Disease relevance of phosphorylated ubiquitin (p-S65-Ub).

abstract：:Macroautophagy/autophagy is a conserved catabolic process that maintains cellular homeostasis under basal growth and stress conditions. In cancer, autophagy can either prevent or promote tumor growth, at early or advanced stages, respectively. We screened public databases to identify autophagy-related somatic mutation...

journal_title：Autophagy

authors： Nuta GC,Gilad Y,Gershoni M,Sznajderman A,Schlesinger T,Bialik S,Eisenstein M,Pietrokovski S,Kimchi A

更新日期：2019-03-01 00:00:00

abstract：:We have previously shown that Kaposi sarcoma-associated herpesvirus (KSHV) impairs monocyte differentiation into dendritic cells (DCs). Macroautophagy/autophagy has been reported to be essential in such a differentiating process. Here we extended these studies and found that the impairment of DC formation by KSHV occu...

journal_title：Autophagy

authors： Santarelli R,Granato M,Pentassuglia G,Lacconi V,Gilardini Montani MS,Gonnella R,Tafani M,Torrisi MR,Faggioni A,Cirone M

更新日期：2016-12-01 00:00:00

abstract：:Autophagy acts as an intrinsic defense system against intracellular bacterial survival. Recently, multiple cellular pathways that target intracellular bacterial pathogens to autophagy have been described. These include the Atg5/LC3 pathway, which targets Shigella, the ubiquitin (Ub)-NDP52-LC3 pathway, which targets Gr...

journal_title：Autophagy

authors： Ogawa M,Yoshikawa Y,Mimuro H,Hain T,Chakraborty T,Sasakawa C

更新日期：2011-03-01 00:00:00

abstract：:Premenopausal women have better survival than men after intracerebral hemorrhage, which is associated with iron overproduction and autophagy induction. To examine the participation of neuronal autophagy and estrogen receptor α (ERα) in the E 2-mediated protection, PC12 neurons treated with Atg7 (autophagy-related prot...

journal_title：Autophagy

authors： Chen CW,Chen TY,Tsai KL,Lin CL,Yokoyama KK,Lee WS,Chiueh CC,Hsu C

更新日期：2012-10-01 00:00:00

abstract：:Loss-of-function mutations in PARK2/PARKIN and PINK1 cause early-onset autosomal recessive Parkinson disease (PD). The cytosolic E3 ubiquitin-protein ligase PARK2 cooperates with the mitochondrial kinase PINK1 to maintain mitochondrial quality. A loss of mitochondrial transmembrane potential (ΔΨ) leads to the PINK1-de...

journal_title：Autophagy

authors： Bertolin G,Ferrando-Miguel R,Jacoupy M,Traver S,Grenier K,Greene AW,Dauphin A,Waharte F,Bayot A,Salamero J,Lombès A,Bulteau AL,Fon EA,Brice A,Corti O

更新日期：2013-11-01 00:00:00

abstract：:The acetylase inhibitor, spermidine and the deacetylase activator, resveratrol, both induce autophagy and prolong life span of the model organism Caenorhabditis elegans in an autophagydependent fashion. Based on these premises, we investigated the differences and similarities in spermidine and resveratrol-induced auto...

journal_title：Autophagy

authors： Mariño G,Morselli E,Bennetzen MV,Eisenberg T,Megalou E,Schroeder S,Cabrera S,Bénit P,Rustin P,Criollo A,Kepp O,Galluzzi L,Shen S,Malik SA,Maiuri MC,Horio Y,López-Otín C,Andersen JS,Tavernarakis N,Madeo F,Kroemer G

更新日期：2011-06-01 00:00:00

abstract：:The two structurally related, major lysosomal membrane proteins LAMP-1 and LAMP-2 were for a long time regarded as crucial for the protection of the lysosomal membrane from the hostile lumenal environment. However, recent studies on the effects of single and combined LAMP-deficiency in mice reveal alternative function...

journal_title：Autophagy

authors： Saftig P,Beertsen W,Eskelinen EL

更新日期：2008-05-01 00:00:00

abstract：:Ferroptosis is a form of regulated cell death caused by iron accumulation and oxidative injury. BECN1 is a key regulator of macroautophagy/autophagy, a catabolic process of degradation induced by starvation or other stressors. Our recent findings reveal a novel alternative mechanism by which BECN1 can promote ferropto...

journal_title：Autophagy

authors： Kang R,Zhu S,Zeh HJ,Klionsky DJ,Tang D

更新日期：2018-01-01 00:00:00

abstract：:IRGM is a genetic risk factor for several autoimmune diseases. However, the mechanism of IRGM-mediated protection in autoimmunity remains undetermined. The abnormal activation of type I interferon (IFN) response is one of the significant factors in the pathogenesis of several autoimmune diseases. In our recent study, ...

journal_title：Autophagy

authors： Nath P,Jena KK,Mehto S,Chauhan NR,Sahu R,Dhar K,Srinivas K,Chauhan S,Chauhan S

更新日期：2020-08-19 00:00:00

abstract：:A hallmark of macroautophagy is the formation of autophagosomes, double-membrane vesicles that enwrap cellular components destined for lysosomal degradation. We examined autophagosomal protein dynamics under various inducing stimuli using a comprehensive mass spectrometry-based proteomics approach in combination with ...

journal_title：Autophagy

authors： Becker AC,Bunkenborg J,Eisenberg T,Harder LM,Schroeder S,Madeo F,Andersen JS,Dengjel J

更新日期：2012-06-01 00:00:00

abstract：:Infection and inflammation are able to induce diet-independent Na+-accumulation without commensurate water retention in afflicted tissues, which favors the pro-inflammatory activation of mouse macrophages and augments their antibacterial and antiparasitic activity. While Na+-boosted host defense against the protozoan ...

journal_title：Autophagy

authors： Neubert P,Weichselbaum A,Reitinger C,Schatz V,Schröder A,Ferdinand JR,Simon M,Bär AL,Brochhausen C,Gerlach RG,Tomiuk S,Hammer K,Wagner S,van Zandbergen G,Binger KJ,Müller DN,Kitada K,Clatworthy MR,Kurts C,Titze J,

更新日期：2019-11-01 00:00:00

abstract：:Aged and damaged mitochondria can be selectively degraded by specific autophagic elimination, termed mitophagy. Defects in mitophagy have been increasingly linked to several diseases including neurodegenerative diseases, metabolic diseases and other aging-related diseases. However, the molecular mechanisms of mitophag...

journal_title：Autophagy

authors： Xu G,Li T,Chen J,Li C,Zhao H,Yao C,Dong H,Wen K,Wang K,Zhao J,Xia Q,Zhou T,Zhang H,Gao P,Li A,Pan X

更新日期：2018-01-01 00:00:00

abstract：:Phosphoinositides (PIs) are a group of low-abundance phospholipids that play a critical role in the control of organelle and membrane traffic. There is strong evidence that specific PIs are also important for the regulation of autophagy. PIs are modified by a complex network of lipid kinases and phosphatases. A recent...

journal_title：Autophagy

authors： Gibbs EM,Feldman EL,Dowling JJ

更新日期：2010-08-01 00:00:00

abstract：:Preclinical studies indicate autophagy inhibition with hydroxychloroquine (HCQ) can augment the efficacy of DNA-damaging therapy. The primary objective of this trial was to determine the maximum tolerated dose (MTD) and efficacy of HCQ in combination with radiation therapy (RT) and temozolomide (TMZ) for newly diagnos...

journal_title：Autophagy

authors： Rosenfeld MR,Ye X,Supko JG,Desideri S,Grossman SA,Brem S,Mikkelson T,Wang D,Chang YC,Hu J,McAfee Q,Fisher J,Troxel AB,Piao S,Heitjan DF,Tan KS,Pontiggia L,O'Dwyer PJ,Davis LE,Amaravadi RK

更新日期：2014-08-01 00:00:00

abstract：:Autophagy is a highly conserved degradation pathway for intracellular macromolecules and organelles. Among those characterized autophagy regulators, the ubiquitin-like protein Atg8 is found to be a membrane modifier that both regulates biogenesis of transport vesicles and interacts with the cargo receptor Atg19 for se...

journal_title：Autophagy

authors： Ho KH,Chang HE,Huang WP

更新日期：2009-05-01 00:00:00

abstract：:Autophagy describes the degradation of unnecessary or dysfunctional cellular components through the lysosomal machinery. Autophagy is essentially required to prevent accumulation of cellular damage and to ensure cellular homeostasis. Indeed, impaired autophagy has been implicated in a variety of different diseases. We...

journal_title：Autophagy

authors： Lin NY,Stefanica A,Distler JH

更新日期：2013-08-01 00:00:00

abstract：:Macroautophagy/autophagy, an evolutionarily conserved eukaryotic bioprocess, plays an important role in the bulk degradation of intracellular macromolecules, organelles, and invading pathogens. PIK3C3/VPS34 (phosphatidylinositol 3-kinase catalytic subunit type 3) functions as a key protein in autophagy initiation and ...

journal_title：Autophagy

authors： Xie W,Jin S,Cui J

更新日期：2020-06-01 00:00:00

abstract：:The class III phosphatidylinositol (PtdIns)-3 kinase, PIK3C3/VPS34, forms multiple complexes and regulates a variety of cellular functions, especially in intracellular vesicle trafficking and autophagy. Even though PtdIns3P, the product of PIK3C3, is thought to be a critical membrane marker for the autophagosome, it i...

journal_title：Autophagy

authors： Kim J,Guan KL

更新日期：2013-07-01 00:00:00

abstract：:Autophagy is a complex, multi-step and biologically important pathway mediated by autophagosomes and autolysosomes. Accurately dissecting and detecting different stages of autophagy is important to elucidate its molecular mechanism and thereby facilitate the discovery of pharmaceutical molecules. We herein reported a ...

journal_title：Autophagy

authors： Chen JJ,Jing J,Chang H,Rong Y,Hai Y,Tang J,Zhang JL,Xu P

更新日期：2013-06-01 00:00:00

abstract：:Mitochondria are the primary site of energy production in animal cells. In mitochondria, the flow of electrons through the electron transport chain creates a potential difference across the inner membrane, which is utilized for ATP production. However, due to inherent inefficiencies in electron transport, reactive oxy...

journal_title：Autophagy

authors： Zhang J,Ney PA

更新日期：2010-04-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) have fewer and immature mitochondria than somatic cells and mainly rely on glycolysis for energy source. During somatic cell reprogramming, somatic mitochondria and other organelles get remodeled. However, events of organelle remodeling and interaction during somatic cell reprogr...

journal_title：Autophagy

authors： Xiang G,Yang L,Long Q,Chen K,Tang H,Wu Y,Liu Z,Zhou Y,Qi J,Zheng L,Liu W,Ying Z,Fan W,Shi H,Li H,Lin X,Gao M,Liu J,Bao F,Li L,Duan L,Li M,Liu X

更新日期：2017-09-02 00:00:00

abstract：:(Macro)autophagy is a membrane-trafficking process that serves to sequester cellular constituents in organelles termed autophagosomes, which target their degradation in the lysosome. Autophagy operates at basal levels in all cells where it serves as a homeostatic mechanism to maintain cellular integrity. The levels an...

journal_title：Autophagy

authors： Wilkinson S,Croft DR,O'Prey J,Meedendorp A,O'Prey M,Dufès C,Ryan KM

更新日期：2011-11-01 00:00:00

abstract：:Many recent studies indicate that dysregulation of autophagy is a common feature of many neurodegenerative diseases. The HIV-1-associated neurological disorder is an acquired cognitive and motor disease that includes a severe neurodegenerative dementia. We find that the neurodegeneration seen in the brain in HIV-1 inf...

journal_title：Autophagy

authors： Alirezaei M,Kiosses WB,Fox HS

更新日期：2008-10-01 00:00:00

abstract：:Efavirenz (EFV) is the most widely used non-nucleoside reverse transcriptase inhibitor applied in highly active antiretroviral therapy (HAART), the combined pharmacological treatment of the human immunodeficiency virus infection. Its use has been associated with the development of several adverse events including hepa...

journal_title：Autophagy

authors： Apostolova N,Gomez-Sucerquia LJ,Gortat A,Blas-Garcia A,Esplugues JV

更新日期：2011-11-01 00:00:00

abstract：:Autophagy is a cellular degradation process with an increasingly recognised importance in many biological pathways such as nutrient sensing, stress responses and development. We present a straightforward assay for autophagy which combines the sensitivity of the EGFP-LC3 reporter protein with the throughput capacity an...

journal_title：Autophagy

authors： Eng KE,Panas MD,Karlsson Hedestam GB,McInerney GM

更新日期：2010-07-01 00:00:00

abstract：:While autophagy is believed to be beneficial for life-span extension, it is controversial which forms or aspects of autophagy are responsible for this effect. We addressed this topic by analyzing the life span of yeast autophagy mutants under caloric restriction, a longevity manipulation. Surprisingly, we discovered t...

journal_title：Autophagy

authors： Tang F,Watkins JW,Bermudez M,Gray R,Gaban A,Portie K,Grace S,Kleve M,Craciun G

更新日期：2008-10-01 00:00:00

abstract：:The aging process drives the progressive deterioration of an organism and is thus subject to a complex interplay of regulatory and executing mechanisms. Our understanding of this process eventually aims at the delay and/or prevention of age-related pathologies, among them the age-dependent decrease in cognitive perfor...

journal_title：Autophagy

authors： Sigrist SJ,Carmona-Gutierrez D,Gupta VK,Bhukel A,Mertel S,Eisenberg T,Madeo F

更新日期：2014-01-01 00:00:00

abstract：:Autophagy helps to maintain cellular homeostasis by removing misfolded proteins and damaged organelles, and generally acts as a cytoprotective mechanism for neuronal survival. Here we showed that mice deficient in the Vici syndrome gene Epg5, which is required for autophagosome maturation, show accumulation of ubiquit...

journal_title：Autophagy

authors： Miao G,Zhao YG,Zhao H,Ji C,Sun H,Chen Y,Zhang H

更新日期：2016-12-01 00:00:00

abstract：:Autophagy genes were first identified in the yeast system and some of their mammalian orthologues have also been characterized. Increasing lines of evidence indicate that various intracellular proteins, including G proteins, mammalian target of rapamycin (mTor) and Pl3K/Akt/PKB, of transmembrane signaling pathways are...

journal_title：Autophagy

authors： Jia G,Cheng G,Agrawal DK

更新日期：2007-01-01 00:00:00

abstract：:In a recent paper we addressed the mechanism by which defective autophagy contributes to TARDBP/TDP-43-mediated neurodegenerative disorders. We demonstrated that TARDBP regulates MTORC1-TFEB signaling by targeting RPTOR/raptor, a key component and an adaptor protein of MTORC1. Loss of TARDBP decreased the mRNA stabili...

journal_title：Autophagy

authors： Ying Z,Xia Q,Hao Z,Xu D,Wang M,Wang H,Wang G

更新日期：2016-01-01 00:00:00