Insulin detemir: A historical perspective on a modern basal insulin analogue.

Abstract:

:Insulin detemir provides prolonged, reproducible blood glucose reduction through a mechanism unique among basal insulins. It was originally studied clinically in predominantly basal + bolus regimens and found to be associated with a low risk of hypoglycaemia compared to insulin NPH, and reduced weight gain compared to other basal insulins. Insulin detemir has been increasingly studied in basal-only insulin regimens in type 2 diabetes, in which an understanding of how to optimize its use has been built incrementally. Glycaemic control and limitation of weight gain tend to be maximized by once-daily (evening) dosing, earlier initiation and careful titration to appropriate fasting glucose targets.

journal_name

Prim Care Diabetes

journal_title

Primary care diabetes

authors

Meneghini L,Liebl A,Abrahamson MJ

doi

10.1016/S1751-9918(10)60007-1

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

S31-42

eissn

1751-9918

issn

1878-0210

pii

S1751-9918(10)60007-1

journal_volume

4 Suppl 1

pub_type

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