Glycogen: the missing link in neuronal autophagy?

abstract：:Two primary forms of autophagy have been identified in the field of cancer therapy based on their apparent functions in the tumor cell; these are the cytoprotective form that could, in theory, be inhibited for the purpose of sensitization to radiation and chemotherapeutic drugs and the "cytotoxic" form that either med...

journal_title：Autophagy

authors： Gewirtz DA

更新日期：2013-09-01 00:00:00

abstract：:In yeast and mammals, selective vacuolar delivery and degradation of whole mitochondria, or mitophagy, represents an important quality control system and is achieved by a cargo recognition mechanism enabling selective elimination of dysfunctional mitochondria. As photosynthetic organelles that need light for energy pr...

journal_title：Autophagy

authors： Izumi M,Nakamura S

更新日期：2017-07-03 00:00:00

abstract：:The dysregulation of mitochondrial function has been implicated in the pathogenesis of Parkinson disease. Mutations in the parkin, PINK1 and DJ-1 genes all result in recessive parkinsonism. Although the protein products of these genes have not been fully characterized, it has been established that all three contribute...

journal_title：Autophagy

authors： McCoy MK,Cookson MR

更新日期：2011-05-01 00:00:00

abstract：:Mesenchymal stem cell (MSC) transplantation has been widely applied as a potential therapeutic for multiple diseases. However, the underlying therapeutic mechanisms are not fully understood, especially the paradox between the low survival rate of transplanted cells and the beneficial therapeutic effects generated by t...

journal_title：Autophagy

authors： Liu H,Liu S,Qiu X,Yang X,Bao L,Pu F,Liu X,Li C,Xuan K,Zhou J,Deng Z,Liu S,Jin Y

更新日期：2020-12-01 00:00:00

abstract：:The flank organ of the Syrian hamster, which shows a biodynamic response to androgen stimulation, is considered a good model for studying the androgen effect on sebaceous gland and hair. This organ is susceptible to programmed cell death (PCD), a prominent feature associated with sexual organ adjustment. We have recen...

journal_title：Autophagy

authors： Vega-Naredo I,Tomas-Zapico C,Coto-Montes A

更新日期：2009-02-01 00:00:00

abstract：:Survival of environmental stress conditions requires the maintenance of cellular homeostasis. To preserve this balance, cells utilize a degradative mechanism known as autophagy. During this process, in response to starvation or other stresses, bulk cytoplasm is non-specifically sequestered within double-membrane vesic...

journal_title：Autophagy

authors： Legakis JE,Yen WL,Klionsky DJ

更新日期：2007-09-01 00:00:00

abstract：:Glioblastoma is one of the most aggressive human cancers with poor prognosis, and therefore a critical need exists for novel therapeutic strategies for management of glioblastoma patients. Itraconazole, a traditional antifungal drug, has been identified as a novel potential anticancer agent due to its inhibitory effec...

journal_title：Autophagy

authors： Liu R,Li J,Zhang T,Zou L,Chen Y,Wang K,Lei Y,Yuan K,Li Y,Lan J,Cheng L,Xie N,Xiang R,Nice EC,Huang C,Wei Y

更新日期：2014-07-01 00:00:00

abstract：:Numerous cardiomyocytes were found to show autophagic vacuolar degeneration in the UM-X7.1 hamster model of human dilated cardiomyopathy, and autophagy-related proteins--i.e., ubiquitin, cathepsin D and Rab7--were upregulated in those hearts. Importantly, Evans blue-positive cardiomyocytes with leaky plasma membranes ...

journal_title：Autophagy

authors： Takemura G,Miyata S,Kawase Y,Okada H,Maruyama R,Fujiwara H

更新日期：2006-07-01 00:00:00

abstract：:Macroautophagy/autophagy involves the formation of an autophagosome, a double-membrane vesicle that delivers sequestered cytoplasmic cargo to lysosomes for degradation and recycling. Closely related, endocytosis mediates the sorting and transport of cargo throughout the cell, and both processes are important for cellu...

journal_title：Autophagy

authors： Palmisano NJ,Rosario N,Wysocki M,Hong M,Grant B,Meléndez A

更新日期：2017-10-03 00:00:00

abstract：:Cargo-based assays have proven invaluable in the study of macroautophagy in yeast and mammalian cells. Proteomic analysis of autolysosomes identified the metabolic enzyme, betaine homocysteine methyltransferase (BHMT), as a potential cargo-based, end-point marker for mammalian macroautophagy. To test whether degradati...

journal_title：Autophagy

authors： Mercer CA,Kaliappan A,Dennis PB

更新日期：2008-02-01 00:00:00

abstract：:Recent studies have suggested that autophagy is involved in a neural death pathway following cerebral ischemia. In vivo detection of autophagy could be important for evaluating ischemic neural cell damage for human stroke patients. Using novel green fluorescent protein (GFP)-fused microtubule-associated protein 1 ligh...

journal_title：Autophagy

authors： Tian F,Deguchi K,Yamashita T,Ohta Y,Morimoto N,Shang J,Zhang X,Liu N,Ikeda Y,Matsuura T,Abe K

更新日期：2010-11-01 00:00:00

abstract：:Flies expressing the most common Parkinson disease (PD)-related mutation, LRRK2-G2019S, in their dopaminergic neurons show loss of visual function and degeneration of the retina, including mitochondrial abnormalities, apoptosis and autophagy. Since the photoreceptors that degenerate are not dopaminergic, this demonstr...

journal_title：Autophagy

authors： Hindle SJ,Elliott CJ

更新日期：2013-06-01 00:00:00

abstract：:Target of rapamycin complex 1 (TORC1) is an evolutionarily conserved protein kinase complex, whose activation in response to nutrients suppresses autophagy. In mammalian cells, amino-acid stimuli induce lysosomal translocation and activation of MTORC1 through the RRAG GTPase heterodimer, which is tethered to the surfa...

journal_title：Autophagy

authors： Fukuda T,Shiozaki K

更新日期：2018-01-01 00:00:00

abstract：:Oxidative stress (OS) stimulates autophagy in different cellular systems, but it remains controversial if this rule can be generalized. We have analyzed the effect of chronic OS induced by the parkinsonian toxin paraquat (PQ) on autophagy in astrocytoma cells and primary astrocytes, which represent the first cellular ...

journal_title：Autophagy

authors： Janda E,Lascala A,Carresi C,Parafati M,Aprigliano S,Russo V,Savoia C,Ziviani E,Musolino V,Morani F,Isidoro C,Mollace V

更新日期：2015-01-01 00:00:00

abstract：:Degradation of intracellular components via macroautophagy is a complex multistep process that starts with the sequestration of cytosolic cargo in a de novo formed double-membrane vesicle or autophagosome. This compartment acquires the hydrolases required for cargo digestion by fusion with lysosomes. In contrast to th...

journal_title：Autophagy

authors： Koga H,Kaushik S,Cuervo AM

更新日期：2010-08-01 00:00:00

abstract：:The Syrian hamster Harderian gland (HG) is a juxtaorbital organ exhibiting marked gender-associated morphological differences. Regarding contents of porphyrins, this gland is a good model for studying physiological oxidative stress effects, since both sexes present strong (in females) and moderate (in males) levels of...

journal_title：Autophagy

authors： Coto-Montes A,Tomás-Zapico C

更新日期：2006-04-01 00:00:00

abstract：:The highly invasive and chemoresistant phenotype of pancreatic cancer highlights the urgency to identify prognostic biomarkers and novel therapeutic targets. Recently, we observed a significant correlation between shorter survival and loss of the cytoband 18q22.3. Here we investigated genes encoded by this cytoband, a...

journal_title：Autophagy

authors： Giovannetti E,Giaccone G

更新日期：2014-04-01 00:00:00

abstract：:Protein synthesis and autophagy work as two opposing processes to control cell growth in response to nutrient supply. The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) pathway, which acts as a master regulator to control protein synthesis, has recently been shown to inhibit autophagy by phosphorylating ...

journal_title：Autophagy

authors： Dunlop EA,Hunt DK,Acosta-Jaquez HA,Fingar DC,Tee AR

更新日期：2011-07-01 00:00:00

abstract：:Microglia are innate immune cells in the central nervous system (CNS), that supplies neurons with key factors for executing autophagosomal/lysosomal functions. Macroautophagy/autophagy is a cellular catabolic process that maintains cell balance in response to stress-related stimulation. Abnormal autophagy occurs with ...

journal_title：Autophagy

authors： Li Y,Zhou D,Ren Y,Zhang Z,Guo X,Ma M,Xue Z,Lv J,Liu H,Xi Q,Jia L,Zhang L,Liu Y,Zhang Q,Yan J,Da Y,Gao F,Yue J,Yao Z,Zhang R

更新日期：2019-03-01 00:00:00

abstract：:Park2/Parkin is a central mediator of selective mitochondrial autophagy for mitochondrial quality control. We showed in mouse hearts that PINK1/Mfn2/Park2 mediated generalized mitophagy is essential to the normal perinatal transition from fetal mitochondria that prefer carbohydrates as metabolic substrates to adult fa...

journal_title：Autophagy

authors： Dorn GW 2nd

更新日期：2016-01-01 00:00:00

abstract：:Alterations in contractile activity influence the intracellular homeostasis of muscle, which results in adaptations in the performance and the phenotype of this tissue. Denervation is an effective disuse model that functions to change the intracellular environment of muscle leading to a rapid loss in mass, a decrease ...

journal_title：Autophagy

authors： O'Leary MF,Hood DA

更新日期：2009-02-01 00:00:00

abstract：:Retinal ischemia is a major cause of vision loss and a common underlying mechanism associated with diseases, such as diabetic retinopathy and central retinal artery occlusion. We have previously demonstrated the robust neuroprotection in retina induced by post-conditioning (post-C), a brief period of ischemia, 24 h, f...

journal_title：Autophagy

authors： Mathew B,Chennakesavalu M,Sharma M,Torres LA,Stelman CR,Tran S,Patel R,Burg N,Salkovski M,Kadzielawa K,Seiler F,Aldrich LN,Roth S

更新日期：2020-05-26 00:00:00

abstract：:Hyperactivation of mechanistic target of rapamycin (MTOR) is a common feature of human cancers, and MTOR inhibitors, such as rapamycin, are thus becoming therapeutics in targeting certain cancers. However, rapamycin has also been found to compromise the efficacy of chemotherapeutics to cells with hyperactive MTOR. Her...

journal_title：Autophagy

authors： Wang Y,Hu Z,Liu Z,Chen R,Peng H,Guo J,Chen X,Zhang H

更新日期：2013-12-01 00:00:00

abstract：:Autophagosomes arise in yeast and animals from the sealing of a cup-shaped double-membrane precursor, the phagophore. The concerted action of about 30 evolutionarily conserved autophagy related (ATG) proteins lies at the core of this process. However, the mechanisms allowing phagophore generation and its differentiati...

journal_title：Autophagy

authors： Le Bars R,Marion J,Satiat-Jeunemaitre B,Bianchi MW

更新日期：2014-10-01 00:00:00

abstract：:The Pacific oyster, Crassostrea gigas, is a mollusk bivalve commercially important as a food source. Pacific oysters are subjected to stress and diseases during culture. The autophagy pathway is involved in numerous cellular processes, including responses to starvation, cell death, and microorganism elimination. Autop...

journal_title：Autophagy

authors： Picot S,Faury N,Arzul I,Chollet B,Renault T,Morga B

更新日期：2020-11-01 00:00:00

abstract：:An increasing body of data links endoplasmic reticulum (ER) function to autophagy. Not surprisingly, then, some aberrant proteins in the ER can be destroyed either via ER associated degradation (ERAD), which is proteasome-mediated, or via autophagy. One such substrate is the "Z" variant of the alpha-1 protease inhibit...

journal_title：Autophagy

authors： Brodsky JL,Scott CM

更新日期：2007-11-01 00:00:00

abstract：:The aging process drives the progressive deterioration of an organism and is thus subject to a complex interplay of regulatory and executing mechanisms. Our understanding of this process eventually aims at the delay and/or prevention of age-related pathologies, among them the age-dependent decrease in cognitive perfor...

journal_title：Autophagy

authors： Sigrist SJ,Carmona-Gutierrez D,Gupta VK,Bhukel A,Mertel S,Eisenberg T,Madeo F

更新日期：2014-01-01 00:00:00

abstract：:As a selective degradation system, chaperone-mediated autophagy (CMA) is essential for maintaining cellular homeostasis and survival under stress conditions. Increasing evidence points to an important role for the dysfunction of CMA in the pathogenesis of Parkinson disease (PD). However, the mechanisms by which CMA re...

journal_title：Autophagy

authors： Wang B,Cai Z,Tao K,Zeng W,Lu F,Yang R,Feng D,Gao G,Yang Q

更新日期：2016-08-02 00:00:00

abstract：:Tumor-associated inflammation is predictive of poor prognosis and drives a variety of tumorigenic phenotypes, including tumor proliferation and survival, angiogenesis, invasiveness, and metastasis. Here, we review mammalian data addressing the interaction of macroautophagy/autophagy with key signaling cascades associa...

journal_title：Autophagy

authors： Monkkonen T,Debnath J

更新日期：2018-01-01 00:00:00

abstract：:Autophagy is a conserved membrane trafficking pathway that mediates the delivery of cytoplasmic substrates to the lysosome for degradation. Impaired autophagic function is implicated in the pathology of various neurodegenerative diseases. We have generated transgenic C. elegans that express human beta-amyloid peptide ...

journal_title：Autophagy

authors： Florez-McClure ML,Hohsfield LA,Fonte G,Bealor MT,Link CD

更新日期：2007-11-01 00:00:00