Extended lymphadenectomy in hilar cholangiocarcinoma: What it will bring?

abstract：AIM:To construct pcDNA3.1-Egr.1p-p16 recombinant plasmid and investigate the expression of p16 in pancreatic cancer JF305 cells induced by radiation and the feasibility of gene radiotherapy for pancreatic carcinoma. METHODS:Human p16 cDNA was ligated to the downstream of Egr-1 promotor to construct pcDNA3.1-Egr.1p-p16...

journal_title：World journal of gastroenterology

authors： Ma HB,Wang XJ,Di ZL,Xia H,Li Z,Liu J,Ma J,Kang HF,Wu CM,Bai MH

更新日期：2007-08-21 00:00:00

abstract：:Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic miRNAs and downregulated tumour-suppressor miRNAs in this type of cancer. In this review, we provide an overview of the role of mi...

journal_title：World journal of gastroenterology

authors： da Silva Oliveira KC,Thomaz Araújo TM,Albuquerque CI,Barata GA,Gigek CO,Leal MF,Wisnieski F,Rodrigues Mello Junior FA,Khayat AS,de Assumpção PP,Rodriguez Burbano RM,Smith MC,Calcagno DQ

更新日期：2016-09-21 00:00:00

abstract：AIM:To optimize the efficacy of noninvasive evaluations in monitoring the endoscopic activity of inflammatory bowel disease (IBD). METHODS:Fecal calprotectin (FC), clinical activity index (CDAI or CAI), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and procalcitonin (PCT) were measured for 136 IBD pa...

journal_title：World journal of gastroenterology

authors： Chen JM,Liu T,Gao S,Tong XD,Deng FH,Nie B

更新日期：2017-12-14 00:00:00

abstract：AIM:To investigate the effect of a single amino acid mutation in human class B scavenger receptor I (SR-BI) on the infectivity of cell culture-derived hepatitis C virus (HCVcc) in SR-BI knock-down Huh7-siSR-BI cells. METHODS:Site-directed mutagenesis was used to construct the SR-BI S112F mutation, and the mutation was...

journal_title：World journal of gastroenterology

authors： Gao R,Gao W,Xu G,Xu J,Ren H

更新日期：2017-07-28 00:00:00

abstract：AIM:To construct and highly express an epitope of hepatitis C virus (HCV) in a foreign epitope presenting vector based on an insect virus, and to study the antigenicity of the epitope. METHODS:The HCV epitope sequence (amino acid residues 315 to 328: EGHRMAWDMMMNWS) of the E1 region was constructed at different positi...

journal_title：World journal of gastroenterology

authors： Peng M,Dai CB,Chen YD

更新日期：2005-06-14 00:00:00

abstract：:Gastric cancer is the second leading cause of cancer mortality worldwide. The diagnosis of gastric cancer has been significantly improved with the broad availability of gastrointestinal endoscopy. Effective technologies for accurate staging and quantitative evaluation are still in demand to merit reasonable treatment ...

journal_title：World journal of gastroenterology

authors： Wu CX,Zhu ZH

更新日期：2014-04-28 00:00:00

abstract：:The normal esophageal mucosa creates a protective epithelial barrier that constrains the acidic reflux in the esophageal lumen. Microscopic findings and functional studies indicate that this barrier might be impaired in patients with non erosive reflux disease (NERD) but not in patients with functional heartburn (FH)....

journal_title：World journal of gastroenterology

authors： Triantos C,Koukias N,Karamanolis G,Thomopoulos K

更新日期：2015-05-21 00:00:00

abstract：AIM:Single nucleotide polymorphisms (SNPs) of uridine-diphosphoglucuro-nosyltransferase 1A7 (UGT1A7) gene are associated with the development of orolaryngeal cancer, hepatocellular carcinoma, and colorectal cancer. We performed this research to establish the techniques for determining UGT1A7 gene and basic data of this...

journal_title：World journal of gastroenterology

authors： Huang MJ,Yang SS,Lin MS,Huang CS

更新日期：2005-02-14 00:00:00

abstract：AIM:To determine the efficacy of Mac-2 binding protein (Mac-2bp) for diagnosis of chronic pancreatitis. METHODS:Fifty-nine healthy volunteers (HV), 162 patients with chronic pancreatitis (CP), and 94 patients with pancreatic ductal adenocarcinoma (PDAC) were enrolled in this study. We measured serum Mac-2bp using our ...

journal_title：World journal of gastroenterology

authors： Maekawa T,Kamada Y,Ebisutani Y,Ueda M,Hata T,Kawamoto K,Takamatsu S,Mizutani K,Shimomura M,Sobajima T,Fujii H,Nakayama K,Nishino K,Yamada M,Kumada T,Ito T,Eguchi H,Nagano H,Miyoshi E

更新日期：2016-05-07 00:00:00

abstract：AIM:To investigate the efficacy of exercise interventions on hepatic fat mobilization in non-alcoholic fatty liver disease (NAFLD) patients. METHODS:Ovid-Medline, PubMed, EMBASE and Cochrane database were searched for randomized trials and prospective cohort studies in adults aged ≥ 18 which investigated the effects o...

journal_title：World journal of gastroenterology

authors： Golabi P,Locklear CT,Austin P,Afdhal S,Byrns M,Gerber L,Younossi ZM

更新日期：2016-07-21 00:00:00

abstract：AIM:To explore the mechanism for interactions of leptin with ghrelin and orexin in the arcuate nucleus (ARC) activating neuropeptide Y (NPY) neurons during physiological regulation of feeding. METHODS:Single neurons from ARC of adult rats with matured feeding function were isolated. [Ca2+]i was measured to monitor the...

journal_title：World journal of gastroenterology

authors： Kohno D,Suyama S,Yada T

更新日期：2008-11-07 00:00:00

abstract：AIM:To clarify the role of neoadjuvant concurrent chemoradiotherapy (NACCRT) followed by surgical resection for localized or locally advanced perihilar cholangiocarcinoma (CCA). METHODS:We retrospectively reviewed 57 patients who underwent surgical resection with or without NACCRT for perihilar CCA; 12 patients receiv...

journal_title：World journal of gastroenterology

authors： Jung JH,Lee HJ,Lee HS,Jo JH,Cho IR,Chung MJ,Park JY,Park SW,Song SY,Bang S

更新日期：2017-05-14 00:00:00

abstract：AIM:To examine the prevalence and prognostic significance of C-kit gene mutation and analysis the correlation of C-kit gene mutation and the clinicalpathologic parameters of GISTs. METHODS:Eighty-two GISTs were studied for the mutation of C-kit gene by PCR-SSCP, DNA sequence. Statistical comparison were used to analys...

journal_title：World journal of gastroenterology

authors： Liu XH,Bai CG,Xie Q,Feng F,Xu ZY,Ma DL

更新日期：2005-07-07 00:00:00

abstract：:Small cell neuroendocrine carcinoma of the ampulla of Vater is extremely rare and different from the common ampullary adenocarcinoma. The ampullary adenoma is also a rare neoplasm and has the potential to develop an adenocarcinoma. Their coexistence has been rarely reported in the literature. We herein describe an unu...

journal_title：World journal of gastroenterology

authors： Sun JH,Chao M,Zhang SZ,Zhang GQ,Li B,Wu JJ

更新日期：2008-08-07 00:00:00

abstract：:Homocysteine is an amino acid generated metabolically by the S-adenosylmethionine-dependent transmethylation pathway. In addition to being a well-known independent risk factor for coronary heart disease, is also a risk factor for cancer. Patients suffering from inflammatory bowel diseases (IBD) including ulcerative co...

journal_title：World journal of gastroenterology

authors： Keshteli AH,Baracos VE,Madsen KL

更新日期：2015-01-28 00:00:00

abstract：:Redox state constitutes an important background of numerous liver disorders. The redox state participates in the course of inflammatory, metabolic and proliferative liver diseases. Reactive oxygen species (ROS) are primarily produced in the mitochondria and in the endoplasmic reticulum of hepatocytes via the cytochrom...

journal_title：World journal of gastroenterology

authors： Cichoż-Lach H,Michalak A

更新日期：2014-07-07 00:00:00

abstract：AIM:To accurately and realistically elucidate human stem cell behaviors in vivo and the fundamental mechanisms controlling human stem cell fates in vivo, which is urgently required in regenerative medicine and treatments for some human diseases, a surrogate human-rat chimera model was developed. METHODS:Human-rat chim...

journal_title：World journal of gastroenterology

authors： Sun Y,Xiao D,Pan XH,Zhang RS,Cui GH,Chen XG

更新日期：2007-05-21 00:00:00

abstract：:Liver injury is a characteristic feature of human immunodeficiency virus (HIV) infection, which is the second most common cause of mortality in HIV-infected patients. Now it is recognized that liver plays a key role in HIV infection pathogenesis. Antiretroviral therapy (ART), which suppresses HIV infection in permissi...

journal_title：World journal of gastroenterology

authors： Ganesan M,Poluektova LY,Kharbanda KK,Osna NA

更新日期：2018-11-14 00:00:00

abstract：BACKGROUND:Accumulating evidence has revealed that several long non-coding ribonucleic acids (lncRNAs) are crucial in the progress of hepatocellular carcinoma (HCC). AIM:To classify a long non-coding RNA, i.e., lncRNA W5, and to determine the clinical significance and potential roles of lncRNA W5 in HCC. METHODS:The ...

journal_title：World journal of gastroenterology

authors： Lei GL,Fan HX,Wang C,Niu Y,Li TL,Yu LX,Hong ZX,Yan J,Wang XL,Zhang SG,Ren MJ,Yang PH

更新日期：2021-01-07 00:00:00

abstract：AIM:To evaluate mucosal healing in patients with small bowel plus colonic Crohn's disease (CD) with a single non-invasive examination, by using PillCam COLON 2 (PCC2). METHODS:Patients with non-stricturing nonpenetrating small bowel plus colonic CD in sustained corticosteroid-free remission were included. At diagnosis...

journal_title：World journal of gastroenterology

authors： Boal Carvalho P,Rosa B,Dias de Castro F,Moreira MJ,Cotter J

更新日期：2015-06-21 00:00:00

abstract：AIM:To investigate whether common variants in the oxidative pathway genes influence inflammatory bowel disease (IBD) risk among Moroccan patients. METHODS:The distribution of (TAAA)n_rs12720460 and (CCTTT)n _rs3833912 NOS2A microsatellite repeats, HIF-1A_rs11549467 and NFKB1-94ins/delATTG_rs28362491 was analyzed in 50...

journal_title：World journal of gastroenterology

authors： Senhaji N,Nadifi S,Zaid Y,Serrano A,Rodriguez DAL,Serbati N,Karkouri M,Badre W,Martín J

更新日期：2017-12-21 00:00:00

abstract：AIM:To investigate the expression and clinical relevance of inhibitor of differentiation (ID) proteins in biliary tract cancer. METHODS:ID protein expression was analyzed in 129 samples from patients with advanced biliary tract cancer (BTC) (45 extrahepatic, 50 intrahepatic, and 34 gallbladder cancers), compared to no...

journal_title：World journal of gastroenterology

authors： Harder J,Müller MJ,Fuchs M,Gumpp V,Schmitt-Graeff A,Fischer R,Frank M,Opitz O,Hasskarl J

更新日期：2013-12-28 00:00:00

abstract：:AIM:To observe the changes in oxygen free radical (OFR) and the curative effect of traditional Chinese medicine Qing Yi Tang in acute necrotizing pancreatitis (ANP).METHODS:After induction of ANP by injection of sodium taurocholate into pancreatic duct, 16 dogs were randomly divided into control group and Chinese medi...

journal_title：World journal of gastroenterology

authors： Li ZL,Wu CT,Lu LR,Zhu XF,Xiong DX

更新日期：1998-08-01 00:00:00

abstract：:In 2004, an association of genetic variation in the discs large homolog 5 (DLG5) gene with inflammatory bowel disease (IBD) was described in two large European study samples. The initial report of DLG5 as a novel IBD susceptibility gene sparked a multitude of studies investigating its effect on CD and IBD, respectivel...

journal_title：World journal of gastroenterology

authors： Friedrichs F,Stoll M

更新日期：2006-06-21 00:00:00

abstract：AIM:To investigate the relationship of serum levels of polyunsaturated fatty acid (PUFA) with kinds of cytokines in colorectal cancer (CRC). METHODS:Serum samples of 100 CRC patients were collected. The concentration of total n-3 PUFA which included C18:3 n-3, C20:5 n-3, C22:5 n-3, C22:6 n-3 and the total n-6 PUFA inc...

journal_title：World journal of gastroenterology

authors： Jia HJ,Zhang PJ,Liu YL,Jiang CG,Zhu X,Tian YP

更新日期：2016-02-28 00:00:00

abstract：AIM:To investigate clinical characteristics and therapy of pancreatic encephalopathy (PE) and Wernicke encephalopathy (WE). METHODS:In a retrospective study of 596 patients with acute pancreatitis (AP), patients with PE were compared to those with WE in regards to history, clinical manifestation, diagnosis, treatment ...

journal_title：World journal of gastroenterology

authors： Sun GH,Yang YS,Liu QS,Cheng LF,Huang XS

更新日期：2006-07-14 00:00:00

abstract：AIM:To assess the cleansing efficacy and safety of a new Colon capsule endoscopy (CCE) bowel preparation regimen. METHODS:This was a multicenter, prospective, randomized, controlled study comparing two CCE regimens. Subjects were asymptomatic and average risk for colorectal cancer. The second generation CCE system (Pi...

journal_title：World journal of gastroenterology

authors： Kastenberg D,Burch WC Jr,Romeo DP,Kashyap PK,Pound DC,Papageorgiou N,Sainz IF,Sokach CE,Rex DK

更新日期：2017-12-28 00:00:00

abstract：BACKGROUND:Liver resection is an effective treatment for benign and malignant liver tumors. However, a method for preoperative evaluation of hepatic reserve has not yet been established. Previously reported assessments of preoperative hepatic reserve focused only on liver failure in the early postoperative period and d...

journal_title：World journal of gastroenterology

authors： Ishii M,Itano O,Shinoda M,Kitago M,Abe Y,Hibi T,Yagi H,Takeuchi A,Tsujikawa H,Abe T,Kitagawa Y

更新日期：2020-02-21 00:00:00

abstract：:Tumor immunity proceeds through multiple processes, which consist of antigen presentation by antigen presenting cells (APCs) to educate effector cells and destruction by the effector cytotoxic cells. However, tumor immunity is frequently repressed at tumor sites. Malignantly transformed cells rarely survive the attack...

journal_title：World journal of gastroenterology

authors： Mukaida N,Nakamoto Y

更新日期：2018-05-07 00:00:00

abstract：:Intraductal papillary mucinous neoplasms (IPMNs) are a well-characterized group of mucin-producing cystic neoplasms of the clear malignant potential type. We report here two cases of intraductal papillary mucinous carcinoma (IPMC) with atypical manifestations. In one case, we discussed a pseudomyxoma peritonei caused ...

journal_title：World journal of gastroenterology

authors： Lee SE,Jang JY,Yang SH,Kim SW

更新日期：2007-03-14 00:00:00