Abstract:
:Autophagy is a process of bulk protein degradation and organelle turnover, and is a current therapeutic target in several diseases. The present study aimed to clarify the significance of myocardial autophagy of patients with dilated cardiomyopathy (DCM). Left ventricular endomyocardial biopsy was performed in 250 consecutive patients with DCM (54.9±13.9 years; male, 79%), initially presenting with decompensated heart failure (HF). The association of these findings with HF mortality or recurrence was examined. Myofilament changes, which are apparent in the degenerated cardiomyocytes of DCM, were recognized in 164 patients (66%), and autophagic vacuoles in cardiomyocytes were identified in or near the area of myofilament changes in 86 patients (34%). Morphometrically, fibrosis (odds ratio [OR], 0.96; 95% confidence interval [CI], 0.93 to 0.99) and mitochondrial abnormality (OR, 2.24; 95% CI, 1.23 to 4.08) were independently related with autophagic vacuoles. During the follow-up period of 4.9±3.9 y, 24 patients (10%) died, including 10 (4%) who died of HF, and 67 (27%) were readmitted for HF recurrence. Multivariate analysis identified a family history of DCM (hazard ratio [HR], 2.117; 95% CI, 1.199 to 3.738), hemoglobin level (HR, 0.845; 95% CI, 0.749 to 0.953), myofilament changes (HR, 13.525; 95% CI, 5.340 to 34.255), and autophagic vacuoles (HR, 0.214; 95% CI, 0.114 to 0.400) as independent predictors of death or readmission due to HF recurrence. In conclusion, autophagic vacuoles in cardiomyocytes are associated with a better HF prognosis in patients with DCM, suggesting autophagy may play a role in the prevention of myocardial degeneration.
journal_name
Autophagyjournal_title
Autophagyauthors
Saito T,Asai K,Sato S,Hayashi M,Adachi A,Sasaki Y,Takano H,Mizuno K,Shimizu Wdoi
10.1080/15548627.2016.1145326subject
Has Abstractpub_date
2016-01-01 00:00:00pages
579-87issue
3eissn
1554-8627issn
1554-8635journal_volume
12pub_type
杂志文章相关文献
Autophagy文献大全abstract::Nanotechnology is the control and manipulation of materials in the size range of 1-100 nm. Due to increasing research into the potential beneficial applications of nanotechnology, there is an urgent need for the study of possible health risks. Several researchers, including those in our laboratory, have demonstrated e...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7142
更新日期:2008-11-01 00:00:00
abstract::The islet in type 2 diabetes mellitus (T2DM) is characterized by a deficit in β-cells and increased β-cell apoptosis attributable at least in part to intracellular toxic oligomers of IAPP (islet amyloid polypeptide). β-cells of individuals with T2DM are also characterized by accumulation of polyubiquitinated proteins ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.28478
更新日期:2014-06-01 00:00:00
abstract::Hyperactivation of mechanistic target of rapamycin (MTOR) is a common feature of human cancers, and MTOR inhibitors, such as rapamycin, are thus becoming therapeutics in targeting certain cancers. However, rapamycin has also been found to compromise the efficacy of chemotherapeutics to cells with hyperactive MTOR. Her...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.26447
更新日期:2013-12-01 00:00:00
abstract::In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle. However, while SIRT5 is ubiquitously expressed, urea cycle and CPS1 are only present in the liver and, to a minor extent, in the kidney. To address the possibility that SIRT5 is involved i...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2015.1009778
更新日期:2015-01-01 00:00:00
abstract::Significant progress has been made over recent years in defining the normal progression and regulation of autophagy, particularly in cultured mammalian cells and yeast model systems. However, apart from a few notable exceptions, our understanding of the physiological roles of autophagy has lagged behind these advances...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.4161/auto.5782
更新日期:2008-07-01 00:00:00
abstract::Autophagy is a catabolic process employed by eukaryotes to degrade and recycle intracellular components. When this pathway is induced by starvation conditions, part of the cytoplasm and organelles are sequestered into double-membrane vesicles called autophagosomes, and delivered into the lysosome/vacuole for degradati...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6657
更新日期:2008-10-01 00:00:00
abstract::Salinomycin is perhaps the first promising compound that was discovered through high throughput screening in cancer stem cells. This novel agent can selectively eliminate breast and other cancer stem cells, though the mechanism of action remains unclear. In this study, we found that salinomycin induced autophagy in hu...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.24632
更新日期:2013-07-01 00:00:00
abstract::Autophagosome formation depends on a carefully orchestrated interplay between membrane-associated protein complexes. Initiation of macroautophagy/autophagy is mediated by the ULK1 (unc-51 like autophagy activating kinase 1) protein kinase complex and the autophagy-specific class III phosphatidylinositol 3-kinase compl...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1581009
更新日期:2019-08-01 00:00:00
abstract::Recent studies have suggested that autophagy is involved in a neural death pathway following cerebral ischemia. In vivo detection of autophagy could be important for evaluating ischemic neural cell damage for human stroke patients. Using novel green fluorescent protein (GFP)-fused microtubule-associated protein 1 ligh...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6.8.13427
更新日期:2010-11-01 00:00:00
abstract::Selective autophagy is critical for the regulation of cellular homeostasis in organisms from yeast to humans. This process is a specific degradation pathway for a wide variety of substrates including unwanted cytosolic components, such as protein aggregates, damaged and/or superfluous organelles, and pathogens. Howeve...
journal_title:Autophagy
pub_type: 社论
doi:10.1080/15548627.2020.1798199
更新日期:2020-10-01 00:00:00
abstract::Inhibition of the autophagic pathway has recently revealed promising results in increasing pro-death activity of multiple cancer therapeutics. Here, we discuss our findings regarding the autophagy-blocking and anti-neoplastic effects of a synthetic sphingosine analog, FTY720, in mantle cell lymphoma (MCL). We also emp...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.19050
更新日期:2012-03-01 00:00:00
abstract::Microtubule-associated protein light chain 3 (LC3) is now widely used to monitor autophagy. One approach is to detect LC3 conversion (LC3-I to LC3-II) by immunoblot analysis because the amount of LC3-II is clearly correlated with the number of autophagosomes. However, LC3-II itself is degraded by autophagy, making int...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.4161/auto.4600
更新日期:2007-11-01 00:00:00
abstract::Autophagy resembles a recycling process in which proteins, organelles, or regions of the cytoplasm are enveloped and degraded. We have found that two of the central autophagy proteins, MAP1LC3 (microtubule-associated protein 1 light chain 3, also described as LC3) and UVRAG (UV radiation resistance associated/UV radia...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.25889
更新日期:2013-10-01 00:00:00
abstract::Autophagy describes the degradation of unnecessary or dysfunctional cellular components through the lysosomal machinery. Autophagy is essentially required to prevent accumulation of cellular damage and to ensure cellular homeostasis. Indeed, impaired autophagy has been implicated in a variety of different diseases. We...
journal_title:Autophagy
pub_type: 评论,杂志文章
doi:10.4161/auto.25467
更新日期:2013-08-01 00:00:00
abstract::Autophagy is a degradation pathway for the turnover of dysfunctional organelles or aggregated proteins in cells. Extracellular accumulation of beta-amyloid peptide has been reported to be a major cause of Alzheimer disease (AD) and large numbers of autophagic vacuoles accumulate in the brain of AD patient. However, ho...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.5.4.8096
更新日期:2009-05-01 00:00:00
abstract::Mitochondria are the primary site of energy production in animal cells. In mitochondria, the flow of electrons through the electron transport chain creates a potential difference across the inner membrane, which is utilized for ATP production. However, due to inherent inefficiencies in electron transport, reactive oxy...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6.3.11245
更新日期:2010-04-01 00:00:00
abstract::Mitochondrial morphological and structural changes play a role in several cellular processes, including apoptosis. We recently reported that mitochondrial elongation is also critical to sustain cell viability during macroautophagy. During macroautophagy unopposed mitochondrial fusion leads to organelle elongation both...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.10.16771
更新日期:2011-10-01 00:00:00
abstract::Macroautophagy is induced under various stresses to remove cytotoxic materials, including misfolded proteins and their aggregates. These protein cargoes are collected by specific autophagic receptors such as SQSTM1/p62 (sequestosome 1) and delivered to phagophores for lysosomal degradation. To date, little is known ab...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2018.1491212
更新日期:2018-01-01 00:00:00
abstract::Dysfunction of macroautophagy/autophagy has been postulated as a major cellular toxicological response to nanomaterials. It has been reported that excessive autophagy activation, induced by silica nanoparticles (SiNPs), contributes to autophagy dysfunction, whereas little is known how SiNPs trigger autophagy activatio...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1763019
更新日期:2020-05-23 00:00:00
abstract::Single microRNA (miRNA) can regulate expression of several or multiple principal targets in a specific microenvironment. In different cellular contexts, the same miRNA may exhibit diverse functions, depending on the repertoire and stoichiometry of its direct mRNA targets. For instance, in breast cancer, microRNA-10b (...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.11.17371
更新日期:2011-11-01 00:00:00
abstract::The role of autophagy, a catabolic lysosome-dependent pathway, has recently been recognized in a variety of disorders, including Pompe disease, which results from a deficiency of the glycogen-degrading lysosomal hydrolase acid-alpha glucosidase (GAA). Skeletal and cardiac muscle are most severely affected by the progr...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.5.1.7293
更新日期:2009-01-01 00:00:00
abstract::The Syrian hamster Harderian gland (HG) is a juxtaorbital organ exhibiting marked gender-associated morphological differences. Regarding contents of porphyrins, this gland is a good model for studying physiological oxidative stress effects, since both sexes present strong (in females) and moderate (in males) levels of...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.2.2.2351
更新日期:2006-04-01 00:00:00
abstract::Under stress conditions cells activate different response pathways which result in cell survival or apoptosis depending on: (1) the nature of the insults, (2) the type, if acute or chronic stress, and (3) how long the stress persists. Generally, autophagy is induced early to sustain cell survival and inhibit cell deat...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.20671
更新日期:2012-08-01 00:00:00
abstract::Burkholderia pseudomallei is the causative agent of melioidosis, a tropical infection of humans and other animals. The bacterium is an intracellular pathogen that can escape from endosomes into the host cytoplasm, where it replicates and infects adjacent cells. We investigated the role played by autophagy in the intra...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6246
更新日期:2008-08-01 00:00:00
abstract::Genetic inactivation of PTEN through either gene deletion or mutation is common in metastatic prostate cancer, leading to activation of the phosphoinositide 3-kinase (PI3K-AKT) pathway, which is associated with poor clinical outcomes. The PI3K-AKT pathway plays a central role in various cellular processes supporting c...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.24921
更新日期:2013-07-01 00:00:00
abstract::We have reported in a variety of mammalian cells the reversible formation of a filamentous actin (F-actin)-enriched aggresome generated by the actin toxin jasplakinolide (Lázaro-Diéguez et al., J Cell Sci 2008; 121:1415-25). Notably, this F-actin aggresome (FAG) resembles in many aspects the pathological Hirano body, ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6345
更新日期:2008-07-01 00:00:00
abstract::In the fungal pathogen Fusarium oxysporum, vegetative hyphal fusion triggers nuclear mitotic division in the invading hypha followed by migration of a nucleus into the receptor hypha and degradation of the resident nucleus. Here we examined the role of autophagy in fusion-induced nuclear degradation. A search of the F...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/15548627.2014.994413
更新日期:2015-01-01 00:00:00
abstract::The vascular system of plants consists of two conducting tissues, xylem and phloem, which differentiate from procambium cells. Xylem serves as a transporting system for water and signaling molecules and is formed by sequential developmental processes, including cell division/expansion, secondary cell wall deposition, ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6.8.13429
更新日期:2010-11-01 00:00:00
abstract::Deficiency in decidualization has been widely regarded as an important cause of spontaneous abortion. Generalized decidualization also includes massive infiltration and enrichment of NK cells. However, the underlying mechanism of decidual NK (dNK) cell residence remains largely unknown. Here, we observe that the incre...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1833515
更新日期:2020-11-01 00:00:00
abstract::We have previously shown that Kaposi sarcoma-associated herpesvirus (KSHV) impairs monocyte differentiation into dendritic cells (DCs). Macroautophagy/autophagy has been reported to be essential in such a differentiating process. Here we extended these studies and found that the impairment of DC formation by KSHV occu...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1235122
更新日期:2016-12-01 00:00:00