Liver as a target of human immunodeficiency virus infection.

Abstract:

:Liver injury is a characteristic feature of human immunodeficiency virus (HIV) infection, which is the second most common cause of mortality in HIV-infected patients. Now it is recognized that liver plays a key role in HIV infection pathogenesis. Antiretroviral therapy (ART), which suppresses HIV infection in permissive immune cells, is less effective in hepatocytes, thereby making these cells a silent reservoir of HIV infection. In addition to direct hepatotoxic effects of HIV, certain ART treatment modalities provide hepatotoxic effects. The exact mechanisms of HIV-triggered chronic hepatitis progression are not elucidated, but the liver is adversely affected by HIV-infection and liver cells are prominently involved in HIV-elicited injury. These effects are potentiated by second hits like alcohol. Here, we will focus on the incidence of HIV, clinical evidence of HIV-related liver damage, interactions between HIV and liver cells and the role of alcohol and co-infection with hepatotropic viruses in liver inflammation and fibrosis progression.

journal_name

World J Gastroenterol

authors

Ganesan M,Poluektova LY,Kharbanda KK,Osna NA

doi

10.3748/wjg.v24.i42.4728

subject

Has Abstract

pub_date

2018-11-14 00:00:00

pages

4728-4737

issue

42

eissn

1007-9327

issn

2219-2840

journal_volume

24

pub_type

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