

journal_title：World journal of gastroenterology

authors： Breuhahn K,Schirmacher P

更新日期：2008-03-21 00:00:00

abstract：:Primary rectal lymphoma is a rare presentation of gastrointestinal lymphomas. Its clinical presentation is indistinguishable from that of rectal carcinoma. Although surgical resection is often technically feasible, optimal therapy for colorectal lymphoma has not yet been identified. We report a case of primary rectal ...

journal_title：World journal of gastroenterology

authors： Bilsel Y,Balik E,Yamaner S,Bugra D

更新日期：2005-01-21 00:00:00

abstract：:Epidemiological and clinical data point to a close association between chronic hepatitis B virus infection or chronic hepatitis C virus infection and development of hepatocellular carcinoma (HCC). HCC develops over several decades and is associated with fibrosis. This sequence suggests that persistent viral infection ...

journal_title：World journal of gastroenterology

authors： Murata M,Yoshida K,Yamaguchi T,Matsuzaki K

更新日期：2014-11-07 00:00:00

abstract：AIM:To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn's disease (CD) and ulcerative colitis (UC). METHODS:The data from 41 patients with CD and 22 patients w...

journal_title：World journal of gastroenterology

authors： Farkas K,Lakatos PL,Szűcs M,Pallagi-Kunstár É,Bálint A,Nagy F,Szepes Z,Vass N,Kiss LS,Wittmann T,Molnár T

更新日期：2014-03-21 00:00:00