Abstract:
:The aging process drives the progressive deterioration of an organism and is thus subject to a complex interplay of regulatory and executing mechanisms. Our understanding of this process eventually aims at the delay and/or prevention of age-related pathologies, among them the age-dependent decrease in cognitive performance (e.g., learning and memory). Using the fruit fly Drosophila melanogaster, which combines a generally high mechanistic conservation with an efficient experimental access regarding aging and memory studies, we have recently unveiled a protective function of polyamines (including spermidine) against age-induced memory impairment (AMI). The flies' age-dependent decline of aversive olfactory memory, an established model for AMI, can be rescued by both pharmacological treatment with spermidine and genetic modulation that increases endogenous polyamine levels. Notably, we find that this effect strictly depends on autophagy, which is remarkable in light of the fact that autophagy is considered a key regulator of aging in other contexts. Given that polyamines in general and spermidine in particular are endogenous metabolites, our findings place them as candidate target substances for AMI treatment.
journal_name
Autophagyjournal_title
Autophagyauthors
Sigrist SJ,Carmona-Gutierrez D,Gupta VK,Bhukel A,Mertel S,Eisenberg T,Madeo Fdoi
10.4161/auto.26918subject
Has Abstractpub_date
2014-01-01 00:00:00pages
178-9issue
1eissn
1554-8627issn
1554-8635pii
26918journal_volume
10pub_type
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