Abstract:
:The relative efficacy of different sodium glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide 1 receptor agonists (GLP-1 RAs) in reducing cardiorenal events in type 2 diabetic adults is unclear. We searched PubMed and Embase. Three primary endpoints were major adverse cardiovascular events (MACE), hospitalization for heart failure (HHF), and kidney function progression (KFP). Bayesian network meta-analysis was conducted to synthesize hazard ratio (HR) and 95% confidence interval (CI). We calculated surface under the cumulative ranking curve (SUCRA) to rank drug treatments. Subcutaneous semaglutide (HR 0.73, 95% CI 0.55-0.96) and albiglutide (HR 0.76, 95% CI 0.63-0.93) significantly reduced MACE versus lixisenatide. Canagliflozin (HRs: 0.69, 0.68, 0.67 and 0.58) and empagliflozin (HRs: 0.70, 0.69, 0.68 and 0.59) significantly reduced HHF versus dulaglutide, exenatide, lixisenatide and subcutaneous semaglutide. Dapagliflozin (HRs: 0.62, 0.60, 0.68 and 0.63) and empagliflozin (HRs: 0.64, 0.61, 0.69 and 0.64) significantly reduced KFP versus dulaglutide, exenatide, liraglutide and lixisenatide. Different drug treatments had the maximum SUCRA values as for preventing different cardiorenal endpoints. Different GLP-1 RAs and SGLT2 inhibitors have different efficacy in preventing cardiorenal endpoints in type 2 diabetes, and the most efficacious drugs are different as for preventing different cardiorenal endpoints.
journal_name
Prim Care Diabetesjournal_title
Primary care diabetesauthors
Wei XB,Wei W,Ding LL,Liu SYdoi
10.1016/j.pcd.2020.08.017subject
Has Abstractpub_date
2020-09-07 00:00:00eissn
1751-9918issn
1878-0210pii
S1751-9918(20)30253-9pub_type
杂志文章abstract:BACKGROUND:Diabetes is known as a major cause of morbidity and mortality worldwide. Portugal is known as the European country with the highest prevalence of this disease. While diabetes prevalence data is updated annually in Portugal, the General Practitioner's (GP) Sentinel Network represents the only data source on d...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2016.05.003
更新日期:2016-10-01 00:00:00
abstract:AIM:To investigate if micro- and macrovascular co-morbidity has an influence on the time to insulin initiation in type 2 diabetes patients. METHODS:Longitudinal data from general practices in Germany, France and UK (Disease Analyzer) from 1995 to 2009 were analyzed, including 44,440 patients in Germany, 10,148 patient...
journal_title:Primary care diabetes
pub_type: 杂志文章,多中心研究
doi:10.1016/j.pcd.2013.02.001
更新日期:2013-07-01 00:00:00
abstract:INTRODUCTION:Diabetes knowledge has a large impact on glycemic control. There is a pressing need for creation of validated tests of knowledge for different ethnic groups. OBJECTIVE:To create and validate a diabetes knowledge test (DKT) for young Indians with type 1 diabetes mellitus (T1DM). METHODS:We created a 34 it...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2018.12.001
更新日期:2019-06-01 00:00:00
abstract:AIMS:To evaluate the incidence and risk factors for carotid artery stenosis amongst asymptomatic type 2 diabetes from a single Malaysian tertiary institution. METHODS:This is a prospective cross-sectional study of asymptomatic type 2 diabetics selected from the outpatient ophthalmology and endocrine clinics for caroti...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2019.10.001
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:To examine the prevalence of chronic kidney disease (CKD) and related cardiovascular morbidity in a cross-sectional population in patients with type 2 diabetes (T2D) treated in a primary care setting in Finland. RESEARCH DESIGN AND METHODS:Data were collected and recorded from 42 primary care centres, which ...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2014.06.001
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Prediction algorithms are increasingly advocated in diabetes screening strategies, particularly in developing countries. We conducted a systematic review to assess the application and applicability of existing non-invasive prevalent diabetes risk models to populations within Africa. DESIGN:syste...
journal_title:Primary care diabetes
pub_type: 杂志文章,评审
doi:10.1016/j.pcd.2015.04.004
更新日期:2015-10-01 00:00:00
abstract:AIM:In the current study the relationship between self-reported nocturnal sleep duration (NSD) and daytime sleepiness with 24-h urinary protein excretion (UPE) and 24-h urinary albumin excretion (UAE) were investigated in patients with newly diagnosed type 2 diabetes mellitus. METHODS:All patients underwent history ta...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2013.01.002
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:The aim of this study was to analyze the mortality trends of diabetes mellitus in Serbia (excluding the Autonomous Province of Kosovo and Metohia). METHODS:A population-based cross sectional study analyzing diabetes mortality in Serbia in the period 1991-2015 was carried out based on official data. The age-sta...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2016.08.019
更新日期:2017-02-01 00:00:00
abstract:AIM:The aim of the study was to determine factors influencing foot care behaviors among adults with type 2 diabetes. METHODS:A correlational descriptive study was conducted with a random sample of 160 adults with type 2 diabetes from the public hospital between April and July 2014. RESULTS:Just over 15% of the sample...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2016.04.002
更新日期:2016-12-01 00:00:00
abstract::Blood pressure management guidelines are widely available. Our aim was to examine differences in blood pressure on the same subjects in primary and secondary care. We identified 661 diabetic subjects with measurements with the aid of the SAIL databank. Blood pressure in primary care was significantly lower than second...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2009.06.001
更新日期:2009-08-01 00:00:00
abstract:AIMS:Raising awareness of diabetic retinopathy (DR) was shown to be a key element for early diagnosis and treatment of this blinding disease. There is very limited data about the knowledge level, attitude, and behavior of diabetic patients regarding DR in Turkey. This study was planned to assess the awareness of DR and...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2013.04.002
更新日期:2013-12-01 00:00:00
abstract:AIMS:To evaluate the impact of the integration of onsite diabetes education teams in primary care on processes of care indicators according to practice guidelines. METHODS:Teams of nurse and dietitian educators delivered individualized self-management education counseling in 11 Ontario primary care sites. Of the 771 a...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2019.06.004
更新日期:2020-04-01 00:00:00
abstract::Seasonal variations in fasting glucose and HbA1c levels in 638 diabetic patients (attending a primary care diabetic clinic during 2003-2007) were examined and found to be significantly higher in colder than in warmer months. Moreover, there were apparent peaks in fasting glucose levels after Christmas and Easter month...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2009.05.004
更新日期:2009-05-01 00:00:00
abstract:AIM:Depression is prevalent in patients with type 2 diabetes. It may have a negative impact on the management of diabetes mellitus and could affect weight. The main aim of the investigation was to evaluate the effect of antidepressant treatment (sertraline) on anthropometric variables and glycemic control in depressed ...
journal_title:Primary care diabetes
pub_type: 临床试验,杂志文章
doi:10.1016/j.pcd.2018.09.003
更新日期:2019-02-01 00:00:00
abstract:AIMS:To evaluate the health-related quality of life (HRQoL) and functional capacity in relation to glycemic control among older home-dwelling primary care patients. METHODS:Electronic patient records were used to identify 527 people over 65 years with diabetes. Of these, 259 randomly selected subjects were invited to ...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2017.07.001
更新日期:2017-12-01 00:00:00
abstract:AIMS:To assess differences in hemoglobin A1c (HbA1c) over time in diabetics treated by internal medicine physicians using the chronic care model (IMP-ancillary) or an advanced practice nurse (APN-IMP). METHODS:Retrospective, 2-group comparative design using administrative databases and matching of IMP-ancillary and AP...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2018.01.008
更新日期:2018-08-01 00:00:00
abstract::Several cases of positive real time-polymerase chain reaction (RT-PCR) results (called "re-positives") after recovery from COVID-19 have emerged worldwide. These cases could represent patients experiencing a "turn positive" of nucleic acid detection attributed to the high false-negative rate of RT-PCR. On the contrary...
journal_title:Primary care diabetes
pub_type: 杂志文章,评审
doi:10.1016/j.pcd.2020.08.002
更新日期:2021-02-01 00:00:00
abstract:AIMS:People with diabetes have heightened levels of depressive symptoms, but less is known about the development of these symptoms in relation to diabetes duration. In this study, we examined the use of prescribed antidepressants in the first five years after diagnosis of diabetes among the working-age population in De...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2018.01.002
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:The aim of this research study was to ascertain the awareness of Maltese family doctors to the prevalence and significance of impaired glucose regulation and early diagnosis of type 2 diabetes and whether practices were influenced by employment status, post-graduate training in diabetes or years since graduat...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2013.12.003
更新日期:2014-10-01 00:00:00
abstract:AIMS:To investigate whether metabolic syndrome (MetS) is associated with erectile dysfunction (ED) among apparently healthy men when depressive symptoms and serum testosterone levels are taken into account. METHODS:A study population of 549 men at risk for cardiovascular disease or type 2 diabetes was drawn from the p...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2019.12.008
更新日期:2020-10-01 00:00:00
abstract:AIMS:To assess to which extent lowering the level of HbA1c influences the 10-year risk of coronary heart disease (CHD) and all-cause mortality in patients with type 2 diabetes mellitus. METHODS:A literature search in Pubmed and Embase was performed, and the absolute risks in the results of the relevant and valid studi...
journal_title:Primary care diabetes
pub_type: 杂志文章,评审
doi:10.1016/j.pcd.2007.12.004
更新日期:2008-02-01 00:00:00
abstract::HbA1c values are heavily relied on to assess glycemic control. Hemoglobin variants may interfere with measurements of HbA1c resulting in falsely low values. We present the first report of a rare variant of Hb in a patient with type 2 diabetes, which lead to a falsely low HbA1c. ...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2008.05.003
更新日期:2008-09-01 00:00:00
abstract::Insulin detemir provides prolonged, reproducible blood glucose reduction through a mechanism unique among basal insulins. It was originally studied clinically in predominantly basal + bolus regimens and found to be associated with a low risk of hypoglycaemia compared to insulin NPH, and reduced weight gain compared to...
journal_title:Primary care diabetes
pub_type: 历史文章,杂志文章
doi:10.1016/S1751-9918(10)60007-1
更新日期:2010-04-01 00:00:00
abstract:AIM:Among adults aged 20-45 years with type 2 diabetes mellitus, we examined the perceived quality of chronic care, and its associations with (i) sociodemographic and clinical characteristics, and (ii) diabetes distress. METHODS:In total, 216/460 (47%) completed a self-administered survey assessing sociodemographic ch...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2020.02.003
更新日期:2020-10-01 00:00:00
abstract:AIM:To investigate the organisation of diabetes care in general practice in Ireland and identify areas for future development. METHODS:Survey of a representative sample of 600 general practitioners (GPs). The questionnaire contained closed and open-ended questions addressing 4 topics; characteristics of the practice, ...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2009.09.002
更新日期:2009-11-01 00:00:00
abstract::Exenatide use in type 2 diabetes is limited in routine clinical practice. We examined a cross-section of 90 patients. Mean weight and HBA(1c) were 114.9+/-20.6 kg, 10.3+/-2.1% at initiation; 108.0+/-15.3 kg (p<0.0001), 9.0+/-2.1% (p<0.001) at 3 months; 109.2+/-18.2 kg (p<0.0001), 9.5+/-2.3% (p=0.08) at 6 months. Exena...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2009.11.001
更新日期:2010-04-01 00:00:00
abstract:AIMS:The goal of this retrospective cohort study was to analyze the incidence of, and factors associated with the antiepileptic drug (AED) therapy in the five years following the diagnosis of diabetic polyneuropathy in patients followed in Germany. METHODS:The study included patients aged 18-80 years with an initial d...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2020.12.005
更新日期:2021-01-06 00:00:00
abstract:AIMS:Was to determine whether the birth weight of the infant predicts prediabetes (impaired fasting glucose, impaired glucose tolerance, or both) and type 2 diabetes (T2DM) during long-term follow-up of women with or without gestational diabetes mellitus (GDM). METHODS:The women with or without GDM during their pregna...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2018.04.002
更新日期:2018-08-01 00:00:00
abstract:AIM:We wanted to investigate third-trimester HbA1c as a predictor of diabetes after gestational diabetes mellitus (GDM). METHODS:Women with GDM were followed up prospectively for five years from pregnancy to detect the development of diabetes. The ability of HbA1c to predict diabetes was evaluated with receiver-operat...
journal_title:Primary care diabetes
pub_type: 杂志文章
doi:10.1016/j.pcd.2016.09.002
更新日期:2017-02-01 00:00:00
abstract:AIMS:Type 2 diabetes mellitus imposes significant burdens on patients and health care systems. Population-level interventions are being implemented to reach large numbers of patients at risk of or diagnosed with diabetes. We describe a population-based evaluation of the Southeastern Diabetes Initiative (SEDI) from the ...
journal_title:Primary care diabetes
pub_type: 杂志文章,多中心研究
doi:10.1016/j.pcd.2017.10.003
更新日期:2018-04-01 00:00:00