Abstract:
:Silica-bonded calcite scaffolds have been successfully 3D-printed by direct ink writing, starting from a paste comprising a silicone polymer and calcite powders, calibrated in order to match a SiO2/CaCO3 weight balance of 35/65. The scaffolds, fabricated with two slightly different geometries, were first cross-linked at 350 °C, then fired at 600 °C, in air. The low temperature adopted for the conversion of the polymer into amorphous silica, by thermo-oxidative decomposition, prevented the decomposition of calcite. The obtained silica-bonded calcite scaffolds featured open porosity of about 56%-64% and compressive strength of about 2.9-5.5 MPa, depending on the geometry. Dissolution studies in SBF and preliminary cell culture tests, with bone marrow stromal cells, confirmed the in vitro bioactivity of the scaffolds and their biocompatibility. The seeded cells were found to be alive, well anchored and spread on the samples surface. The new silica-calcite composites are expected to be suitable candidates as tissue-engineering 3D scaffolds for regeneration of cancellous bone defects.
journal_name
Biofabricationjournal_title
Biofabricationauthors
Fiocco L,Elsayed H,Badocco D,Pastore P,Bellucci D,Cannillo V,Detsch R,Boccaccini AR,Bernardo Edoi
10.1088/1758-5090/aa6c37subject
Has Abstractpub_date
2017-05-11 00:00:00pages
025012issue
2eissn
1758-5082issn
1758-5090journal_volume
9pub_type
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