Natural products as potential drug permeation enhancer in transdermal drug delivery system.

abstract：:The effects of oral 8-methoxypsoralen-photochemotherapy (PUVA-therapy) on the inflammatory infiltrate in 14 psoriatic skin lesions and on normal skin of 7 controls were investigated by means of autoradiography and planimetry. Under PUVA-therapy, one finds a significant decrease in dermal cells per millimeter lesion in...

journal_title：Archives of dermatological research

authors： Landthaler M,Plewig G,Hofmann C,Braun-Falco O

更新日期：1980-01-01 00:00:00

abstract：:To investigate biological characteristics of syringomas, three-dimensional (3-D) architectures of epithelial tumor nests and luminal structures of syringomas, hair follicles, and epidermal basement membrane in skin lesions were reconstructed using a computer stereographic analysis. Each lesion was composed of many sph...

journal_title：Archives of dermatological research

authors： Ito M,Yokoyama H,Ikeda K,Sato Y

更新日期：1990-01-01 00:00:00

abstract：:A recently described endogenous proteolytic process in pieces of human plantar stratum corneum incubated in vitro has been further studied. This process leads to a decrease in cohesion between the cells that had been facing outwards in vivo. Using two methods, that differed with respect to efficiency, to detach surfac...

journal_title：Archives of dermatological research

authors： Lundström A,Egelrud T

更新日期：1990-01-01 00:00:00

abstract：:Typical confluent lesions of lichen planus were transplanted onto nude mice and cultured in organ culture. The characteristic histologic appearance of lichen planus disappeared after grafting and became similar to normal skin within 6 weeks on nude mice; the dense lymphocyte infiltrate in dermis disappeared, the basal...

journal_title：Archives of dermatological research

authors： Tammi R,Hyyryläinen A,Fräki JE

更新日期：1988-01-01 00:00:00

abstract：:Organ size regulation is a highly coordinated process involving complex mechanisms. Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif, also known as WWTR1 (TAZ) have recently been linked to organ size determination and cell proliferation. Pilomatrixoma (PM) is a benign tumor of the a...

journal_title：Archives of dermatological research

authors： Cappellesso R,Bellan A,Saraggi D,Salmaso R,Ventura L,Fassina A

更新日期：2015-05-01 00:00:00

abstract：:Female hairless mice (strain mutant hr/hr) have been irradiated with increasing doses of UV-B over a period of 4 weeks. They were compared with untreated controls Additional groups of 30 mice were treated with milk base or cream base or milk SPF6 or cream SPF6 or cream SPF8 daily before irradiation. No changes of body...

journal_title：Archives of dermatological research

authors： Vogel HG,Alpermann HG,Futterer E

更新日期：1981-01-01 00:00:00

abstract：:Artificial light at night (LAN) is a pervasive phenomenon in today's society, and the detrimental consequences of LAN exposure are becoming apparent. LAN is associated with the increased incidence of metabolic disorders, cancers, mood alterations, and immune dysfunction in mammals. Consequently, we examined the effect...

journal_title：Archives of dermatological research

authors： Walker WH 2nd,Meléndez-Fernández OH,Nelson RJ

更新日期：2019-09-01 00:00:00

abstract：:Recently, we could show that the expression levels of the key regulators of the microRNA (miRNA) maturation and transport were dysregulated in inflamed hidradenitis suppurativa (HS) tissue (Heyam et al. in Wiley Interdiscip Rev RNA 6:271-289, 2015). The RNA-induced silencing complex (RISC) is the central element of th...

journal_title：Archives of dermatological research

authors： Hessam S,Sand M,Skrygan M,Bechara FG

更新日期：2017-09-01 00:00:00

abstract：:Apoptosis is an important cofactor in the pathogenesis of a plethora of malignancies. However, little is known about modulation of the expression of bcl gene family in melanocytic tumors. To determine the role of bcl-2, bcl-x and bax in melanocytic tumors we investigated the differential expression of these genes via ...

journal_title：Archives of dermatological research

authors： Leiter U,Schmid RM,Kaskel P,Peter RU,Krähn G

更新日期：2000-05-01 00:00:00

abstract：:Tumor-associated antigens were demonstrated in phenol water extracts of human malignant melanoma by migration tests with leukocytes from melanoma patients and controls: in 25 out of 60 melanoma patients weak reactivity was observed, usually stimulation of leukocyte migration, while leukocytes from 37 controls were neg...

journal_title：Archives of dermatological research

authors： Suter L,Tilkorn H,Kövary PM

更新日期：1979-02-23 00:00:00

abstract：:Interleukin-33 is a novel and an unconventional member of IL-1 family. It is an inflammation-induced factor with dual function exercising its role as an intracellular regulator of gene expression, as well as, an extracellular alarm mediator. It is a ligand for ST2, a heterodimeric membrane-bound receptor of the orphan...

journal_title：Archives of dermatological research

authors： Balato A,Raimondo A,Balato N,Ayala F,Lembo S

更新日期：2016-07-01 00:00:00

abstract：:Mice homozygous for three different recessive mutations known to cause pleiotropic defects in the immune system and in the skin were used to evaluate the relationship between the classical immune system and dendritic epidermal cell populations. Numbers of Langerhans cells (LCs) and Thy-1+ dendritic cells (Thy-1+DEC) w...

journal_title：Archives of dermatological research

authors： Sprecher E,Becker Y,Kraal G,Hall E,Shultz LD

更新日期：1990-01-01 00:00:00

abstract：:A number of studies have demonstrated an increased frequency of allergen-specific T cells producing increased amounts of interleukin-4 (IL-4) and IL-5, but little interferon-y in both the peripheral blood and skin lesions of patients with atopic dermatitis (AD). In this study, to further clarify the characteristics of...

journal_title：Archives of dermatological research

authors： Kawamura MS,Aiba S,Tagami H

更新日期：1998-11-01 00:00:00

abstract：:Nephrogenic systemic fibrosis (NSF) is a disease characterized by fibrosis of the systemic organs in patients with renal failure. Following the findings of recent epidemiological studies and the finding of gadolinium (Gd) in the skin tissue of NSF patients, it is now definitely known that the use of Gd contrast agents...

journal_title：Archives of dermatological research

authors： Ozawa Y,Hayashi S,Hamasaki Y,Hatamochi A

更新日期：2016-12-01 00:00:00

abstract：:The mechanistic target of rapamycin (mTOR) is involved in the regulation of cellular growth, proliferation, lipid synthesis, and protein translation. The mTOR pathway involves two complexes: the mechanistic target of rapamycin complex 1 (mTORC1) and the mechanistic target of rapamycin complex 2 (mTORC2). Both mTOR com...

journal_title：Archives of dermatological research

authors： Leo MS,Sivamani RK

更新日期：2014-12-01 00:00:00

abstract：:We investigated the effect of interferon-gamma (IFN-gamma) on skin equivalents. Keratinocytes from involved and uninvolved skin from psoriatic subjects and from healthy subjects were grown on preproduced dermal equivalents (DE) containing fibroblasts from healthy skin or psoriatic lesions. Healthy keratinocytes were a...

journal_title：Archives of dermatological research

authors： Fransson J,Shen Q,Scheynius A,Hammar H

更新日期：1996-12-01 00:00:00

abstract：:An ultrastructural study of the skin lesion of a young patient affected by pseudo-Kaposi's sarcoma of the Bluefarb-Stewart type (BSS) is reported. The neoplasm consisted of a proliferation of vascular structures mostly consisting of a solid bud of endothelial cells surrounded by a thinned and polystratified basement m...

journal_title：Archives of dermatological research

authors： Fimiani M,Simoni S,Miracco C,De Santi M,Luzi P,Andreassi L

更新日期：1989-01-01 00:00:00

abstract：:The study aimed at detecting differentially expressed proteins in the stratum corneum of dandruff versus non-dandruff scalps to better understand dandruff aetiology. iTRAQ-based quantitative proteomic analysis revealed a total of 68 differentially expressed biomarkers. A detailed analysis of their known physiological ...

journal_title：Archives of dermatological research

authors： Cavusoglu N,Delattre C,Donovan M,Bourassa S,Droit A,El Rawadi C,Jourdain R,Bernard D

更新日期：2016-11-01 00:00:00

abstract：:Genetic abnormalities for different subtypes of epidermolysis bullosa (EB) have been described. In dominant simplex type EB, mutations of the K5 or K14 gene lead to disruption of basal cells and the formation of bullae. The recessive simplex types include EB with muscular dystrophy due to abnormal plectin, EB without ...

journal_title：Archives of dermatological research

authors： Mitsuhashi Y,Hashimoto I

更新日期：2003-04-01 00:00:00

abstract：:Metalloproteinase-mediated proteolysis plays an important role during all stages of wound repair. In acute murine wounds, murine collagenase, matrix metalloproteinase (MMP)-9, stromelysin-1, stromelysin-2 and tissue inhibitor of metalloproteinase (TIMP)-1 are strongly induced within 24 h after wounding. At the time of...

journal_title：Archives of dermatological research

authors： Madlener M

更新日期：1998-07-01 00:00:00

abstract：:Solar radiation in the UVB range is absorbed primarily by the epidermal DNA where characteristic photodamage results in altered immune responses and mutagenic lesions. UVB exposure of the skin results in a profound upregulation of the anti-inflammatory cytokine, IL-10 and suppression of contact hypersensitivity (CHS)....

journal_title：Archives of dermatological research

authors： Ma LJ,Guzmán EA,DeGuzman A,Walter B,Muller HK,Walker AM,Owen LB

更新日期：2006-03-01 00:00:00

abstract：:CD271, a receptor of nerve growth factor (NGF), affects the biological properties of epidermal stem cells (eSCs) which are essential for skin wound closure. Tropomyosin-receptor kinase A (TrkA), another receptor of NGF, combined with CD271 has been involved with nervous system and skin keratinocytes. However, the exac...

journal_title：Archives of dermatological research

authors： Zhang M,Zhang Y,Ding J,Li X,Zang C,Yin S,Ma J,Wang Y,Cao Y

更新日期：2018-11-01 00:00:00

abstract：:Studies aimed at understanding the pathology, genetics, and therapeutic response of vitiligo rely on asking a single question about 'physician-diagnosed' vitiligo on surveys to identify subjects for research. However, this type of self-reporting is not sufficient. Our objective was to determine if the patient-administ...

journal_title：Archives of dermatological research

authors： Sheth VM,Gunasekera NS,Silwal S,Qureshi AA

更新日期：2015-01-01 00:00:00

abstract：:The beta-adrenergic receptors, previously shown to be present on the membranes of cultured human epidermal keratinocytes, were found to be functionally coupled to membrane-bound adenylate cyclase. Using membrane preparations, the enzyme could be activated by guanosine triphosphate (GTP), the stable GTP analog GPP(HN)p...

journal_title：Archives of dermatological research

authors： Cavey MT,Cavey D,Shroot B,Reichert U,Gazith J

更新日期：1986-01-01 00:00:00

abstract：:Tropospheric ozone (O3) is a source of oxidative stress. This study examined the ability of a topical antioxidant (WEL-DS) to inhibit O3-mediated damage in a human epidermal skin model. Four groups of tissues (N = 24) were compared: Group 1 (control) were untreated and unexposed; Group 2 were untreated and exposed to ...

journal_title：Archives of dermatological research

authors： Pecorelli A,McDaniel DH,Wortzman M,Nelson DB

更新日期：2020-05-08 00:00:00

abstract：:Atopic dermatitis (AD) can be exacerbated by various factors, including emotional stress, scratching and sweating. The aim of the present study was to evaluate the hypothesis that the inflammatory reaction in AD is also neurogenic. For this purpose, the levels of vasoactive intestinal polypeptide were measured radioim...

journal_title：Archives of dermatological research

authors： Pincelli C,Fantini F,Romualdi P,Lesa G,Giannetti A

更新日期：1991-01-01 00:00:00

abstract：:The composition of the aerobic and anaerobic bacterial skin flora was investigated quantitatively and qualitatively in 25 patients with seborrheic eczema (SE) and in 35 healthy persons. In SE patients, the geometric mean count for propionibacteria in the pilosebaceous ducts of the forehead was reduced to a statistical...

journal_title：Archives of dermatological research

authors： Höffler U,Gloor M,Peters G,Ko HL,Bräutigan A,Thurn A,Pulverer G

更新日期：1980-01-01 00:00:00

abstract：:Transcutaneous oxygen pressure (TcPO2) and skin blood flow (as evaluated by laser doppler) (LD) were investigated in 24 systemic sclerosis (SSc) patients in sclerotic skin (dorsal aspect of the hand) and non-sclerotic skin (interscapular region) and in 24 controls matched for sex and age for the same sites. The two pa...

journal_title：Archives of dermatological research

authors： Valentini G,Leonardo G,Moles DA,Apaia MR,Maselli R,Tirri G,Del Guercio R

更新日期：1991-01-01 00:00:00

abstract：:Thymocyte selection-associated high-mobility group box (TOX) is aberrantly expressed in cutaneous T-cell lymphomas. In a recent study, TOX expression was noted unexpectedly in the follicle center (germinal center) B-cells of reactive lymph nodes and tonsils, used as external controls. To evaluate whether TOX is also e...

journal_title：Archives of dermatological research

authors： Schrader AM,Jansen PM,Willemze R

更新日期：2016-08-01 00:00:00

abstract：:Mast cell chymase is a chymotrypsin-like serine proteinase primarily stored in secretory mast cell granules. Mast cell chymase has various effects on angiotensin, metalloproteases, lipoproteins, procollagen, neuropeptides and cytokines. Recent studies have demonstrated that chymase inhibitors inhibit skin inflammation...

journal_title：Archives of dermatological research

authors： Badertscher K,Brönnimann M,Karlen S,Braathen LR,Yawalkar N

更新日期：2005-04-01 00:00:00