Abstract:
:(Macro)autophagy is a membrane-trafficking process that serves to sequester cellular constituents in organelles termed autophagosomes, which target their degradation in the lysosome. Autophagy operates at basal levels in all cells where it serves as a homeostatic mechanism to maintain cellular integrity. The levels and cargoes of autophagy can, however, change in response to a variety of stimuli, and perturbations in autophagy are known to be involved in the aetiology of various human diseases. Autophagy must therefore be tightly controlled. We report here that the Drosophila cyclin-dependent kinase PITSLRE is a modulator of autophagy. Loss of the human PITSLRE orthologue, CDK11, initially appears to induce autophagy, but at later time points CDK11 is critically required for autophagic flux and cargo digestion. Since PITSLRE/CDK11 regulates autophagy in both Drosophila and human cells, this kinase represents a novel phylogenetically conserved component of the autophagy machinery.
journal_name
Autophagyjournal_title
Autophagyauthors
Wilkinson S,Croft DR,O'Prey J,Meedendorp A,O'Prey M,Dufès C,Ryan KMdoi
10.4161/auto.7.11.16646subject
Has Abstractpub_date
2011-11-01 00:00:00pages
1295-301issue
11eissn
1554-8627issn
1554-8635pii
16646journal_volume
7pub_type
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