Predictors of the patency of self-expandable metallic stents in malignant gastroduodenal obstruction.

Abstract:

AIM:To investigate the predictive factors of self-expandable metallic stent patency after stent placement in patients with inoperable malignant gastroduodenal obstruction. METHODS:A total of 116 patients underwent stent placements for inoperable malignant gastroduodenal obstruction at a tertiary academic center. Clinical success was defined as acceptable decompression of the obstructive lesion within the malignant gastroduodenal neoplasm. We evaluated patient comorbidities and clinical statuses using the World Health Organization's scoring system and categorized patient responses to chemotherapy using the Response Evaluation Criteria in Solid Tumors criteria. We analyzed the relationships between possible predictive factors and stent patency. RESULTS:Self-expandable metallic stent placement was technically successful in all patients (100%), and the clinical success rate was 84.2%. In a multivariate Cox proportional hazards model, carcinoembryonic antigen (CEA) levels were correlated with a reduction in stent patency [P = 0.006; adjusted hazard ratio (aHR) = 2.92, 95%CI: 1.36-6.25]. Palliative chemotherapy was statistically associated with an increase in stent patency (P = 0.009; aHR = 0.27, 95%CI: 0.10-0.72). CONCLUSION:CEA levels can easily be measured at the time of stent placement and may help clinicians to predict stent patency and determine the appropriate stent procedure.

journal_name

World J Gastroenterol

authors

Kim SH,Chun HJ,Yoo IK,Lee JM,Nam SJ,Choi HS,Kim ES,Keum B,Seo YS,Jeen YT,Lee HS,Um SH,Kim CD

doi

10.3748/wjg.v21.i30.9134

subject

Has Abstract

pub_date

2015-08-14 00:00:00

pages

9134-41

issue

30

eissn

1007-9327

issn

2219-2840

journal_volume

21

pub_type

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