Targeting host factors: a novel rationale for the management of hepatitis C virus.

abstract：:We report a case of severe thrombocytopenia following pegylated interferon-alpha 2a (Peg-IFN-alpha 2a) treatment of hepatitis C virus infection and summarize the clinical characteristics of 16 cases of IFN-alpha induced severe thrombocytopenia and its immune-mediated mechanism. Discontinuation of IFN-alpha and early a...

journal_title：World journal of gastroenterology

authors： Li L,Han DK,Lu J

更新日期：2010-03-21 00:00:00

abstract：AIM:To investigate the interstitial cells of Cajal (ICC) number using a new rat model. METHODS:Sprague-Dawley rats were assigned to two groups. The first group received gavage with Campylobacter jejuni (C. jejuni) 81-176. The second group was gavaged with placebo. Three months after clearance of Campylobacter from the...

journal_title：World journal of gastroenterology

authors： Jee SR,Morales W,Low K,Chang C,Zhu A,Pokkunuri V,Chatterjee S,Soffer E,Conklin JL,Pimentel M

更新日期：2010-08-07 00:00:00

abstract：:Despite advancements in medical therapy of Crohn's disease (CD), majority of patients with CD will eventually require surgical intervention, with at least a third of patients requiring multiple surgeries. It is important to understand the role and timing of surgery, with the goals of therapy to reduce the need for sur...

journal_title：World journal of gastroenterology

authors： Toh JW,Stewart P,Rickard MJ,Leong R,Wang N,Young CJ

更新日期：2016-10-28 00:00:00

abstract：:Corticosteroids and immunomodulators have been the mainstay therapies for Crohn's disease. Corticosteroids are highly effective to control symptoms in the short-term, but they are not effective in maintaining remission, they heal the mucosa in a reduced proportion of cases, and long-time exposure is associated with an...

journal_title：World journal of gastroenterology

authors： Ricart E,García-Bosch O,Ordás I,Panés J

更新日期：2008-09-28 00:00:00

abstract：:Recently, inflammatory bowel disease (IBD) has been the subject of considerable research, with increasing attention being paid to the loss of intestinal epithelial cell barrier function as a mechanism of pathogenesis. Ste20-related proline/alanine-rich kinase (SPAK) is involved in regulating barrier function. SPAK is ...

journal_title：World journal of gastroenterology

authors： Yan Y,Merlin D

更新日期：2008-10-28 00:00:00

abstract：AIM:To detect the expression of DPC4 in malignant and non-malignant specimens of human pancreas, and observe the inhibition of retroviral pLXSN containing DPC4 on pancreatic carcinoma cells in vitro. METHODS:The expression of DPC4 was determined in 40 pancreatic adenocarcinoma and 36 non-malignant pancreatic specimens...

journal_title：World journal of gastroenterology

authors： Shen W,Tao GQ,Li DC,Zhu XG,Bai X,Cai B

更新日期：2008-10-28 00:00:00

abstract：AIM:To evaluate the accuracy of spot urinary Na/K and Na/creatinine (Cr) ratios as an alternative to 24-h urinary sodium in monitoring dietary compliance in patients with liver cirrhosis and ascites treated with diuretics. METHODS:The study was carried on 40 patients with liver cirrhosis and ascites treated with diure...

journal_title：World journal of gastroenterology

authors： El-Bokl MA,Senousy BE,El-Karmouty KZ,Mohammed Iel K,Mohammed SM,Shabana SS,Shalaby H

更新日期：2009-08-07 00:00:00

abstract：:Hepatitis C is a major cause of liver-related morbidity and mortality worldwide. In fact, chronic hepatitis C is considered as one of the primary causes of chronic liver disease, cirrhosis and hepatocellular carcinoma, and is the most common reason for liver transplantation. The primary objectives for the treatment of...

journal_title：World journal of gastroenterology

authors： Festi D,Sandri L,Mazzella G,Roda E,Sacco T,Staniscia T,Capodicasa S,Vestito A,Colecchia A

更新日期：2004-01-01 00:00:00

abstract：AIM:To identify the actual clinical management and associated factors of delayed perforation after gastric endoscopic submucosal dissection (ESD). METHODS:A total of 4943 early gastric cancer (EGC) patients underwent ESD at our hospital between January 1999 and June 2012. We retrospectively assessed the actual managem...

journal_title：World journal of gastroenterology

authors： Suzuki H,Oda I,Sekiguchi M,Abe S,Nonaka S,Yoshinaga S,Nakajima T,Saito Y

更新日期：2015-11-28 00:00:00

abstract：:Inflammatory bowel disease is an important cause of gastrointestinal pathology in children and adolescents. The incidence of pediatric inflammatory bowel disease is increasing; therefore, it is important for the clinician to be aware of the presentation of this disease in the pediatric population. Laboratory tests, ra...

journal_title：World journal of gastroenterology

authors： Diefenbach KA,Breuer CK

更新日期：2006-05-28 00:00:00

abstract：:Complete response to chemoradiotherapy for rectal cancer is becoming a common clinical entity. Techniques to diagnose complete response and how to survey these patients without operative intervention are still unclear. We review the most recent evidence. Barriers to firm conclusions regarding this are heterogeneity of...

journal_title：World journal of gastroenterology

authors： Couch DG,Hemingway DM

更新日期：2016-01-14 00:00:00

abstract：AIM:To analyze, retrospectively in a population-based study, the management and survival of patients with recurrent rectal cancer initially treated with a macroscopically radical resection obtained with total mesorectal excision (TME). METHODS:All rectal carcinomas diagnosed during 1998 to 2000 and initially treated w...

journal_title：World journal of gastroenterology

authors： Bakx R,Visser O,Josso J,Meijer S,Slors JF,van Lanschot JJ

更新日期：2008-10-21 00:00:00

abstract：:Ulcerative colitis (UC) is a chronic inflammatory bowel condition characterised by a relapsing and remitting course. Symptom control has been the traditional mainstay of medical treatment. It is well known that histological inflammatory activity persists despite adequate symptom control and absence of endoscopic infla...

journal_title：World journal of gastroenterology

authors： Mohammed N,Subramanian V

更新日期：2016-11-14 00:00:00

abstract：:Acute liver failure is a rare presentation of hematologic malignancy. Acute on chronic liver failure (ACLF) is a newly recognized clinical entity that describes acute hepatic decompensation in persons with preexisting liver disease. Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin's lymphoma (NHL) wi...

journal_title：World journal of gastroenterology

authors： Siba Y,Obiokoye K,Ferstenberg R,Robilotti J,Culpepper-Morgan J

更新日期：2014-11-28 00:00:00

abstract：AIM:To investigate the role of Delta-like ligand 4 (DLL4) on tumour growth in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) in vivo. METHODS:We suppressed DLL4 expression in an HBV expressing HCC cell line, HepG2.2.15 and analysed the growth ability of cells as subcutaneous tumours in nude mice. Th...

journal_title：World journal of gastroenterology

authors： Kunanopparat A,Issara-Amphorn J,Leelahavanichkul A,Sanpavat A,Patumraj S,Tangkijvanich P,Palaga T,Hirankarn N

更新日期：2018-09-14 00:00:00

abstract：AIM:To investigate the efficacy of neoadjuvant chemoradiotherapy (NACRT) for resectability of locally advanced gastric cancer (LAGC). METHODS:Between November 2007 and January 2014, 29 patients with LAGC (clinically T3 with distal esophagus invasion/T4 or bulky regional node metastasis) that were treated with NACRT fo...

journal_title：World journal of gastroenterology

authors： Kim MS,Lim JS,Hyung WJ,Lee YC,Rha SY,Keum KC,Koom WS

更新日期：2015-03-07 00:00:00

abstract：AIM:To evaluate the significance of hsp90alpha expression in human gastric cancer tissues. METHODS:Immunohistochemical staining was used in clinical specimens from 33 cases of gastric cancer and 33 cases of gastritis with rabbit anti-human hsp90alpha multi-clonal antibody in order to explore the relationship between t...

journal_title：World journal of gastroenterology

authors： Zuo DS,Dai J,Bo AH,Fan J,Xiao XY

更新日期：2003-11-01 00:00:00

abstract：AIM:This study is aimed at investigating the expression and possible significances of very low-density lipoprotein receptor (VLDLR) subtypes in gastroenteric adenocarcinoma tissues and cells with various differentiations. METHODS:Thirty-one cases of gastroenteric carcinoma/adjacent normal tissues were enrolled in the ...

journal_title：World journal of gastroenterology

authors： Chen T,Wu F,Chen FM,Tian J,Qu S

更新日期：2005-05-14 00:00:00

abstract：AIM:To assess the impact of preoperative neoadjuvant bevacizumab (Bev) on the outcome of patients undergoing resection for colorectal liver metastases (CLM). METHODS:Eligible trials were identified from Medline, Embase, Ovid, and the Cochrane database. The data were analyzed with fixed-effects or random-effects models...

journal_title：World journal of gastroenterology

authors： Li DB,Ye F,Wu XR,Wu LP,Chen JX,Li B,Zhou YM

更新日期：2013-02-07 00:00:00

abstract：AIM:To investigate the immunogenicity of candidate DNA vaccine against hepatitis C virus (HCV) delivered by two plasmids expressing HCV envelope protein 1 (E1) and envelope protein 2 (E2) antigens respectively and to study the effect of CpG adjuvant on this candidate vaccine. METHODS:Recombinant plasmids expressing HC...

journal_title：World journal of gastroenterology

authors： Zhu LX,Liu J,Ye Y,Xie YH,Kong YY,Li GD,Wang Y

更新日期：2004-09-01 00:00:00

abstract：AIM:To conduct a prospective assessment of anti-hepatitis E virus (HEV) IgG seroprevalence in the Western Cape Province of South Africa in conjunction with evaluating risk factors for exposure. METHODS:Consenting participants attending clinics and wards of Groote Schuur, Red Cross Children's Hospital and their affilia...

journal_title：World journal of gastroenterology

authors： Madden RG,Wallace S,Sonderup M,Korsman S,Chivese T,Gavine B,Edem A,Govender R,English N,Kaiyamo C,Lutchman O,van der Eijk AA,Pas SD,Webb GW,Palmer J,Goddard E,Wasserman S,Dalton HR,Spearman CW

更新日期：2016-11-28 00:00:00

abstract：AIM:To investigate functional change of dendritic cells (DCs) derived from allogeneic partial liver graft undergoing acute rejection in rats. METHODS:Allogeneic (SD rat to LEW rat) whole and 50 % partial liver transplantation were performed. DCs from liver grafts 0 hr and 4 days after transplantation were isolated and...

journal_title：World journal of gastroenterology

authors： Xu MQ,Yao ZX

更新日期：2003-01-01 00:00:00

abstract：:A primary clear cell adenocarcinoma of the colon is a rare oncologic entity. We herein report a case of such a tumor of the sigmoid colon in a 71-year-old woman who was successfully treated by an endoscopic polypectomy in our hospital. We also reviewed the published reports regarding cases of primary clear cell tumors...

journal_title：World journal of gastroenterology

authors： Soga K,Konishi H,Tatsumi N,Konishi C,Nakano K,Wakabayashi N,Mitsufuji S,Kataoka K,Okanoue T,Mukaisho K,Hattori T

更新日期：2008-02-21 00:00:00

abstract：AIM:To determine the expression characteristics of connective tissue growth factor (CTGF/CCN2) in human hepatocellular carcinoma (HCC) in histology and to elucidate the roles of CCN2 on hepatoma cell cycle progression and metastasis in vitro. METHODS:Liver samples from 36 patients (who underwent hepatic resection for ...

journal_title：World journal of gastroenterology

authors： Xiu M,Liu YH,Brigstock DR,He FH,Zhang RJ,Gao RP

更新日期：2012-12-21 00:00:00

abstract：AIM:to approach the relationship between alveolar echinococcosis (AE) pathology and level of sIL-2R,TNF-alpha and IFN-gamma in sera and the significance of cytokines in development of AE. METHODS:After 23 patients with AE were confirmed by ELISA and ultrasound, their sera were collected and the concentrations of sIL-2...

journal_title：World journal of gastroenterology

authors： Shi DZ,Li FR,Bartholomot B,Vuitton DA,Craig PS

更新日期：2004-12-15 00:00:00

abstract：:Gluten-sensitive enteropathy, also known as coeliac disease (CD), is an autoimmune disorder occurring in genetically susceptible individuals that damages the small intestine and interferes with the absorption of other nutrients. As it is triggered by dietary gluten and related prolamins present in wheat, rye and barle...

journal_title：World journal of gastroenterology

authors： Sziksz E,Pap D,Veres G,Fekete A,Tulassay T,Vannay Á

更新日期：2014-06-07 00:00:00

abstract：AIM:To establish a quantitative method to measure the amount of lipids. METHODS:The livers of 53 male Wistar rats (225 g) with different degrees of hepatic steatosis were studied. This model of hepatic steatosis was based on a high carbohydrate, fat-free modified diet. Biopsies were classified into four grades dependi...

journal_title：World journal of gastroenterology

authors： Hijona E,Hijona L,Larzabal M,Sarasqueta C,Aldazabal P,Arenas J,Bujanda L

更新日期：2010-03-28 00:00:00

abstract：AIM:To determine the incidence of Epstein Barr virus associated gastric carcinoma (GC) in Brazil and compare the expressions of apoptosis related proteins and nitric oxide synthases between EBV positive and negative gastric carcinoma. METHODS:In situ hybridization of EBV-encoded small RNA-1 (EBER-1) and PCR was perfor...

journal_title：World journal of gastroenterology

authors： Begnami MD,Montagnini AL,Vettore AL,Nonogaki S,Brait M,Simoes-Sato AY,Seixas AQ,Soares FA

更新日期：2006-08-21 00:00:00

abstract：:Hilar tumors have proven to be a challenge to treat and manage because of their poor sensitivity to conventional therapies and our inability to prevent or to detect early tumor formation. Endoscopic stent drainage has been proposed as an alternative to biliary-enteric bypass surgery and percutaneous drainage to pallia...

journal_title：World journal of gastroenterology

authors： De Palma GD,Masone S,Rega M,Simeoli I,Salvatori F,Siciliano S,Maione F,Girardi V,Celiento M,Persico G

更新日期：2007-08-14 00:00:00

abstract：:Traditional serrated adenoma (TSA) is a type of serrated polyp of the colorectum and is thought to be a precancerous lesion. There are three types of serrated polyps, namely, hyperplastic polyps, sessile serrated adenomas/polyps, and TSAs. TSA is the least common of the three types and accounts for about 5% of serrate...

journal_title：World journal of gastroenterology

authors： Kondo S,Mori H,Nishiyama N,Kondo T,Shimono R,Okada H,Kusaka T

更新日期：2017-06-28 00:00:00