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Graves' disease in subjects with type 1 diabetes mellitus: a prevalence study in western Sicily (Italy).

Abstract：

OBJECTIVE:To assess the prevalence of Graves' disease in patients with type 1 diabetes mellitus all coming from a defined geographical area (western Sicily-Italy) and to investigate the clinical features of these subjects. METHODS:The records of 470 consecutive patients with type 1 diabetes mellitus referred in a 5-year period were analyzed. RESULTS:During the period of the survey, out of 470 patients with type 1 diabetes, 14 (3%) had a previous diagnosis of Graves' disease. There were 9 female and 5 male; these patients showed a high age at diabetes onset (mean 38 years). Diagnosis of Graves' disease was often pre-existing or simultaneous to that of diabetes. Vitiligo was coexisting in 4 subjects; none of them presented other autoimmune diseases. Graves' orbitopathy was present in two cases. CONCLUSIONS:Our data confirm the frequent association between Graves' disease and type 1 diabetes. Graves' disease often preceded diagnosis of type 1 diabetes, particularly in female subjects with a high age at diabetes onset; therefore, in these subjects, an active search for the presence of pancreatic autoimmunity is warranted for many years after thyroid dysfunction appearance.

journal_name

Prim Care Diabetes

journal_title

Primary care diabetes

authors

Greco D,Pisciotta M,Gambina F,Maggio F

doi

10.1016/j.pcd.2011.06.001

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

241-4

issue

4

eissn

1751-9918

issn

1878-0210

pii

S1751-9918(11)00047-7

journal_volume

5

pub_type

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