Abstract：
AIMS:We investigated to clarify factors associated with the efficacy of sitagliptin, a dipeptidyl peptidase (DPP)-IV inhibitor, for glycemic control including the confounding effect of concomitant drugs in patients with type 2 diabetes. METHODS:We included type 2 diabetes patients with HbA1c levels of ≥7% who were not under insulin treatment and were administered sitagliptin (50mg/day for 6 months). Reduction or discontinuation of insulin sensitizers was not permitted during the study period. Outcomes included HbA1c level variations and attaining a target HbA1c level of <7%. Associated factors with each outcome were examined using multivariate analysis. RESULTS:Of the 313 patients enrolled in this study, 147 (47.0%) attained HbA1c levels of <7%. High baseline HbA1c levels were associated with HbA1c level variations but inversely associated with attaining the target HbA1c level of <7%. Concomitant use of an insulin sensitizer and a α-glucosidase inhibitor and maintenance of the baseline dose of concomitant drugs were significantly associated with each outcome. CONCLUSIONS:Our results suggest that concomitant sitagliptin administration (50mg/day) will improve glycemic control if treatment is initiated before HbA1c levels deteriorate. Other medication should be continued at initiation of sitagliptin administration.
journal_name
Prim Care Diabetesjournal_title
Primary care diabetesauthors
Hirata T,Inukai K,Morimoto J,Katayama S,Ishida Hdoi
10.1016/j.pcd.2014.01.008subject
Has Abstractpub_date
2014-10-01 00:00:00pages
265-70issue
3eissn
1751-9918issn
1878-0210pii
S1751-9918(14)00009-6journal_volume
8pub_type
杂志文章,多中心研究abstract：:Insulin detemir provides prolonged, reproducible blood glucose reduction through a mechanism unique among basal insulins. It was originally studied clinically in predominantly basal + bolus regimens and found to be associated with a low risk of hypoglycaemia compared to insulin NPH, and reduced weight gain compared to...
journal_title：Primary care diabetes
pub_type： 历史文章,杂志文章
doi：10.1016/S1751-9918(10)60007-1
更新日期：2010-04-01 00:00:00
abstract：INTRODUCTION:Diabetes knowledge has a large impact on glycemic control. There is a pressing need for creation of validated tests of knowledge for different ethnic groups. OBJECTIVE:To create and validate a diabetes knowledge test (DKT) for young Indians with type 1 diabetes mellitus (T1DM). METHODS:We created a 34 it...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2018.12.001
更新日期：2019-06-01 00:00:00
abstract：AIM:To identify risk factors of diabetic retinopathy (DR) among people with Type 2 diabetes mellitus in UK primary care. METHODS:A case-control study nested in a cohort of incident Type 2 diabetes identified in The Health Improvement Network database from 2000 to 2007. Cases were people with DR (N=7735) and controls w...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2016.01.002
更新日期：2016-08-01 00:00:00
abstract：AIMS:To analyze the use of pain medication among community-dwelling people aged 65 years or older with and without type 2 diabetes in primary care. METHODS:A total of 187 patients with and 176 patients without diabetes were randomly selected from a primary care sample of 389 patients with diabetes and 604 age- and gen...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2020.05.016
更新日期：2020-12-01 00:00:00
abstract：:There are several tools for the assessment of quality of life (QOL) in diabetes mellitus. In the current research, two standard questionnaires for evaluating of QOL were selected. First one was a questionnaire from the World Health Organization quality of life (WHOQOL-BREF 26) and the second one, The Iranian diabetics...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2011.02.001
更新日期：2011-07-01 00:00:00
abstract：OBJECTIVE:The previous study served impaired fasting glucose (IFG), a pre-diabetic state which was much greater than that of diabetic patients, have reached no consensus on its cut-off value. In this study, we aimed to explore the cut-off value of IFG via the associations of blood lipids with fasting plasma glucose (FP...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2019.07.004
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:The way that GP practices organize their services impacts as much on glycaemia in type 2 diabetes as does prescribing. AIM:Our aim was to evaluate the link between patients' own perception of support within primary care and the % patients at each GP practice at target glycaemic control (TGC) and at high gly...
journal_title：Primary care diabetes
pub_type： 杂志文章,多中心研究
doi：10.1016/j.pcd.2019.04.005
更新日期：2020-02-01 00:00:00
abstract：AIMS:To assess to which extent lowering the level of HbA1c influences the 10-year risk of coronary heart disease (CHD) and all-cause mortality in patients with type 2 diabetes mellitus. METHODS:A literature search in Pubmed and Embase was performed, and the absolute risks in the results of the relevant and valid studi...
journal_title：Primary care diabetes
pub_type： 杂志文章,评审
doi：10.1016/j.pcd.2007.12.004
更新日期：2008-02-01 00:00:00
abstract：AIMS:Raising awareness of diabetic retinopathy (DR) was shown to be a key element for early diagnosis and treatment of this blinding disease. There is very limited data about the knowledge level, attitude, and behavior of diabetic patients regarding DR in Turkey. This study was planned to assess the awareness of DR and...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2013.04.002
更新日期：2013-12-01 00:00:00
abstract：AIMS:To identify risk factors for falls in older people with diabetes mellitus (DM) and to develop a low-cost fall risk screening tool. METHODS:Older adults with DM (n = 103; age = 61.6 + 6.0 years) were recruited from diabetic clinics. Demographic, DM specific factors, lower limb strength and sensation, cognition, fe...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2020.05.006
更新日期：2020-12-01 00:00:00
abstract：AIMS:To investigate associations between diabetes distress and productivity, and to identify the potential risk factors that could affect these particular associations. METHODS:This cross-sectional study was conducted in three outpatient healthcare institutions. Patients aged ≥21 years with uncontrolled T2DM and polyp...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2020.04.004
更新日期：2020-10-01 00:00:00
abstract：AIMS:The purpose of our investigation was to identify the genetic and clinical risk factors of type 2 diabetes mellitus (T2DM) and to predict the incidence of T2DM in Korean adults aged 40-69 at follow-up intervals of 5, 7, and 10years. METHODS:Korean Genome and Epidemiology Study (KoGES) cohort data (n=10,030) were u...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2018.07.004
更新日期：2019-02-01 00:00:00
abstract：AIMS:To describe the diabetic population receiving primary care from the Tshwane district public health services and to assess the quality of care of members of this population, their level of disease control and the extent of their complications. METHODS:A cluster-randomised trial was conducted in 12 primary care cli...
journal_title：Primary care diabetes
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pcd.2014.05.002
更新日期：2015-04-01 00:00:00
abstract：AIM:We wanted to investigate third-trimester HbA1c as a predictor of diabetes after gestational diabetes mellitus (GDM). METHODS:Women with GDM were followed up prospectively for five years from pregnancy to detect the development of diabetes. The ability of HbA1c to predict diabetes was evaluated with receiver-operat...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2016.09.002
更新日期：2017-02-01 00:00:00
abstract：AIMS:To evaluate the health-related quality of life (HRQoL) and functional capacity in relation to glycemic control among older home-dwelling primary care patients. METHODS:Electronic patient records were used to identify 527 people over 65 years with diabetes. Of these, 259 randomly selected subjects were invited to ...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2017.07.001
更新日期：2017-12-01 00:00:00
abstract：:Our study demonstrates that Ipswich Touch Test is reliable and comparable to established standardized tests that identify the risk of foot ulceration among Saudi patients with diabetes mellitus. The simplicity of the test will assist in overcoming the barriers to screen for and detect the risk of foot ulceration. ...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2014.10.007
更新日期：2015-08-01 00:00:00
abstract：AIMS:Type 2 diabetes mellitus imposes significant burdens on patients and health care systems. Population-level interventions are being implemented to reach large numbers of patients at risk of or diagnosed with diabetes. We describe a population-based evaluation of the Southeastern Diabetes Initiative (SEDI) from the ...
journal_title：Primary care diabetes
pub_type： 杂志文章,多中心研究
doi：10.1016/j.pcd.2017.10.003
更新日期：2018-04-01 00:00:00
abstract：AIMS:The prevalence of Type 2 Diabetes Mellitus among adolescents in the United States continues to rise, following the trajectory of the obesity epidemic which posits not only a substantial health burden to our society, but also a significant threat to the wellbeing of America's youth. While a number of studies have e...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2020.05.017
更新日期：2021-02-01 00:00:00
abstract：AIM:Depression is prevalent in patients with type 2 diabetes. It may have a negative impact on the management of diabetes mellitus and could affect weight. The main aim of the investigation was to evaluate the effect of antidepressant treatment (sertraline) on anthropometric variables and glycemic control in depressed ...
journal_title：Primary care diabetes
pub_type： 临床试验,杂志文章
doi：10.1016/j.pcd.2018.09.003
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:The influenza virus is an important cause of morbidity and mortality for diabetics. The seasonal influenza vaccine's immunologic effectiveness is proven within the type 1 and type 2 diabetic populations, but the level of evidence is low. This article presents a systematic review for the bias in the measure o...
journal_title：Primary care diabetes
pub_type： 杂志文章,评审
doi：10.1016/j.pcd.2016.05.005
更新日期：2016-12-01 00:00:00
abstract：AIMS:This study investigated (factors related to) (a) the response to a screening procedure for depression and anxiety in people with type 2 diabetes in primary care, and (b) participation in a subsequent randomised controlled trial targeting depressive or anxiety symptoms. METHODS:People with type 2 diabetes (n=1837)...
journal_title：Primary care diabetes
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pcd.2017.02.006
更新日期：2017-06-01 00:00:00
abstract：AIMS:To investigate whether long-term mortality or clinical outcomes differed between patients diagnosed with type 2 diabetes mellitus and presenting with HbA1c within or above normal range at time of diagnosis. METHODS:Data were from a population-based sample of 1136 individuals with newly diagnosed type 2 diabetes m...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2012.09.001
更新日期：2013-04-01 00:00:00
abstract：:Diabetes mellitus (DM) is a frequent disorder affecting individuals of all ages. Glycohemoglobin (GHb) has a key role in the assessment of glycemic control in diabetic patients. Generally, GHb is measured as hemoglobin (Hb) A1C and is the result of an irreversible non-enzymatic glycation of the beta chain of hemoglobi...
journal_title：Primary care diabetes
pub_type： 杂志文章,评审
doi：10.1016/j.pcd.2007.07.004
更新日期：2007-09-01 00:00:00
abstract：AIM:The aim of the study was to determine factors influencing foot care behaviors among adults with type 2 diabetes. METHODS:A correlational descriptive study was conducted with a random sample of 160 adults with type 2 diabetes from the public hospital between April and July 2014. RESULTS:Just over 15% of the sample...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2016.04.002
更新日期：2016-12-01 00:00:00
abstract：AIM:This paper determines whether patients with and without Diabetic Peripheral Neuropathy use suitable footwear, taking into account that these persons are subject to a significant loss of sensitivity in the feet. METHODS:Cross-sectional observational study was conducted of 108 participants with diabetes mellitus. In...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2020.08.009
更新日期：2021-02-01 00:00:00
abstract：OBJECTIVE:The objective of this observational open label trial was to characterize changes in diabetes self-management and psychological distress associated with a mobile health (mHealth) interactive voice response (IVR) self-management support program. METHODS:For 3-6 months, 301 patients with diabetes received weekl...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2014.06.003
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:The collaborative care model has been shown in studies to be effective in achieving sustained treatment outcomes in chronic disease management. Its success is highly dependent on active patient engagement, provider endorsement and effective care management. This study sought to ask patients and providers wha...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2012.03.003
更新日期：2012-10-01 00:00:00
abstract：:Seasonal variations in fasting glucose and HbA1c levels in 638 diabetic patients (attending a primary care diabetic clinic during 2003-2007) were examined and found to be significantly higher in colder than in warmer months. Moreover, there were apparent peaks in fasting glucose levels after Christmas and Easter month...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2009.05.004
更新日期：2009-05-01 00:00:00
abstract：AIMS:The goal of this retrospective cohort study was to analyze the incidence of, and factors associated with the antiepileptic drug (AED) therapy in the five years following the diagnosis of diabetic polyneuropathy in patients followed in Germany. METHODS:The study included patients aged 18-80 years with an initial d...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2020.12.005
更新日期：2021-01-06 00:00:00
abstract：AIMS:To study the frequency and intensity of depressive symptoms and associations with physician resource utilisation following insulin initiation in patients with type 2 diabetes mellitus. METHODS:SOLVE was a 24-week observational study. In this sub-analysis of data from Poland, depressive symptoms were evaluated usi...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2015.01.002
更新日期：2015-10-01 00:00:00
