Non-alcoholic fatty liver disease and type 2 diabetes mellitus: the liver disease of our age?

abstract：:We report a rare case of hypereosinophilic syndrome (HES) presenting with intractable gastric ulcers. A 71-year-old man was admitted with epigastric pain. Initial endoscopic findings revealed multiple, active gastric ulcers in the gastric antrum. He underwent Helicobacter pylori (H pylori) eradication therapy followed...

journal_title：World journal of gastroenterology

authors： Park TY,Choi CH,Yang SY,Oh IS,Song ID,Lee HW,Kim HJ,Do JH,Chang SK,Cho AR,Cha YJ

更新日期：2009-12-28 00:00:00

abstract：AIM:To investigate the level of gastric ghrelin in stomach mucosa of dyspeptic patients in relation to Helicobacter pylori (H pylori) infection, bacterial cytotoxicity, topography and gender. METHODS:The study comprised 40 premenopausal women (19 H pylori positive) and 48 men (17 H pylori positive) with functional dys...

journal_title：World journal of gastroenterology

authors： Stec-Michalska K,Malicki S,Michalski B,Peczek L,Wisniewska-Jarosinska M,Nawrot B

更新日期：2009-11-21 00:00:00

abstract：:Hepatocellular carcinoma (HCC), the fifth most common cancer in the world, shows increasing incidence worldwide. Curative treatments such as hepatectomy, liver transplantation, and radiofrequency ablation are applied in only 30%-60% of cases. Most remaining patients receive transarterial chemoembolization (TACE). Pati...

journal_title：World journal of gastroenterology

authors： Yamakado K,Hirota S

更新日期：2015-10-07 00:00:00

abstract：:The bacterial pathogen Helicobacter pylori (H. pylori) colonizes in over half of the world's population. H. pylori that establishes life-long infection in the stomach is definitely associated with gastro-duodenal diseases and a wide variety of non-gastrointestinal tract conditions such as immune thrombocytopenia. Trip...

journal_title：World journal of gastroenterology

authors： Takeuchi H,Trang VT,Morimoto N,Nishida Y,Matsumura Y,Sugiura T

更新日期：2014-07-21 00:00:00

abstract：:A 49 years old Vietnamese male with a history of thalassemia, presented with gastrointestinal symptoms and signs of hemolysis. He was diagnosed with yersinia enterocolitis. Yersinia is a gram-negative rod that most frequently occurs in children especially during the winter months. In the current case, the bone marrow ...

journal_title：World journal of gastroenterology

authors： Selsky N,Forouhar F,Wu GY

更新日期：2013-10-07 00:00:00

abstract：AIM:To study the expression of vascular endothelial growth factor A (VEGF-A) and VEGF-C and to determine whether the presence of VEGF-A and VEGF-C was associated with the clinicopathologic characteristics of pancreatic cancer. METHODS:VEGF-A and VEGF-C mRNA transcripts were examined by Northern blot in 6 human pancrea...

journal_title：World journal of gastroenterology

authors： Tang RF,Wang SX,Peng L,Wang SX,Zhang M,Li ZF,Zhang ZM,Xiao Y,Zhang FR

更新日期：2006-01-14 00:00:00

abstract：AIM:To investigate the microRNA expression profile in esophageal neosquamous epithelium from patients who had undergone ablation of Barrett's esophagus. METHODS:High throughput screening using TaqMan® Array Human MicroRNA quantitative PCR was used to determine expression levels of 754 microRNAs in distal esophageal mu...

journal_title：World journal of gastroenterology

authors： Sreedharan L,Mayne GC,Watson DI,Bright T,Lord RV,Ansar A,Wang T,Kist J,Astill DS,Hussey DJ

更新日期：2017-08-14 00:00:00

abstract：AIM:To investigate the fluid shear stress induced changes of (Ca(2+))i in neutrophils in pancreatic microcirculation of experimental acute pancreatitis (AP). METHODS:Wistar rats (n = 36) were randomized into three groups. A model of AP was established by subcutaneous injection of caerulein. Low-shear 30 viscometer was...

journal_title：World journal of gastroenterology

authors： Zhou ZG,Chen YQ,Liu XB,Hu WM,Tian BL,Chen HQ

更新日期：2004-11-01 00:00:00

abstract：AIM:To investigate the anti-tumor effects of combined cytotoxic drug (gemcitabine) and photodynamic therapy (PDT) on human pancreatic cancer xenograft in nude mice. METHODS:Human pancreatic cancer cell line SW1990 was used in the investigation of the in vivo effect of combined gemcitabine and PDT on human pancreatic c...

journal_title：World journal of gastroenterology

authors： Xie Q,Jia L,Liu YH,Wei CG

更新日期：2009-02-14 00:00:00

abstract：AIM:To establish the rapid, specific, and sensitive method for detecting O157:H7 with DNA microchips. METHODS:Specific oligonucleotide probes (26-28 nt) of bacterial antigenic and virulent genes of E. coli O157:H7 and other related pathogen genes were pre-synthesized and immobilized on a solid support to make microchi...

journal_title：World journal of gastroenterology

authors： Jin HY,Tao KH,Li YX,Li FQ,Li SQ

更新日期：2005-10-07 00:00:00

abstract：AIM:To estimate the effect of a therapeutic vaccine against pancreatic carcinoma based on dendritic cell (DC) vaccine modified with tumor lysate and Interleukin-18 gene. METHODS:The BALB/C mice model of pancreatic carcinoma was induced with DMBA. DC vaccine was constructed through pulsed with tumor lysate and transfec...

journal_title：World journal of gastroenterology

authors： Tang ZH,Qiu WH,Wu GS,Yang XP,Zou SQ,Qiu FZ

更新日期：2002-10-01 00:00:00

abstract：:Recently, there have been reports from liver biopsies that showed the progression of liver fibrosis in liver transplant patients after the cessation of immunosuppression. Herein, we focused on activated hepatic stellate cells expressing alpha smooth muscle actin (α-SMA) to understand the correlation between immunosupp...

journal_title：World journal of gastroenterology

authors： Hirabaru M,Mochizuki K,Takatsuki M,Soyama A,Kosaka T,Kuroki T,Shimokawa I,Eguchi S

更新日期：2014-06-14 00:00:00

abstract：BACKGROUND:Irritable bowel syndrome (IBS) is a common chronic non-organic disease of the digestive system. Berberine (BBR) has been used to treat patients with IBS, but the underlying therapeutic mechanism is little understood. We believe that BBR achieves its therapeutic effect on IBS by preventing stress intestinal i...

journal_title：World journal of gastroenterology

authors： Yu ZC,Cen YX,Wu BH,Wei C,Xiong F,Li DF,Liu TT,Luo MH,Guo LL,Li YX,Wang LS,Wang JY,Yao J

更新日期：2019-08-07 00:00:00

abstract：AIM:To investigate the antioxidant effect of caffeic acid phenethyl ester (CAPE) in hepatic stellate cell-T6 (HSC-T6) cells cultured in vitro and the potential mechanisms. METHODS:HSC-T6 cells were cultured in vitro and treated with various concentrations of CAPE for 24, 48 and 72 h, respectively. Cell proliferation w...

journal_title：World journal of gastroenterology

authors： Yang N,Shi JJ,Wu FP,Li M,Zhang X,Li YP,Zhai S,Jia XL,Dang SS

更新日期：2017-02-21 00:00:00

abstract：AIM:To evaluate the pharmaceutical safety of a Chinese herbal formula, chunggan extract (CGX), traditionally prescribed as a hepatotherapeutic drug via systemic acute and subacute toxicological study. METHODS:Twenty male dogs and 20 female dogs were fed doses 50 times and 4 times greater than the clinically-recommende...

journal_title：World journal of gastroenterology

authors： Choi WJ,Shin JW,Son JY,Seo DS,Park HS,Han SH,Sung HJ,Cho JH,Cho CK,Yoo HS,Lee YW,Son CG

更新日期：2006-12-14 00:00:00

abstract：:The Prague C and M Criteria have been developed for the objective endoscopic diagnosis of Barrett's esophagus (BE). BE arises between the squamocolumnar junction and the gastroesophageal junction at the proximal margin of the gastric folds. In this study, we reported that 43.0% of the subjects examined were diagnosed ...

journal_title：World journal of gastroenterology

authors： Akiyama T,Sekino Y,Iida H,Koyama S,Gotoh E,Maeda S,Nakajima A,Inamori M

更新日期：2012-07-14 00:00:00

abstract：:The biosynthesis of prostaglandins and thromboxanes has been a focus of interest in the management of many liver diseases. Cyclooxygenases are the enzymes involved in the first step of the biosynthesis of these lipid mediators and selective inhibitors for these isoenzymes as well as pharmacological analogues of prosta...

journal_title：World journal of gastroenterology

authors： Martín-Sanz P,Casado M,Boscá L

更新日期：2017-05-28 00:00:00

abstract：:In mammals, the intestinal epithelium is a tissue that contains two distinct pools of stem cells: active intestinal stem cells and reserve intestinal stem cells. The former are located in the crypt basement membrane and are responsible for maintaining epithelial homeostasis under intact conditions, whereas the latter ...

journal_title：World journal of gastroenterology

authors： Cui S,Chang PY

更新日期：2016-08-21 00:00:00

abstract：AIM:To describe the imaging features of solitary fibrous tumors (SFTs) in the abdomen and pelvis, and the clinical and pathologic correlations. METHODS:Fifteen patients with pathologically confirmed SFTs in the abdomen and pelvis were retrospectively studied with imaging techniques by two radiologists in consensus. Pa...

journal_title：World journal of gastroenterology

authors： Li XM,Reng J,Zhou P,Cao Y,Cheng ZZ,Xiao Y,Xu GH

更新日期：2014-05-07 00:00:00

abstract：AIM:To evaluate the risk factors-other than nonsteroidal anti-inflammatory drugs-for colonic diverticular bleeding in a westernized population. METHODS:One hundred and forty patients, treated for symptomatic diverticular disease in a community based hospital, were included. Thirty (21%) had signs of diverticular bleed...

journal_title：World journal of gastroenterology

authors： Jansen A,Harenberg S,Grenda U,Elsing C

更新日期：2009-01-28 00:00:00

abstract：AIM:To explore the role of mammalian target of rapamycin (mTOR) in the pathogenesis of cirrhotic cardiomyopathy and the potential of rapamycin to improve this pathologic condition. METHODS:Male albino Wistar rats weighing 100-120 g were treated with tetrachloride carbon (CCl4) for 8 wk to induce cirrhosis. Subsequentl...

journal_title：World journal of gastroenterology

authors： Saeedi Saravi SS,Ghazi-Khansari M,Ejtemaei Mehr S,Nobakht M,Mousavi SE,Dehpour AR

更新日期：2016-05-21 00:00:00

abstract：:Hepatitis C is recognized as a major threat to global public health. The current treatment of patients with chronic hepatitis C is the addition of ribavirin to interferon-based therapy which has limited efficacy, poor tolerability, and significant expense. New treatment options that are more potent and less toxic are ...

journal_title：World journal of gastroenterology

authors： Khattab MA

更新日期：2009-07-28 00:00:00

abstract：BACKGROUND:Progressive familial intrahepatic cholestasis (PFIC) encompasses a group of autosomal recessive disorders with high morbidity and mortality. Variants in the gene encoding tight junction protein-2 (TJP2) have been linked to PFIC type 4 (PFIC4), which predominantly presents in childhood. However, there are onl...

journal_title：World journal of gastroenterology

authors： Wei CS,Becher N,Friis JB,Ott P,Vogel I,Grønbæk H

更新日期：2020-02-07 00:00:00

abstract：:Anti-tumour necrosis factor α (anti-TNFα) therapy is an established treatment in inflammatory bowel disease. However, this treatment is associated with high costs and the possibility of severe adverse events representing a true challenge for patients, clinicians and health care systems. Consequently, a crucial questio...

journal_title：World journal of gastroenterology

authors： Papamichael K,Vermeire S

更新日期：2015-04-28 00:00:00

abstract：:Transient thrombocytopenia is a common phenomenon after liver transplantation. After liver transplantation (LT), platelet count decreases and reaches a nadir on postoperative days 3-5, with an average reduction in platelet counts of 60%; platelet count recovers to preoperative levels approximately two weeks after LT. ...

journal_title：World journal of gastroenterology

authors： Takahashi K,Nagai S,Safwan M,Liang C,Ohkohchi N

更新日期：2018-04-07 00:00:00

abstract：:The treatment of alcoholic hepatitis remains one of the most debated topics in medicine and a field of continued research. In this review, we discuss the evolution of scoring systems, including the recent development of the Glasgow alcoholic hepatitis score, role of liver biopsy and current treatment interventions. St...

journal_title：World journal of gastroenterology

authors： Rongey C,Kaplowitz N

更新日期：2006-11-21 00:00:00

abstract：BACKGROUND:Extrahepatic metastasis (EHM) of hepatocellular carcinoma (HCC) is associated with poor outcomes. However, the clinical features and risk factors of EHM of HCC after radiofrequency ablation (RFA) remain unclear. AIM:To elucidate the characteristics and risk factors of EHM after RFA for HCC. METHODS:From Ja...

journal_title：World journal of gastroenterology

authors： Yoon JH,Goo YJ,Lim CJ,Choi SK,Cho SB,Shin SS,Jun CH

更新日期：2020-08-28 00:00:00

abstract：AIM:To evaluate the role of RARalpha gene in mediating the growth inhibitory effect of all-trans retinoic acid (ATRA) on gastric cancer cells. METHODS:The expression levels of retinoic acid receptors (RARs) in gastric cancer cells were detected by Northern blot. Transient transfection and chlorophenicol acetyl transfe...

journal_title：World journal of gastroenterology

authors： Liu S,Wu Q,Chen ZM,Su WJ

更新日期：2001-10-01 00:00:00

abstract：AIM:To investigate usefulness of adherence to gastro-esophageal reflux disease (GERD) guideline established by the Spanish Association of Gastroenterology. METHODS:Prospective, observational and multicentre study of 301 patients with typical symptoms of GERD who should be managed in accordance with guidelines and were...

journal_title：World journal of gastroenterology

authors： Mearin F,Ponce J,Ponce M,Balboa A,González MA,Zapardiel J

更新日期：2012-09-21 00:00:00

abstract：BACKGROUND:Treatments for hepatic sinusoidal obstruction syndrome (HSOS) are limited. AIM:To evaluate transjugular intrahepatic portosystemic shunting (TIPS) as a treatment for pyrrolidine alkaloid-related HSOS (PA-HSOS). METHODS:This retrospective analysis included patients with PA-HSOS admitted to the First Affilia...

journal_title：World journal of gastroenterology

authors： Zhou CZ,Wang RF,Lv WF,Fu YQ,Cheng DL,Zhu YJ,Hou CL,Ye XJ

更新日期：2020-06-28 00:00:00