Abstract:
AIM:To assess the role of IgM and IgG immunohistochemistry (IHC) in the evaluation of autoimmune liver conditions--autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC). METHODS:Forty one biopsies from untreated patients diagnosed with autoimmune liver disease (AIH, n = 20; PBC, n = 13; PSC, n = 8) and fourteen biopsies of patients with chronic hepatitis C were selected. IgM and IgG-positive plasma cells were counted in each sample. RESULTS:A predominance of IgG-positive plasma cells was seen in AIH (90% of cases), PSC (75% of cases), and chronic hepatitis C (100% of cases), while IgM-positive plasma cells predominated in PBC (92.8% of cases). The IgM /IgG ratio (< 1 or > or = 1) accurately distinguished PBC from AIH in 90.9% of cases (sensitivity = 92.3%, specificity = 90%), and PBC from either AIH or PSC in 87.8% of cases (sensitivity = 92.3%, specificity = 85.7%). CONCLUSION:Plasmacytic infiltrates expressing predominantly IgM are characteristic of PBC, while other forms of liver disease analyzed in this study, including AIH, typically show an IgG-predominant plasma cell infiltrate. Our data indicate that IgM and IgG IHC may be a useful tool when PBC is a diagnostic consideration.
journal_name
World J Gastroenteroljournal_title
World journal of gastroenterologyauthors
Moreira RK,Revetta F,Koehler E,Washington MKdoi
10.3748/wjg.v16.i4.453subject
Has Abstractpub_date
2010-01-28 00:00:00pages
453-7issue
4eissn
1007-9327issn
2219-2840journal_volume
16pub_type
杂志文章abstract:AIM:To analyze RASSF6 expression in pancreatic ductal adenocarcinoma (PDAC) and to determine whether RASSF6 has an independent prognostic value in PDAC. METHODS:We studied RASSF6 expression in 96 histologically confirmed PDAC samples and 20 chronic pancreatitis specimens using immunohistochemistry and real-time quanti...
journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v21.i21.6621
更新日期:2015-06-07 00:00:00
abstract::More than 30 years after the discovery of human hepatitis B virus (HBV) this virus remains to be one of the major global health problems. In infected adolescents or adults, 5%-10% will lead to a chronic carrier state, whereas in infected neonates up to 90% develop chronicity. It is estimated that about 370 million peo...
journal_title:World journal of gastroenterology
pub_type: 社论,评审
doi:10.3748/wjg.v13.i1.8
更新日期:2007-01-07 00:00:00
abstract::The treatment of chronic hepatitis C (CHC) is still far from optimal, particularly for those subpopulations that do not respond to the standard combination therapy with Interferon-alpha (IFNalpha) plus ribavirin. Although in some cases the use of higher doses or longer treatment periods may be effective, these approac...
journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.3748/wjg.v12.i17.2730
更新日期:2006-05-07 00:00:00
abstract:AIM:To establish a more sensitive method for detection of free cancer cells in peritoneal washes from gastric cancer patients during surgery and to evaluate its clinical significance. METHODS:The carcinoembryonic antigen (CEA) mRNA levels in peritoneal washes from 65 cases of gastric cancer were detected by real-time ...
journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v12.i9.1408
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v26.i42.6614
更新日期:2020-11-14 00:00:00
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pub_type: 杂志文章
doi:10.3748/wjg.15.5200
更新日期:2009-11-07 00:00:00
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pub_type: 杂志文章
doi:10.3748/wjg.v11.i34.5377
更新日期:2005-09-14 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
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更新日期:2015-03-28 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.3748/wjg.15.2609
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
doi:10.3748/wjg.v16.i23.2926
更新日期:2010-06-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,评审
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更新日期:2014-10-07 00:00:00
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pub_type: 杂志文章
doi:10.3748/wjg.v20.i23.7488
更新日期:2014-06-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v13.i21.2918
更新日期:2007-06-07 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.14.2174
更新日期:2008-04-14 00:00:00
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pub_type: 评论,信件
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更新日期:2011-06-07 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.3748/wjg.v22.i8.2621
更新日期:2016-02-28 00:00:00
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pub_type: 杂志文章
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更新日期:2017-06-14 00:00:00
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pub_type: 杂志文章
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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更新日期:2005-09-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v26.i11.1156
更新日期:2020-03-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v26.i12.1329
更新日期:2020-03-28 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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更新日期:2014-11-21 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
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journal_title:World journal of gastroenterology
pub_type: 杂志文章
doi:10.3748/wjg.v9.i3.612
更新日期:2003-03-01 00:00:00
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journal_title:World journal of gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2017-12-28 00:00:00