解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Scaffold-free 3D cell cultures (e.g. pellet cultures) are widely used in medical science, including cartilage regeneration. Their drawbacks are high time/reagent consumption and lack of early readout parameters. While optimisation was achieved by automation or simplified spheroid generation, most culture systems remai...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/abe186
更新日期:2021-01-29 00:00:00
abstract::Critical understanding of the complex metastatic cascade of prostate cancer is necessary for the development of a therapeutic interventions for treating metastatic prostate cancer. Increasing evidence supports the synergistic role of biochemical and biophysical cues in cancer progression at metastases. The biochemical...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/abd9d6
更新日期:2021-01-08 00:00:00
abstract::Cell-imprinting technology is a novel method for directing stem cell fate using substrates molded from target cells. Here, we fabricated and studied cell-imprinted substrates for neural priming in human adipose-derived stem cells in the absence of chemical cues. We molded polydimethylsiloxane (PDMS) silicone substrate...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/abc66f
更新日期:2020-10-30 00:00:00
abstract::Cardiovascular diseases (CVDs) are considered the principal cause of worldwide death, being atherosclerosis the main etiology. Up to now, the predominant treatment for CVDs has been bypass surgery from autologous source. However, due to previous harvest or the type of disease, this is not always an option. For this re...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/abbd27
更新日期:2020-09-30 00:00:00
abstract::Drop-on-demand (DoD) inkjet printing has been explored for a range of applications, including those to selectively deposit cellular material, due to the high accuracy and scalability of such systems when compared with alternative bioprinting techniques. Despite this, there remain considerable limitations when handling...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/aba2f8
更新日期:2020-08-12 00:00:00
abstract::Tissue engineering aims to create implantable biomaterials for the repair and regeneration of damaged tissues. In vitro tissue engineering is generally based on static culture, which limits access to nutrients and lacks mechanical signaling. Using shear stress is controversial because in some cases it can lead to cell...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/aba412
更新日期:2020-08-10 00:00:00
abstract::Recent research has been focusing on the generation of living personalized osteochondral constructs for joint repair. Native articular cartilage has a zonal structure, which is not reflected in current constructs and which may be a cause of the frequent failure of these repair attempts. Therefore, we investigated the ...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/ab94ce
更新日期:2020-07-01 00:00:00
abstract::The precise positioning and arrangement of cell spheroids and organoids are critical to reconstructing complex tissue architecture for tissue engineering and regenerative medicine. Here, we present a digital acoustofluidic method to manipulate cell spheroids and organoids with unprecedented dexterity. By introducing l...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/ab9582
更新日期:2020-07-01 00:00:00
abstract::Nature has evolved to grow and regenerate tissues and organs using self-assembling processes capable of organizing a wide variety of molecular building-blocks at multiple size scales. As the field of biofabrication progresses, it is essential to develop innovative ways that can enhance our capacity to build more compl...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/ab84cb
更新日期:2020-06-01 00:00:00
abstract::Nerve tissues contain hierarchically ordered nerve fibers, while each of the nerve fibers has nano-oriented fibrous extracellular matrix and a core-shell structure of tubular myelin sheath with elongated axons encapsulated. Here, we report, for the first time, a ready approach to fabricate biomimetic nerve fibers whic...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/ab860d
更新日期:2020-05-12 00:00:00
abstract::In this paper we explore the printability of reversible networks formed by catechol functionalized PEG solutions and metal cations (Al3+, Fe3+ or V3+). The printability and shape fidelity were dependent on the ink composition (metal ion type, pH, PEG molecular weight) and printing parameters (extrusion pressure and pr...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/ab673a
更新日期:2020-04-29 00:00:00
abstract::How to pack materials into well-defined volumes efficiently has been a longstanding question of interest to physicists, material scientists, and mathematicians as these materials have broad applications ranging from shipping goods in commerce to seeds in agriculture and to spheroids in tissue engineering. How many mar...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/ab76d9
更新日期:2020-03-31 00:00:00
abstract::Despite the widespread use as platforms for various biomedical applications, engineering hydrogels to impart multifunctionality and control physical properties, while closely mimicking the native cellular microenvironment, is still a significant challenge. Herein, nanofibers consisting of hydrophilic and photocrosslin...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/ab5385
更新日期:2019-12-19 00:00:00
abstract::The high attrition rate of neuro-pharmaceuticals as they proceed to market necessitates the development of clinically-relevant in vitro neural microphysiological systems that can be utilized during the preclinical screening phase to assess the safety and efficacy of potential compounds. Historically, proposed models h...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/ab41b4
更新日期:2019-10-21 00:00:00
abstract::Four-dimensional (4D) bioprinting of cell-laden constructs with programmable shape-morphing structures has gained increasing attention in the field of biofabrication and tissue engineering. Currently, most of the widely used materials for 4D printing, including N-isopropylacrylamide-based polymers, are not commonly us...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/ab39c5
更新日期:2019-09-13 00:00:00
abstract::In this study, we report the step-gradient nanocomposite (NC) hydrogel generated easily by spatial connection of different nanocomposite hydrogel pastes varying in the concentrations of nanomaterials with the aid of a 3D printing technique. The prepared 3D printed gradient NC hydrogel has self-adhesive properties and ...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/ab3582
更新日期:2019-08-22 00:00:00
abstract::Tissue rings with incorporated microscaffolds have been engineered as promising building blocks for constructing biological tubes from the bottom up. However, the microscaffolds available for incorporation are very limited at present. In this paper we provide an efficient strategy to first incorporate microfluidic spu...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/ab1ee5
更新日期:2019-06-25 00:00:00
abstract::Bioprinting of living cells is rapidly developing as an advanced biofabrication approach to engineer tissues. Bioinks can be extruded in three-dimensions (3D) to fabricate complex and hierarchical constructs for implantation. However, a lack of functionality can often be attributed to poor bioink properties. Indeed, a...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/ab19fd
更新日期:2019-06-12 00:00:00
abstract::A critical consideration in tissue engineering is to recapitulate the microstructural organization of native tissues that is essential to their function. Scaffold-based techniques have focused on achieving this via the contact guidance principle wherein topographical cues offered by scaffold fibers direct migration an...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/ab15cf
更新日期:2019-04-26 00:00:00
abstract::Current technologies for manufacturing of microfluidic devices include soft-lithography, wet and dry etching, thermoforming, micro-machining and three-dimensional (3D) printing. Among them, soft-lithography has been the mostly preferred one in medical and pharmaceutical fields due to its ability to generate polydimeth...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/ab10ae
更新日期:2019-04-16 00:00:00
abstract::A bio-inspired hydrogel for 3D bioprinting of soft free-standing neural tissues is presented. The novel filler-free bioinks were designed by combining natural polymers for extracellular matrix biomimicry with synthetic polymers to endow desirable rheological properties for 3D bioprinting. Crosslinking of thiolated Plu...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/ab02c9
更新日期:2019-02-25 00:00:00
abstract::To overcome the drawbacks of in vitro liver testing during drug development, numerous liver-on-a-chip models have been developed. However, current liver-on-a-chip technologies are labor-intensive, lack extracellular matrix (ECM) essential for liver cells, and lack a biliary system essential for excreting bile acids, w...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/aaf9fa
更新日期:2019-01-16 00:00:00
abstract::Advances in three-dimensional cell cultures offer new opportunities in biomedical research and drug development. However, there are still challenges to overcome, including the lack of reliability, repeatability and complexity of tissues obtained by these techniques. In this study, we describe a new bioprinting system ...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/aaf625
更新日期:2018-12-27 00:00:00
abstract::Calcified cartilage regeneration plays an important role in successful osteochondral repair, since it provides a biological and mechanical transition from the unmineralized cartilage at the articulating surface to the underlying mineralized bone. To biomimic native calcified cartilage in engineered constructs, here we...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/aaf44a
更新日期:2018-12-27 00:00:00
abstract::Nowadays, 3D bioprinting technologies are rapidly emerging in the field of tissue engineering and regenerative medicine as effective tools enabling the fabrication of advanced tissue constructs that can recapitulate in vitro organ/tissue functions. Selecting the best strategy for bioink deposition is often challenging...
journal_title:Biofabrication
pub_type: 杂志文章,评审
doi:10.1088/1758-5090/aae605
更新日期:2018-11-09 00:00:00
abstract::Three-dimensional bioprinting of biomaterials shows great potential for producing cell-encapsulated scaffolds to repair nerves after injury or disease. For this, preparation of biomaterials and bioprinting itself are critical to create scaffolds with both biological and mechanical properties appropriate for nerve rege...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/aacd30
更新日期:2018-06-29 00:00:00
abstract::As an alternative to conventional cell culture and animal testing, an organ-on-a-chip is applied to study the biological phenomena of organ development and disease, as well as the interactions between human tissues and external stimuli such as chemicals, forces and electricity. The pattern design of a microfluidic cha...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/aaa900
更新日期:2018-02-05 00:00:00
abstract::A major limitation of existing 3D implantable structures for bone tissue engineering is that most of the cells rapidly attach on the outer edges of the structure, restricting the cells penetration into the inner parts and causing the formation of a necrotic core. Furthermore, these structures generally possess a rando...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/aaa718
更新日期:2018-02-05 00:00:00
abstract::Plant cell cultures produce active agents for pharmaceuticals, food and cosmetics. However, up to now process control for plant cell suspension cultures is challenging. A positive impact of cell immobilization, such as encapsulation in hydrogel beads, on secondary metabolites production has been reported for several p...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/aa8854
更新日期:2017-11-14 00:00:00
abstract::Bone healing is regulated by multiple microenvironmental signals provided by the extracellular matrix (ECM). This study aimed to mimic the native osteoinductive microenvironment by developing an ECM using gene-transduced cells. The LIM mineralization protein-1 (LMP-1) gene was transferred to murine pre-osteoblast cell...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/aa8dd1
更新日期:2017-11-14 00:00:00
abstract::Tissue engineering needs innovative solutions to better fit the requirements of a minimally invasive approach, providing at the same time instructive cues to cells. The use of shape memory polyurethane has been investigated by producing 4D scaffolds via additive manufacturing technology. Scaffolds with two different p...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/aa8114
更新日期:2017-08-02 00:00:00
abstract::Calcium alginate hydrogels are widely used as biocompatible materials in a substantial number of biomedical applications. This paper reports on a hybrid 3D printing and electrodeposition approach for forming 3D calcium alginate hydrogels in a controllable manner. Firstly, a specific 3D hydrogel printing system is deve...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/aa6ed8
更新日期:2017-06-07 00:00:00
abstract::We report on the fabrication of silicon-reinforced carbon (C:Si) structures by combinatorial pulsed laser deposition to search for the best design for a new generation of multi-functional coated implants. The synthesized films were characterized from the morphological, structural, compositional, mechanical and microbi...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/aa7076
更新日期:2017-06-01 00:00:00
abstract::The physical and mechanical properties of cells modulate their behavior such proliferation rate, migration and extracellular matrix remodeling. In order to study cell behavior in a tissue-like environment in vitro, it is of utmost importance to develop biologically and physically relevant 3D cell models. Here, we char...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/aa6ed5
更新日期:2017-05-11 00:00:00
abstract::Three-dimensional (3D) printed poly(ε-caprolactone) (PCL) based scaffolds have being proposed for different tissue engineering applications. This study addresses the design and fabrication of 3D PCL constructs with different struts alignments at 90°, 45° and 90° with offset. The morphology and the mechanical behavior ...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/aa698e
更新日期:2017-05-11 00:00:00
abstract::Silica-bonded calcite scaffolds have been successfully 3D-printed by direct ink writing, starting from a paste comprising a silicone polymer and calcite powders, calibrated in order to match a SiO2/CaCO3 weight balance of 35/65. The scaffolds, fabricated with two slightly different geometries, were first cross-linked ...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/aa6c37
更新日期:2017-05-11 00:00:00
abstract::Engineering surfaces with functional polymers is a crucial issue in the field of micro/nanofabrication and cell-material interface studies. For many applications of surface patterning, it does not need cells to attach on the whole surface. Herein, we introduce a novel polymer fabrication protocol of off-stoichiometry ...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/aa669c
更新日期:2017-04-24 00:00:00
abstract::A recently emerged approach for tissue engineering is to biofabricate tissues using cellular spheroids as building blocks. Human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), can be cultured to generate large numbers of cells and can presumably...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/aa663b
更新日期:2017-04-24 00:00:00
abstract::In the past few decades, 3D printing has played a significant role in fabricating scaffolds with consistent, complex structure that meet patient-specific needs in future clinical applications. Although many studies have contributed to this emerging field of additive manufacturing, which includes material development a...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/aa6370
更新日期:2017-04-12 00:00:00
abstract::Technical limitations of traditional electrospinning make it hard to produce three-dimensional (3D) scaffolds with hierarchical pore structures. Here, porous polycaprolactone (PCL) nanofiber meshes with different nano-hydroxyapatite (nHA) concentrations were prepared by electrospinning with stainless steel mesh as the...
journal_title:Biofabrication
pub_type: 杂志文章
doi:10.1088/1758-5090/aa5c99
更新日期:2017-02-14 00:00:00