Abstract:
AIM:To detect microsatellite instability (MSI) in patients with hereditary nonpolyposis colorectal cancer or ordinary hereditary colorectal cancer and to provide criteria for screening the kindreds with hereditary nonpolyposis colorectal cancer at molecular level. METHODS:MSI was detected in the specimens from 20 cases with HNPCC, 20 cases with ordinary hereditary colorectal cancer and 20 cases with sporadic colorectal cancer by means of polymerase chain reaction-single strand conformation polymorphism. RESULTS:The positive rate of MSI was 85% (17/20) in HNPCC group, 40% (8/20) in ordinary hereditary colorectal cancer group and 10% (2/20) in the sporadic colorectal cancer group respectively. The differences were significant. The mean ages of the three groups were 43.6, 52.2, and 61.8 years respectively, which increased gradually. The incidence of right hemicolon cancer was 64.7%, 37.5%, and 0% respectively, which decreased gradually and had significant difference. The expression ratio of BAT26 and BAT25 was 94.1% respectively, which was highest in the 5 gene sites studied. The incidence of poorly differentiated adenocarcinoma was 70.6% in HNPCC group among high frequency microsatellite instability (MSI-H), which was higher than the other two groups, which had 50% and 50% respectively. CONCLUSION:The incidence of MSI-H is higher in HNPCC group. The detection of MSI is simple and economical and has high correlation with the clinicopathologic feature of HNPCC and can be used as a screening method to detect the germ line mutation of the mismatch repair gene.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Liu WZ,Jin F,Zhang ZH,Wang SBdoi
10.3748/wjg.v12.i29.4745subject
Has Abstractpub_date
2006-08-07 00:00:00pages
4745-9issue
29eissn
1007-9327issn
2219-2840journal_volume
12pub_type
杂志文章abstract:AIM:To investigate the effect of transfected survivin antisense oligonucleotide (ASODN) on proliferation and apoptosis of gastric cancer cells. METHODS:The authors designed ASODNs targeting different regions of survivin mRNA, including surviving ASODN1, ASODN2 and ASODN3. ASODNs were transfected into gastric cancer ce...
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pub_type: 杂志文章
doi:10.3748/wjg.v10.i8.1121
更新日期:2004-04-15 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v22.i32.7342
更新日期:2016-08-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
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journal_title:World journal of gastroenterology
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pub_type: 杂志文章,meta分析
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更新日期:2000-10-01 00:00:00
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更新日期:2012-03-07 00:00:00
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pub_type: 杂志文章
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
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更新日期:2011-09-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 评论,信件
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更新日期:2011-06-07 00:00:00
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更新日期:2010-06-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v10.i13.1890
更新日期:2004-07-01 00:00:00
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pub_type: 杂志文章,meta分析
doi:10.3748/wjg.v25.i35.5376
更新日期:2019-09-21 00:00:00
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pub_type: 杂志文章
doi:10.3748/wjg.v17.i19.2407
更新日期:2011-05-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v16.i8.997
更新日期:2010-02-28 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2010-10-07 00:00:00
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pub_type: 杂志文章
doi:10.3748/wjg.v22.i6.2149
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2007-11-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,多中心研究
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更新日期:2008-01-07 00:00:00
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pub_type: 杂志文章
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更新日期:2005-02-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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更新日期:2019-11-21 00:00:00
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pub_type: 杂志文章
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更新日期:2003-08-01 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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更新日期:2011-04-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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更新日期:2013-06-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
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更新日期:2014-08-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v20.i38.13936
更新日期:2014-10-14 00:00:00
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更新日期:2014-12-14 00:00:00