Abstract:
AIM:To investigate the characteristics of slow electrical waves and the presence of transient receptor potential melastatin-type 7 (TRPM7) in the human gastrointestinal (GI) tract. METHODS:Conventional microelectrode techniques were used to record intracellular electrical responses from human GI smooth muscle tissue. Immunohistochemistry was used to identify TRPM7 channels in interstitial cells of Cajal (ICCs). RESULTS:The human GI tract generated slow electrical waves and had ICCs which functioned as pacemaker cells. Flufenamic acid, a nonselective cation channel blocker, and 2-APB (2-aminoethoxydiphenyl borate) and La(3+), TRPM7 channel blockers, inhibited the slow waves. Also, TRPM7 channels were expressed in ICCs in human tissue. CONCLUSION:These results suggest that the human GI tract generates slow waves and that TRPM7 channels expressed in the ICCs may be involved in the generation of the slow waves.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Kim BJ,Park KJ,Kim HW,Choi S,Jun JY,Chang IY,Jeon JH,So I,Kim SJdoi
10.3748/wjg.15.5799subject
Has Abstractpub_date
2009-12-14 00:00:00pages
5799-804issue
46eissn
1007-9327issn
2219-2840journal_volume
15pub_type
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