Organoids of liver diseases: From bench to bedside.

Abstract:

:Understanding the occurrence, development, and treatment of liver diseases is the main goal of hepatopathology research. Liver diseases are not only diverse but also highly heterogeneous among individuals. At present, research on liver diseases is conducted mainly through cell culture, animal models, pathological specimens, etc. However, these methods cannot fully reveal the pathogenic mechanism and therapeutic characteristics of individualized liver diseases. Recent advances in three-dimensional cell culture technology (organoid culture techniques) include pluripotent stem cells and adult stem cells that are cultured in vitro to form self-organizing properties, making it possible to achieve individualized liver disease research. This review provides a comprehensive overview of the development of liver organoids, the existing and potential applications of liver regenerative medicine, the pathogenesis of liver disease heterogeneity, and drug screening.

journal_name

World J Gastroenterol

authors

Wu LJ,Chen ZY,Wang Y,Zhao JG,Xie XZ,Chen G

doi

10.3748/wjg.v25.i16.1913

subject

Has Abstract

pub_date

2019-04-28 00:00:00

pages

1913-1927

issue

16

eissn

1007-9327

issn

2219-2840

journal_volume

25

pub_type

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