Fabrication of omentum-based matrix for engineering vascularized cardiac tissues.

abstract：:Omentum-based matrices fabricated by decellularization have the potential to serve as autologous scaffolds for tissue engineering. Transplantation of such scaffolds prepared from the patient's own biomaterial may reduce the immunogenic response after transplantation. Recently we reported on the potential of the decell...

journal_title：Biofabrication

authors： Soffer-Tsur N,Shevach M,Shapira A,Peer D,Dvir T

更新日期：2014-09-01 00:00:00

abstract：:Traditional drug discovery involves the screening of lead compounds from a chemical library by using cell-based high throughput screening (HTS) procedures. This has created a demand for the development of cell-based microarray chips for HTS of compounds. Although several cell-based microarray devices and procedures fo...

journal_title：Biofabrication

authors： Fujita S,Onuki-Nagasaki R,Ikuta K,Hara Y

更新日期：2016-12-05 00:00:00

abstract：:In the pharmaceutical industry, new drugs are tested to find appropriate compounds for therapeutic purposes for contemporary diseases. Unfortunately, novel compounds emerge at expensive prices and current target evaluation processes have limited throughput, thus leading to an increase of cost and time for drug develop...

journal_title：Biofabrication

authors： Rodríguez-Dévora JI,Zhang B,Reyna D,Shi ZD,Xu T

更新日期：2012-09-01 00:00:00

abstract：:Silica-bonded calcite scaffolds have been successfully 3D-printed by direct ink writing, starting from a paste comprising a silicone polymer and calcite powders, calibrated in order to match a SiO2/CaCO3 weight balance of 35/65. The scaffolds, fabricated with two slightly different geometries, were first cross-linked ...

journal_title：Biofabrication

authors： Fiocco L,Elsayed H,Badocco D,Pastore P,Bellucci D,Cannillo V,Detsch R,Boccaccini AR,Bernardo E

更新日期：2017-05-11 00:00:00

abstract：:Human induced pluripotent stem cells (hiPSCs) can be differentiated at high efficiency into cells of a targeting type but the resulting cell population has to be of high purity for clinical therapies to avoid teratomas. Herein, we report a microfluidic device with integrated and surface functionalised fishnet-like str...

journal_title：Biofabrication

authors： Li X,Yu L,Li J,Minami I,Nakajima M,Noda Y,Kotera H,Liu L,Chen Y

更新日期：2016-09-08 00:00:00

abstract：:Cell-imprinting technology is a novel method for directing stem cell fate using substrates molded from target cells. Here, we fabricated and studied cell-imprinted substrates for neural priming in human adipose-derived stem cells in the absence of chemical cues. We molded polydimethylsiloxane (PDMS) silicone substrate...

journal_title：Biofabrication

authors： Ghazali ZS,Eskandari M,Bonakdar S,Renaud P,Mashinchian O,Shalileh S,Bonini F,Uckay I,Preynat-Seauve O,Braschler T

更新日期：2020-10-30 00:00:00

abstract：:The aim of this study was to comparatively evaluate the angiogenic capacity of cocultures using either human bone marrow- or human adipose tissue-derived mesenchymal stem cells (MSCs) (BM- or AT-MSCs) with human umbilical vein endothelial cells (HUVECs) both in vitro and in vivo at early time points (i.e. days 3 and 7...

journal_title：Biofabrication

authors： Ma J,Yang F,Both SK,Prins HJ,Helder MN,Pan J,Cui FZ,Jansen JA,van den Beucken JJ

更新日期：2014-03-01 00:00:00

abstract：:A recently emerged approach for tissue engineering is to biofabricate tissues using cellular spheroids as building blocks. Human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), can be cultured to generate large numbers of cells and can presumably...

journal_title：Biofabrication

authors： Lin H,Li Q,Lei Y

更新日期：2017-04-24 00:00:00

abstract：:Recent research has been focusing on the generation of living personalized osteochondral constructs for joint repair. Native articular cartilage has a zonal structure, which is not reflected in current constructs and which may be a cause of the frequent failure of these repair attempts. Therefore, we investigated the ...

journal_title：Biofabrication

authors： Mancini IAD,Schmidt S,Brommer H,Pouran B,Schäfer S,Tessmar J,Mensinga A,van Rijen MHP,Groll J,Blunk T,Levato R,Malda J,van Weeren PR

更新日期：2020-07-01 00:00:00

abstract：:Cell mechanical microenvironment (CMM) significantly affects cell behaviors such as spreading, migration, proliferation and differentiation. However, most studies on cell response to mechanical stimulation are based on two-dimensional (2D) planar substrates, which cannot mimic native three-dimensional (3D) CMM. Accumu...

journal_title：Biofabrication

authors： Huang G,Wang L,Wang S,Han Y,Wu J,Zhang Q,Xu F,Lu TJ

更新日期：2012-12-01 00:00:00

abstract：:How to pack materials into well-defined volumes efficiently has been a longstanding question of interest to physicists, material scientists, and mathematicians as these materials have broad applications ranging from shipping goods in commerce to seeds in agriculture and to spheroids in tissue engineering. How many mar...

journal_title：Biofabrication

authors： Ren T,Steiger W,Chen P,Ovsianikov A,Demirci U

更新日期：2020-03-31 00:00:00

abstract：:Laser-assisted bioprinting (LaBP) allows the realization of computer-generated 3D tissue grafts consisting of cells embedded in a hydrogel environment. In this study, human adipose-derived stem cells (hASCs) were printed in a free-scalable 3D grid pattern by means of LaBP. We demonstrate that neither the proliferation...

journal_title：Biofabrication

authors： Gruene M,Pflaum M,Deiwick A,Koch L,Schlie S,Unger C,Wilhelmi M,Haverich A,Chichkov BN

更新日期：2011-03-01 00:00:00

abstract：:A critical consideration in tissue engineering is to recapitulate the microstructural organization of native tissues that is essential to their function. Scaffold-based techniques have focused on achieving this via the contact guidance principle wherein topographical cues offered by scaffold fibers direct migration an...

journal_title：Biofabrication

authors： Chansoria P,Narayanan LK,Schuchard K,Shirwaiker R

更新日期：2019-04-26 00:00:00

abstract：:Bioprinting of living cells is rapidly developing as an advanced biofabrication approach to engineer tissues. Bioinks can be extruded in three-dimensions (3D) to fabricate complex and hierarchical constructs for implantation. However, a lack of functionality can often be attributed to poor bioink properties. Indeed, a...

journal_title：Biofabrication

authors： Cidonio G,Alcala-Orozco CR,Lim KS,Glinka M,Mutreja I,Kim YH,Dawson JI,Woodfield TBF,Oreffo ROC

更新日期：2019-06-12 00:00:00

abstract：:The physical and mechanical properties of cells modulate their behavior such proliferation rate, migration and extracellular matrix remodeling. In order to study cell behavior in a tissue-like environment in vitro, it is of utmost importance to develop biologically and physically relevant 3D cell models. Here, we char...

journal_title：Biofabrication

authors： Pillet F,Gibot L,Madi M,Rols MP,Dague E

更新日期：2017-05-11 00:00:00

abstract：:Current technologies for manufacturing of microfluidic devices include soft-lithography, wet and dry etching, thermoforming, micro-machining and three-dimensional (3D) printing. Among them, soft-lithography has been the mostly preferred one in medical and pharmaceutical fields due to its ability to generate polydimeth...

journal_title：Biofabrication

authors： Ozbolat V,Dey M,Ayan B,Ozbolat IT

更新日期：2019-04-16 00:00:00

abstract：:In the body, cells are surrounded by an interconnected mesh of insoluble, bioactive protein fibres to which they adhere in a well-controlled manner, embedded in a hydrogel-like highly hydrated matrix. True morphological and biochemical mimicry of this so-called extracellular matrix (ECM) remains a challenge but appear...

journal_title：Biofabrication

authors： Schulte VA,Hahn K,Dhanasingh A,Heffels KH,Groll J

更新日期：2014-06-01 00:00:00

abstract：:Technical limitations of traditional electrospinning make it hard to produce three-dimensional (3D) scaffolds with hierarchical pore structures. Here, porous polycaprolactone (PCL) nanofiber meshes with different nano-hydroxyapatite (nHA) concentrations were prepared by electrospinning with stainless steel mesh as the...

journal_title：Biofabrication

authors： Song J,Zhu G,Wang L,An G,Shi X,Wang Y

更新日期：2017-02-14 00:00:00

abstract：:Three-dimensional (3D) tissue models are invaluable tools that can closely reflect the in vivo physiological environment. However, they are usually difficult to develop, have a low throughput and are often costly; limiting their utility to most laboratories. The recent availability of inexpensive additive manufacturin...

journal_title：Biofabrication

authors： Flood P,Alvarez L,Reynaud EG

更新日期：2016-10-11 00:00:00

abstract：:Critical understanding of the complex metastatic cascade of prostate cancer is necessary for the development of a therapeutic interventions for treating metastatic prostate cancer. Increasing evidence supports the synergistic role of biochemical and biophysical cues in cancer progression at metastases. The biochemical...

journal_title：Biofabrication

authors： Jasuja H,Kar S,Katti DR,Katti K

更新日期：2021-01-08 00:00:00

abstract：:Cell therapy represents a promising option for revascularization of ischemic tissues. However, injection of dispersed cells is not optimal to ensure precise homing into the recipient's vasculature. Implantation of cell-engineered scaffolds around the occluded artery may obviate these limitations. Here, we employed the...

journal_title：Biofabrication

authors： Carrabba M,De Maria C,Oikawa A,Reni C,Rodriguez-Arabaolaza I,Spencer H,Slater S,Avolio E,Dang Z,Spinetti G,Madeddu P,Vozzi G

更新日期：2016-03-24 00:00:00

abstract：:Nowadays, 3D bioprinting technologies are rapidly emerging in the field of tissue engineering and regenerative medicine as effective tools enabling the fabrication of advanced tissue constructs that can recapitulate in vitro organ/tissue functions. Selecting the best strategy for bioink deposition is often challenging...

journal_title：Biofabrication

authors： Costantini M,Colosi C,Święszkowski W,Barbetta A

更新日期：2018-11-09 00:00:00

abstract：:Tissue rings with incorporated microscaffolds have been engineered as promising building blocks for constructing biological tubes from the bottom up. However, the microscaffolds available for incorporation are very limited at present. In this paper we provide an efficient strategy to first incorporate microfluidic spu...

journal_title：Biofabrication

authors： Sun T,Shi Q,Yao Y,Sun J,Wang H,Huang Q,Fukuda T

更新日期：2019-06-25 00:00:00

abstract：:Three-dimensional bioprinting of biomaterials shows great potential for producing cell-encapsulated scaffolds to repair nerves after injury or disease. For this, preparation of biomaterials and bioprinting itself are critical to create scaffolds with both biological and mechanical properties appropriate for nerve rege...

journal_title：Biofabrication

authors： Ning L,Sun H,Lelong T,Guilloteau R,Zhu N,Schreyer DJ,Chen X

更新日期：2018-06-29 00:00:00

abstract：:Degeneration of the intervertebral disc (IVD) represents a significant musculoskeletal disease burden. Tissue engineering has proposed several strategies comprising the use of biodegradable materials to prepare scaffolds that can present mechanical properties similar to those of native IVD tissues. However, this might...

journal_title：Biofabrication

authors： van Uden S,Silva-Correia J,Correlo VM,Oliveira JM,Reis RL

更新日期：2015-01-21 00:00:00

abstract：:Advances in three-dimensional cell cultures offer new opportunities in biomedical research and drug development. However, there are still challenges to overcome, including the lack of reliability, repeatability and complexity of tissues obtained by these techniques. In this study, we describe a new bioprinting system ...

journal_title：Biofabrication

authors： da Conceicao Ribeiro R,Pal D,Ferreira AM,Gentile P,Benning M,Dalgarno K

更新日期：2018-12-27 00:00:00

abstract：:An important unsolved challenge in tissue engineering has been the inability to replicate the geometry and function of vascular networks and blood vessels. Here, we engineer a user-defined 3D microfluidic vascular channel using 3D printing-enabled hydrogel casting. First, a hollow L-shaped channel is developed using a...

journal_title：Biofabrication

authors： Yang L,Shridhar SV,Gerwitz M,Soman P

更新日期：2016-08-26 00:00:00

abstract：:Cardiovascular diseases (CVDs) are considered the principal cause of worldwide death, being atherosclerosis the main etiology. Up to now, the predominant treatment for CVDs has been bypass surgery from autologous source. However, due to previous harvest or the type of disease, this is not always an option. For this re...

journal_title：Biofabrication

authors： Bosch Rué E,Delgado LM,Gil FJ,Perez RA

更新日期：2020-09-30 00:00:00

abstract：:Tissue engineering based on building blocks is an emerging method to fabricate 3D tissue constructs. This method requires depositing and assembling building blocks (cell-laden microgels) at high throughput. The current technologies (e.g., molding and photolithography) to fabricate microgels have throughput challenges ...

journal_title：Biofabrication

authors： Xu F,Moon SJ,Emre AE,Turali ES,Song YS,Hacking SA,Nagatomi J,Demirci U

更新日期：2010-03-01 00:00:00

abstract：:We report on the fabrication of silicon-reinforced carbon (C:Si) structures by combinatorial pulsed laser deposition to search for the best design for a new generation of multi-functional coated implants. The synthesized films were characterized from the morphological, structural, compositional, mechanical and microbi...

journal_title：Biofabrication

authors： Mihailescu IN,Bociaga D,Popescu-Pelin G,Stan GE,Duta L,Socol G,Chifiriuc MC,Bleotu C,Lazar V,Husanu MA,Zgura I,Miculescu F,Negut I,Hapenciuc C

更新日期：2017-06-01 00:00:00