当前位置： SCI文献检索 > WORLD JOURNAL OF GASTROENTEROLOGY期刊下所有文献 > Viral blips during long-term treatment with standard or double dose lamivudine in HBe antigen negative chronic hepatitis B.

Viral blips during long-term treatment with standard or double dose lamivudine in HBe antigen negative chronic hepatitis B.

Abstract：

AIM:To evaluate safety and effect on hepatitis B virus (HBV) suppression of a long-term treatment with lamivudine (LAM) at standard (100 mg/d) or double (200 mg/d) dose in chronic hepatitis B. METHODS:This was a case study with matched controls (1:3) in patients with chronic hepatitis B with anti-HBe antibodies. RESULTS:Twelve patients received LAM 200 mg/d and 35 LAM 100 mg/d, for a median of 28 mo. A primary response (PR; i.e. negative HBV-DNA with Amplicor assay) was achieved in 100% of LAM-200 patients and 83% of LAM-100 patients. A virological breakthrough occurred in 16.7 and 24.7%, respectively, of the PR-patients, with the appearance of typical LAM resistance mutations in all but one patient. Viremia blips (i.e. transient HBV-DNA below 80 IU/mL in patients who tested negative at Amplicor assay) were detected using a real time polymerase chain reaction (PCR) and occurred in seven out of nine patients with subsequent BT and in four out of 32 patients with end-of-study response (77.7% vs 12.5%; P = 0.001) at chi-square test). At the end of the study, 51.4% of LAM-100 patients and 83.3% of LAM-200 patients had remained stably HBV-DNA negative. Double-dose LAM was well tolerated. CONCLUSION:Long-term treatment of anti-HBe positive chronic hepatitis B with double dose lamivudine causes a more profound and stable viral suppression as compared to conventional treatment.

journal_name

World J Gastroenterol

journal_title

World journal of gastroenterology

authors

Stornaiuolo G,Stanzione M,Brancaccio G,Cuomo G,Precone V,Di Biase S,Felaco FM,Piccinino F,Gaeta GB

doi

10.3748/wjg.v13.i42.5642

subject

Has Abstract

pub_date

2007-11-14 00:00:00

pages

5642-7

issue

42

eissn

1007-9327

issn

2219-2840

journal_volume

13

pub_type

杂志文章

相关文献

WORLD JOURNAL OF GASTROENTEROLOGY文献大全
  • Acalculous cholecystitis due to Salmonella enteritidis.

    abstract：:Acute acalculous cholecystitis (AAC) is defined as an acute inflammation of the gallbladder in the absence of stones. We herein report a case of a young man who developed AAC after a Salmonella enteritidis gastrointestinal infection. ...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.14.6408

    authors： Ruiz-Rebollo ML,Sánchez-Antolín G,García-Pajares F,Vallecillo-Sande MA,Fernández-Orcajo P,Velicia-Llames R,Caro-Patón A

    更新日期：2008-11-07 00:00:00

  • TIP30 regulates apoptosis-related genes in its apoptotic signal transduction pathway.

    abstract：AIM:To investigate the role of TIP30 in apoptotic signal pathway in hepatoblastoma cells and to provide a basis for TIP30 as a gene therapy candidate in the regression of hepatoblastoma cells. METHODS:Apoptosis of human hepatoblastoma cell lines HepG2 (p53 wild), Hep3B (p53 null) and PLC/RPF/5 (p53 mutant) infected wi...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v11.i2.221

    authors： Shi M,Zhang X,Wang P,Zhang HW,Zhang BH,Wu MC

    更新日期：2005-01-14 00:00:00

  • On-treatment monitoring of liver fibrosis with serum hepatitis B core-related antigen in chronic hepatitis B.

    abstract：BACKGROUND:Non-invasive evaluation for liver fibrosis is clinically important, especially in patients with undetectable hepatitis B virus (HBV) DNA treated with nucleoside analogs. AIM:To clarify the monitoring power of hepatitis B core-related antigen (HBcrAg) for hepatic histologic changes in patients with chronic h...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.3748/wjg.v25.i32.4764

    authors： Chang XJ,Sun C,Chen Y,Li XD,Yu ZJ,Dong Z,Bai WL,Wang XD,Li ZQ,Chen D,Du WJ,Liao H,Jiang QY,Sun LJ,Li YY,Zhang CH,Xu DP,Chen YP,Li Q,Yang YP

    更新日期：2019-08-28 00:00:00

  • Rebamipide suppresses diclofenac-induced intestinal permeability via mitochondrial protection in mice.

    abstract：AIM:To investigate the protective effect and mechanism of rebamipide on small intestinal permeability induced by diclofenac in mice. METHODS:Diclofenac (2.5 mg/kg) was administered once daily for 3 d orally. A control group received the vehicle by gavage. Rebamipide (100 mg/kg, 200 mg/kg, 400 mg/kg) was administered i...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v18.i10.1059

    authors： Diao L,Mei Q,Xu JM,Liu XC,Hu J,Jin J,Yao Q,Chen ML

    更新日期：2012-03-14 00:00:00

  • Changes in the esophageal mucosa of patients with non erosive reflux disease: How far have we gone?

    abstract：:The normal esophageal mucosa creates a protective epithelial barrier that constrains the acidic reflux in the esophageal lumen. Microscopic findings and functional studies indicate that this barrier might be impaired in patients with non erosive reflux disease (NERD) but not in patients with functional heartburn (FH)....

    journal_title：World journal of gastroenterology

    pub_type： 社论,评审

    doi：10.3748/wjg.v21.i19.5762

    authors： Triantos C,Koukias N,Karamanolis G,Thomopoulos K

    更新日期：2015-05-21 00:00:00

  • Natural orifice transluminal endoscopic surgery vs laparoscopic ovariectomy: complications and inflammatory response.

    abstract：AIM:To compare natural orifice transluminal endoscopic surgery (NOTES) vs standard laparoscopic ovariectomy in mini pigs with respect to technical aspects, complications and parameters of systemic inflammatory response. METHODS:This was a randomized, experimental, survival study. Ten female mini pigs underwent NOTES t...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v18.i27.3558

    authors： Martínek J,Ryska O,Filípková T,Doležel R,Juhas S,Motlík J,Holubová M,Nosek V,Rotnáglová B,Zavoral M,Ryska M

    更新日期：2012-07-21 00:00:00

  • Do clinical factors help to predict disease course in inflammatory bowel disease?

    abstract：:While therapeutic strategies able to change the natural history of the disease are developing, it is of major importance to have available predictive factors for aggressive disease to try and target these therapeutic strategies. Clinical predictors have probably been the most broadly studied. In both Crohn's disease (...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v16.i21.2600

    authors： Louis E,Belaiche J,Reenaers C

    更新日期：2010-06-07 00:00:00

  • Guillain-Barré syndrome following hepatitis E.

    abstract：:Guillain-Barré syndrome (GBS) is often triggered by a preceding bacterial or viral infection. Occasionally, it has been observed in association with acute hepatitis A, B and C, and three cases have been previously described in India in which GBS was associated with acute hepatitis E. A molecular mimicry mechanism is s...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.15.1645

    authors： Loly JP,Rikir E,Seivert M,Legros E,Defrance P,Belaiche J,Moonen G,Delwaide J

    更新日期：2009-04-07 00:00:00

  • Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus.

    abstract：AIM:To establish whether there are fundamental differences in the biochemistries of adenocarcinomas of the gastroesophageal junction (GEJ) and the squamous cell carcinomas of the lower third of the esophagus (LTE). METHODS:Between February 1, 1997 and February 1, 2000, we obtained tissue samples at the moment of resec...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v11.i37.5751

    authors： Altorjay A,Paal B,Sohar N,Kiss J,Szanto I,Sohar I

    更新日期：2005-10-07 00:00:00

  • Combined glucocorticoid and antiviral therapy of hepatitis B virus-related liver failure.

    abstract：:Acute hepatic failure due to hepatitis B virus (HBV) can occur both during primary infection as well as after reactivation of chronic infection. Guidelines recommend considering antiviral therapy in both situations, although evidence supporting this recommendation is weak. Since HBV is not directly cytopathic, the mec...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v21.i7.2214

    authors： Bockmann JH,Dandri M,Lüth S,Pannicke N,Lohse AW

    更新日期：2015-02-21 00:00:00

  • Therapeutic procedures for submucosal tumors in the gastrointestinal tract.

    abstract：:This review is part three of three and will present an update on the therapeutic options and procedures concerning gastrointestinal (GI) submucosal tumors (SMTs). The aim of this paper is to investigate the treatments of GI SMTs and to present a case of a gastrointestinal stromal tumor (GIST). Literature searches were...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.3748/wjg.v13.i24.3316

    authors： Ponsaing LG,Hansen MB

    更新日期：2007-06-28 00:00:00

  • Hypoestoxide inhibits tumor growth in the mouse CT26 colon tumor model.

    abstract：AIM:To evaluate the effect of the natural diterpenoid, hypoestoxide (HE) on the growth of established colon cancer in mice. METHODS:The CT26.WT mouse colon carcinoma cell line was grown and expanded in vitro. Following the expansion, BALB/c mice were inoculated s.c. with viable tumor cells. After the tumors had establ...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v13.i34.4586

    authors： Ojo-Amaize EA,Cottam HB,Oyemade OA,Okogun JI,Nchekwube EJ

    更新日期：2007-09-14 00:00:00

  • Effect of b value on monitoring therapeutic response by diffusion-weighted imaging.

    abstract：AIM:To explore the diffusion gradient b-factor that optimizes both apparent diffusion coefficient (ADC) measurement and contrast-to-noise (CNR) for assessing tumor response to transarterial chemoembolization (TACE) in a rabbit model. METHODS:Twelve New Zealand white rabbits bearing VX2 tumors in the liver were treated...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.14.5893

    authors： Jiang ZX,Peng WJ,Li WT,Tang F,Liu SY,Qu XD,Wang JH,Lu HF

    更新日期：2008-10-14 00:00:00

  • What's new in hepatitis C virus infections in children?

    abstract：:The number of hepatitis C virus (HCV) infection cases is relatively low in children. This low number may be connected with the lack of screening tests and the asymptomatic course of infection. Currently, mother-to-infant transmission is the most common cause of HCV infection amongst children in developed countries. It...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.3748/wjg.v21.i38.10783

    authors： Pawlowska M,Domagalski K,Pniewska A,Smok B,Halota W,Tretyn A

    更新日期：2015-10-14 00:00:00

  • Correction to "Maturity of associating liver partition and portal vein ligation for staged hepatectomy-derived liver regeneration in a rat model [World J Gastroenterol 2018 March 14; 24(10): 1107-1119]".

    abstract：:[This corrects the article on p. 1107 in vol. 21, PMID: 26640344.]. ...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章,已发布勘误

    doi：10.3748/wjg.v24.i39.4517

    authors： Tong YF,Cai XJ

    更新日期：2018-10-21 00:00:00

  • Effect of early preoperative 5-fluorouracil on the integrity of colonic anastomoses in rats.

    abstract：AIM:To determine the effect of chemotherapy on wound healing by giving early preoperative 5-fluorouracil (5-FU) to rats with colonic anastomoses. METHODS:Sixty Albino-Wistar male rats (median weight, 235 g) were used in this study. The rats were fed with standard laboratory food and given tap water ad libitum. The ani...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.15.4156

    authors： Ozel L,Ozel MS,Toros AB,Kara M,Ozkan KS,Tellioglu G,Krand O,Koyuturk M,Berber I

    更新日期：2009-09-07 00:00:00

  • Prospective randomized controlled trial investigating the type of sutures used during hepatectomy.

    abstract：AIM:To determine whether absorbable sutures or non-absorbable sutures are better in preventing surgical site infection (SSI), in this paper we discuss the results of a randomized clinical trial which examined the type of sutures used during hepatectomy. METHODS:All hepatic resections performed from January 2007 to Nov...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章,随机对照试验

    doi：10.3748/wjg.v17.i18.2338

    authors： Harimoto N,Shirabe K,Abe T,Yukaya T,Tsujita E,Gion T,Kajiyama K,Nagaie T

    更新日期：2011-05-14 00:00:00

  • Acceptance on colorectal cancer screening upper age limit in South Korea.

    abstract：BACKGROUND:The Korea National Cancer Screening Program currently provides screening for colorectal cancer (CRC) for adults older than 50 years with no upper age limit. In general, people are likely to only pay attention to the benefits of cancer screening and to neglect its risks. Most consider the benefits of cancer s...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v26.i27.3963

    authors： Luu XQ,Lee K,Lee YY,Suh M,Kim Y,Choi KS

    更新日期：2020-07-21 00:00:00

  • Brucea javanica oil emulsion improves the effect of radiotherapy on esophageal cancer cells by inhibiting cyclin D1-CDK4/6 axis.

    abstract：BACKGROUND:Esophageal cancer is one of the most common cancers around the world, and it has high incidence and mortality rates. The conventional therapy for esophageal cancer is radiotherapy, although its effect is highly limited by the resistance of esophageal cancer cells. Thus, strong radiosensitizers can be very cr...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v25.i20.2463

    authors： Qiu ZH,Zhang WW,Zhang HH,Jiao GH

    更新日期：2019-05-28 00:00:00

  • Natural history of hepatic metastases from colorectal cancer--pathobiological pathways with clinical significance.

    abstract：:Colorectal cancer hepatic metastases represent the final stage of a multi-step biological process. This process starts with a series of mutations in colonic epithelial cells, continues with their detachment from the large intestine, dissemination through the blood and/or lymphatic circulation, attachment to the hepati...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.3748/wjg.v20.i14.3719

    authors： Paschos KA,Majeed AW,Bird NC

    更新日期：2014-04-14 00:00:00

  • Prognostic and predictive significance of MSI in stages II/III colon cancer.

    abstract：:In colon cancer, classic disease staging remains the key prognosis and treatment determinant. Although adjuvant chemotherapy has an established role in stage III colon cancer patients, in stage II it is still a subject of controversy due to its restriction to a small subgroup of patients with high-risk histopathologic...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.3748/wjg.v20.i22.6809

    authors： Saridaki Z,Souglakos J,Georgoulias V

    更新日期：2014-06-14 00:00:00

  • Ulcerative colitis patients in clinical remission demonstrate correlations between fecal immunochemical test results, mucosal healing, and risk of relapse.

    abstract：AIM:To assess the risk of relapse in ulcerative colitis (UC) patients in clinical remission using mucosal status and fecal immunochemical test (FIT) results. METHODS:The clinical outcomes of 194 UC patients in clinical remission who underwent colonoscopy were based on evaluations of Mayo endoscopic subscores (MESs) an...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v22.i21.5079

    authors： Nakarai A,Kato J,Hiraoka S,Takashima S,Takei D,Inokuchi T,Sugihara Y,Takahara M,Harada K,Okada H

    更新日期：2016-06-07 00:00:00

  • Eradication of Helicobacter pylori infection: which regimen first?

    abstract：:Helicobacter pylori (H. pylori) is a well-known human pathogen that plays an essential role in the pathogenesis of chronic gastritis, peptic ulcer disease, and gastric malignancies. Although H. pylori is susceptible to several antimicrobials, this infection has proven challenging to cure because of the increasing prev...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.3748/wjg.v20.i3.665

    authors： Federico A,Gravina AG,Miranda A,Loguercio C,Romano M

    更新日期：2014-01-21 00:00:00

  • Decreased expression of gastrokine 1 in gastric mucosa of gastric cancer patients.

    abstract：AIM:To investigate the expression of gastrokine 1 (GKN1) in normal gastric mucosa, precancerous lesions and gastric cancer tissues, and to analyse its correlations with tumour site and pathological pattern. METHODS:Thirty gastric cancer patients (12 cases of diffuse type and 18 cases of intestinal type), 13 atrophic g...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v20.i44.16702

    authors： Guo XY,Dong L,Qin B,Jiang J,Shi AM

    更新日期：2014-11-28 00:00:00

  • Increased activity of Pgp multidrug transporter in patients with Helicobacter pylori infection.

    abstract：AIM:To determine whether local antibiotic resistance involves P-glycoprotein (Pgp)-mediated active drug out-pumping during Helicobacter pylori (H pylori) infection treatment with classic antibiotic therapy. METHODS:Pgp activity was determined in gastric mucosa biopsy specimens obtained from 53 patients with pathohisto...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v11.i18.2720

    authors： Babic Z,Svoboda-Beusan I,Kucisec-Tepes N,Dekaris D,Troskot R

    更新日期：2005-05-14 00:00:00

  • HCV NS5A abrogates p53 protein function by interfering with p53-DNA binding.

    abstract：AIM:To evaluate the inhibition effect of HCV NS5A on p53 transactivation on p21 promoter and explore its possible mechanism for influencing p53 function. METHODS:p53 function of transactivation on p21 promoter was studied with a luciferase reporter system in which the luciferase gene is driven by p21 promoter, and the...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v10.i15.2223

    authors： Gong GZ,Jiang YF,He Y,Lai LY,Zhu YH,Su XS

    更新日期：2004-08-01 00:00:00

  • Endoscopic occlusion with silicone spigots for the closure of refractory esophago-bronchiole fistula after esophagectomy.

    abstract：:A 65-year-old man with cT1bN0M0 stage I middle thoracic esophageal cancer underwent subtotal esophagectomy and gastric tube reconstruction through the posterior mediastinal route after preoperative carbon-ion radiotherapy and chemotherapy in a clinical trial. Anastomotic leakage occurred, but it spontaneously improved...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v23.i28.5253

    authors： Uesato M,Kono T,Akutsu Y,Murakami K,Kagaya A,Muto Y,Nakano A,Aikawa M,Tamachi T,Amagai H,Arasawa T,Muto Y,Matsubara H

    更新日期：2017-07-28 00:00:00

  • Treatment of pig serum-induced rat liver fibrosis with Boschniakia rossica, oxymatrine and interferon-alpha.

    abstract：AIM:To investigate the effect of Boschniakia rossica (BR), oxymatrine (OM) and interferon-alpha (IFN-alpha) 1b on the therapy of rat liver fibrosis and its mechanism. METHODS:By establishing a rat model of pig serum-induced liver fibrosis, liver/weight index and serum alanine transaminase (ALT) were observed to invest...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v11.i1.122

    authors： Wu CS,Piao XX,Piao DM,Jin YR,Li CH

    更新日期：2005-01-07 00:00:00

  • Sclerosing encapsulating peritonitis in a liver transplant patient: a case report.

    abstract：:We report a patient with HBV-related hepatocellular carcinoma (HCC) and refractory ascites who had received a peritoneal-venous shunt (PVS) 1 year before liver transplantation. Urgent surgical intervention following bowel obstruction and failure of immunosuppression therapy. No intestinal obstruction was found during ...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v11.i34.5412

    authors： Lin CH,Yu JC,Chen TW,Chan DC,Chen CJ,Hsieh CB

    更新日期：2005-09-14 00:00:00

  • Prognostic significance of preoperative circulating vascular endothelial growth factor messenger RNA expression in resectable hepatocellular carcinoma: a prospective study.

    abstract：AIM:To investigate the prognostic value of vascular endothelial growth factor messenger RNA (VEGF mRNA) in the peripheral blood (PB) of patients with hepatocellular carcinoma (HCC) undergoing curative resection. METHODS:Using a reverse-transcription polymerase chain reaction (RT-PCR)-based assay, VEGF mRNA in the PB w...

    journal_title：World journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3748/wjg.v10.i5.643

    authors： Jeng KS,Sheen IS,Wang YC,Gu SL,Chu CM,Shih SC,Wang PC,Chang WH,Wang HY

    更新日期：2004-03-01 00:00:00