Abstract:
:In macroautophagy (hereafter autophagy), a morphological hallmark is the formation of double-membrane vesicles called autophagosomes that sequester and deliver cytoplasmic components to the lysosome/vacuole for degradation. This process begins with an initial sequestering compartment, the phagophore, which expands into the mature autophagosome. A tremendous amount of work has been carried out to elucidate the mechanism of how the autophagosome is formed. However, an important missing piece in this puzzle is where the membrane comes from. Independent lines of evidence have shown that preexisting organelles may continuously supply lipids to support autophagosome formation. In our analysis, we identified several components of the late stage secretory pathway that may redirect Golgi-derived membrane to autophagosome formation in response to starvation conditions.
journal_name
Autophagyjournal_title
Autophagyauthors
Geng J,Klionsky DJdoi
10.4161/auto.6.7.13009subject
Has Abstractpub_date
2010-10-01 00:00:00pages
950-1issue
7eissn
1554-8627issn
1554-8635pii
13009journal_volume
6pub_type
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