Abstract：
AIM:To compare once- versus twice-daily insulin detemir added on OADS therapy in insulin-naive type 2 diabetes patients in terms of efficacy and safety. METHODS:An open-label study performed at a single center, comprised a randomized, crossover 24 week with insulin-naive type 2 diabetes patients. Insulin detemir was initiated with mean 0.12 U/kg in all patients (Group I once-daily, Group II twice-daily) and titrated for 24 week. RESULTS:A total of 50 patients completed the study (Group I n:25, Group II n:25). With use of once- and twice-daily insulin, HbA1c values were decreased by 1.8% (±2.0) and 1.5% (±1.4) within the first 12 weeks (p<0.01), whereas increased by 0.21% (±0.7) and 0.14% (±0.8) in the second 12 weeks (p>0.05). The increases in the insulin doses were found as 0.22 U/kg and 0.35 U/kg with once- and twice-daily insulin use, respectively (p:0.04). Although minor hypoglycemic events were similar in both groups in the first 12 weeks, 2-fold increase was found in the patients shifting from once- to twice-daily dose. Within the first and second periods, the body weight of the patients was observed an increase of 0.4 and 1.6 kg with once-daily dose, whereas a decrease of 0.1 and 2.1 kg in the twice-daily dose, in the same period. CONCLUSION:Once-daily use of insulin detemir up to 0.4 U/kg was found to have similar efficacy and safety as twice-daily use. Twice dose use of insulin did not provide a prominent glycemic control advantage on 1.5-fold higher use of insulin.
journal_name
Prim Care Diabetesjournal_title
Primary care diabetesauthors
Cander S,Dizdar OS,Oz Gul O,Guclu M,Unal OK,Tuncel E,Erturk E,Imamoglu S,Ersoy Cdoi
10.1016/j.pcd.2014.01.010subject
Has Abstractpub_date
2014-10-01 00:00:00pages
256-64issue
3eissn
1751-9918issn
1878-0210pii
S1751-9918(14)00011-4journal_volume
8pub_type
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2008-12-01 00:00:00
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更新日期：2020-10-01 00:00:00
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更新日期：2019-02-01 00:00:00
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journal_title：Primary care diabetes
pub_type： 杂志文章,多中心研究
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更新日期：2014-10-01 00:00:00
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journal_title：Primary care diabetes
pub_type： 杂志文章,评审
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journal_title：Primary care diabetes
pub_type： 杂志文章
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更新日期：2009-08-01 00:00:00
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journal_title：Primary care diabetes
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更新日期：2009-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-12-01 00:00:00
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journal_title：Primary care diabetes
pub_type： 杂志文章
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更新日期：2015-10-01 00:00:00
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journal_title：Primary care diabetes
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doi：10.1016/j.pcd.2018.01.008
更新日期：2018-08-01 00:00:00
