Hepatocellular carcinoma occurring in a Crohn's disease patient.

Abstract:

:We report a case of hepatocellular carcinoma (HCC) occurring in a patient with Crohn's disease (CD) without chronic hepatitis or liver cirrhosis, and review the clinicopathological features of HCC in CD patients. A 37-year-old Japanese man with an 8-year history of CD and a medication history of azathioprine underwent resection of a liver tumor. The histopathology of the liver tumor was pseudoglandular type HCC. In the non-neoplastic liver, focal hepatocyte glycogenosis (FHG) was observed, however, there was no evidence of liver cirrhosis or primary sclerosing cholangitis. Only nine cases of HCC in CD patients have been reported previously in the English-language literature. Eight of 10 cases (including the present case) had received azathioprine treatment, and four of these cases also showed FHG, which is considered a preneoplastic liver lesion, within the non-neoplastic liver. Although the precise mechanism of the development of HCC in CD patients is controversial, these results suggest that azathioprine therapy and FHG in the non-neoplastic liver contribute to the development of HCC. These findings also indicate that it is important to survey CD patients treated with prolonged azathioprine therapy for potential liver tumors.

journal_name

World J Gastroenterol

authors

Ishida M,Naka S,Shiomi H,Tsujikawa T,Andoh A,Nakahara T,Saito Y,Kurumi Y,Takikita-Suzuki M,Kojima F,Hotta M,Tani T,Fujiyama Y,Okabe H

doi

10.3748/wjg.v16.i25.3215

subject

Has Abstract

pub_date

2010-07-07 00:00:00

pages

3215-8

issue

25

eissn

1007-9327

issn

2219-2840

journal_volume

16

pub_type

杂志文章
  • Characteristics of nonvariceal upper gastrointestinal hemorrhage in patients with chronic kidney disease.

    abstract:AIM:To evaluate the clinical characteristics of nonvariceal upper gastrointestinal hemorrhage (NGIH) in patients with chronic kidney disease (CKD). METHODS:From 2003 to 2010, a total of 72 CKD patients (male n = 52, 72.2%; female n = 20, 27.8%) who had undergone endoscopic treatments for NGIH were retrospectively iden...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i43.7719

    authors: Bang CS,Lee YS,Lee YH,Sung H,Park HJ,Kim HS,Kim JB,Baik GH,Kim YS,Yoon JH,Kim DJ,Suk KT

    更新日期:2013-11-21 00:00:00

  • Multi-modal radiomics model to predict treatment response to neoadjuvant chemotherapy for locally advanced rectal cancer.

    abstract:BACKGROUND:Neoadjuvant chemotherapy is currently recommended as preoperative treatment for locally advanced rectal cancer (LARC); however, evaluation of treatment response to neoadjuvant chemotherapy is still challenging. AIM:To create a multi-modal radiomics model to assess therapeutic response after neoadjuvant chem...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i19.2388

    authors: Li ZY,Wang XD,Li M,Liu XJ,Ye Z,Song B,Yuan F,Yuan Y,Xia CC,Zhang X,Li Q

    更新日期:2020-05-21 00:00:00

  • Prominent role of gamma-glutamyl-transpeptidase on the growth of Helicobacter pylori.

    abstract:AIM:gamma-glutamyl transpeptidase (GGT) has been reported as a virulence and colonizing factor of Helicobacter pylori (H pylori). This study examined the effect of GGT on the growth of H pylori. METHODS:Standard H pylori strain NCTC 11637 and 4 clinical isolates with different levels of GGT activity as measured by an ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i20.2994

    authors: Gong M,Ho B

    更新日期:2004-10-15 00:00:00

  • Low RASSF6 expression in pancreatic ductal adenocarcinoma is associated with poor survival.

    abstract:AIM:To analyze RASSF6 expression in pancreatic ductal adenocarcinoma (PDAC) and to determine whether RASSF6 has an independent prognostic value in PDAC. METHODS:We studied RASSF6 expression in 96 histologically confirmed PDAC samples and 20 chronic pancreatitis specimens using immunohistochemistry and real-time quanti...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i21.6621

    authors: Ye HL,Li DD,Lin Q,Zhou Y,Zhou QB,Zeng B,Fu ZQ,Gao WC,Liu YM,Chen RW,Li ZH,Chen RF

    更新日期:2015-06-07 00:00:00

  • A tribute to Dr. Frank I Tovey on his 90th birthday.

    abstract::This paper pays a tribute to Dr. Frank I Tovey on his 90th birthday which happens on September 1, 2011, and briefly describes the major findings in his research career and contributions as follows. The geographical prevalence of duodenal ulceration is related to staple diets. Unrefined wheat and maize, soya, certain p...

    journal_title:World journal of gastroenterology

    pub_type: 社论

    doi:10.3748/wjg.v17.i31.3565

    authors: Ma LS

    更新日期:2011-08-21 00:00:00

  • Hepatocyte transformation and tumor development induced by hepatitis C virus NS3 c-terminal deleted protein.

    abstract:AIM:To study the effect of hepatitis C virus nonstructural protein 3 c-terminal deleted protein (HCV NS3-5') on hepatocyte transformation and tumor development. METHODS:QSG7701 cells were transfected with plasmid pRcHCNS3-5' (expressing HCV NS3 c-terminal deleted protein) by lipofectamine and selected in G418. The exp...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i3.474

    authors: He QQ,Cheng RX,Sun Y,Feng DY,Chen ZC,Zheng H

    更新日期:2003-03-01 00:00:00

  • Effect of Helicobacter pylori eradication on gastric hyperplastic polyposis in Cowden's disease.

    abstract::A 21-year-old woman with complaints of hematochezia was diagnosed as having Cowden's disease (CD), an autosomal dominant condition characterized by multiple hamartomas, since facial papules and gingival papillomas were identified. On endoscopy, multiple hyperplastic polyps were seen in the rectum and left-side colon. ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i10.1567

    authors: Isomoto H,Furusu H,Ohnita K,Takehara Y,Wen CY,Kohno S

    更新日期:2005-03-14 00:00:00

  • Impact of parietal cell autoantibodies and non-organ-specific autoantibodies on the treatment outcome of patients with hepatitis C virus infection: a pilot study.

    abstract:AIM:Various side effects have been reported in patients infected with hepatitis C virus (HCV) who were treated with interferon-alpha (IFN-alpha), including the appearance or exacerbation of underlying autoimmune diseases and the development of a variety of organ and non-organ specific autoantibodies (NOSA). However, ve...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i4.482

    authors: Gatselis NK,Georgiadou SP,Tassopoulos N,Zachou K,Liaskos C,Hatzakis A,Dalekos GN

    更新日期:2005-01-28 00:00:00

  • Endoscopic submucosal dissection for stomach neoplasms.

    abstract::Recent advances in techniques of therapeutic endoscopy for stomach neoplasms are rapidly achieved. One of the major topics in this field is endoscopic submucosal dissection (ESD). ESD is a new endoscopic technique using cutting devices to remove the tumor by the following three steps: injecting fluid into the submucos...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审

    doi:10.3748/wjg.v12.i32.5108

    authors: Fujishiro M

    更新日期:2006-08-28 00:00:00

  • Cancers in Eastern Libya: first results from Benghazi Medical Center.

    abstract:AIM:To study the pattern of cancer incidence and determine the incidence rates in Eastern Libya (for the first time in a decade). METHODS:A hospital-based registry of cancer patients was formed using records from the primary oncology center in eastern Libya - focusing on those diagnosed in the year 2012. RESULTS:The ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i20.6293

    authors: Bodalal Z,Azzuz R,Bendardaf R

    更新日期:2014-05-28 00:00:00

  • Liver-directed therapies for liver metastases from neuroendocrine neoplasms: Can laser ablation play any role?

    abstract::Aggressive cytoreduction can prolong survival in patients with unresectable liver metastases (LM) from neuroendocrine neoplasms (NEN), and minimally invasive, liver-directed therapies are gaining increasing interest. Catheter-based treatments are used in disseminated disease, whereas ablation techniques are usually in...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v26.i23.3118

    authors: Sartori S,Bianchi L,Di Vece F,Tombesi P

    更新日期:2020-06-21 00:00:00

  • Targeted and immune therapies for hepatocellular carcinoma: Predictions for 2019 and beyond.

    abstract::Systemic therapy for hepatocellular carcinoma (HCC) has markedly advanced since the survival benefit of a molecular targeted agent, sorafenib, were demonstrated in the SHARP and Asia Pacific trials in 2007. Treatment options for patients with advanced HCC increased by sorafenib, and long-term survival for patients wit...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v25.i7.789

    authors: Kudo M

    更新日期:2019-02-21 00:00:00

  • Role of detection of microsatellite instability in Chinese with hereditary nonpolyposis colorectal cancer or ordinary hereditary colorectal cancer.

    abstract:AIM:To detect microsatellite instability (MSI) in patients with hereditary nonpolyposis colorectal cancer or ordinary hereditary colorectal cancer and to provide criteria for screening the kindreds with hereditary nonpolyposis colorectal cancer at molecular level. METHODS:MSI was detected in the specimens from 20 case...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i29.4745

    authors: Liu WZ,Jin F,Zhang ZH,Wang SB

    更新日期:2006-08-07 00:00:00

  • Honey prevents hepatic damage induced by obstruction of the common bile duct.

    abstract:AIM:To examine the possible effects of honey supplementation on hepatic damage due to obstruction of the common bile duct in an experimental rat model. METHODS:The study was performed with 30 male rats divided into three groups: a sham group, an obstructive jaundice group, and an obstructive jaundice plus honey group....

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.3729

    authors: Erguder BI,Kilicoglu SS,Namuslu M,Kilicoglu B,Devrim E,Kismet K,Durak I

    更新日期:2008-06-21 00:00:00

  • Laparoscopic liver resection: wedge resections to living donor hepatectomy, are we heading in the right direction?

    abstract::Despite inception over 15 years ago and over 3000 completed procedures, laparoscopic liver resection has remained mainly in the domain of selected centers and enthusiasts. Requirement of extensive open liver resection (OLR) experience, in-depth understanding of anatomy and considerable laparoscopic technical expertise...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i37.13369

    authors: Cherian PT,Mishra AK,Kumar P,Sachan VK,Bharathan A,Srikanth G,Senadhipan B,Rela MS

    更新日期:2014-10-07 00:00:00

  • Anisodamine accelerates spontaneous passage of single symptomatic bile duct stones ≤ 10 mm.

    abstract:AIM:To investigate the rate of spontaneous passage of single and symptomatic common bile duct (CBD) stones ≤ 10 mm in diameter in 4 wk with or without a 2-wk course of anisodamine. METHODS:A multicenter, randomized, placebo-controlled trial was undertaken. A total of 197 patients who met the inclusion criteria were en...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.3748/wjg.v19.i39.6618

    authors: Gao J,Ding XM,Ke S,Zhou YM,Qian XJ,Ma RL,Ning CM,Xin ZH,Sun WB

    更新日期:2013-10-21 00:00:00

  • Prognostic value of sorting nexin 10 weak expression in stomach adenocarcinoma revealed by weighted gene co-expression network analysis.

    abstract:AIM:To detect significant clusters of co-expressed genes associated with tumorigenesis that might help to predict stomach adenocarcinoma (SA) prognosis. METHODS:The Cancer Genome Atlas database was used to obtain RNA sequences as well as complete clinical data of SA and adjacent normal tissues from patients. Weighted ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v24.i43.4906

    authors: Zhang J,Wu Y,Jin HY,Guo S,Dong Z,Zheng ZC,Wang Y,Zhao Y

    更新日期:2018-11-21 00:00:00

  • Resection of the uncinate process of the pancreas due to a ganglioneuroma.

    abstract::A 33-year-old woman who presented with epigastric discomfort and diarrhea underwent an abdominal ultrasound (US). This investigation and subsequent contrast-enhanced computed tomography, magnetic resonance imaging and endoscopic US with fine needle aspiration (FNA) revealed a 40 mm well-circumscribed mass in the uncin...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.4334

    authors: Poves I,Burdío F,Iglesias M,Martínez-Serrano Mde L,Aguilar G,Grande L

    更新日期:2009-09-14 00:00:00

  • Small bowel capsule endoscopy and treat-to-target in Crohn's disease: A systematic review.

    abstract:BACKGROUND:Crohn's disease (CD) can affect the entire gastrointestinal tract. Proximal small bowel (SB) lesions are associated with a significant risk of stricturing disease and multiple abdominal surgeries. The assessment of SB in patients with CD is therefore necessary because it may have a significant impact on prog...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v25.i31.4534

    authors: Le Berre C,Trang-Poisson C,Bourreille A

    更新日期:2019-08-21 00:00:00

  • Microbiota-based treatments in alcoholic liver disease.

    abstract::Gut microbiota plays a key role in the pathogenesis of alcoholic liver disease (ALD). Consumption of alcohol leads to increased gut permeability, small intestinal bacterial overgrowth, and enteric dysbiosis. These factors contribute to the increased translocation of microbial products to the liver via the portal tract...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i29.6673

    authors: Sung H,Kim SW,Hong M,Suk KT

    更新日期:2016-08-07 00:00:00

  • Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection -- a prospective cross-sectional study.

    abstract:AIM:Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore, these mutations may also affect the course of HIV/HCV coinfection. METHODS:We determined allele frequenci...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i48.7631

    authors: Ahlenstiel G,Iwan A,Nattermann J,Bueren K,Rockstroh JK,Brackmann HH,Kupfer B,Landt O,Peled A,Sauerbruch T,Spengler U,Woitas RP

    更新日期:2005-12-28 00:00:00

  • Diagnostic efficacy of the Japan Narrow-band-imaging Expert Team and Pit pattern classifications for colorectal lesions: A meta-analysis.

    abstract:BACKGROUND:Pit pattern classification using magnifying chromoendoscopy is the established method for diagnosing colorectal lesions. The Japan Narrow-band-imaging (NBI) Expert Team (JNET) classification is a novel NBI magnifying endoscopic classification that focuses on the vessel, and surface patterns. AIM:To determin...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i40.6279

    authors: Zhang Y,Chen HY,Zhou XL,Pan WS,Zhou XX,Pan HH

    更新日期:2020-10-28 00:00:00

  • Toxicological study of the hepatotherapeutic herbal formula, chunggan extract, in beagle dogs.

    abstract:AIM:To evaluate the pharmaceutical safety of a Chinese herbal formula, chunggan extract (CGX), traditionally prescribed as a hepatotherapeutic drug via systemic acute and subacute toxicological study. METHODS:Twenty male dogs and 20 female dogs were fed doses 50 times and 4 times greater than the clinically-recommende...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i46.7497

    authors: Choi WJ,Shin JW,Son JY,Seo DS,Park HS,Han SH,Sung HJ,Cho JH,Cho CK,Yoo HS,Lee YW,Son CG

    更新日期:2006-12-14 00:00:00

  • Antiviral therapy and resistance with hepatitis B virus infection.

    abstract::Hepatitis B virus (HBV) infection is still the most common cause of hepatocellular carcinoma and liver cirrhosis world wide. Recently, however, there has been quite dramatic improvement in the understanding of HBV associated liver disease and its treatment. It has become clear that high viral replication is a major ri...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v13.i1.125

    authors: Tillmann HL

    更新日期:2007-01-07 00:00:00

  • Predictors of common bile duct lithiasis in laparoscopic era.

    abstract:AIM:To analyze retrospectively the records of 294 consecutive patients operated upon for gallbladder stones, to determine the predictive factors of synchronous common bile duct (CBD) stones and validate prospectively the generated model. METHODS:The prognostic estimation of a biochemical test and ultrasonography alone...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i21.3267

    authors: Sgourakis G,Dedemadi G,Stamatelopoulos A,Leandros E,Voros D,Karaliotas K

    更新日期:2005-06-07 00:00:00

  • Hepatitis B-related events in autologous hematopoietic stem cell transplantation recipients.

    abstract:AIM:To investigate the frequency of occult hepatitis B, the clinical course of hepatitis B virus (HBV) reactivation and reverse seroconversion and associated risk factors in autologous hematopoietic stem cell transplantation (HSCT) recipients. METHODS:This study was conducted in 90 patients undergoing autologous HSCT....

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i14.1765

    authors: Ceneli O,Ozkurt ZN,Acar K,Rota S,Aki SZ,Yeğin ZA,Yağci M,Ozenirler S,Sucak GT

    更新日期:2010-04-14 00:00:00

  • Clinical value of liver and spleen shear wave velocity in predicting the prognosis of patients with portal hypertension.

    abstract:AIM:To explore the relationship of liver and spleen shear wave velocity in patients with liver cirrhosis combined with portal hypertension, and assess the value of liver and spleen shear wave velocity in predicting the prognosis of patients with portal hypertension. METHODS:All 67 patients with liver cirrhosis diagnos...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i45.8044

    authors: Zhang Y,Mao DF,Zhang MW,Fan XX

    更新日期:2017-12-07 00:00:00

  • Synchronous anorectal melanoma.

    abstract::Anorectal melanoma is a very rare tumor with poor prognosis. Rectal bleeding is the most frequent symptom and surgical treatment ranges from local excision to radical abdominoperineal resection. We report a case of a 75-years-old male patient who presented with a history of recurrent rectal bleeding, and whose histopa...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i21.3453

    authors: Balicevic D,Tomic K,Bekavac-Beslin M,Kovacevic I,Mijic A,Belicza M,Kruslin B

    更新日期:2006-06-07 00:00:00

  • Novel CagA ELISA exhibits enhanced sensitivity of Helicobacter pylori CagA antibody.

    abstract:AIM:To develop a novel Helicobacter pylori (H. pylori) CagA antibody enzyme-linked immunosorbent assay (ELISA) suitable for detecting serum anti-CagA antibodies with high sensitivity. METHODS:Recombinant East Asian-type CagA protein was purified and immobilized for ELISA. Serum samples from 217 Vietnamese individuals ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i1.48

    authors: Matsuo Y,Kido Y,Akada J,Shiota S,Binh TT,Trang TT,Dung HD,Tung PH,Tri TD,Thuan NP,Tam LQ,Nam BC,Khien VV,Yamaoka Y

    更新日期:2017-01-07 00:00:00

  • Quantitative analysis of transforming growth factor beta 1 mRNA in patients with alcoholic liver disease.

    abstract:AIM:To investigate the expression of the transforming growth factor beta 1(TGF-beta 1) mRNA in different stages of alcoholic liver disease (ALD) and its clinical value. METHODS:One hundred and seven male alcoholics were grouped by clinical findings into four groups: alcohol abusers without liver impairment (n =22), al...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v8.i2.379

    authors: Chen WX,Li YM,Yu CH,Cai WM,Zheng M,Chen F

    更新日期:2002-04-01 00:00:00