Abstract：
AIMS:The purpose of our investigation was to identify the genetic and clinical risk factors of type 2 diabetes mellitus (T2DM) and to predict the incidence of T2DM in Korean adults aged 40-69 at follow-up intervals of 5, 7, and 10years. METHODS:Korean Genome and Epidemiology Study (KoGES) cohort data (n=10,030) were used to develop T2DM prediction models. Both clinical-only and integrated (clinical factors+genetic factors) models were derived using the Cox proportional hazards model. Internal validation was performed to evaluate the prediction capabilities of the clinical and integrated models. RESULTS:The clinical model included 10 selected clinical risk factors. The selected SNPs for the integrated model were rs9311835 in PTPRG, rs10975266 in RIC1, rs11057302 in TMED2, rs17154562 in ADAM12, and rs8038172 in CGNL1. For the clinical model, validated c-indices with time points of 5, 7, and 10 years were 0.744, 0.732, and 0.732, respectively. Slightly higher validated c-indices were observed for the integrated model at 0.747, 0.736, and 0.738, respectively. The p-values of the survival net reclassification improvement (NRI) for the SNP point-based score were statistically significant. CONCLUSIONS:Clinical and integrated models can be effectively used to predict the incidence of T2DM in Koreans.
journal_name
Prim Care Diabetesjournal_title
Primary care diabetesauthors
Kim SH,Lee ES,Yoo J,Kim Ydoi
10.1016/j.pcd.2018.07.004subject
Has Abstractpub_date
2019-02-01 00:00:00pages
3-10issue
1eissn
1751-9918issn
1878-0210pii
S1751-9918(18)30197-9journal_volume
13pub_type
杂志文章abstract：AIM:To investigate the effect of the BATHE therapeutic interview technique on the empowerment of diabetes mellitus patients in primary care. METHOD:A cluster randomised controlled study using the BATHE interview technique was conducted on diabetes mellitus patients in primary care. Physicians in the intervention group...
journal_title：Primary care diabetes
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pcd.2016.12.003
更新日期：2017-04-01 00:00:00
abstract：AIM:Depression is prevalent in patients with type 2 diabetes. It may have a negative impact on the management of diabetes mellitus and could affect weight. The main aim of the investigation was to evaluate the effect of antidepressant treatment (sertraline) on anthropometric variables and glycemic control in depressed ...
journal_title：Primary care diabetes
pub_type： 临床试验,杂志文章
doi：10.1016/j.pcd.2018.09.003
更新日期：2019-02-01 00:00:00
abstract：:HbA1c values are heavily relied on to assess glycemic control. Hemoglobin variants may interfere with measurements of HbA1c resulting in falsely low values. We present the first report of a rare variant of Hb in a patient with type 2 diabetes, which lead to a falsely low HbA1c. ...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2008.05.003
更新日期：2008-09-01 00:00:00
abstract：AIMS:To assess changes over two years in the health status and management of a cohort of people with Type 2 diabetes from different ethnic groups within a primary care diabetes annual review programme in New Zealand. METHODS:The study evaluated changes in clinical measures and proportions achieving guideline targets f...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2008.08.002
更新日期：2008-12-01 00:00:00
abstract：AIMS:The goal of this retrospective cohort study was to analyze the incidence of, and factors associated with the antiepileptic drug (AED) therapy in the five years following the diagnosis of diabetic polyneuropathy in patients followed in Germany. METHODS:The study included patients aged 18-80 years with an initial d...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2020.12.005
更新日期：2021-01-06 00:00:00
abstract：AIMS:To identify risk factors for falls in older people with diabetes mellitus (DM) and to develop a low-cost fall risk screening tool. METHODS:Older adults with DM (n = 103; age = 61.6 + 6.0 years) were recruited from diabetic clinics. Demographic, DM specific factors, lower limb strength and sensation, cognition, fe...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2020.05.006
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Albuminuria is an early marker of kidney disease in patients with diabetes and/or hypertension undetected or untreated albuminuria is a leading cause of chronic kidney disease and cardiovascular events, The purpose of the present survey was to assess the prevalence of albuminuria in patients with diabetes an...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2018.08.008
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:The previous study served impaired fasting glucose (IFG), a pre-diabetic state which was much greater than that of diabetic patients, have reached no consensus on its cut-off value. In this study, we aimed to explore the cut-off value of IFG via the associations of blood lipids with fasting plasma glucose (FP...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2019.07.004
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Type 2 Diabetes (T2D) continues to be an escalating public health problem contributes to increased morbidity and mortality. Although the complications of T2D is a major threat to the health of women of Arab descent, there is lack of information about their health practices and diabetes self-management behavi...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2020.10.009
更新日期：2020-11-08 00:00:00
abstract：AIMS:We investigated to clarify factors associated with the efficacy of sitagliptin, a dipeptidyl peptidase (DPP)-IV inhibitor, for glycemic control including the confounding effect of concomitant drugs in patients with type 2 diabetes. METHODS:We included type 2 diabetes patients with HbA1c levels of ≥7% who were not...
journal_title：Primary care diabetes
pub_type： 杂志文章,多中心研究
doi：10.1016/j.pcd.2014.01.008
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Diabetes is known as a major cause of morbidity and mortality worldwide. Portugal is known as the European country with the highest prevalence of this disease. While diabetes prevalence data is updated annually in Portugal, the General Practitioner's (GP) Sentinel Network represents the only data source on d...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2016.05.003
更新日期：2016-10-01 00:00:00
abstract：:Our study demonstrates that Ipswich Touch Test is reliable and comparable to established standardized tests that identify the risk of foot ulceration among Saudi patients with diabetes mellitus. The simplicity of the test will assist in overcoming the barriers to screen for and detect the risk of foot ulceration. ...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2014.10.007
更新日期：2015-08-01 00:00:00
abstract：AIMS:To evaluate the health-related quality of life (HRQoL) and functional capacity in relation to glycemic control among older home-dwelling primary care patients. METHODS:Electronic patient records were used to identify 527 people over 65 years with diabetes. Of these, 259 randomly selected subjects were invited to ...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2017.07.001
更新日期：2017-12-01 00:00:00
abstract：AIMS:Type 2 diabetes mellitus imposes significant burdens on patients and health care systems. Population-level interventions are being implemented to reach large numbers of patients at risk of or diagnosed with diabetes. We describe a population-based evaluation of the Southeastern Diabetes Initiative (SEDI) from the ...
journal_title：Primary care diabetes
pub_type： 杂志文章,多中心研究
doi：10.1016/j.pcd.2017.10.003
更新日期：2018-04-01 00:00:00
abstract：:Many patients with type 2 diabetes continue to have poor glycaemic control and would benefit from insulin therapy. However, resistance to the introduction of insulin therapy can be high on both the part of the healthcare provider and the patient. A number of new, long-acting basal insulins are in development that prov...
journal_title：Primary care diabetes
pub_type： 杂志文章,评审
doi：10.1016/j.pcd.2013.09.003
更新日期：2014-07-01 00:00:00
abstract：:The relative efficacy of different sodium glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide 1 receptor agonists (GLP-1 RAs) in reducing cardiorenal events in type 2 diabetic adults is unclear. We searched PubMed and Embase. Three primary endpoints were major adverse cardiovascular events (MACE), hos...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2020.08.017
更新日期：2020-09-07 00:00:00
abstract：OBJECTIVE:The aim of this research study was to ascertain the awareness of Maltese family doctors to the prevalence and significance of impaired glucose regulation and early diagnosis of type 2 diabetes and whether practices were influenced by employment status, post-graduate training in diabetes or years since graduat...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2013.12.003
更新日期：2014-10-01 00:00:00
abstract：AIM:This paper determines whether patients with and without Diabetic Peripheral Neuropathy use suitable footwear, taking into account that these persons are subject to a significant loss of sensitivity in the feet. METHODS:Cross-sectional observational study was conducted of 108 participants with diabetes mellitus. In...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2020.08.009
更新日期：2021-02-01 00:00:00
abstract：AIMS:This study investigates whether diabetes patients visiting a primary care setting are interested in using a telemonitoring platform and if so, whether characteristics of interested users could be distinguished. METHODS:Three questionnaires were administered by 92 diabetes persons recruited between May and Septemb...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2012.10.085
更新日期：2013-07-01 00:00:00
abstract：AIMS:To investigate associations between diabetes distress and productivity, and to identify the potential risk factors that could affect these particular associations. METHODS:This cross-sectional study was conducted in three outpatient healthcare institutions. Patients aged ≥21 years with uncontrolled T2DM and polyp...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2020.04.004
更新日期：2020-10-01 00:00:00
abstract：AIMS:This study investigated (factors related to) (a) the response to a screening procedure for depression and anxiety in people with type 2 diabetes in primary care, and (b) participation in a subsequent randomised controlled trial targeting depressive or anxiety symptoms. METHODS:People with type 2 diabetes (n=1837)...
journal_title：Primary care diabetes
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pcd.2017.02.006
更新日期：2017-06-01 00:00:00
abstract：AIMS:The prevalence of Type 2 Diabetes Mellitus among adolescents in the United States continues to rise, following the trajectory of the obesity epidemic which posits not only a substantial health burden to our society, but also a significant threat to the wellbeing of America's youth. While a number of studies have e...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2020.05.017
更新日期：2021-02-01 00:00:00
abstract：AIM:To compare once- versus twice-daily insulin detemir added on OADS therapy in insulin-naive type 2 diabetes patients in terms of efficacy and safety. METHODS:An open-label study performed at a single center, comprised a randomized, crossover 24 week with insulin-naive type 2 diabetes patients. Insulin detemir was i...
journal_title：Primary care diabetes
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pcd.2014.01.010
更新日期：2014-10-01 00:00:00
abstract：AIMS:Raising awareness of diabetic retinopathy (DR) was shown to be a key element for early diagnosis and treatment of this blinding disease. There is very limited data about the knowledge level, attitude, and behavior of diabetic patients regarding DR in Turkey. This study was planned to assess the awareness of DR and...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2013.04.002
更新日期：2013-12-01 00:00:00
abstract：AIMS:To investigate whether metabolic syndrome (MetS) is associated with erectile dysfunction (ED) among apparently healthy men when depressive symptoms and serum testosterone levels are taken into account. METHODS:A study population of 549 men at risk for cardiovascular disease or type 2 diabetes was drawn from the p...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2019.12.008
更新日期：2020-10-01 00:00:00
abstract：:Insulin detemir provides prolonged, reproducible blood glucose reduction through a mechanism unique among basal insulins. It was originally studied clinically in predominantly basal + bolus regimens and found to be associated with a low risk of hypoglycaemia compared to insulin NPH, and reduced weight gain compared to...
journal_title：Primary care diabetes
pub_type： 历史文章,杂志文章
doi：10.1016/S1751-9918(10)60007-1
更新日期：2010-04-01 00:00:00
abstract：:Several cases of positive real time-polymerase chain reaction (RT-PCR) results (called "re-positives") after recovery from COVID-19 have emerged worldwide. These cases could represent patients experiencing a "turn positive" of nucleic acid detection attributed to the high false-negative rate of RT-PCR. On the contrary...
journal_title：Primary care diabetes
pub_type： 杂志文章,评审
doi：10.1016/j.pcd.2020.08.002
更新日期：2021-02-01 00:00:00
abstract：AIMS:Incidence of type 1 diabetes mellitus (T1DM) is increasing worldwide. We aimed to study trends in presentation and incidence of childhood diabetes in the last 15years in south-western Iran. METHODS:During a detailed review of compiled records of the main tertiary children's hospital of southwest of Iran, from Jan...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2018.07.013
更新日期：2019-02-01 00:00:00
abstract：AIMS:To evaluate the incidence and risk factors for carotid artery stenosis amongst asymptomatic type 2 diabetes from a single Malaysian tertiary institution. METHODS:This is a prospective cross-sectional study of asymptomatic type 2 diabetics selected from the outpatient ophthalmology and endocrine clinics for caroti...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2019.10.001
更新日期：2020-08-01 00:00:00
abstract：OBJECTIVES:Novel interventions are needed for long-term maintenance of diabetes control. We studied the effects of a group diabetes clinic (GDC) on diabetes control when compared to usual care with primary care providers (PCP). RESEARCH DESIGN/METHODS:Data from the electronic medical records of 56 patients were collec...
journal_title：Primary care diabetes
pub_type： 杂志文章
doi：10.1016/j.pcd.2010.09.004
更新日期：2010-12-01 00:00:00
