Delivery of an LGA infant and the maternal risk of diabetes: A prospective cohort study.

Abstract:

AIMS:Was to determine whether the birth weight of the infant predicts prediabetes (impaired fasting glucose, impaired glucose tolerance, or both) and type 2 diabetes (T2DM) during long-term follow-up of women with or without gestational diabetes mellitus (GDM). METHODS:The women with or without GDM during their pregnancies in Kuopio University Hospital in 1989-2009 (n=876) were contacted and invited for an evaluation. They were stratified into two groups according to the newborn's birth weight: 10-90th percentile (appropriate-for-gestational-age; AGA) (n=662) and >90th percentile (large-for-gestational-age; LGA) (n=116). Glucose tolerance was investigated with an oral glucose tolerance test after a mean follow-up time of 7.3 (SD 5.1) years. RESULTS:The incidence of T2DM was 11.8% and 0% in the women with and without GDM, respectively, after an LGA delivery. The incidence of prediabetes increased with offspring birth weight categories in the women with and without GDM: from 46.3% and 26.2% (AGA) to 52.9% and 29.2% (LGA), respectively. CONCLUSIONS:GDM women with LGA infants are at an increased risk for subsequent development of T2DM and therefore represent a target group for intervention to delay or prevent T2DM development. In contrast, an LGA delivery without GDM does not increase T2DM risk.

journal_name

Prim Care Diabetes

journal_title

Primary care diabetes

authors

Hakkarainen H,Huopio H,Cederberg H,Voutilainen R,Heinonen S

doi

10.1016/j.pcd.2018.04.002

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

364-370

issue

4

eissn

1751-9918

issn

1878-0210

pii

S1751-9918(18)30075-5

journal_volume

12

pub_type

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