Loss of heterozygosity on chromosome 10q22-10q23 and 22q11.2-22q12.1 and p53 gene in primary hepatocellular carcinoma.

abstract：:High-throughput short-read sequencing of exomes and whole cancer genomes in multiple human hepatocellular carcinoma (HCC) cohorts confirmed previously identified frequently mutated somatic genes, such as TP53, CTNNB1 and AXIN1, and identified several novel genes with moderate mutation frequencies, including ARID1A, AR...

journal_title：World journal of gastroenterology

authors： Gu DL,Chen YH,Shih JH,Lin CH,Jou YS,Chen CF

更新日期：2013-12-21 00:00:00

abstract：AIM:To compare outcome of stapled hemorrhoidopexy (SH) vs LigaSure hemorrhoidectomy (LH) by a meta-analysis of available randomized controlled trials (RCTs). METHODS:Databases, including PubMed, EMBASE, the Cochrane Library, and the Science Citation Index updated to December 2012, were searched. The main outcomes meas...

journal_title：World journal of gastroenterology

authors： Yang J,Cui PJ,Han HZ,Tong DN

更新日期：2013-08-07 00:00:00

abstract：AIM:To investigate the relationship between Helicobacter pylori (H. pylori) and mucin expression in gastric mucosa. METHODS:English Medical literature searches were conducted for gastric mucin expression in H. pylori infected people vs uninfected people. Searches were performed up to December 31(th) 2014, using MEDLIN...

journal_title：World journal of gastroenterology

authors： Niv Y

更新日期：2015-08-21 00:00:00

abstract：AIM:To identify the clinicopathological predictors of lymph node (LN) metastasis and evaluate the outcomes of endoscopic submucosal dissection (ESD) in papillary adenocarcinoma-type early gastric cancers (EGCs). METHODS:From January 2005 to May 2013, 49 patients who underwent surgical operation and 24 patients who und...

journal_title：World journal of gastroenterology

authors： Lee HJ,Kim GH,Park DY,Lee BE,Jeon HK,Jhi JH,Song GA

更新日期：2015-04-07 00:00:00

abstract：AIM:To construct pcDNA3.1-Egr.1p-p16 recombinant plasmid and investigate the expression of p16 in pancreatic cancer JF305 cells induced by radiation and the feasibility of gene radiotherapy for pancreatic carcinoma. METHODS:Human p16 cDNA was ligated to the downstream of Egr-1 promotor to construct pcDNA3.1-Egr.1p-p16...

journal_title：World journal of gastroenterology

authors： Ma HB,Wang XJ,Di ZL,Xia H,Li Z,Liu J,Ma J,Kang HF,Wu CM,Bai MH

更新日期：2007-08-21 00:00:00

abstract：AIM:Complete resection of the bile duct carcinoma is sometimes difficult by subepithelial spread in the duct wall or direct invasion of adjacent blood vessels. Nonresected extrahepatic bile duct carcinoma has a dismal prognosis, with a life expectancy of about 6 mo to 1 year. To improve the treatment results of locally...

journal_title：World journal of gastroenterology

authors： Kamisawa T,Tu Y,Egawa N,Karasawa K,Matsuda T,Tsuruta K,Okamoto A

更新日期：2005-07-21 00:00:00

abstract：AIM:To investigate the effect of Danzhijiangtang capsule (DJC) on monocyte chemoattractant protein-1 (MCP-1) mRNA expression in newly diagnosed type 2 diabetes mellitus (T2DM) subclinical vascular lesions. METHODS:Sixty-two patients with newly diagnosed T2DM subclinical vascular lesions were randomly divided into a co...

journal_title：World journal of gastroenterology

authors： Fang ZH,Liu Y,Bao TT,Ni YQ,Liu J,Shi GB,Wu JP,Yang JP,Zhang H

更新日期：2013-05-21 00:00:00

abstract：:Endoscopic retrograde cholangiopancreatography (ERCP) is a state of the art diagnostic and therapeutic procedure for various pancreatic and biliary problems. In spite of the well-established safety of the procedure, there is still a risk of complications such as pancreatitis, cholangitis, bleeding and perforation. Air...

journal_title：World journal of gastroenterology

authors： Yilmaz B,Roach EC,Koklu S,Aydin O,Unlu O,Kilic YA

更新日期：2015-04-21 00:00:00

abstract：AIM:To explore a safe and efficient strategy of tumor therapy using anti-angiogenetic agents. METHODS:Endostatin gene with a signal sequence of human IgGgamma chain was amplified by PCR and cloned into pVAX1 plasmid which was the only vector authorized by FDA in clinical trial to construct a recombinant plasmid named ...

journal_title：World journal of gastroenterology

authors： Ma CH,Zhang Y,Wang XY,Gao LF,Liu H,Guo C,Liu SX,Cao YL,Zhang LN,Sun WS

更新日期：2004-10-01 00:00:00

abstract：AIM:To compare long-term occurrence of gastroesophageal reflux disease (GERD) between two different types of peroral endoscopic myotomy (POEM) for achalasia. METHODS:We included all patients with achalasia who underwent POEM at our hospital from August 2011 to October 2012 and had complete GERD evaluation with ≥ 3 yea...

journal_title：World journal of gastroenterology

authors： Wang XH,Tan YY,Zhu HY,Li CJ,Liu DL

更新日期：2016-11-14 00:00:00

abstract：AIM:To investigate the expression profiles of hsa-miR-29c and hsa-miR-135b in gastric mucosal samples and their values as gastric carcinogenesis biomarkers. METHODS:The expression levels of hsa-miR-29c and hsa-miR-135b in normal gastric mucosa, non-atrophic chronic gastritis, intestinal metaplasia and intestinal-type ...

journal_title：World journal of gastroenterology

authors： Vidal AF,Cruz AM,Magalhães L,Pereira AL,Anaissi AK,Alves NC,Albuquerque PJ,Burbano RM,Demachki S,Ribeiro-dos-Santos Â

更新日期：2016-02-14 00:00:00

abstract：AIM:To assess the impact of preoperative neoadjuvant bevacizumab (Bev) on the outcome of patients undergoing resection for colorectal liver metastases (CLM). METHODS:Eligible trials were identified from Medline, Embase, Ovid, and the Cochrane database. The data were analyzed with fixed-effects or random-effects models...

journal_title：World journal of gastroenterology

authors： Li DB,Ye F,Wu XR,Wu LP,Chen JX,Li B,Zhou YM

更新日期：2013-02-07 00:00:00

abstract：AIM:To cure typically life-threatening esophagogastric anastomosis in rats, lacking anastomosis healing and sphincter function rescue, in particular. METHODS:Because we assume esophagogastric fistulas represent a particular NO-system disability, we attempt to identify the benefits of anti-ulcer stable gastric pentadec...

journal_title：World journal of gastroenterology

authors： Djakovic Z,Djakovic I,Cesarec V,Madzarac G,Becejac T,Zukanovic G,Drmic D,Batelja L,Zenko Sever A,Kolenc D,Pajtak A,Knez N,Japjec M,Luetic K,Stancic-Rokotov D,Seiwerth S,Sikiric P

更新日期：2016-11-07 00:00:00

abstract：AIM:To examine the expressions of matrix metalloproteinases-2 (MMP-2) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in rat fibrotic liver and in normal rat hepatic stellate cells, and to investigate the changes in their expressions in response to treatment with interleukin-10 (IL-10) and platelet-derived growth...

journal_title：World journal of gastroenterology

authors： Zhang LJ,Chen YX,Chen ZX,Huang YH,Yu JP,Wang XZ

更新日期：2004-09-01 00:00:00

abstract：AIM:To investigate whether potent acid inhibition is effective in non-erosive reflux disease (NERD) refractory to standard rabeprazole (RPZ) treatment. METHODS:We treated 10 Japanese patients with NERD resistant to standard dosages of RPZ: 10 mg or 20 mg od, 20 mg bid, or 10 mg qid for 14 d. All patients completed a f...

journal_title：World journal of gastroenterology

authors： Sugimoto M,Nishino M,Kodaira C,Yamade M,Uotani T,Ikuma M,Umemura K,Furuta T

更新日期：2011-04-14 00:00:00

abstract：AIM:To study the expression levels of E- selectin, integrin beta1 and immunoglobulin superfamily member-intercellular adhesion molecule-1 (ICAM-1) in human gastric carcinoma cells, and to explore the relationship between these three kinds of cell adhesion molecules and gastric carcinoma. METHODS:The serum contents of ...

journal_title：World journal of gastroenterology

authors： Ke JJ,Shao QS,Ling ZQ

更新日期：2006-06-14 00:00:00

abstract：AIM:To examine the characteristics of colonic polyps, where it is difficult to distinguish adenomatous polyps from hyperplastic polyps, with the aid of acetic acid chromoendoscopy. METHODS:Acetic acid spray was applied to colonic polyps smaller than 10 mm before complete excision. Endoscopic images were taken before a...

journal_title：World journal of gastroenterology

authors： Kim JH,Lee SY,Kim BK,Choe WH,Kwon SY,Sung IK,Park HS,Jin CJ

更新日期：2008-03-28 00:00:00

abstract：AIM:To investigate the location alteration of Smad2 and Smad4 mRNAs in the liver during and after fibrogenesis in rats. METHODS:Eighty male Wistar rats weighing approximately 200 g each were used. The rat models of experimental hepatic fibrosis were established by injection with carbon tetrachloride (CCl4), normal rat...

journal_title：World journal of gastroenterology

authors： Liu Y,Wang LF,Zou HF,Song XY,Xu HF,Lin P,Zheng HH,Yu XG

更新日期：2006-03-14 00:00:00

abstract：AIM:To investigate the anti-tumor effects of combined cytotoxic drug (gemcitabine) and photodynamic therapy (PDT) on human pancreatic cancer xenograft in nude mice. METHODS:Human pancreatic cancer cell line SW1990 was used in the investigation of the in vivo effect of combined gemcitabine and PDT on human pancreatic c...

journal_title：World journal of gastroenterology

authors： Xie Q,Jia L,Liu YH,Wei CG

更新日期：2009-02-14 00:00:00

abstract：AIM:To investigate the efficacy and potential mechanism of Xiaotan Tongfu granules (XTTF) in stress ulcers. METHODS:One hundred sixty rats were randomly divided into 4 groups (n = 10) as follows: the model group (MP group), the control group (CP group), the ranitidine group (RP group) and the XTTF granule group (XP gr...

journal_title：World journal of gastroenterology

authors： Yan B,Shi J,Xiu LJ,Liu X,Zhou YQ,Feng SH,Lv C,Yuan XX,Zhang YC,Li YJ,Wei PK,Qin ZF

更新日期：2013-09-07 00:00:00

abstract：AIM:To research the etiology, portal vein thrombosis and other features of Budd-Chiari syndrome (BCS) patients prospectively. METHODS:A total of 75 patients (40 female, 35 male) who were diagnosed between January 2002 and July 2004 as having BCS were studied prospectively. Findings from on physical examination, ultras...

journal_title：World journal of gastroenterology

authors： Uskudar O,Akdogan M,Sasmaz N,Yilmaz S,Tola M,Sahin B

更新日期：2008-05-14 00:00:00

abstract：:A 49 years old Vietnamese male with a history of thalassemia, presented with gastrointestinal symptoms and signs of hemolysis. He was diagnosed with yersinia enterocolitis. Yersinia is a gram-negative rod that most frequently occurs in children especially during the winter months. In the current case, the bone marrow ...

journal_title：World journal of gastroenterology

authors： Selsky N,Forouhar F,Wu GY

更新日期：2013-10-07 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a critical risk factor for the carcinogenesis and progression of hepatocellular carcinoma (HCC). It promotes HCC development by inducing liver fibrogenesis, genetic and epigenetic alterations, and the expression of active viral-coded proteins. Effective antiviral treatments...

journal_title：World journal of gastroenterology

authors： Zhang YQ,Guo JS

更新日期：2015-04-07 00:00:00

abstract：AIM:To investigate the distribution pattern of lymphatic vessels and microvessels in sporadic colorectal carcinoma (SCRC) and their relationship to metastasis and prognosis. METHODS:The lymphatic vessel density (LVD) and microvessel density (MVD) in tumor tissue obtained from 132 patients with primary SCRC, including ...

journal_title：World journal of gastroenterology

authors： Yan G,Zhou XY,Cai SJ,Zhang GH,Peng JJ,Du X

更新日期：2008-01-07 00:00:00

abstract：AIM:To investigate the expression of programmed death (PD)-1, PD ligand 1 (PD-L1) and PD-L2 in liver tissues in the context of chronic hepatitis and hepatocellular carcinoma (HCC). METHODS:Liver biopsies and HCC specimens from patients were collected and histologically examined. The expression of PD-1, PD-L1, and PD-L...

journal_title：World journal of gastroenterology

authors： Wang BJ,Bao JJ,Wang JZ,Wang Y,Jiang M,Xing MY,Zhang WG,Qi JY,Roggendorf M,Lu MJ,Yang DL

更新日期：2011-07-28 00:00:00

abstract：AIM:To explore the diffusion gradient b-factor that optimizes both apparent diffusion coefficient (ADC) measurement and contrast-to-noise (CNR) for assessing tumor response to transarterial chemoembolization (TACE) in a rabbit model. METHODS:Twelve New Zealand white rabbits bearing VX2 tumors in the liver were treated...

journal_title：World journal of gastroenterology

authors： Jiang ZX,Peng WJ,Li WT,Tang F,Liu SY,Qu XD,Wang JH,Lu HF

更新日期：2008-10-14 00:00:00

abstract：:A case of pedunculated Brunner's gland hamartoma (BGH) of the duodenum causing upper gastrointestinal (GI) hemorrhage is reported. The patient was a 47-year-old man who visited our hospital for further evaluation of tarry stools and shortness of breath. Endoscopic examination of the upper digestive tract revealed a la...

journal_title：World journal of gastroenterology

authors： Hirasaki S,Kubo M,Inoue A,Miyake Y,Oshiro H

更新日期：2009-01-21 00:00:00

abstract：AIM:To investigate the association of serum gamma-glutamyl transferase (GGT) levels with chronic hepatitis B infection and hepatitis B e antigen (HBeAg) seroconversion. METHODS:A retrospective study was performed on clinical data collected from patients who had been positive for hepatitis B surface antigen for > 6 mo ...

journal_title：World journal of gastroenterology

authors： Huang R,Yang CC,Liu Y,Xia J,Su R,Xiong YL,Wang GY,Sun ZH,Yan XM,Lu S,Wu C

更新日期：2015-09-14 00:00:00

abstract：:A rare case of multiple small bowel ruptures due to ischemic enteritis (ISE) is reported. The patient was admitted to the hospital with acute abdominal pain followed by bloody diarrhoeas. Preoperative colonoscopic findings were similar to those presented in Crohn's disease. Intraoperatively, ischemic lesions and multi...

journal_title：World journal of gastroenterology

authors： Delikoukos S,Christodoulidis G,Zacharoulis D,Poultsidi A,Hatzitheofilou C

更新日期：2006-07-14 00:00:00

abstract：AIM:To investigate the impact of chronic fatigue on disease-related worries in inflammatory bowel disease (IBD) and the potential multicolinearity between subjective questionnaires. METHODS:Patients in remission or with mild-to-moderate disease activity completed the fatigue questionnaire (FQ), the rating form of IBD ...

journal_title：World journal of gastroenterology

authors： Jelsness-Jørgensen LP,Bernklev T,Henriksen M,Torp R,Moum B

更新日期：2012-02-07 00:00:00