Abstract:
:Neuroblastoma is the most common extracranial solid tumor in childhood. Despite intense multimodal therapy and many improvements through basic scientific and clinical research, the successful response of advanced-stage patients to chemotherapy remains poor. Autophagy is a cytoprotective mechanism that may help advanced cancer cells survive stressful conditions such as chemotherapy. Here we review our recent findings describing HDAC10 as a promoter of autophagy-mediated survival in neuroblastoma cells and identifying this HDAC isozyme as a druggable regulator of advanced-stage tumor cell survival. These results propose a new and promising way to considerably improve treatment response in the neuroblastoma patient subgroup with the poorest outcome.
journal_name
Autophagyjournal_title
Autophagyauthors
Oehme I,Lodrini M,Brady NR,Witt Odoi
10.4161/auto.26450subject
Has Abstractpub_date
2013-12-01 00:00:00pages
2163-5issue
12eissn
1554-8627issn
1554-8635pii
26450journal_volume
9pub_type
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