Abstract:
:Macroautophagy/autophagy, an evolutionarily conserved eukaryotic bioprocess, plays an important role in the bulk degradation of intracellular macromolecules, organelles, and invading pathogens. PIK3C3/VPS34 (phosphatidylinositol 3-kinase catalytic subunit type 3) functions as a key protein in autophagy initiation and progression. The activity of PIK3C3 is tightly regulated by multiple post-translational modifications, including ubiquitination, however, the regulatory mechanisms underpinning the reversible deubiquitination of PIK3C3 remain poorly understood. Recently, we identified the E3 ubiquitin ligase NEDD4/NEDD4-1 as a positive regulator of autophagy through decreasing the K48-linked ubiquitination of PIK3C3 by recruiting USP13.
journal_name
Autophagyjournal_title
Autophagyauthors
Xie W,Jin S,Cui Jdoi
10.1080/15548627.2020.1743071subject
Has Abstractpub_date
2020-06-01 00:00:00pages
1150-1151issue
6eissn
1554-8627issn
1554-8635journal_volume
16pub_type
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