Preoperative administration of bevacizumab is safe for patients with colorectal liver metastases.

Abstract:

AIM:To assess the impact of preoperative neoadjuvant bevacizumab (Bev) on the outcome of patients undergoing resection for colorectal liver metastases (CLM). METHODS:Eligible trials were identified from Medline, Embase, Ovid, and the Cochrane database. The data were analyzed with fixed-effects or random-effects models using Review Manager version 5.0. RESULTS:Thirteen nonrandomized studies with a total of 1431 participants were suitable for meta-analysis. There was no difference in overall morbidity and severe complications between the Bev + group and Bev - group (43.3% vs 36.8%, P = 0.06; 17.1% vs 11.4%, P = 0.07, respectively). Bev-related complications including wound and thromboembolic/bleeding events were also similar in the Bev + and Bev - groups (14.4% vs 8.1%, P = 0.21; 4.1% vs 3.8%, P = 0.98, respectively). The incidence and severity of sinusoidal dilation were lower in patients treated with Bev than in patients treated without Bev (43.3% vs 63.7%, P < 0.001; 16.8% vs 46.5%, P < 0.00, respectively). CONCLUSION:Bev can be safely administered before hepatic resection in patients with CLM, and has a protective effect against hepatic injury in patients treated with oxaliplatin chemotherapy.

journal_name

World J Gastroenterol

authors

Li DB,Ye F,Wu XR,Wu LP,Chen JX,Li B,Zhou YM

doi

10.3748/wjg.v19.i5.761

subject

Has Abstract

pub_date

2013-02-07 00:00:00

pages

761-8

issue

5

eissn

1007-9327

issn

2219-2840

journal_volume

19

pub_type

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