Des-gamma-carboxy prothrombin as an important prognostic indicator in patients with small hepatocellular carcinoma.

Abstract:

AIM:To clarify the effect of a high des-gamma-carboxy prothrombin (DCP) level on the invasiveness and prognosis of small hepatocellular carcinoma. METHODS:Among 142 consecutive patients with known DCP levels, who underwent hepatectomy because of hepatocellular carcinoma, 85 patients met the criteria for small hepatocellular carcinoma, i.e. oneor=400 mAU/mL (P=0.02) were independent prognostic factors. In the group of patients who met the criteria for small hepatocellular carcinoma, DCP>or=400 mAU/mL was found to be an independent prognostic factor for recurrence-free (P=0.02) and overall survival (P=0.0005). In patients who did not meet the criteria, the presence of vascular invasion was an independent factor for recurrence-free (P=0.02) and overall survivals (P=0.01). In 75% of patients with small hepatocellular carcinoma and high DCP levels, recurrence occurred extrahepatically. CONCLUSION:For small hepatocellular carcinoma, a high preoperative DCP level appears indicative for tumor recurrence. Because many patients with a high preoperative DCP level develop extrahepatic recurrence, it is necessary to screen the whole body.

journal_name

World J Gastroenterol

authors

Hakamada K,Kimura N,Miura T,Morohashi H,Ishido K,Nara M,Toyoki Y,Narumi S,Sasaki M

doi

10.3748/wjg.14.1370

subject

Has Abstract

pub_date

2008-03-07 00:00:00

pages

1370-7

issue

9

eissn

1007-9327

issn

2219-2840

journal_volume

14

pub_type

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